Predictive Medicine and Therapeutics Laboratory
(Director: Youwen Zhou, MD, PhD)
Name: Zhou, Youwen
Academic Titles: Assoc...
1. Metastatic melanoma:
Novel extracellular matrix molecules have been identified from metastatic melanoma tissues
and cul...
Cutis 2008; 82:267-272
8. Tao J, Huang C, Yu N, Wu Y., Liu Y, Li Y, Tian J, Yang L, Zhang J, Li J, Zhou, Y and
Tu Y. Olmst...
Clinical Cancer Research. 2003; 9:4409-4414.
25. Zhou, Y, Rothenthal D, Dutz J, and Ho V. Mycophenolate Mofetil for psoria...
2006 NSFC Young Investigator Collaborator Award
2003 Young Investigator Award, Canadian Dermatology Foundation
2001 New Op...
2006 NSFC Young Investigator Collaborator Award
2003 Young Investigator Award, Canadian Dermatology Foundation
2001 New Op...
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Dr. Youwen Zhou

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Dr. Youwen Zhou

  1. 1. Predictive Medicine and Therapeutics Laboratory (Director: Youwen Zhou, MD, PhD) Name: Zhou, Youwen Academic Titles: Associate Professor, Department of Dermatology and Skin Science, University of British Columbia Degrees / Designations: MD, PhD, FRCPC Primary Area of Research: Novel Genomic Markers of Skin Diseases Secondary Area(s) of Research: Skin Cancers, Skin Pigmentation, and Hyperhidrosis Email: ywzhou@interchange.ubc.ca Phone: 604-875-4747 Fax: 604-873-9919 Assistant: Bay Gumboc Assistant Phone: 604-875-4747 Mailing Address: Department of Dermatology and Skin Science, Faculty of Medicine, University of British Columbia 835 West 10th Ave Vancouver, BC V6Z 4E8 Clinical Appointments Skin oncologist, British Columbia Cancer Agency Staff dermatologist, Vancouver General Hospital Research Areas The focus of the Predictive Medicine and Therapeutic Lab is on the development of diagnostic tools and therapeutic targets for inflammatory and malignant skin diseases Summary Genomic tools such as transcriptional profiling and whole genome SNP scanning are used to identify disease-specific gene markers for common skin diseases such as melanoma, skin lymphoma, vitiligo and hyperhidrosis. These markers are then evaluated for their significance as diagnostic markers or therapeutic targets. Current Projects
  2. 2. 1. Metastatic melanoma: Novel extracellular matrix molecules have been identified from metastatic melanoma tissues and cultured cell lines, including collagen-triple-helix-repeat containing protein 1 (CTHRC1) and alpha-1 antichymotrypsin (ACT1). Using in vitro and in vivo models, the contribution of these proteins to melanoma metastasis and mortality is being studied. In addition, the prognostic value of these markers in predicting melanoma patients’ survival is tested. 2. Mechanism of melanocyte cell death in vitiligo: Vitiligo is the most common depigmentation disease of the skin that affects approximately 1.5% of population worldwide. The mechanism of pathogenesis is unknown. Genomic markers identified in this lab highlight the importance of both autoimmunity and melanocyte development in this disease. The current focus is on the role of NK T cells and tissue microenvironment in the death of melanocytes in this disease. 3. Cutaneous T cell lymphoma and Sezary syndrome: Sezary syndrome is an aggressive form of skin T cell lymphoma that has high mortality. The malignant cells in this disease, the Sezary cells have been purified and found to contain unique molecular markers. These markers, including T-plastin and SATB1, are studied for their diagnostic value and functional significance in malignant transformation of T lymphocytes. 4. Primary focal hyperhidrosis: Primary focal hyperhidrosis is characterized by uncontrollable perspiration of hands, feet and the underarms. Affecting about 5% of worldwide population, this condition frequently causes severe negative impact on the psychosocial wellbeing of the affected children and adults. Preliminary research from this laboratory suggests that this condition is an autosomal dominantly inherited disease with manifestation in the skin and the central nervous system. We are interested in building a clinical database with banking of the blood samples to isolate the gene mutations or polymorphism associated with the development of this disease. Selected Publications 1. Kennah E, Ringrose A, Zhou LL, Esmailzadeh S, Qian H, Su M-w, Zhou Y, and Jiang X Identification of tyrosine kinase, HCK, and tumor suppressor, BIN1, as potential mediators of AHI-1 oncogene in primary and transformed CTCL cells, Blood, 2009 (Accepted) 2. Wei S, Zhang T, Zhou Y, Zhang B, Zhu H, Li J, Huang Z, Deng L and Zhang X Fine Mapping of the Disseminated Superficial Porokeratosis Locus to a 2.7Mb Region on 18p11.3 British Journal of Dermatology, 2009 (Accepted) 3. Fumerton R, Martinka M and Zhou Y Refractory Cutaneous Rosai-Dorfman Disease Responsive to Cryotherapy. Cutis 2009 (Accepted) 4. Huang C, Tian J, Tao J, Liu Y, Li Y, Yang L, Zhang J, Li Y, Chen S, Lin N, Shen G, Tu Y, and Zhou Y Endothelin signaling axis activates osteopontin expression through PI3 kinase pathway in A375 melanoma cells. Journal of Dermatological Science. 2008;52:130-134 5. Tang, L., Huang C, Su, MW, Zhang, Y, Ip, W, Martinka, M, and Zhou, Y. Endothelin 3 autocrine pathway in metastatic melanoma. J. Cutaneous Med. Surg. 2008;12(2):64-70 6. Zhang J, Adam D, Stebbing E, Gerbrandt J, Lui H, Shapiro J, and Zhou Y. Efficacy of a day-care program in the treatment of psoriasis. Journal of Cutaneous Medicine and Surgery. 2008;12:211-216 7. Adam, D, Beleznay K, Randhawa R, Marton M, and Zhou Y. Review of Intravascular Lymphoma with a report of treatment with allogenic peripheral blood stem cell transplant.
  3. 3. Cutis 2008; 82:267-272 8. Tao J, Huang C, Yu N, Wu Y., Liu Y, Li Y, Tian J, Yang L, Zhang J, Li J, Zhou, Y and Tu Y. Olmsted syndrome: a case report and review of literature. International Journal of Dermatology 2008;47:432-437 9. Liang, Y., Yang, S., Zhou, Y., Cui, J., Ren, Y., Chen, J., Fan, X., Sun, L., Xiao, F., Gao, M., Fang, Q., Xu, S., Huang, W., and Zhang, X. Evidence for two susceptibility loci on Chromosome 22q12 and 6p21-p22 in Chinese generalized vitiligo families. J Invest Dermatol. 2007; 127(11):2552-57 10. Zhang, Y, Tang T, Su, MW, Eisen, D, Zloty, D, Warshawski, L, and Zhou, Y. Expression of endothelins and their receptors in non-melanoma skin cancers. J. Cutaneous Med. Surg. 2006; 10 (6): 269-276 11. Ringrose A, Zhou Y, Pang E, Zhou L, Lin AE-J, Sheng G, Li XJ, Weng A, Su M-W, Pittelkow MR and Jiang X. Evidence for an Oncogenic Role of AHI-1 in Sezary Syndrome, a Leukemic Variant of Human Cutaneous T-cell Lymphomas. Leukemia. 2006; 20:1593-601 12. Tang, L, Dai, D, Martinka, M., Su, MW, Zhang, Y, Li, G and Zhou, Y Aberrant Expression of CTHRC1 in human cancers. Clinical Cancer Research. 2006;12:3716-3722 13. Zhou, Y. Therapeutic options for common pigmentation disorders. CME Journal, 2007, Jan 64-67. 14. Zhou, Y. Hyperhidrosis, Skin Therapy Letters 2006;1: 6-7 15. Xiao C., Zhao, L., Lu, C., H., Zha, Q., Yan, X., Wang, J., Zhang, Y., Zhou, Y., Xu, S., Li, S., and Lu. Comparison on Gene Expression Profile of Periphery CD4 Positive Cells in Rheumatoid Arthritis with Positive and Negative Rheumatoid Factor. Chin. J. of Integr.Tradit. and West. Med. 2006;26 (8): 689-693 16. Xiao, C., Lu, C., Zhao, L, Jia, H., Zha, Q., Yan, X., Wang, J., Zhang, Y., Zhou, Y., Xu, S., Li, S., and Lu, A. Comparison on gene expression profiles of the peripheral blood CD4 positive cells in active and stable stages of rheumatoid arthritis. Chin. J. of Information on Tradit. Chin Med. 2006;13 (3):14-17 17. Lu, C., Xiao, C., Zhao, L, Jia, H., Zha, Q., Yan, X., Wang, J., Zhang, Y., Zhou, Y., Xu, S., Li, S., and Lu, Comparison of gene profile of peripheral CD4+ lymphocytes in rheumatoid arthritis with “cold” and “heat” syndromes. Chin. J. of Basic Med. in Tradit. Chin. Med. 2006;12(2): 130-133 18. Lu, C., Xiao, C., Zhao, L, Jia, H., Zha, Q., Yan, X., Wang, J., Zhang, Y., Zhou, Y., Xu, S., Li, S., and Lu. Gene expression profile of periphery CD4 positive in Rheumatoid Arthritis. Chin J. Rheum. 2006;10:438-439 19. Lu C., Zhao L., Xiao C., Zha Q., Yan X., Wang J., Zhang Y., Yang W., Zhou Y, Li S., Lu A. Gene expression profile of periphery CD4 positive in Early and late Rheumatoid Arthritis. Current Immunology. 2006;26(4);336-339 20. Huang, CZ and Zhou, Y. Familial bullous lichen planus (FBLP): clinical characteristics and inheritance analysis. J. Cutaneous Medicine and Surgery. 2005; 9:217-222 21. Zhou, Y, Dai D, Martinka M, Su M, Zhang Y, Campos E, Dorocicz I, Tang L, Huntsman D, Nelson C, Ho, V, Li G. Osteopontin expression correlates with melanoma invasion. J Invest Dermatol 2005; 124(5):1044-52. 22. Afifi T, De Gannes G, Huang C, Zhou Y. Topical Treatments for Psoriasis. Canadian Family Physicians, 2005; 51:519-525 23. Su MW, Dorocicz I, Degawska V, Voss N, Ho V, Li G, Gascoyne R and Zhou, Y. Aberrant Expression of T-plastin gene in Sezary Cells. Cancer Research. 2003; 63:7122- 7127. 24. Dai D, Makretsov N, Campos E, Martinka M, Huang C, Zhou, Y, Huntsman D, and Li G. Increased expression of integrin linked kinase correlates with melanoma invasion.
  4. 4. Clinical Cancer Research. 2003; 9:4409-4414. 25. Zhou, Y, Rothenthal D, Dutz J, and Ho V. Mycophenolate Mofetil for psoriasis: a two center, prospective, open-label clinical trial. J. Cutaneous Medicine and Surgery. 2003;7:193-197 26. Zhou, Y, Dutz J, and Ho V. Mycophenolate mofetil for dermatological diseases. J. Cutaneous Medicine and Surgery. 2001; 5 (3 supplement): 26-29 27. Su M, Merz DC, Killeen MT, Zhou, Y, Zheng H, Kramer JM, Hedgecock EM, and Culotti JG. Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans. Development. 2000;127:585-594 28. Zhou,Y, Barnet M, Rivers J. Clinical significance of skin biopsies in the diagnosis and management of graft-vs-host disease in early postallogeneic bone marrow transplantation. Archives of Dermatology. 2000;136:717-721 29. Zhou Y, Lee H-S T, Koosheh F, Fujisawa H, Sauder DN, Kondo S. Effects of UVB irradiation on keratinocyte growth factor and its receptors expression in cultured human keratinocytes. Exper Dermatol 1996; 5:138-144. 30. Hamelin M, Zhou Y, Su M, Scott I, Culotti JG. Expression of the unc-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 1993; 364:327-330 31. McAllister WT, Zhou, Y, MacDonald L, Raskin C. Regulation of transcription elongation and termination. J Cell. Biochem 1993; 147 (15G):223-275 32. MacDonald LE, Zhou Y, McAllister WT. Termination and slippage by bacteriophage T7 RNA polymerase. J Molecular Biol 1993; 87:1030-1047 33. Leung-Hagesteijn C, Spence AM, Stern BD, Zhou, Y, Su M, Hedgecock EM, Culotti JG. Unc-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegansC. Cell 1992; 71:289-299 34. Rodriguez D, Zhou Y, Rodriguez JR, Durbin R, McAllister WT, Esteban M. Regulated expression of a nuclear gene by T3 RNA polymerase and lac repressor delivered by recombinant vaccinia viruses. J Virology 1990; 64:4851-4857. 35. Baricos WH, Cortez SL, Le QC, Zhou,Y, Dicarlos RM, O’Connor SE, Shah SV. Glomerular basement membrane degradation by endogenous cystein proteinases in isolated rat glomeruli. Kidney International 1990; 38:395-401. 36. Zhou Y, Giordano T, Durbin R, McAllister WT. Synthesis of functional messenger RNA in mammalian cells by bacteriophage T 3 RNA polymerase. Molecular and Cellular Biology 1990; 10:4529-4537. 37. Baricos WH, Zhou, Y, Mason RW, Barrett AJ. Human kidney cathepsons B and L: characterization and potential role in degradation of glomerular basement membrane. Biochem J 1988; 252:301-304 38. Baricos WH, Murphy G, Zhou Y, Nguyen HH, Shah SV. Degradation of glomerular basement membrane by purified mammalian metalloproteinases. Biochemi J 1988; 254:609-612. 39. Baricos WH, Zhou,Y, Feurst R, Barrett A, Shah SV. The role of aspartic and cysteine proteinases in albumin degradation by rat kidney cortical lysosomes. Arch Biochem Biophysics 1987; 256:687-691 40. Wang YH, Zhang XY, Khan R, Zhou, Y, Huang L-H, Ehrlich M. Methylated DNA- binding protein from human placenta recognizes specific methylated sites on several prokaryotic DNAs. Nucleic Acid Res 1986; 14:9843-9860 Honours & Awards 2007 Established Clinician Scientist Award (Vancouver Hospital Foundation)
  5. 5. 2006 NSFC Young Investigator Collaborator Award 2003 Young Investigator Award, Canadian Dermatology Foundation 2001 New Opportunity Award, Canada Foundation for Innovation 2001 Young Investigator Award, Banting Research Foundation 1990-1991 Network of Centers of Excellence Postdoctoral Fellowship Award Research Group Members Mingwan Su, PhD (Senior research associate) Wency Ip, Graduate student) Shencai wei, MD, PhD (Post-doctoral fellow) Yang Wang, MD (Post graduate trainee) Yvonne Y Zhang (Graduate student) Helen Jiang (Undergraduate medical student) Anna Hinek (Dermatology resident) Raina Fumerton (Pathology resident) Christina Han (Dermatology resident) Henry Tran (Undergraduate medical student)
  6. 6. 2006 NSFC Young Investigator Collaborator Award 2003 Young Investigator Award, Canadian Dermatology Foundation 2001 New Opportunity Award, Canada Foundation for Innovation 2001 Young Investigator Award, Banting Research Foundation 1990-1991 Network of Centers of Excellence Postdoctoral Fellowship Award Research Group Members Mingwan Su, PhD (Senior research associate) Wency Ip, Graduate student) Shencai wei, MD, PhD (Post-doctoral fellow) Yang Wang, MD (Post graduate trainee) Yvonne Y Zhang (Graduate student) Helen Jiang (Undergraduate medical student) Anna Hinek (Dermatology resident) Raina Fumerton (Pathology resident) Christina Han (Dermatology resident) Henry Tran (Undergraduate medical student)

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