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Healthy and Harmful Halogens Iodine and Fluoride






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  • But in one Indian village studied in detail, Bhanakpur near Delhi, water with between 0.7 and 1.6 ppm of fluoride was enough to leave 17 per cent of the population suffering from the bent bones of skeletal fluorosis. A well-fed child consuming plenty of calcium, and vitamins A and C should not be at risk from the sort of fluoride doses that can cripple a child in India.
  • The halogens are five non-metallic elements found in group 17 of the periodic table. The term "halogen" means "salt-former" and compounds containing halogens are called "salts". All halogens have 7 electrons in their outer shells, giving them an oxidation number of -1. The halogens exist, at room temperature, in all three states of matter: Solid - Iodine, Astatine Liquid - Bromine Gas - Fluorine, Chlorine The Halogens are:
  • Fluorine Chlorine Bromine Iodine Astatine The longest-lived isotope, 210At, has a half-life of only 8.3 hours. There are about 20 isotopes known, all of which are radioactive. Astatine is a halogen and possibly accumulates in the thyroid like iodine. Isolation Here is a brief summary of the isolation of astatine. Astatine is radioactive and essentially unavailable in nature. It is not possible to make other than in a nuclear reactor
  • In Dr. Strangelove, Capt. Jack D. Ripper (I.), classic anti-fluoride nut, asks his aide, "Have you ever seen a commie drink a glass of water?"
  • Based on LD50 data from Robert E. Gosselin et al, Clinical Toxicology of Commercial Products 5th ed., 1984 Standards established by the U.S. Environmental Protection Agency
  • Osteofluorosis ( A cross section of metatarsal bones from cows of same breed, size and age showing normal appearance on the left and severe osteofluorosis on the right
  • Osteofluorosis ( A cross section of metatarsal bones from cows of same breed, size and age showing normal appearance on the left and severe osteofluorosis on the right
  • TGI (Topway Global Inc) water systems
  • The conventional medical view is that the only known function of iodine in the human body is as an essential component of the thyroid hormones thyroxine (T^sub 4^) and triiodothyronine (T^sub 3^). T^sub 4^ contains four atoms (59% by weight) and T^sub 3^ contains three atoms (65% by weight) of iodine per molecul
  • T3 attaches to receptors on the DNA of the genes that control a cell’s function and thereby regulate its cellular oxidation and protein synthesis. It also promotes other metabolic activities, which includes nitrogen retention, glucose metabolism and its absorption, breakup of fats.
  • IPCUS—International Programme on Chemical Safety, a collaborative venture of WHO, UN Environment Programme, International labour Organization. FAO—Food and Agricultural Organization of the United Nations These authorities include the American Medical Association, the NIH National Research Council, the joint Food and Agricultural Organization of the United Nations and World Health Organization Expert Committee, and the European Union International Programme on Chemical Safety, which is a collaborative venture of WHO, UN Environment Programme, and the International labour Organization.
  • Based on Measurements of Median Urinary Iodine Excretion Median Urinary Iodine Concentration (mcg/L)Corresponding Approximate Iodine Intake (mcg/day) Iodine Nutrition299 >449 Possible excess Median Urinary Iodine Concentration (mcg/L) Corresponding Approximate Iodine Intake (mcg/day)
  • In 1964 the Nutrition Section in the Bureau of Public Health in Japan published a study on Japanese food intake by food group. Their intake of seaweed averaged 4.5 grams a day. The measured the iodine content of the seaweed consumed and found sufficient to provide an average iodine intake of 13.8 mg/day. 95 percent of the iodine they consume comes from seaweed. Without measuring its iodine content, public health officials say that Japanese seaweed consumption in 2001 had risen to 14.6 grams a day. Assuming the same concentration of iodine in the seaweed, this would provide a current day iodine intake of 43.8 mg/day.
  • Medical authorities in the United States have established a RDA for iodine of 150 ug/day, which is “adequate to maintain normal thyroid function, growth, and development.” This allowance is designed to prevent goiter formation. The main source of iodine consumption by Americans is table salt. Iodide is added to table salt, in a concentration of 70 ug of iodine per gram of salt. The average daily intake of iodine in the U.S. is 249 ug, or 0.24 mg, approximately 1/100 th of Japanese consumption. This is half the amount consumed by Americans 30 years ago, when iodine, rather than bromine, was used as a dough conditioner for making bread. Less than 50 ug/L in 11.7%, a 4-5 fold increase
  • The incidence of breast cancer in this country is the highest in the world. One in 7 American women will get breast cancer. Japan has the lowest incidence of breast cancer. The life expectancy in the U.S. 77.85 years, 48 th in the 226 countries surveyed. In Japan it is 81.25 years. It is number 6, after Andorra, Macau, San Marino, Singapore, and Hong Kong. And the infant mortality rate in Japan is the lowest in the world, half that in the United States. Could this disparity in health be due to these countries respective difference in iodine consumption
  • Life arose on the planet around 3.8 BYA in the form of single-cell bacteria. About 500 M years later a new kind of bacteria evolved called cyanobacteria, also known as Blue-Green Algae. This bacteria produces a protein, chlorophyll, that can absorb the energy in sunlight and use it to power a chemical reaction that turns water and carbon dioxide into food. Cyanobacteria take 6 molecules of CO2 and 6 molecules of water and produce one molecule of sugar and six molecules of oxygen. It uses the sugar, dextrose, to make ATP (adenosine triphosphate), the chemical “fuel” that sustains all living things. Oxygen is a waste product that it discharges into the atmosphere. Over the last several billion years, cyanobacteria have been expelling oxygen into the atmosphere, where it has maintained a level of 21 percent for the last billion years. In addition to making oxygen, cyanobacteria were the first life forms to develop an affinity for iodine. Why? It turns out this organism needs iodine to protect itself from the toxic effects of oxygen that it produces. 1 st atmosphere H and He from solar nebula Lost to solar wind 2 nd atmosphere H 2 0, CO 2 and SO 2 from volcanic degassing Transformed by photosynthesis Current atmosphere N2, O2, from photosynthesis and constant N2 production Photosynthesis by cyanobacteria began > 3.5-2.7 Ga CO 2 + H 2 O ---> CH 2 O + O 2 No evidence for free O 2 before ~2.4 Ga Reduced gases in atmosphere & reduced crust consume O 2 produced during 3.5-2.4 Ga Hydrogen escape irreversibly oxidizes atmosphere Mantle dynamics & redox evolution reduce O 2 sink over time Geologic & geochemical evidence for O 2 : Oxidized Fe & Mn mineral deposits Detrital uraninite & pyrite Paleosols Redbeds Sulfur isotopes Eukaryotes Conclusion : Rapid rise of free O 2 2.4-2.2 Ga 4.6 bya Formation of the Earth 3.5 bya Abiotic synthesis, 3.2 bya Denitrification 2.3 bya Oxygen-producing photosynthesis by cyanobacteria Start of ozone formation 1.8 bya Nitrification (aerobic) 1.5 bya Nitrogen fixation (aerobic) 1.4 bya Earliest eukaryotes 0.57 bya First shelled invertebrates 0.43-0.5 bya Primitive fish 0.395-0.43 bya First land plants -- oxygen and ozone increase
  • Inside the cells of living things, oxygen breeds reactive oxygen species, superoxide anion, hydrogen peroxide, and the hydroxyl radical. The hydroxyl radical wreaks havoc and damages the cell by reacting with lipids in the cellular membranes, nucleotides in DNA, and the tyrosine and sulphydryl groups in proteins. In algae, in a species of kelp, Kupper et al. have shown that iodine functions as an antioxidant. It neutralizes hydrogen peroxide by converting it first to hypiodious acid and then water, thereby blocking the conversion of hydrogen peroxide into the highly destructive hydroxyl radical. This ability of inorganic iodine to neutralize free radicals and other reactive oxygen species made photosynthesis possible. Free radicals are a byproduct of biological oxidation HIO = hypiodious acid Iodine spontaneously reacts with hydrogen peroxide to form HIO ROS cause damage by reacting with lipids in cellular membranes, nucleotides in DNA, sulphydryl groups in proteins, and cross-linking/fragmentation of ribonucleoproteins Fenton reaction (catalyzed by copper or iron): H2O2 in OH ROS cause cancer. Involved in both the initiation and progression of cancer. Other ROS: singlet oxygen and hypochlorite ROS also have a regulatory role in cellular metabolism
  • Fig. 3. KI induces apoptosis in >95% H1299 NIS/TPO cells after a 48-h incubation. A , H1299 NIS/TPO cells in KI; B , H1299CV cells in KI; C , H1299NIS cells in KI; D , H1299 NIS/TPO cells in KCl. Apoptotic cells were stained red , whereas viable cells remain unstained or pale pink .
  • Fig. 5. Nonradioactive iodide effectively limits the growth of NIS/TPO -modified tumor xenografts in SCID mice. A , KI markedly reduces tumor volume in NIS/TPO -modified tumor xenografts. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with nontreated H1299 NIS/TPO tumors. B , photographs of tumors from each group of mice. H1299CV, n = 9; H1299CV+KI, n = 9; H1299 NIS/TPO , n = 9; H1299 NIS/TPO +KI, n = 12; bars , ±SD.
  • Choroid plexus--A vascular proliferation of the cerebral ventricles that serves to regulate intraventricular pressure by secretion or absorption of cerebrospinal fluid. vascular complex in 3rd and 4th ventricle that forms cerebrospinal fluid (CSF).
  • Gram amounts: Wright JV. ONE MINERAL CAN HELP A MYRIAD OF CONDITIONS FROM ATHEROSCLEROSIS TO "COPD"TO ZITS. Availabable at: www.tahoma-clinic.com/iodide.shtml. Accessed June 21, 2006.
  • Iodine essential for normal growth and development is organically bound in thyroid hormones. Inorganic, nonradioactive iodine Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc. Iopanoic acid an oral tracer, used for cholangiography; propyliodone is insufflated into the lungs for bronchography Thee isotopes used: I-123, I-125, I-131
  • Treatment for COPD, up to 36 gm/day Peace Corps workers 50 mg a day, 44% got a goiter “ Underlying thyroid disease.” Iodism: Rare; tends to be dose related Unpleasant taste, frontal headache, acne Resolves after stopping iodine actually caused by bromine release Iodine-induced hyperthyroidism “ Long standing iodine deficiency can cause hyperactive nodules . When start taking iodine, symptoms can occur as nodules absorb iodine.” Hyperthyroidism, then, starts as an iodine-deficiency disorder decrease dose and proceed slowly. Delange, FM. Iodine Deficiency. The Thyroid . Lippencott Williams, Wilkens, 2000. p. 295-329
  • Many women are troubled with painful, lumpy breasts. The incidence of fibrocystic breast disease in American women was found to be very low, 3 percent, when studied in the 1920s. Today 90 percent of women have fibrocystic breast disease. In this disorder, epithelial hyperplasia occurs, along with apocrine gland metaplasia, and fluid-filled cysts form, accompanied by fibrosis. Six million women with fibrocystic disease have moderate to severe breast pain and tenderness that lasts more than 6 days during the menstrual cycle. In animal studies, female rats fed an iodine-free diet develop fibrocystic changes in their breasts. Iodine in its diatomic, elemental form, as I2, cures it. Several studies, most notably this one by Ghent and colleagues, show that iodine effectively relieves signs and symptoms of fibrocystic breast disease in 70 percent of patients. This paper is a composite of three clinical studies, two in Canada and one in Seattle. The study done in Seattle, by two surgeons at the Virginia Mason Clinic, Drs. Donald Low and Lucius Hill, is the most impressive. It is a randomized, double-blind, placebo-controlled trial designed to compare elemental iodine, I-2, in a dose of 3 to 5 mg, to a placebo, in this case an aqueous mixture of a brown vegetable dye with quinine. They were followed for six months and subjective and objective changes in their fibrocystic breast disease tracked.
  • There is a growing amount evidence showing that iodine prevents breast cancer. Animal studies show that iodine protects rats given a carcinogen from developed breast cancer. Iodine kills human breast cancer cells grown in a test tube. Cells in the breast that develop cancer are the same one that absorb iodine. People with iodine deficiency disorders manifested by a goiter have a 3 times greater incidence of breast cancer, and people who consume a lot of iodine have a low incidence of breast cancer.
  • Total body iodine sufficiency 1,500 mg. Stantdard view is that the body contains 50-80 mg of iodine, of which 30 mg is in the thyroid galnd Must be a complete nutritional programs, with selenium, magnesium, and Omega 3 fatty acids in particular. Iodoral: 27 cents a dose (90 for 43.93); Lugol’s 4 cents a dose (300 doses—2 drops—for 10.99)
  • Overall sense of well-being Consuming iodine in mg doses should be coupled with a complete nutritional program that includes adequate amounts of selenium, magnesium, and Omega 3 fatty acids, in particular. An iodine intake that is 100x the RDA, as one observer puts it, is “the simplest, safest, most effective and least expensive way to help solve the health care crisis crippling our nation.” Americans would do well to emulate the Japanese and increase their iodine intake, if not by eating seaweed, then with two drops of Lugol’s solution a day. Less than 1 percent, and those patients, if followed by a physician schooled in the extrathyroidal benefits, cut back on the amount of iodine consumed and have no long-term consequences.

Healthy and Harmful Halogens Iodine and Fluoride Presentation Transcript

  • 1. Healthy and Harmful Halogens Iodine and Fluoride
    • LewRockwell.com Conference
    • Be Healthy, Wealthy, and Wise
    • Center for Libertarian Studies
    • Foster City, CA
    • December 2, 2006
        • Donald W. Miller, Jr., M.D .
        • Professor of Surgery
        • Division of Cardiothoracic Surgery
        • University of Washington School of Medicine
  • 2. Halogens
    • Atomic Wt. Discovered
    • Fluorine 19 1886
    • Chlorine 35 1809
    • Bromine 80 1826
    • Iodine 127 1811
    • Astatine 210 1940
  • 3. Halogens in War Iodine Bromine Chlorine Fluoride Iodine Fluoride
  • 4. Elements that Compose the Human Body Periodic Table of Elements Iodine Chlorine
  • 5. Origin of Fluoridation
  • 6. Manhattan Project
  • 7. Edward Bernays
  • 8. Fluoride in Dr. Strangelove “ Have you ever seen a commie drink a glass of water ?” Capt. Jack D. Ripper
  • 9.  
  • 10. Dental Fluorosis
  • 11. Cosmetic Correction of Fluorosis $14,000 later
  • 12. Lead, Fluoride and Arsenic
    • Toxicity Maximum Contaminant Levels
  • 13. Manifestations of Fluoride Poisoning
    • Skeletal Fluorosis
      • Arthritis
      • Osteoporosis/Fracture
      • Crippling deformities
    • Neurotoxicity
      • Abnormal brain development
      • Alzheimer’s disease
    • Hypothyroidism
  • 14. Manifestations of Fluoride Poisoning
    • Increases risk for cancer
      • Osteosarcoma
      • Hepatocholangiocarcinoma
    • Early onset of puberty
      • Due to impaired melatonin production
    • Reduced male fertility
  • 15. Water Filters that Remove Fluoride Reverse Osmosis Distiller
  • 16. Water Fluoridation in U.S. Goal (Objective 21-9): Increase proportion of U.S. population served by fluoridated community water systems to 75 percent
  • 17. Iodine in Thyroid Hormones Iodine atom
  • 18. Actions of Triiodothyronine (T 3 )
      • Regulate cellular oxidation
        • Calorigenesis
        • Thermoregulation
        • Intermediary Metabolism
      • Necessary for protein synthesis
      • Promotes
        • Nitrogen retention
        • Glycogenolysis
        • Intestinal absorption of glucose and galactose
        • Lipolysis
        • Uptake of glucose by adipocytes
  • 19. Iodine Deficiency Disorders Goiter Mental Retardation Cretinism
  • 20. Reference Daily Intake (RDI) for Iodine
    • According to the AMA, NIH National Research Council, Joint UN FAO/WHO Expert Committee on Food Additives, and the EU IPCS
    • RDI: 100-150 μ g/day
  • 21. Worldwide Iodine Nutrition Median urinary iodine concentration of 100-199 ug/L with corresponding approximate iodine intake 150-299 ug/day International Council for the Control of Iodine Deficiency Disorders. Current IDD Status Database, 2003
  • 22. Iodine Intake in Japan Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health, Ministry of Health and Welfare, Tokyo, Japan, March 1965 Iodine Intake 1950-1963: 13.8 mg/per capita/day (average 4.5 gm seaweed a day. Measured Iodine content 0.3mg/gm) Seaweed consumption in 2001: 14.6 gm (dry weight) Iodine Intake 2001: 43.8 mg If Iodine content the same (was not measured)
  • 23. Iodine Intake in the United States Urinary iodine levels ( µ g/L) in the United States, age 6-74 Current Average Daily Intake of Iodine: 240 µg (0.24 mg) Iodine Intake in 1970s: 480 µg (0.48 mg) 320 145 161   NHANES I, 1971-74 1 NHANES III, 1988-91 1 NHANES 2000 Median 32.00 14.5 16.1 SE 0.6   0.3 0.7 1 Hollowell, JE et al. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-74 and 1988-94). J Clin Endocrinol Metab 83:3401-3408. 1998.
  • 24. Health Comparisons: United States and Japan United States Japan Incidence of Breast Highest in World Lowest Cancer Life Expectancy 77.85 years 81.25 years (48 th /226 countries) (No. 6) Infant Mortality Rate 7.0 3.5 (deaths under age 1 per (Lowest in World) 1,000 live births)
  • 25. The Earth’s 3 rd Atmosphere, from 2.2 Ga Oxygen Level in Atmosphere (Percent) 4.6 3.6 2.6 1.6 0.6 Billion Years Ago
    • Photosynthesis first done by Cyanobacteria:
      • 6CO 2 + 6H 2 O -> C 6 H 12 O 6 + 6O 2
    • Cyanobacteria are also the first life forms to tolerate and use……………………...
  • 26. Iodine as an Antioxidant I - + H 2 O 2 HIO + OH - HIO + I - + H + I 2 + H 2 O Reactive Oxygen Species Kupper FC, et al. Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide. Planta 1998;207:163-171.
  • 27. Function of Iodine in Humans and Other Animals
    • Thyroidal -- Organic
      • A Component of Thyroxine and T3
    • Extrathyroidal -- Inorganic
      • An Antioxidant
      • Triggers Apoptosis
      • Other
        • Detoxify chemicals and biological toxins
        • Anti-allergic, coat external proteins rendering them non allergic
        • Suppess auto-immunity
        • Strengthen immune system
        • Provide antisepsis in the stomach
  • 28. Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells. Cancer Research 2003;63:5065-5072 Iodine-Induced Apoptosis in Lung Cancer Iodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer Cells
  • 29. Effect of Iodine on Tumor Growth in Mice Genetically Modified Tumor Xenograft Controls Genetically Modified Tumor Xenograft with Iodine Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells. Cancer Research 2003;63:5065-5072
  • 30. Organs with Iodine Concentrating Ability Via the Sodium/Iodine Symporter Pump
    • Stomach Mucosa
    • Mammary Glands
    • Salivary Glands
    • Other: Ovaries
    • Thymus
    • Epidermis
    • Choroid Plexus
    • Articular, Arterial, and Skeletal Systems
    125 I total-body scintiscans 30 min 6 hr 20 hr Venturi S, et al. Role of Iodine in Evolution and Carcinogenesis of Thyroid, Breast and Stomach. Adv Clin Path 2000;4:11-17.
  • 31. The Real Truth on Iodine Dose-Related Benefits
    • In microgram ( μ g) amounts:
    • In milligram (mg) amounts:
    • In gram (g) amounts:
    • For thyroid hormone
    • Achieve optimal health
    • Prevent (and treat) fibrocystic disease of the breast
    • Prevent cancer
    • Civil Defense
    • Treat multiple diseases: dermatologic, pulmonary, cardiovascular, fungal
  • 32. Different Kinds of Iodine
    • Inorganic, Nonradioactive ( 127 I)
      • KI, SSKI, Lugol’s Solution, Iodoral,
      • Tincture of Iodine, Povidone-Iodine)
    • Organic
      • Endogenous
        • Thyroid hormones
      • Synthetic
        • Amiodarone
        • Radiocontrast media
          • Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.
    • (Inorganic) Radioactive Isotopes
  • 33. Forms of Inorganic, Nonradioactive Iodine
    • KI (Potassium Iodide)
      • A 130 mg tablet contains 100 mg of iodide
    • SSKI (Saturated Solution of Potassium Iodide)
      • 38 mg/drop iodide (760 mg/ml)
        • 19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench
    • Lugol’s Solution -- 5% iodine (I 2 ) and 10% KI
      • 6.5 mg/drop blend of iodine and iodide (130 mg/ml)
    • Iodoral -- 5% iodine and 10% KI
      • One tablet = 12.5 mg blend of iodine and iodide
  • 34. Iodine Poisoning Ingested 15 gm of Iodine – 100,000 x the RDA of 0.00015 gm (150 μ g) Serum Iodide level was 2,950 ug/dL (normal is 3.5 μ g/dL with daily intake of 150 ug Iodine) Salivary Iodide Level 60,000 ug/dL (normal 105 μ g/dL)
  • 35. Iodine in Dermatology Pyoderma Gangrenosum Nodular Vasculitis Sporotrichosis Sterling JB, Heymann WR. Potassium Iodide In Dermatology: A 19 th Century Drug for the 21 st Century—Uses, Pharmacology, Adverse Effects, and Contraindications. J Am Acad Dermatol 2000;43:691-697.
  • 36. Fibrocystic Breast Disease Cyst Fibrous tissue Epithelial and apocrine hyperplasia Elemental Iodine, I 2 , more effective than Iodide, I - Ghent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement in Fibrocystic Disease of the Breast. Can J Surg 1993;36:453-460.
  • 37. Iodine Prevents Breast Cancer
    • Animal Studies
      • Reduces incidence in rats given carcinogens
    • Human Studies
      • Kills cancer cells grown in vitro
      • Absorbed by cancer-prone ductal epithelium
    • Epidemiological Studies
      • Increased incidence with goiter
      • Lower incidence in people who eat seaweed and fish
  • 38. The Iodine Project
            • Hypothesis: Whole body sufficiency of iodine requires mg (12.5 mg), not μ g (150 μ g ) daily amounts
    • Principle Investigators
    • Guy Abraham MD, 1997: Optimox Corp., Torrance, CA
    • Jorge Flechas MD, 2000 (1,000 pts.): Flechas Family Practice, Hendersonville, NC
    • David Brownstein MD, 2003 (3,000 pts.): Center for Holistic Medicine, West Bloomfield, MI
    • Iodine Loading Test
      • Take 50 mg iodine, urine collected for 24 hours
      • Less than 90 % excretion indicates iodine insufficiency
  • 39. Health Benefits of mg-Dose Iodine at 100x the RDI
    • Feel Healthier
      • Sense of Well-Being
      • Lifting of Brain Fog
      • Increased Energy –
      • Achieve More in Less Time
    • Feel Warmer in Cold
    • Environments
    • Need Less Sleep
    • Regular Bowel Movements
    • Improved Skin Complexion
    • Strengthens Immune System
    • Prevents Cancer
    • Blocks 131 I Absorption from Radioactive Fallout