Healthy and Harmful Halogens Iodine and Fluoride


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  • But in one Indian village studied in detail, Bhanakpur near Delhi, water with between 0.7 and 1.6 ppm of fluoride was enough to leave 17 per cent of the population suffering from the bent bones of skeletal fluorosis. A well-fed child consuming plenty of calcium, and vitamins A and C should not be at risk from the sort of fluoride doses that can cripple a child in India.
  • The halogens are five non-metallic elements found in group 17 of the periodic table. The term "halogen" means "salt-former" and compounds containing halogens are called "salts". All halogens have 7 electrons in their outer shells, giving them an oxidation number of -1. The halogens exist, at room temperature, in all three states of matter:
    Solid- Iodine, Astatine
    Liquid- Bromine
    Gas- Fluorine, Chlorine
    The Halogens are:
  • Fluorine
    The longest-lived isotope, 210At, has a half-life of only 8.3 hours. There are about 20 isotopes known, all of which are radioactive. Astatine is a halogen and possibly accumulates in the thyroid like iodine.
    Here is a brief summary of the isolation of astatine. Astatine is radioactive and essentially unavailable in nature. It is not possible to make other than in a nuclear reactor
  • In Dr. Strangelove, Capt. Jack D. Ripper (I.), classic anti-fluoride nut, asks his aide, "Have you ever seen a commie drink a glass of water?"
  • Based on LD50 data from Robert E.Gosselin et al, Clinical Toxicology ofCommercial Products 5th ed., 1984
    Standards established by theU.S. Environmental Protection Agency
  • Osteofluorosis
    ( A cross section of metatarsal bones from cows of same breed, size and age showing normal appearance on the left and severe osteofluorosis on the right
  • Osteofluorosis
    ( A cross section of metatarsal bones from cows of same breed, size and age showing normal appearance on the left and severe osteofluorosis on the right
  • TGI (Topway Global Inc) water systems
  • The conventional medical view is that the only known function of iodine in the human body is as an essential component of the thyroid hormones thyroxine (T^sub 4^) and triiodothyronine (T^sub 3^). T^sub 4^ contains four atoms (59% by weight) and T^sub 3^ contains three atoms (65% by weight) of iodine per molecul
  • T3 attaches to receptors on the DNA of the genes that control a cell’s function and thereby regulate its cellular oxidation and protein synthesis. It also promotes other metabolic activities, which includes nitrogen retention, glucose metabolism and its absorption, breakup of fats.
  • IPCUS—International Programme on Chemical Safety, a collaborative venture of WHO, UN Environment Programme, International labour Organization.
    FAO—Food and Agricultural Organization of the United Nations
    These authorities include the American Medical Association, the NIH National Research Council, the joint Food and Agricultural Organization of the United Nations and World Health Organization Expert Committee, and the European Union International Programme on Chemical Safety, which is a collaborative venture of WHO, UN Environment Programme, and the International labour Organization.
  • Based on Measurements of Median Urinary Iodine Excretion
    Median Urinary Iodine Concentration (mcg/L)Corresponding Approximate Iodine Intake (mcg/day)
    Iodine Nutrition<20 <30 Severe deficiency
    20-49 30-74 Moderate deficiency
    50-99 75-149 Mild deficiency
    100-199 150-299 Optimal
    200-299 300-449 More than adequate
    >299 >449 Possible excess
    Median Urinary Iodine Concentration (mcg/L) Corresponding Approximate Iodine Intake (mcg/day)
  • In 1964 the Nutrition Section in the Bureau of Public Health in Japan published a study on Japanese food intake by food group. Their intake of seaweed averaged 4.5 grams a day. The measured the iodine content of the seaweed consumed and found sufficient to provide an average iodine intake of 13.8 mg/day. 95 percent of the iodine they consume comes from seaweed. Without measuring its iodine content, public health officials say that Japanese seaweed consumption in 2001 had risen to 14.6 grams a day. Assuming the same concentration of iodine in the seaweed, this would provide a current day iodine intake of 43.8 mg/day.
  • Medical authorities in the United States have established a RDA for iodine of 150 ug/day, which is “adequate to maintain normal thyroid function, growth, and development.” This allowance is designed to prevent goiter formation. The main source of iodine consumption by Americans is table salt. Iodide is added to table salt, in a concentration of 70 ug of iodine per gram of salt.
    The average daily intake of iodine in the U.S. is 249 ug, or 0.24 mg, approximately 1/100th of Japanese consumption. This is half the amount consumed by Americans 30 years ago, when iodine, rather than bromine, was used as a dough conditioner for making bread.
    Less than 50 ug/L in 11.7%, a 4-5 fold increase
  • The incidence of breast cancer in this country is the highest in the world. One in 7 American women will get breast cancer. Japan has the lowest incidence of breast cancer.
    The life expectancy in the U.S. 77.85 years, 48th in the 226 countries surveyed. In Japan it is 81.25 years. It is number 6, after Andorra, Macau, San Marino, Singapore, and Hong Kong.
    And the infant mortality rate in Japan is the lowest in the world, half that in the United States.
    Could this disparity in health be due to these countries respective difference in iodine consumption
  • Life arose on the planet around 3.8 BYA in the form of single-cell bacteria. About 500 M years later a new kind of bacteria evolved called cyanobacteria, also known as Blue-Green Algae. This bacteria produces a protein, chlorophyll, that can absorb the energy in sunlight and use it to power a chemical reaction that turns water and carbon dioxide into food. Cyanobacteria take 6 molecules of CO2 and 6 molecules of water and produce one molecule of sugar and six molecules of oxygen. It uses the sugar, dextrose, to make ATP (adenosine triphosphate), the chemical “fuel” that sustains all living things. Oxygen is a waste product that it discharges into the atmosphere. Over the last several billion years, cyanobacteria have been expelling oxygen into the atmosphere, where it has maintained a level of 21 percent for the last billion years.
    In addition to making oxygen, cyanobacteria were the first life forms to develop an affinity for iodine. Why? It turns out this organism needs iodine to protect itself from the toxic effects of oxygen that it produces.
    1st atmosphere H and He from solar nebula
    Lost to solar wind
    2nd atmosphereH20, CO2 and SO2 from volcanic degassingTransformed by photosynthesis
    Current atmosphereN2, O2, from photosynthesis and constant N2 production
    Photosynthesis by cyanobacteria began > 3.5-2.7 Ga
    CO2 + H2O ---> CH2O + O2
    No evidence for free O2 before ~2.4 Ga
    Reduced gases in atmosphere & reduced crust consume O2 produced during 3.5-2.4 Ga
    Hydrogen escape irreversibly oxidizes atmosphere
    Mantle dynamics & redox evolution reduce O2 sink over time
    Geologic & geochemical evidence for O2 :
    Oxidized Fe & Mn mineral deposits
    Detrital uraninite & pyrite
    Sulfur isotopes
    Conclusion: Rapid rise of free O2 2.4-2.2 Ga
    4.6 byaFormation of the Earth
    3.5 byaAbiotic synthesis,
    3.2 byaDenitrification
    2.3 byaOxygen-producing photosynthesis by cyanobacteria
    Start of ozone formation
    1.8 byaNitrification (aerobic)
    1.5 byaNitrogen fixation (aerobic)
    1.4 byaEarliest eukaryotes
    0.57 byaFirst shelled invertebrates
    0.43-0.5 byaPrimitive fish
    0.395-0.43 byaFirst land plants -- oxygen and ozone increase
  • Inside the cells of living things, oxygen breeds reactive oxygen species, superoxide anion, hydrogen peroxide, and the hydroxyl radical. The hydroxyl radical wreaks havoc and damages the cell by reacting with lipids in the cellular membranes, nucleotides in DNA, and the tyrosine and sulphydryl groups in proteins. In algae, in a species of kelp, Kupper et al. have shown that iodine functions as an antioxidant. It neutralizes hydrogen peroxide by converting it first to hypiodious acid and then water, thereby blocking the conversion of hydrogen peroxide into the highly destructive hydroxyl radical.
    This ability of inorganic iodine to neutralize free radicals and other reactive oxygen species made photosynthesis possible.
    Free radicals are a byproduct of biological oxidation
    HIO = hypiodious acid Iodine spontaneously reacts with hydrogen peroxide to form HIO
    ROS cause damage by reacting with lipids in cellular membranes, nucleotides in DNA, sulphydryl groups in proteins, and cross-linking/fragmentation of ribonucleoproteins
    Fenton reaction (catalyzed by copper or iron): H2O2 in OH
    ROS cause cancer. Involved in both the initiation and progression of cancer.
    Other ROS: singlet oxygen and hypochlorite
    ROS also have a regulatory role in cellular metabolism
  • Fig. 3. KI induces apoptosis in >95% H1299NIS/TPOcells after a 48-h incubation. A, H1299NIS/TPOcells in KI; B, H1299CV cells in KI; C, H1299NIS cells in KI; D, H1299NIS/TPO cells in KCl. Apoptotic cells were stained red, whereas viable cells remain unstained or pale pink.
  • Fig. 5. Nonradioactive iodide effectively limits the growth of NIS/TPO-modified tumor xenografts in SCID mice. A, KI markedly reduces tumor volume in NIS/TPO-modified tumor xenografts. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with nontreated H1299NIS/TPOtumors. B, photographs of tumors from each group of mice. H1299CV, n = 9; H1299CV+KI, n = 9; H1299NIS/TPO, n = 9; H1299NIS/TPO+KI, n = 12; bars, ±SD.
  • Choroid plexus--A vascular proliferation of the cerebral ventricles that serves to regulate intraventricular pressure by secretion or absorption of cerebrospinal fluid. vascular complex in 3rd and 4th ventricle that forms cerebrospinal fluid (CSF).
  • Gram amounts:
  • Iodine essential for normal growth and development is organically bound in thyroid hormones. Inorganic, nonradioactive iodine
    Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.
    Iopanoic acid an oral tracer, used for cholangiography; propyliodone is insufflated into the lungs for bronchography
    Thee isotopes used: I-123, I-125, I-131
  • Treatment for COPD, up to 36 gm/day
    Peace Corps workers 50 mg a day, 44% got a goiter
    “Underlying thyroid disease.”
    Rare; tends to be dose related
    Unpleasant taste, frontal headache, acne
    Resolves after stopping iodine
    actually caused by bromine release
    Iodine-induced hyperthyroidism
    “Long standing iodine deficiency can cause hyperactive nodules. When start taking iodine, symptoms can occur as nodules absorb iodine.”
    Hyperthyroidism, then, starts as an iodine-deficiency disorder
    decrease dose and proceed slowly.
    Delange, FM. Iodine Deficiency. The Thyroid. Lippencott Williams, Wilkens, 2000. p. 295-329
  • Many women are troubled with painful, lumpy breasts. The incidence of fibrocystic breast disease in American women was found to be very low, 3 percent, when studied in the 1920s. Today 90 percent of women have fibrocystic breast disease. In this disorder, epithelial hyperplasia occurs, along with apocrine gland metaplasia, and fluid-filled cysts form, accompanied by fibrosis. Six million women with fibrocystic disease have moderate to severe breast pain and tenderness that lasts more than 6 days during the menstrual cycle.
    In animal studies, female rats fed an iodine-free diet develop fibrocystic changes in their breasts. Iodine in its diatomic, elemental form, as I2, cures it.
    Several studies, most notably this one by Ghent and colleagues, show that iodine effectively relieves signs and symptoms of fibrocystic breast disease in 70 percent of patients. This paper is a composite of three clinical studies, two in Canada and one in Seattle. The study done in Seattle, by two surgeons at the Virginia Mason Clinic, Drs. Donald Low and Lucius Hill, is the most impressive. It is a randomized, double-blind, placebo-controlled trial designed to compare elemental iodine, I-2, in a dose of 3 to 5 mg, to a placebo, in this case an aqueous mixture of a brown vegetable dye with quinine. They were followed for six months and subjective and objective changes in their fibrocystic breast disease tracked.
  • There is a growing amount evidence showing that iodine prevents breast cancer. Animal studies show that iodine protects rats given a carcinogen from developed breast cancer. Iodine kills human breast cancer cells grown in a test tube. Cells in the breast that develop cancer are the same one that absorb iodine. People with iodine deficiency disorders manifested by a goiter have a 3 times greater incidence of breast cancer, and people who consume a lot of iodine have a low incidence of breast cancer.
  • Total body iodine sufficiency 1,500 mg. Stantdard view is that the body contains 50-80 mg of iodine, of which 30 mg is in the thyroid galnd
    Must be a complete nutritional programs, with selenium, magnesium, and Omega 3 fatty acids in particular.
    Iodoral: 27 cents a dose (90 for 43.93); Lugol’s 4 cents a dose (300 doses—2 drops—for 10.99)
  • Overall sense of well-being
    Consuming iodine in mg doses should be coupled with a complete nutritional program that includes adequate amounts of selenium, magnesium, and Omega 3 fatty acids, in particular. An iodine intake that is 100x the RDA, as one observer puts it, is “the simplest, safest, most effective and least expensive way to help solve the health care crisis crippling our nation.” Americans would do well to emulate the Japanese and increase their iodine intake, if not by eating seaweed, then with two drops of Lugol’s solution a day.
    Less than 1 percent, and those patients, if followed by a physician schooled in the extrathyroidal benefits, cut back on the amount of iodine consumed and have no long-term consequences.
  • Healthy and Harmful Halogens Iodine and Fluoride

    1. 1. Healthy and Harmful HalogensHealthy and Harmful Halogens IodineIodine andand FluorideFluoride Conference Be Healthy, Wealthy, and WiseBe Healthy, Wealthy, and Wise Center for Libertarian StudiesCenter for Libertarian Studies Foster City, CAFoster City, CA December 2, 2006December 2, 2006 Donald W. Miller, Jr., M.DDonald W. Miller, Jr., M.D.. Professor of SurgeryProfessor of Surgery Division of Cardiothoracic SurgeryDivision of Cardiothoracic Surgery University of Washington School of MedicineUniversity of Washington School of Medicine
    2. 2. HalogensHalogens Atomic Wt. DiscoveredAtomic Wt. Discovered FluorineFluorine 1919 18861886 ChlorineChlorine 3535 18091809 BromineBromine 8080 18261826 IodineIodine 127127 18111811 AstatineAstatine 210210 19401940
    3. 3. IodineIodine BromineBromine ChlorineChlorine FluorideFluoride IodineIodine FluorideFluoride Halogens in WarHalogens in War
    4. 4. Elements that Compose the Human BodyElements that Compose the Human Body Periodic Table of ElementsPeriodic Table of Elements IodineIodine ChlorineChlorine
    5. 5. Origin of FluoridationOrigin of Fluoridation
    6. 6. Manhattan ProjectManhattan Project
    7. 7. Edward BernaysEdward Bernays
    8. 8. Fluoride inFluoride in Dr. StrangeloveDr. Strangelove “Have you ever seen a commie drink a glass of water?” Capt. Jack D. Ripper
    9. 9. Dental FluorosisDental Fluorosis
    10. 10. Cosmetic Correction of FluorosisCosmetic Correction of Fluorosis $14,000 later
    11. 11. Lead, Fluoride and ArsenicLead, Fluoride and Arsenic Toxicity Maximum ContaminantToxicity Maximum Contaminant LevelsLevels
    12. 12. Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning • Skeletal FluorosisSkeletal Fluorosis – ArthritisArthritis – Osteoporosis/FractureOsteoporosis/Fracture – Crippling deformitiesCrippling deformities • NeurotoxicityNeurotoxicity – Abnormal brain developmentAbnormal brain development – Alzheimer’s diseaseAlzheimer’s disease • HypothyroidismHypothyroidism
    13. 13. Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning • Increases risk for cancerIncreases risk for cancer – OsteosarcomaOsteosarcoma – HepatocholangiocarcinomaHepatocholangiocarcinoma • Early onset of pubertyEarly onset of puberty – Due to impaired melatonin productionDue to impaired melatonin production • Reduced male fertilityReduced male fertility
    14. 14. Water Filters that Remove FluorideWater Filters that Remove Fluoride Reverse Osmosis DistillerReverse Osmosis Distiller
    15. 15. Water Fluoridation in U.S.Water Fluoridation in U.S. Goal (Objective 21-9):Goal (Objective 21-9): Increase proportionIncrease proportion of U.S. population served by fluoridatedof U.S. population served by fluoridated community water systems to 75 percentcommunity water systems to 75 percent
    16. 16. Iodine in Thyroid HormonesIodine in Thyroid Hormones Iodine atomIodine atom
    17. 17. Actions of Triiodothyronine (TActions of Triiodothyronine (T33))  Regulate cellular oxidationRegulate cellular oxidation  CalorigenesisCalorigenesis  ThermoregulationThermoregulation  Intermediary MetabolismIntermediary Metabolism  Necessary for protein synthesisNecessary for protein synthesis  PromotesPromotes  Nitrogen retentionNitrogen retention  GlycogenolysisGlycogenolysis  Intestinal absorption of glucose and galactoseIntestinal absorption of glucose and galactose  LipolysisLipolysis  Uptake of glucose by adipocytesUptake of glucose by adipocytes
    18. 18. Iodine Deficiency DisordersIodine Deficiency Disorders Goiter Mental RetardationGoiter Mental Retardation CretinismCretinism
    19. 19. Reference Daily IntakeReference Daily Intake (RDI) for Iodine(RDI) for Iodine According to the AMA, NIH National ResearchAccording to the AMA, NIH National Research Council, Joint UN FAO/WHO Expert CommitteeCouncil, Joint UN FAO/WHO Expert Committee on Food Additives, and the EU IPCSon Food Additives, and the EU IPCS RDI:RDI: 100-150100-150 μμg/dayg/day
    20. 20. Worldwide Iodine NutritionWorldwide Iodine Nutrition Median urinary iodine concentration of 100-199 ug/L with corresponding approximate iodine intake 150-299 ug/day International Council for the Control of Iodine Deficiency Disorders.International Council for the Control of Iodine Deficiency Disorders. Current IDD Status Database, 2003Current IDD Status Database, 2003
    21. 21. Iodine Intake in JapanIodine Intake in Japan Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health,Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health, Ministry of Health and Welfare, Tokyo, Japan, March 1965Ministry of Health and Welfare, Tokyo, Japan, March 1965 Iodine Intake 1950-1963:Iodine Intake 1950-1963: 13.8 mg/per capita/day13.8 mg/per capita/day (average 4.5 gm seaweed(average 4.5 gm seaweed a day. Measured Iodinea day. Measured Iodine content 0.3mg/gm)content 0.3mg/gm) Seaweed consumption in 2001:Seaweed consumption in 2001: 14.6 gm (dry weight)14.6 gm (dry weight) Iodine Intake 2001:Iodine Intake 2001: 43.8 mg43.8 mg If Iodine content theIf Iodine content the same (was notsame (was not measured)measured)
    22. 22. Iodine Intake in the United StatesIodine Intake in the United States Urinary iodine levels (Urinary iodine levels (µµg/L) ing/L) in the United States, age 6-74the United States, age 6-74 NHANES I, 1971-741 NHANES III, 1988-911 NHANES 2000 Median 32.00 14.5 16.1 SE 0.6 0.3 0.7 1 Hollowell, JE et al. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-74 and 1988-94). J Clin Endocrinol Metab 83:3401-3408. 1998. Current Average DailyCurrent Average Daily Intake of Iodine:Intake of Iodine: 240 µg (0.24 mg)240 µg (0.24 mg) Iodine Intake in 1970s:Iodine Intake in 1970s: 480 µg (0.48 mg)480 µg (0.48 mg) 320 145 161
    23. 23. Health Comparisons:Health Comparisons: United States and JapanUnited States and Japan United States JapanUnited States Japan Incidence of BreastIncidence of Breast Highest in World LowestHighest in World Lowest CancerCancer Life ExpectancyLife Expectancy 77.85 years 81.25 years77.85 years 81.25 years (48(48thth /226 countries) (No. 6)/226 countries) (No. 6) Infant Mortality RateInfant Mortality Rate 7.0 3.57.0 3.5 (deaths under age 1 per (Lowest in World)(deaths under age 1 per (Lowest in World) 1,000 live births)1,000 live births)
    24. 24. The Earth’s 3The Earth’s 3rdrd Atmosphere, from 2.2 GaAtmosphere, from 2.2 Ga OxygenOxygen Level inLevel in AtmosphereAtmosphere (Percent)(Percent) 4.6 3.6 2.6 1.6 0.64.6 3.6 2.6 1.6 0.6 Billion Years AgoBillion Years Ago Photosynthesis first done byPhotosynthesis first done by Cyanobacteria:Cyanobacteria: 6CO6CO22 + 6H+ 6H22OO →→ CC 66HH1212 OO66 + 6O+ 6O22 CyanobacteriaCyanobacteria are also the first life forms to tolerate andare also the first life forms to tolerate and use……………………...use……………………... IODINEIODINE
    25. 25. Iodine as an AntioxidantIodine as an Antioxidant II-- + H+ H22OO22 HIO + OHHIO + OH-- HIO +HIO + II-- + H+ H++ II22 + H+ H22OO Reactive Oxygen SpeciesReactive Oxygen Species Kupper FC, et al. Iodine uptake in Laminariales involves extracellular,Kupper FC, et al. Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide.haloperoxidase-mediated oxidation of iodide. PlantaPlanta 1998;207:163-171.1998;207:163-171.
    26. 26. Function of Iodine in HumansFunction of Iodine in Humans and Other Animalsand Other Animals Thyroidal -- OrganicThyroidal -- Organic  A Component of Thyroxine and T3A Component of Thyroxine and T3 Extrathyroidal -- InorganicExtrathyroidal -- Inorganic  An AntioxidantAn Antioxidant  Triggers ApoptosisTriggers Apoptosis  OtherOther • Detoxify chemicals and biological toxinsDetoxify chemicals and biological toxins • Anti-allergic, coat external proteins rendering themAnti-allergic, coat external proteins rendering them non allergicnon allergic • Suppess auto-immunitySuppess auto-immunity • Strengthen immune systemStrengthen immune system • Provide antisepsis in the stomachProvide antisepsis in the stomach
    27. 27. Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in GeneticallyZhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells.Modified Lung Cancer Cells. Cancer ResearchCancer Research 2003;63:5065-50722003;63:5065-5072 Iodine-Induced Apoptosis in Lung CancerIodine-Induced Apoptosis in Lung Cancer Iodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer CellsIodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer Cells
    28. 28. Effect of Iodine on Tumor Growth in MiceEffect of Iodine on Tumor Growth in Mice Genetically Modified TumorGenetically Modified Tumor Xenograft ControlsXenograft Controls Genetically Modified TumorGenetically Modified Tumor XenograftXenograft with Iodinewith Iodine Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis inZhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells.Genetically Modified Lung Cancer Cells. Cancer ResearchCancer Research 2003;63:5065-50722003;63:5065-5072
    29. 29. Organs with Iodine Concentrating AbilityOrgans with Iodine Concentrating Ability Via the Sodium/Iodine Symporter PumpVia the Sodium/Iodine Symporter Pump Stomach MucosaStomach Mucosa Mammary GlandsMammary Glands Salivary GlandsSalivary Glands Other:Other: OvariesOvaries ThymusThymus EpidermisEpidermis Choroid PlexusChoroid Plexus Articular, Arterial, andArticular, Arterial, and Skeletal SystemsSkeletal Systems 125125 I total-body scintiscansI total-body scintiscans 30 min 6 hr 20 hr30 min 6 hr 20 hr Venturi S, et al. Role of Iodine in Evolution and Carcinogenesis ofVenturi S, et al. Role of Iodine in Evolution and Carcinogenesis of Thyroid, Breast and Stomach.Thyroid, Breast and Stomach. Adv Clin PathAdv Clin Path 2000;4:11-17.2000;4:11-17.
    30. 30. The Real Truth on IodineThe Real Truth on Iodine Dose-Related BenefitsDose-Related Benefits In microgram (In microgram (μμg)g) amounts:amounts: In milligram (mg)In milligram (mg) amounts:amounts: In gram (g)In gram (g) amounts:amounts: For thyroid hormoneFor thyroid hormone Achieve optimal healthAchieve optimal health Prevent (and treat) fibrocysticPrevent (and treat) fibrocystic disease of the breastdisease of the breast Prevent cancerPrevent cancer Civil DefenseCivil Defense Treat multiple diseases:Treat multiple diseases: dermatologic, pulmonary,dermatologic, pulmonary, cardiovascular, fungalcardiovascular, fungal
    31. 31. Different Kinds of IodineDifferent Kinds of Iodine  Inorganic, Nonradioactive (Inorganic, Nonradioactive (127127 I)I) – KI, SSKI, Lugol’s Solution, Iodoral,KI, SSKI, Lugol’s Solution, Iodoral, – Tincture of Iodine, Povidone-Iodine)Tincture of Iodine, Povidone-Iodine)  OrganicOrganic – EndogenousEndogenous • Thyroid hormonesThyroid hormones – SyntheticSynthetic • AmiodaroneAmiodarone • Radiocontrast mediaRadiocontrast media – Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.  (Inorganic) Radioactive Isotopes(Inorganic) Radioactive Isotopes
    32. 32. Forms of Inorganic, NonradioactiveForms of Inorganic, Nonradioactive IodineIodine • KIKI (Potassium Iodide)(Potassium Iodide) – A 130 mg tablet contains 100 mg of iodideA 130 mg tablet contains 100 mg of iodide • SSKISSKI (Saturated Solution of Potassium Iodide)(Saturated Solution of Potassium Iodide) – 38 mg/drop iodide (760 mg/ml)38 mg/drop iodide (760 mg/ml) • 19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench • Lugol’s SolutionLugol’s Solution ---- 5% iodine (I5% iodine (I22) and 10% KI) and 10% KI – 6.5 mg/drop blend of iodine and iodide (130 mg/ml)6.5 mg/drop blend of iodine and iodide (130 mg/ml) • Iodoral --Iodoral -- 5% iodine and 10% KI5% iodine and 10% KI – One tablet = 12.5 mg blend of iodine and iodideOne tablet = 12.5 mg blend of iodine and iodide
    33. 33. Iodine PoisoningIodine Poisoning IngestedIngested 15 gm15 gm of Iodine –of Iodine – 100,000 x100,000 x the RDA of 0.00015 gm (150the RDA of 0.00015 gm (150 μμg)g) Serum Iodide level wasSerum Iodide level was 2,950 ug/dL2,950 ug/dL (normal is 3.5(normal is 3.5 μμg/dL with daily intakeg/dL with daily intake of 150 ug Iodine)of 150 ug Iodine) Salivary Iodide LevelSalivary Iodide Level 60,000 ug/dL60,000 ug/dL (normal 105(normal 105 μμg/dL)g/dL)
    34. 34. Iodine in DermatologyIodine in Dermatology PyodermaPyoderma GangrenosumGangrenosum NodularNodular VasculitisVasculitis SporotrichosisSporotrichosis Sterling JB, Heymann WR. Potassium IodideSterling JB, Heymann WR. Potassium Iodide In Dermatology: A 19In Dermatology: A 19thth Century Drug for the 21Century Drug for the 21stst Century—Uses, Pharmacology, Adverse Effects,Century—Uses, Pharmacology, Adverse Effects, and Contraindications.and Contraindications. J Am Acad DermatolJ Am Acad Dermatol 2000;43:691-697.2000;43:691-697.
    35. 35. Fibrocystic Breast DiseaseFibrocystic Breast Disease CystCyst FibrousFibrous tissuetissue EpithelialEpithelial andand apocrineapocrine hyperplasiahyperplasia ElementalElemental Iodine, IIodine, I22, more, more effective thaneffective than Iodide, IIodide, I-- Ghent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement inGhent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement in Fibrocystic Disease of the Breast.Fibrocystic Disease of the Breast. Can J SurgCan J Surg 1993;36:453-1993;36:453-
    36. 36. Iodine Prevents Breast CancerIodine Prevents Breast Cancer Animal StudiesAnimal Studies Reduces incidence in rats given carcinogensReduces incidence in rats given carcinogens Human StudiesHuman Studies Kills cancer cells grownKills cancer cells grown in vitroin vitro Absorbed by cancer-prone ductal epitheliumAbsorbed by cancer-prone ductal epithelium Epidemiological StudiesEpidemiological Studies Increased incidence with goiterIncreased incidence with goiter Lower incidence in people who eat seaweed andLower incidence in people who eat seaweed and fishfish
    37. 37. The Iodine ProjectThe Iodine Project Hypothesis:Hypothesis: Whole body sufficiencyWhole body sufficiency of iodine requires mg (12.5 mg),of iodine requires mg (12.5 mg), notnot μμg (150g (150 μμg ) daily amountsg ) daily amounts Principle InvestigatorsPrinciple Investigators Guy Abraham MD, 1997: Optimox Corp., Torrance, CAGuy Abraham MD, 1997: Optimox Corp., Torrance, CA Jorge Flechas MD, 2000 (1,000 pts.): Flechas FamilyJorge Flechas MD, 2000 (1,000 pts.): Flechas Family Practice, Hendersonville, NCPractice, Hendersonville, NC David Brownstein MD, 2003 (3,000 pts.): Center for HolisticDavid Brownstein MD, 2003 (3,000 pts.): Center for Holistic Medicine, West Bloomfield, MIMedicine, West Bloomfield, MI Iodine Loading TestIodine Loading Test Take 50 mg iodine, urine collected for 24 hoursTake 50 mg iodine, urine collected for 24 hours Less than 90 % excretion indicates iodine insufficiencyLess than 90 % excretion indicates iodine insufficiency
    38. 38. Health Benefits of mg-DoseHealth Benefits of mg-Dose Iodine atIodine at 100x the RDI100x the RDI  Feel HealthierFeel Healthier  Sense of Well-BeingSense of Well-Being  Lifting of Brain FogLifting of Brain Fog  Increased Energy –Increased Energy – Achieve More in Less TimeAchieve More in Less Time  Feel Warmer in ColdFeel Warmer in Cold EnvironmentsEnvironments  Need Less SleepNeed Less Sleep  Regular Bowel MovementsRegular Bowel Movements  Improved Skin ComplexionImproved Skin Complexion  Strengthens Immune SystemStrengthens Immune System  Prevents CancerPrevents Cancer  BlocksBlocks 131131 I Absorption from Radioactive FalloutI Absorption from Radioactive Fallout