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-Introduction- BIO-NANO TECH IN USA

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  • 1. -Introduction- BIO-NANO TECH IN USA 在台公司 . 醫妍膚品生技企業行 高雄市 81366 左營區富民路 422-1 號 TEL:+886-7-556-3370 FAX:+886-7-558-2841
  • 2. Brand Story MLE GOWOONSESANG is an anti-aging product of NeoPharm for sensitive skin. New paradigm of skin science “MLE” and scientific know how of GOWOONSESANG clinic cosmetics for skin care meet new & unique skin physiology activator, K5. This will provide the customers with the differentiated product, faith and trust.
  • 3. MLE – an Another Skin Ref. Journal of Investigative Dermatology, 121:794-801,2003 The skin barrier function weaken with the age. The stratum corneum is the most important for skin barrier function, which is composed of corneocyte and lamellar structured intercellular lipids. 1) The disturbance of lamellar structure of intercellular lipid is main reason of the weakness of skin barrier function, resulted in sensitive and dry skin, make accelerate the skin ageing. The lamellar structure show very characteristic “Maltese cross” texture under cross polarized microscope. Maltese cross was the symbol of Christian warriors known as the Knights Hospitaller. 2) Recently, skin science have tried to make same lamellar structure with the that of the skin because the well-ordered lamellar is very important for healthy and beautiful skin. NeoPharm developed the same lamellar structure with that of skin. It shows “Maltese Cross” texture under cross polarized microscope, 3) show the same lamellar patterns with that of skin. 4) MLE has same structure with skin, show high compatibility with skin. It is “an Another skin” because it recover skin barrier function of sensitive and dry skin due to the ageing and results in healthy and beautiful skin give the skin barrier function. 1) Lamellar structure of skin lipid 4) Lamellar structure of MLE 2) “Maltese Cross” of Skin lipid 3) “Maltese cross” of MLE
  • 4. “ NeoPharm, a Korean company that makes a skin care line called ATOPALM, has taken it a step further. They have proven that their moisturizer is able to mimic the same three- dimensional structure that your native skin barrier has.” Ref. Skin Type Solution by MD. Leslie Baumann, Random House p.360 (2006) NeoPharm’s MLE is “new Paradigm of Skin Science” which was credited internationally. CERANADE (U.S.A) K2 Shaving Product (UK) “ MLE” c redited by Dr. Baumann from Miami Univ in USA MLE – New Paradigm of Skin Science -MLE in the World-
  • 5. Annals of Dermatology Journal of Investigative Dermatology Russian Journal of Dermatology World congress of Dermatology(Paris) Bulletin of Chem Technology Cosmetics & Toiletry Annual meeting of society of Investigative Dermatology Korean Journal of Skin Barrier Research Korean society of Cosmetic Dermatology MLE – Public confidence
  • 6. GWSS – Representative Cosmeceutical Brand GOWOONSESANG is, based on the best infrastructure of medical skin care in which 8 medical doctors, 43 skin specialists, 114 nurses and 110 aestheticians specializing in skin in the GOWOONSESANG dermatology are all participating in the development, aiming at the top representative Cosmeceutical brand in Korea. Based on the understanding for the actual visiting customers’ skin troubles, this reliable product developed by participation of skin specialists and the customers has been loved not only by the customers in Korea but by those in Japan, Hong Kong and South East Asia. “ GOWOONSESANG”
  • 7. MLE GOWOONSESANG is a fusion brand of MLE that is New paradigm for skin care science credited worldwide and GOWOONSESANG Cosmetics that is a leader in medical skin care field, based on the counseling by dermatologists and skincare specialists MLE New Paradigm of Skin Science GOWOONSESANG Medical Skincare (Cosmeceutical) MLE - GOWOONSESANG “ Sensitive Anti-Aging 1 st Century with MLE GOWOONSESANG”
  • 8. Recommended Anti-Aging care by Ph.D.Ahn Recommended by Ph.D. Ahn of Gowoosesang “ Professional Anti-Aging care” As the skin aging starts to make steady progress since one’s thirties, most of women are complaining the skin troubles like dryness, wrinkles, skin pigmentation problems, sensitiveness and friableness etc. This is because the skin elasticity becomes lower and the skin barrier of epidermis is weakened, the skin becomes dry and sensitive and the skin functions are damaged from ultraviolet rays. Especially for the sensitive skin, the skin barrier function are weaker than that of the healthy and beautiful skin, it can accelerate ageing process of sensitiveness and dryness skin. Women are also complaining the difficulties of anti-aging care because of the skin-irritation from the existing anti-aging products. So, in case of anti-aging care for sensitive skin, it is more important to care the recovery skin barrier function from the damaged skin barrier, considering the peculiarities of sensitive skin. On the outside, we should prevent continuously from the sensitiveness and dryness of epidermis and on the inside we should care the anti-aging carefully to provide the dermis with the functional activation through low-irritation functional material, in combination.
  • 9. Solution for sensitive anti-ageing The collaborative research staffs of MLE GOWOONSESANG pay attention to troubles are like sensitization, dryness, over keratinization, friableness, wrinkles and oxidation. We present solutions for sensitive anti-ageing through K5 and MLE technology. K5 is new & unique skin physiology activator and MLE is New paradigm of skin care.
  • 10.
    • Ref:
    • Journal of Lipid Research. Vol.48(2007.9)
    • Korean Journal of Cosmetic Dermatology, Vol. 2. No.1, 9 ~ 17 pp
    • Patent in Korea : KR 10-0607438
    • http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20070829-21062800-bc-skorea-lipids.xml
    • http://www.cosmeticsdesign-europe.com/news-by-product/news.asp?id=79325&k=psoriasis-ceramides-lipid
    • http://www.medicalnewstoday.com/articles/80823.php
    K5 – New Anti-aging Activator Stimulate fibroblast proliferation collagen synthesis & keratinocyte differentiation (Double action in dermis and epidermis ) Dry, Sensitive Anti-aging care & Anti-Wrinkles K5(K6PC-5) INCI name : Dihydroxyisopropyl Capryloylcaprylamide K5(K6PC-5), low skin-irritation and anti-aging material K5 is an novel and unique ingredient for low skin-irritation and anti-aging function that works in epidermis and dermis. This is the new concept of material to prevent from skin aging and also improve the wrinkles from the skin surface without skin-irritation. This is an essential factor to realize the low skin-irritation and anti-aging of MLE GOWOONSESANG. It has been proved that it normalizes the differentiate of keratinocyte, increase the proliferation of fibroblast and collagen synthesis and has an effect of reducing wrinkles.
  • 11. Ref : Journal of Lipid Research. Vol.48(2007.9) Ref : SID Meeting (2007.5) Ref : SID Meeting (2007.5) K5 increases the levels of differentiation of Protein in the epidermis of aged skin. K5 increase Collagen synthesis and prevent degradation induced by Photo-aging. K5 stimulated Collagen Synthesis and increase skin barrier function K5 – In vivo data of K5 K5 is non-irritable anti-ageing material. K5 did not show the skin irritation compared with Retinoic acid. K5 promotes fibroblast proliferation by the same level of Retinoic acid. Ref :Korean Journal of Cosmetic Dermatology, Vol. 2. No.1
  • 12. Anti-Aging In Vivo test of MLE containing K5(N = 32) The clinical study conducted with 32 subjects determines if K5 could show wrinkle-improving effects. After 8 weeks application, instrumental analysis revealed that it decrease the eye wrinkles significantly. Ref: Korean Journal of Cosmetic Dermatology, Vol. 2. No.1, 9~17 pp K5 Placebo before After 8 weeks K5 – Anti-Aging effect by K5 Many participants also said that the K5 cream improved their skin conditions K5 cream : 65.6%, control cream : 6.3%, both : 28.1%
  • 13. Ascorbyl Pentapeptide Ascorbyl Pentapeptide is compounds of Vitamin C and Pentapeptide and it promote Collagen synthesis.
  • 14. Skin barrier Anti-Aging Strengthen of damaged Skin barrier function by MLE In & Out Multiple Anti-Aging IN – Activation of dermis, Promote fibroblast proliferation OUT – Normalized of differentiation of keratinocyte Silk-Skin Anti-Aging Collagen Synthesis and Anti-Oxidant by Ascorbyl Pentapeptide and Amino Compound Product Concept Whitening & Anti-Aging Arbutin 2%, MLE formulation, Photo-aging care Aged skin from Weakening of dermis function Aged skin from UV Aged skin from damaged skin barrier function 4 Anti-aging cares for Sensitive Skin New paradigm for Aged Sensitive Skin Skin troubles are like sensitization, dryness, friableness, wrinkles and oxidation
  • 15. Product Map Daily skin care Daily Anti-Aging Special Care Sensitive Skinewal Foam Cleanser 180ml Sensitive Anti-Aging Activator 30ml Sensitive Anti-Aging Eye Serum 15 ml Sensitive Skinewal Facial mask 6sheets/pack Sensitive Skinewal Eye gel sheet 10sheets/pack Sensitive Skinewal Toner 150ml Sensitive Skinewal Emulsion 150ml Sensitive Skinewal Day Cream SPF10 50ml Sensitive Skinewal Night Cream SPF10 50ml
  • 16. Product Characteristic Weak acid Washable gel type Foam Cleanser Characteristic
    • Weak acid and low skin irritation gel type washable cleanser
    • Anti-inflammation and anti-oxidation
    • formation skin protection layer after use
    • Prevent skin irritation by soothe materials
    • Containing natural fragrance to relax the skin
    • Protect the skin from harmful environment
    Main ingredients 7 kinds of Plant extracts compound 180ml To Use Wet face with warm water. Pump a generous amount of cleanser into the palm. Massage gently in a circular motion over the entire face. Rinse thoroughly, pat dry. Sensitive Skinewal Foam Cleanser
  • 17.
    • Containing K6PC-5 Liposome
    • Maintain skin pH balance
    • Maintain ideal water balance
    • Full moisturizing and emollient effect
    K5, Inulin , Niacinamide , Portulaca oleracea Extract, Glucan , Sodium hyaluronate 150ml Provide nutrition and maintain skin balance Low irritation and Weak acid Toner To Use After wash the face, apply to entire face with a cotton ball or cotton square Product Characteristic Characteristic Main ingredients Sensitive Skinewal Toner
  • 18.
    • Provide Anti-Aging effect by K6PC-5
    • Promote skin penetration by MLE Formulation
    • Maintain skin balance
    • Formation protection layer on the skin
    K5, Ceramide, Niacinamide , Greentea seed oil, Glucan Product Characteristic Provide nutrition and maintain skin balance Low irritation and Weak acid Emulsion Sensitive Skinewal Emulsion After toner, apply to entire face and neck. 150ml To Use Characteristic Main ingredients
  • 19. Moisturizing and UV protection during the day time
    • No sticky and greasy MLE formulation
    • UV protection / SPF10
    • Provide Long term moisturizing and skin tightening effect
    • Improve rough skin and formation protection layer on the skin.
    Anti-UV :  Ethylhexyl methoxycinnamate , Ethylhexyl salicylate ,Octocrylene k5, Lactoglobulin , Hydrolyzed extensin , Inulin, hyaluronate, Xanthan gum, Ceramide, Niacinamide , Portulaca oleracea Extract Product Characteristic Sensitive Skinewal Day Cream SPF10 50ml To Use Characteristic Main ingredients In the mongning, apply to entire face and neck in the final step of skincare.
  • 20. Provide moisturizing, nutrition and tightening during the night time High concentrated Balm type Cream
    • Rich & high concentrated Balm type night cream
    • Prompt skin rejuvenating effect by Panthenol
    • Activating the weary skin caused by stress and UV
    • Recovering the harmful skin barrier function by Ceramide
    Panthenol , K5, Ceramide ,  Inuline , Hydrolyzed extensin , Olive butter Product Characteristic Sensitive Skinewal Night Cream In the night, apply to entire face and neck in the final step of skincare. 50ml To Use Characteristic Main ingredients
  • 21. Total Anti-Aging treatment to reduce the wrinkles, freckles and black spots
    • Containing K6PC-5,Arbutin, Peptide to improve skin problems likes wrinkles and freckles.
    • Skin friendly MLE formulation and low irritation skin treatment cream
    K5, Amino acid, Arbutin, Ascorbyl Pentapeptide, Ceramide Herb extracts compound, 7 plants extract compound , Portulaca oleracea Extract 30ml After Toner & Emulsion, apply to entire face and neck. Pay special attention to the areas with fine lines, roughness, wrinkles, laugh lines. Sensitive Anti-Aging Activator Product Characteristic To Use Characteristic Main ingredients
  • 22. Low skin irritation Total Anti-Aging Eye Care Reduce the wrinkles on the eyes and lips areas.
    • Silicon complex with K5, Arbutin, Peptide
    • Focused on wrinkles on the eyes and lips areas.
    K5 , Arbutin, Ascorbyl Pentapeptide , Ceramide , Niacinamide , Sodium hyaluronate After Toner & Emulsion, apply to eyes and lips areas. Pay special attention to the fine lines and laugh lines. Product Characteristic 15ml Sensitive Anti-Aging Eye Serum To Use Characteristic Main ingredients
  • 23. High concentrated Soothing & moisturizing Essential mask with Anti-Aging Activator and pseudo Ceramide (PC-9S)
    • High concentrated Essential mask with Anti-Aging Activator
    • Ceramide and Plants extract sooth the skin
    K5 Liposome, Ginko Biloba Extract, Witch Hazel Extract,   B etaine , Sodium hyaluronate After toner, gently over entire face. Remain for 20 to 30 minutes. Sensitive Skinewal Facial mask Product Characteristic 6 sheets To Use Characteristic Main ingredients
  • 24. Containing Repair active and Pseudo Ceramide Hydrogel sheet for eyes treatment
    • High concentrated Hydrogel eye sheet with Anti-Aging Activator
    • Ceramide and Plants extract sooth the skin
    K5 liposome , Ginko biloba extract , Witch hazel extract , Betaine ,Sodium hyaluronate Product Characteristic After toner, remove the plastic seal and apply each patch under eyes or arounds lips for 20~30mins. 10 sheets To Use Characteristic Main ingredients Sensitive Skinewal Eye gel sheets
  • 25. Sensitive Anti-Aging Eye Serum 1m Sensitive Anti-Aging Activator 1ml Sensitive Skinewal Toner 8ml Sensitive Skinewal Emulsion 8ml Sensitive Skinewal Toner 30ml Sensitive Skinewal Emulsion 30ml Sample Composition Promotion Sample
  • 26. Launching Package Sensitive Skinewal Skincare Set Sensitive Anti-Aging Eye Serum 1m Sensitive Anti-Aging Activator 1ml Sensitive Skinewal Toner 8ml Sensitive Skinewal Emulsion 8ml Sensitive Skinewal Toner 30ml Sensitive Skinewal Emulsion 30ml
  • 27. Step for Use Toner Foam Cleanser Eye Serum Emulsion Activator Day Cream Make up Day care Night care Toner Foam Cleanser Eye Serum Emulsion Activator Night Cream
  • 28. Step for Use Toner Eye Serum Facial Mask Activator Special Facial Treatment (1~2 time / week) Special Eye Treatment (1~2 time / week) Toner Eye Serum Eye gel sheet Activator Emulsion
  • 29. BIO-NANO TECH IN USA 在台公司 . 醫妍膚品生技企業行 高雄市 81366 左營區富民路 422-1 號 TEL:+886-7-556-3370 FAX:+886-7-558-2841