Division of Critical Care and Clinical Support Services 1.doc.doc

Publications by Members of Staff 2000 9

LTHT Publications 2000 Publications by Members of Staff of The Leeds Teaching Hospitals NHS Trust in 2000 The following information relates to material published by members of staff of LTHT during the calendar year of 2000. We thank all researchers for submitting details of their publications and apologise for any errors or omissions. An index by department can be found at the end of this document The Leeds Teaching Hospitals NHS Trust – Publications by Members of Staff 2000 2

LTHT Publications 2000 CONTENTS Division of Critical Care and Clinical Support Services 1 Accident & Emergency 1 Anaesthetics 2 Dietetics 5 Physiotherapy 5 Psychology 5 Speech & Language Therapy 6 Division of Acute Medicine and Cardiovascular Services 7 Cardiology 7 Cardiothoracic Surgery 8 Cardiovascular 9 General Medicine 10 Medicine for the Elderly 11 Psychiatry 12 Respiratory Medicine 14 Vascular Medicine/Surgery 14 Division of Head, Neck and Musculoskeletal Services 17 Dentistry 17 ENT 20 Neurology 21 Neurosurgery 22 Ophthalmology 22 Orthopaedic Surgery 23 Otolaryngology 25 Plastic Surgery 25 Rheumatology & Rehabilitation 26 Division of Medicine, Surgery and Oncology 29 Cancer Medicine (including Medical Oncology, Clinical Oncology and Radiotherapy) 29 Dermatology 32 Epidemiology 34 Gastroenterology 35 Genito-Urinary Medicine 37 General Surgery 38 Gynaecology 41 3

LTHT Publications 2000 CONTENTS Continued.. Haematology 41 Palliative Care 43 Renal & Liver Services 43 Urology 44 Division of Laboratory, Radiology and Pharmacy Services 46 Chemical Pathology 46 Clinical Genetics 46 Cytogenetics 47 Histopathology 47 Immunology 50 Medical Physics 51 Microbiology 53 Pharmacy 55 Radiology 56 Molecular Medicine 59 Division of Children’s Services and Obstetrics 63 Assisted Conception Unit 63 Midwifery 63 Obstetrics 64 Paediatrics and Child Health 69 Paediatric Cardiology 72 Paediatric Endocrinology 72 Paediatric Neurology 72 Paediatric Oncology/Haematology 73 Paediatric Surgery 74 Division of Corporate Services 75 Nursing 75 Clinical Effectiveness 76 Research & Development 76 Statistics 77 4

LTHT Publications 2000 The Leeds Teaching Hospitals NHS Trust Publications 2000 Division of Critical Care and Clinical Support Services Accident & Emergency 1. Brenchley, J., Sloan, J., Thompson, P. Echoes of things to come: ultrasound in UK emergency medicine practice. Journal of Accident & Emergency Medicine 2000;17( 3):170. 2. Bush, S., Gray, A., McGowan, A., Nichol, N. Letter. Journal of Accident & Emergency Medicine 2000;17:309. 3. Bush, S. Letter. Journal of Accident & Emergency Medicine 2000;17:310-311. 4. Carrigan, T. D., Field, H., Illingworth, R. N., Gaffney, P., Hamer, D. W. Toxicological screening in trauma. Journal of Accident & Emergency Medicine 2000;17(1):33-37. 5. Gaffney, P. The domestic iron. A danger to young children. Journal of Accident & Emergency Medicine 2000;17(3):199-200. 6. Gaffney, P and Holbrook, S. An unusual cause of stridor. Journal of Accident & Emergency Medicine 2000;17(5):386. 7. Gaffney, P., Carrigan, T., Johnson, G. Survey of needlestick injuries in paramedics and technicians in the West Yorkshire Metropolitan Ambulance Service. Pre-Hospital Immediate Care 2000;4(1):30-33. 8. Gaffney, P and Guthrie, J. A. Spontaneous spinal epidural haematoma: an unusual cause of neck pain. Journal of Accident & Emergency Medicine 2000;17(3):229-230. 9. Hardern, R. Are generalists still needed in a specialised world? Additional issues need to be addressed. BMJ 2000;320(7251):1728-1729. 10. Hardern, R. D. Acute medicine: the physician's role. A working party report of the Federation of Royal Colleges of Physicians of the United Kingdom. Journal of Accident & Emergency Medicine 2000;17:391. 11. Lewis, R. Diabetic emergencies: part 2. Hyperglycaemia. Accident & Emergency Nursing 2000;8(1):24-30. 12. McGowan, A. Emergency Medical Treatment: The Practical Approach. T.Wardle. 2000; BMJ Publishing Group. 13. Mohammed, A., Hassan, T., Hamer, W. Myocardial infarction and left bundle branch block. Journal of Accident & Emergency Medicine 2000;17(3):233. 14. Shepherd, M and Hardern, R. Acute myocardial infarction in patients with left bundle branch block. Journal of Accident & Emergency Medicine 2000;17(1):74. 15. Sloan, J. P and Brenchley, J. Emergency casebooks. An unusual cause of pilonidal sinus. Journal of Accident & Emergency Medicine 2000;17(3):232. 16. Walker, A and Brenchley, J. A survey of the use of rapid sequence induction in A&E. Journal of Accident & Emergency Medicine 2000;17:95-97. 17. Walker, A and Brenchley, J. It's a knockout: survey of the management of avulsed teeth. Accident & Emergency Nursing 2000; 8(2):66-70. 1

LTHT Publications 2000 Anaesthetics 1. Adams, J. P and Murphy, P. G. Obesity in anaesthesia and intensive care. British Journal of Anaesthesia 2000;85(1):91-108. 2. Attia, M. S., Prasad, K. J., Bellamy, M. C., Lodge, J. P. A. Organ retrieval - fluids and techniques. Ed. J.L.R.Forsythe. In: A Companion to Surgical Practice: Transplantation Surgery. 2000;2nd edition, London, Balliere Tindall. 3. Barry, B and Bodenham, A. Airway management in the ICU. British Journal of Intensive Care 2000; (Feb):22-29. 4. Bellamy, M. C and Davy-Quinn, A. Gas exchange. Eds. P.M.Hopkins and J.C.Hemmings. Fundamental Anaesthesia. 2000;473-483.London, Mosby & Co.. 5. Bellamy, M. C. Haematology. Eds. P.M.Hopkins and J.C.Hemmings. In: Fundamental Anaesthesia. 2000;525-536. London, Mosby & Co. 6. Bodenham, A and Whiteley.S. General responses to injury and acute illness. Eds. B.W.Ellis and S.Patterson Brown. In: Hamilton Baileys Emergency Surgery. 2000;3-7. London, Arnold. 7. Bodenham, A and Whiteley.S. Respiratory emergencies. Eds. B.W.Ellis and S.Patterson Brown. In: Hamilton Baileys Emergency Surgery. 2000;37-47. London, Arnold. 8. Clarke, P. R., Murdoch, S. D., Bellamy, M. C. Does methylene blue inhibit fibrinolysis following reperfusion injury? British Journal of Anaesthesia 2000;85(4):643. 9. Cohen, A. T. The hazards of inter-hospital transfer of patients [Editorial]. Care of the Critically Ill 2000;16(2):44-45. 10. Corbett, E. J., Barry, B. N., Pollard, S. G., Lodge, J. P., Bellamy, M. C. Laser doppler flowmetry is useful in the clinical management of small bowel transplantation. Gut 2000;47(4):580-583. 11. Davies, L. A., Gibson, C. N., Boyett, M. R., Hopkins, P. M., Harrison, S. M. Effects of isoflurane, sevoflurane, and halothane on myofilament Ca2+ sensitivity and sarcoplasmic reticulum Ca2+ release in rat ventricular myocytes. Anesthesiology 2000;93(4):1034-1044. 12. Davies, L. A., Hopkins, P. M., Boyett, M. R., Harrison, S. M. Effects of halothane on the transient outward K+ current in rat ventricular myocytes. British Journal of Pharmacology, 2000;131(2):223-230. 13. Fletcher, S and Bodenham, A. Safe placement of central venous catheters; where should catheter tip lie? British Journal of Anaesthesia 2000;85:1-4. 14. Giannoudis, P. V., Smith, R. M., Perry, S. L., Windsor, A. J., Dickson, R. A., Bellamy, M. C. Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intensive Care Medicine 2000;26(8):1076-1081. 15. Goodchild, C. S., Guo, Z., Freeman, J., Gent, J. P. 5-HT spinal antinociception involves mu opioid receptors: cross tolerance and antagonist studies. British Journal of Anaesthesia 2000;78(5):563-569. 16. Gorton, H. and Lyons, G. Epidural pain relief in labour. Current Anaesthesia 2000;11:92-96. 17. Gorton, H., Wilson, R., Robinson, A., Lyons, G. Survivors of childhood cancers: implications for obstetric anaesthesia. British Journal of Anaesthesia 2000; 85:911-913. 18. Gorton, H., Warren, E., Simpson, N., Lyons, G., Columb, M. O. Thromboelastography identifies gender related differences in coagulation. Anesthesia and Analgesia 2000;91:1279-1281. 2

LTHT Publications 2000 19. Gorton, H., Lyons, G., Manraj, P. Preparation for regional anaesthesia induces changes in thromboelastography. British Journal of Anaesthesia 2000;84(3):403-404. 20. Hamilton, D. L., Boyett, M. R., Harrison, S. M., Davies, L. A., Hopkins, P. M. The concentration-dependent effects of propofol on rat ventricular myocytes. Anesthesia & Analgesia 2000;91(2):276-282. 21. Hopkins, P. M. Malignant hyperthermia: advances in clinical management and diagnosis. British Journal of Anaesthesia 2000;85(1):118-128. 22. Hopkins, P. M. Ryanodine contracture tests. Eds. J.Schulte am Esch., J.Scholz., and F.Wappler. In: Malignant Hyperthermia. 2000;262-270. Lengerich, Pabst Science Publishers. 23. Hopkins, P. M. A shame about the patient? British Journal of Anaesthesia 2000;84(1):1-2. 24. Hopkins, P. M. and Hunter, J. M. Endocrine and metabolic disorders in anaesthesia and intensive care. British Journal of Anaesthesia 2000;85(1):1-2. 25. Hughes, P., Scott, C., Bodenham, A. Ultrasonography of the femoral vessels in the groin: implications for vascular access. Anaesthesia 2000;55(12):1198-1202. 26. Janzen, P. R., Hall, W. J., Hopkins, P. M. Setting targets for sedation with a target-controlled propofol infusion. Anaesthesia 2000;55(7):666-669. 27. Johnson, R. V., Lyons, G., Wilson, R. C., Robinson, A. P. C. Training in obstetric general anaesthesia is a vanishing art. Anaesthesia 2000;55:179-183. 28. Jovanovic, S., Hansbro, S. D., Munsch, C. M., Cross, M. H. Redo cardiac surgery in a Jehovah's witness: the importance of a multidisciplinary approach to blood conservation. Perfusion 2000;15:251-255. 29. Lodge, J. P., Ammori, B. J., Prasad, K. R., Bellamy, M. C. Ex vivo and in situ resection of inferior vena cava with hepatectomy for colorectal metastases. Annals of Surgery 2000;231(4):471-479. 30. Lumb, A. B. and Vail, A. Difficulties with anonymous shortlisting of medical school applications and its effects on candidates with non-European names: prospective cohort study. BMJ 2000;320 (7227):82-85. 31. Lumb, A. B. Nunn's Applied Respiratory Physiology. 2000;5thOxford, Butterworth-Heinemann. 32. Lyons, G. Phamacology of local anesthetics. Eds. D.Birnbach., S.Datta., and S.Gatt. In: International Textbook of Obstetric Anesthesia. 2000; New York, Churchill Livingstone. 33. Maas, I. R., Dearden, N. M., Servadei, F., Stocchetti, N., Unterberg, A. Current recommendations for neurotrauma. Current Opinion in Critical Care 2000;6(4) 34. Mallick, A and Bodenham, A. Fluid and electrolyte balance and disorders. Eds. H.Hemmings and P.Hopkins. In: Foundations of Anaesthesia, Basic and Clinical Science. 2000;571-583. London, Mosby. 35. McKinlay, J and Moss, E. Pharmacology of drugs used in neuroanaesthesia. Eds. E.Moss and F.R.Ellis. In: Bailliere's Best Practice and Research, Clinical Anaesthesiology - Neuroanaesthesia. 2000;13.4(2):499-510. 36. Mendonça, A. de., Vincent, J. L., Suter, P. M., Moreno, R., Dearden, N. M. Acute renal failure in the ICU: risk factors and outcome evaluated by SOFA score. Intensive Care Medicine 2000;26:915-921. 37. Moss, E. Anaesthetic management of intracranial aneurysms, arteriovenous malformations and carotid endarterectomy. In: Bailliere's Best Practice and Research, Clinical Anaesthesiology - Neuroanaesthesia. Eds. E.Moss and F.R.Ellis. 2000;13.4(6):545-556. 38. Murdoch, S. and Cohen, A. Intensive care sedation: a review of British practice. Intensive Care Medicine 2000;26:922-928. 3

LTHT Publications 2000 39. Murdoch, S. D., Cohen, A. T., Bellamy, M. C. Pulmonary artery catheterization and mortality in critically ill patients. British Journal of Anaesthesia 2000;85( 4):611-615. 40. O'Riordan, J. A., Hopkins, P. M., Ravenscroft, A., Stevens, J. D. Postoperative urinary retention and the influence of analgesia in patients undergoing lower limb joint replacement. European Journal of Anaesthesiology 2000;17(7):431-435. 41. Parekh, N., Husaini, S. W., Russell, I. F. Caesarean section for placenta praevia: a retrospective study of anaesthetic management. British Journal of Anaesthesia 2000;84 (6):725-730. 42. Ravenscroft, A. and Bell, M. D. D. 'End of life' decision making within intensive care - objective, consistent, defensible? Journal of Medical Ethics 2000;26(6):435-440. 43. Robinson, R. L., Curran, J. L., Ellis, F. R., Halsall, P. J., Hall, W. J., Hopkins, P. M., Iles, D. E., West, S. P., Shaw, M-A. Multiple interacting gene products may influence susceptibility to malignant hyperthermia. Annals of Human Genetics 2000;64:307-320. 44. Servadei, F., Murray, G. D., Teasdale, G. M., Dearden, N. M., Penny, K. The value of "worst" CT scan in clinical studies of moderate and severe head injury. Neurosurgery 2000;46(1):71-77. 45. Simpson, K. H. Philosophy of cancer pain management. Eds. K.H.Simpson and K.Budd. In: Management of Cancer Pain. 2000; Oxford University Press. 46. Simpson, K. H. and Lynch, L. Physiology and pharmacology of nausea and vomiting. In: Foundations of Anaesthesia. Basic & Clinical Sciences. Eds. Hemmings & Hopkins. Mosby-Wolfe. 2000;623-631. 47. Simpson, K. H. Cancer Pain Management, a Comprehensive Approach. Eds. K.H.Simpson and K.Budd. 2000; Oxford University Press. 48. Smith, R. M., Giannoudis, P. V., Bellamy, M. C., Perry, S. L., Dickson, R. A., Guillou, P. J. Interleukin-10 release and monocyte human leukocyte antigen-DR expression during femoral nailing. Clinical Orthopaedics & Related Research 2000;(373):233-240. 49. Swallow, J. E., Briggs, M., Semple, P. Pain at home: childrens' experience of tonsillectomy. Journal of Child Health Care 2000;4(3):93-98. 50. Watkins, E. J., Dresner, M., Calow, C. E. Severe vasovagal attack during regional anaesthesia for caesarean section. British Journal of Anaesthesia 2000;84(1):118-120. 51. Watkins, E. J., Mitchell, S., Allgar, V., Brown, J. Failure of oral transmucosal Fentanyl as a premedicant for paediatric day case surgery. British Journal of Anaesthesia 2000;84(7) 52. Whiteley.S and Bodenham, A. Cardiac emergencies. Eds. B.W.Ellis and S.Patterson Brown. In: Hamilton Baileys Emergency Surgery. 2000;48-57. London, Arnold. 53. Whiteley.S and Bodenham, A. Shock. Eds. B.W.Ellis and S.Patterson Brown. In: Hamilton Baileys Emergency Surgery. 2000;31-36. London, Arnold. 54. Wilson, R. C and Lyons, G. Spinal analgesia. Ed. F.Reynolds. In: Regional Analgesia in Obstetrics - A Millennium Update. 2000; London. Springer-Verlag. 55. Yates, A. P. Anaesthesia. A.Gupta., S.Kay., and L.Scheker. The Growing Hand. 2000;1(15):107-112. 4

LTHT Publications 2000 Dietetics 1. Abbott, J., Conway, S., Etherington, C., Fitzjohn, J., Gee, L., Morton, A., Musson, H., Webb, A. K. Perceived body image and eating behaviour in young adults with cystic fibrosis and their healthy peers. Journal of Behavioural Medicine 2000;23(6):501-517. 2. Conway, S. P., Morton, A., Wolfe, S. Enteral tube feeding for cystic fibrosis. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD001198. 3. Conway, S. P., Morton, A. M., Oldroyd, B., Truscott, J. G., White, H., Smith, A. H., Haigh, I. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 2000;55(9):798-804. 4. Wolfe, S. P. Growth and development and nutrition. Eds. M.E.Hodson and D.M.Geddes. In: Cystic Fibrosis. 2000;2nd edition:243-261. Physiotherapy 1. Bellew, M., Kay, S. P., Webb, F., Ward, A. Developmental and behavioural outcome in obstetric brachial plexus palsy. Journal of Hand Surgery - British Volume 2000;25(1):49-51. 2. Ubhi, T., Bhakta, B. B., Ives, H. L., Allgar, V., Roussounis, S. H. Randomised double blind placebo controlled trial of the effect of Botulinum toxin on walking in cerebral palsy. Archives of Disease in Childhood 2000;83(6):481-487. Psychology 1. Bellew, M., Kay, S. P., Webb, F., Ward, A. Developmental and behavioural outcome in obstetric brachial plexus palsy. Journal of Hand Surgery - British Volume 2000;25(1):49-51. 2. Blundell, J. E. and Cooling, J. Routes to obesity: phenotypes, food choices and activity. British Journal of Nutrition 2000; 83(Suppl 1):S33-S38. 3. Blundell, J. E. What foods do people habitually eat? A dilemma for nutrition, an enigma for psychology. American Journal of Clinical Nutrition 2000;71(1):3-5. 4. Blundell, J. E. and King, N. A. Exercise, appetite control, and energy balance. Nutrition 2000;16(7-8):519-522. 5. Cooling, J. and Blundell, J. E. Lean male high- and low-fat phenotypes--different routes for achieving energy balance. International Journal of Obesity & Related Metabolic Disorders 2000;24(12):1561-1566. 6. Dye, L., Lluch, A., Blundell, J. E. Macronutrients and mental performance. Nutrition 2000;16(10):1021-1034. 7. Flint, A., Raben, A., Blundell, J. E., Astrup, A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. International Journal of Obesity & Related Metabolic Disorders 2000;24(1):38-48. 8. Green, S. M., Wales, J. K., Lawton, C. L., Blundell, J. E. Comparison of high-fat and high-carbohydrate foods in a meal or snack on short-term fat and energy intakes in obese women. British Journal of Nutrition 2000;84(4):521-530. 9. Halford, J. C. and Blundell, J. E. Separate systems for serotonin and leptin in appetite control. Annals of Medicine 2000;32(3):222-232. 5

LTHT Publications 2000 10. Halford, J. C. and Blundell, J. E. Pharmacology of appetite suppression. Progress in Drug Research 2000;54:25-58. 11. Hanks, H. G. I and Wynne, J. M. Sexual abuse of children by women - an approach to assessment. Ed. M.C.Calder. In: Complete Guide to Sexual Abuse Assessments. 2000. 12. Lawton, C. L., Delargy, H. J., Brockman, J., Smith, F. C., Blundell, J. E. The degree of saturation of fatty acids influences post-ingestive satiety. British Journal of Nutrition 2000;83(5):473-482. 13. Lluch, A., Hubert, P., King, N. A., Blundell, J. E. Selective effects of acute exercise and breakfast interventions on mood and motivation to eat. Physiology & Behaviour 2000;68(4):515-520. 14. Lluch, A., King, N. A., Blundell, J. E. No energy compensation at the meal following exercise in dietary restrained and unrestrained women. British Journal of Nutrition 2000;84(2):219-225. 15. Madill, A., Jordan, A., Shirley, C. Objectivity and reliability in qualitative analysis: realist, contextualist and radical constructionist epistemologies. British Journal of Psychology 2000;91(Pt 1):1-20. 16. Rodgers, R. J., Halford, J. C., Nunes, de Souza RL, Canto, de Souza AL, Piper, D. C., Arch, J. R., Blundell, J. E. Dose-response effects of orexin-A on food intake and the behavioural satiety sequence in rats. Regulatory Peptides 2000;96(1-2):71-84. 17. Stubbs, R. J., Hughes, D. A., Johnstone, A. M., Rowley, E., Reid, C., Elia, M., Stratton, R., Delargy, H., King, N., Blundell, J. E. The use of visual analogue scales to assess motivation to eat in human subjects: a review of their reliability and validity with an evaluation of new hand-held computerized systems for temporal tracking of appetite ratings. British Journal of Nutrition 2000;84(4):405-415. 18. Veldtman, G. R., Matley, S. L., Kendall, L., Quirk, J. , Gibbs, J. L., Parsons, J. M., Hewison, J. Illness understanding in children and adolescents with heart disease. Heart (British Cardiac Society: Online) 2000;84:395-397. Speech & Language Therapy 1. Turnbull, J. The transtheoretical model of change: examples from stammering. Counselling Psychology Quarterly 2000;13(1):13-21. 6

LTHT Publications 2000 Division of Acute Medicine and Cardiovascular Services Cardiology 1. Ball, S. G. Discontinuation of Doxazosin arm of ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack. The Lancet 2000;355(9214):1558. 2. Ball, S. G., Baldock, C., Kielty, C. M., Shuttleworth, A. The role of the C1 and C2 A-domains in type VI collagen assembly. Journal of Biological Chemistry 2000;October 17. 3. De Boer, R. A., van Veldhuisen, D. J., Volkers, C., Henning, R. H., Olthof, E., Hall, A. S. , et al. Preserved efficacy of metoprolol in patients with heart failure homozygous for the hypofunctional gly389 variant of the beta 1 -adrenergic receptor. Hypertension 2000;36(4):667. 4. Flather, M. D., Yusuf, S., Kober, L., Pfeffer, M., Hall, A., Murray, G., Torp-Pedersen, C., Ball, S., Pogue, J., Moye, L., Braunwald, E., for the ACE-Inhibitor Myocardial Infarction Collaborative Group. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. The Lancet 2000;355:1575-1581. 5. Greenwood, J. P., Scott, E. M., Stoker, J. B., Mary, D. A. Chronic I1-imidazoline agonism: sympathetic mechanisms in hypertension. Hypertension 2000;35(6):1264-1269. 6. Hall, A. S. Sub-optimal ACE-inhibitor prescribing an increased all-cause mortality risk. A critical evaluation of routine clinical care. International Journal of Clinical Practice 2000;(Suppl.110):23. 7. Hall, A. S. Comparison of Losartan and Captopril in ELITE II. The Lancet 2000;356:851. 8. Hall, A. S., Balmforth, A. J., Samani, N. J., Ball, S. G. Memorandum by the ADLIB Project. Human Genetic Databases: Written Evidence; House of Lords, Science and Technology Committee: Session 1999-2000. Published by the London Stationery Office Ltd; 2000. 9. Lawrance, R. A., White, H., Hall, A. S. ACE in ischemic heart disease. Summaries of ten seminar papers. Dialogues in Cardiovascular Medicine. 2000;Vol 5(2):111-121. 10. Molinari, C., Grossini, E., Mary, D. A., Vacca, G. The effect of distension of the gallbladder on plasma renin activity in anesthetized pigs. Circulation 2000;101(21):2539-2545. 11. Molinari, C., Battaglia, A., Bona, G., Grossini, E., Mary, D. A., Vacca, G. The role of nitric oxide in the coronary vasoconstriction caused by growth hormone in anaesthetized pigs. Experimental Physiology 2000;85(2):203-208. 12. Nagy, Z. L., Fisher, J., Walker, P. G., Watterson, K. G. The in vitro hydrodynamic characteristics of the porcine pulmonary valve and root with regard to the Ross procedure. Journal of Thoracic & Cardiovascular Surgery 2000;120(2):284-289. 13. Pepper, C. B., Batin, P. D., Ryder, M., Bannister, J., Cowan, J. C., Mackintosh, A. F. Antiarrhythmic management and implantable defibrillator use in survivors of prehospital cardiac arrest without myocardial infarction in West Yorkshire. Heart 2000;83( 3):312-315. 14. Plein, S and Williams, G. J. Developments in cardiac ultrasound. Hospital Medicine (London) 2000;61(London):240-245. 15. Ruggeri, P., Battaglia, A., Ermirio, R., Grossini, E., Molinari, C., Mary, D. A., Vacca, G. Role of nitric oxide in the control of the heart rate within the nucleus ambiguus of rats. NeuroReport 2000;11(3):481-485. 16. Ruggeri, P., Cogo, C. E., Picchio, V., Ermirio, R., Mary, D. A. Reflex cardiovascular responses to somatic stimulation in spontaneously hypertensive rats. Journal of Hypertension 2000;18(5):595-600. 7

LTHT Publications 2000 17. Scott, E. M., Greenwood, J. P., Stoker, J. B., Gilbey, S. G., Mary, D. A. Water drinking and sympathetic activation. The Lancet 2000;356(9246):2013. 18. Smith, W. H and Ball, S. G. Ramipril. International Journal of Clinical Practice 2000;54(4):255-260. 19. Smith, W. H. Cardiac interstitum in heart failure: more important than muscle? Eds. J.McMurray and J.Cleland. In: Heart Failure in Clinical Practice. 2000;139-154. London, Martin Dunitz. 20. Smith, W. H and Ball, S. G. ACE inhibitors in heart failure: an update. Basic Research in Cardiology 2000;95(Suppl 11):18-114. 21. Tan, L. B. How did life start on earth? The Lancet 2000;355(9212):1371-1372. 22. White, H and Hall, A. S. ACE inhibitors are better than AT(1) receptor blockers (ARBs) - controversies in heart failure. European Journal of Heart Failure 2000;2:237-240. 23. Williams, S. G and Tan, L. B. Aldosterone antagonists: current and future perspectives. Current Opinion in Cardiovascular, Pulmonary and Renal Investigational Drugs 2000;2:310-315. 24. Williams, S. G., Wright, D. J., Tan, L. B. Transmyocardial laser revascularization. New England Journal of Medicine 2000;342(6):436-437. 25. Williams, S. G., Wright, D. J., Tan, L. B. Management of cardiogenic shock complicating acute myocardial infarction: towards evidence based medical practice. Heart 2000;83(6):621. Cardiothoracic Surgery 1. Casha, A and Chandrasekaran, V. Pericardiectomy using an oscillating saw. Annals of Thoracic Surgery 2000;69(2):613-614. 2. Davidson, L. A., Sadaba, J. R., Munsch, C. M. Cystic tumour of the atrioventricular node region: report of a case successfully treated with surgery. Heart 2000;83:e6. 3. Gibbs, J. L. Interventional catheterisation. Opening up I: the ventricular outflow tracts and great arteries. Heart 2000;83( 1):111-115. 4. Gibbs, J. L. Interventional catheterisation. Opening up II: venous return, the atrial septum, the arterial duct, aortopulmonary shunts, and aortopulmonary collaterals. Heart 2000;83(2):237-240. 5. Jovanovic, S., Hansbro, S. D., Munsch, C. M., Cross, M. H. Redo cardiac surgery in a Jehovah's witness: the importance of a multidisciplinary approach to blood conservation. Perfusion 2000;15:251-255. 6. Mulpur, A and Nair, R. U. Partial circumflex artery injury during mitral valve replacement - late presentation. Journal of Cardiovascular Surgery 2000;41:333-334. 7. Nagy, Z., Parsons, J., Watterson, K. G. Repair of hypoplastic left heart syndrome without using graft material. European Journal of Cardio-Thoracic Surgery 2000;17:85-87. 8. Nagy, Z., Fisher, J., Walker, P., Watterson, K. G. The effect of sizing on the hydrodynamic parameters of the medtronic freestyle valve. Annals of Thoracic Surgery 2000;69:1408-1413. 9. Nair, R. U., Sharpe, D., Mulpur, A. Total coronary artery revascularisation through a minimally invasive sternotomy. Surgical Technology International 2000;9:237-245. 10. Ngaage, D. L., Mulpur, A., Nair, R. U. Mitral valve surgery using a modified superior left atrial approach. Surgical Technology International 2000;9:224-227. 8

LTHT Publications 2000 11. Ramnarine, I. R., Mulpur, A. K., McMahon, M. J., Thorpe, J. A. C. Pleuro-biliary fistula from a ruptured choledochal cyst. European Journal of Cardio-Thoracic Surgery 2000;19(2) 12. Sadaba, J. R., Oswal, D., Munsch, C. M. Management of isolated sternal fractures: determining the risk of blunt cardiac injury. Annals of the Royal College of Surgeons of England 2000;82(3):162-166. 13. Sadaba, J. R., Mathew, K., Munsch, C. M., Beech, D. J. Vasorelaxant properties of nicorandil on human radial artery. European Journal of Cardio-Thoracic Surgery 2000;17(3):319-324. 14. Stark, J., Gallivan, S., Lovegrove, J., Hamilton, J., Monro, J., Watterson, K. G. Mortality rates after surgery for congenital heart defects in children and surgeon's performance. The Lancet 2000;355:1004-1007. 15. Thomson, J. D., Allen, J., Gibbs, J. L. Left sided valvar regurgitation in normal children and adolescents. Heart 2000;83(2):185-187. 16. Veldtman, G. R., Matley, S. L., Kendall, L., Quirk, J., Gibbs, J. L., Parsons, J. M., Hewison, J. Illness understanding in children and adolescents with heart disease. Heart (British Cardiac Society: Online) 2000;84:395-397. 17. Walker, P., Howe, T., Davies, R., Fisher, J., Watterson, K. G. Distribution of hepatic venous blood in the total cavo pulmonary connection: an in vitro study. European Journal of Cardio-Thoracic Surgery 2000;17:658-665. Cardiovascular 1. Brown, C and Hainsworth, R. Assessment of capillary shifts fluid shifts during orthostatic stress in normal subjects and subjects with orthostatic intolerance. Clinical Autonomic Research 2000;9:203-208. 2. Brown, C. M and Hainsworth, R. Forearm vascular responses during orthostatic stress in control subjects and patients with posturally related syncope. Clinical Autonomic Research 2000;10(2):57-61. 3. Bush, V. E., Wight, V., Brown, C., Hainsworth, R. Vascular responses to orthostatic stress in patients with postural tachycardia syndrome (POTS), in patients with low orthostatic tolerance and in asymptomatic controls. Clinical Autonomic Research 2000;10:278-284. 4. Carpenter, E., Hatton, C. J., Peers, C. Effects of hypoxia and anoxia on catecholamine release from isolated type I cells of the rat carotid body. Journal of Physiology 2000;523(Pt 3):719-729. 5. Fearon, I. M., Randall, A. D., Perez-Reyes, E., Peers, C. Modulation of recombinant T-type Ca2+ channels by hypoxia and glutathione. Pflugers Archive 2000;441:181-188. 6. Fearon, I. M., Palmer, A. C., Balmforth, A. J., Ball, S. G., Varadi, G., Peers, C. Hypoxic and redox inhibition of the human cardiac L-type Ca2+ channel. Advances in Experimental Medicine & Biology 2000;475:209-218. 7. Fearon, I. M., Varadi, G., Koch, S., Isaacsohn, I., Ball, S. G., Peers, C. Splice variants reveal the region involved in oxygen sensing by recombinant human L-type Ca2+ channels. Circulation Research 2000;87(Online):537-539. 8. Fearon, I. M., Ball, S. G., Peers, C. Clotrimazole inhibits the recombinant human cardiac L-type Ca2+ channel alpha1C subunit. British Journal of Pharmacology 2000;129(3):547-554. 9. Hainsworth, R. Lung function testing. Eds. H.Hemmings and P.Hopkins. In: Foundations of Anesthesia. 2000;457-464. London, Harcourt Publishers. 10. McMahon, N. C., Drinkhill, M. J., Myers, D. S., Hainsworth, R. Reflex responses from the main pulmonary artery and bifurcation in anaesthetised dogs. Experimental Physiology 2000;85(4):411-420. 9

LTHT Publications 2000 11. McMahon, N. C., Drinkhill, M. J., Myers, D. S., Hainsworth, R. Absence of reflex vascular responses from the intrapulmonary circulation in anaesthetised dogs. Experimental Physiology 2000;85(4):421-430. 12. O'Kelly, I., Peers, C., Kemp, P. J. O2 sensing by model airway chemoreceptors. Advances in Experimental Medicine & Biology 2000;475:611-622. 13. O'Kelly, I., Lewis, A., Peers, C., Kemp, P. J. O2 sensing by airway chemoreceptor-derived cells: protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. Journal of Biological Chemistry 2000;275:7684-7692. 14. Taylor, S. C and Peers, C. Oxygen and acid chemoreception by pheochromocytoma (PC12) cells. Advances in Experimental Medicine & Biology 2000;475:527-537. 15. Taylor, S. C., Green, K. N., Carpenter, E., Peers, C. Protein kinase C evokes quantal catecholamine release from PC12 cells via activation of L-type Ca2+ channels. Journal of Biological Chemistry 2000;275(35):26786-26791. 16. Taylor, S. C and Peers, C. Three distinct Ca2+ influx pathways couple acetylcholine receptor activation to catecholamine secretion from PC12 cells. Journal of Neurochemistry 2000;75(4):1583-1589. 17. Taylor, S. C., Shaw, S. M., Peers, C. Mitochondrial inhibitors evoke catecholamine release from pheochromocytoma cells. Biochemical & Biophysical Research Communications 2000;273(1):17-21. 18. Wright, C., Drinkhill, M. J., Hainsworth, R. Reflex effects of independent stimulation of coronary and left ventricular mechanoreceptors in anaesthetised dogs. Journal of Physiology 2000;528:349-358. General Medicine 1. Abbott, J., Conway, S., Etherington, C., Fitzjohn, J. , Gee, L., Morton, A., Musson, H., Webb, A. K. Perceived body image and eating behaviour in young adults with cystic fibrosis and their healthy peers. Journal of Behavioural Medicine 2000;23(6):501-517. 2. Anwar, R., Gallivan, L., Miloszewski, K. J., Markham, A. F. Factor XIII deficiency causing mutation, Ser295Arg, in exon 7 of the factor XIIIA gene. Thrombosis & Haemostasis 2000;84(4):591-594. 3. Bodansky, H. J. and the Global Lower Extremity Amputation Study Group. Epidemiology of lower extremity amputation in centres in Europe, North America and East Asia. British Journal of Surgery 2000;87(328):337. 4. Bodansky, H. J. and the EURODIAB ACE Study Group. Variation and trends in incidence of childhood diabetes in Europe. The Lancet 2000;355:873-876. 5. Bodger, K., Eastwood, P. G., Manning, S. I., Daly, M. J., Heatley, R. V. Dyspepsia workload in urban general practice and implications of the British Society of Gastroenterology Dyspepsia guidelines (1996). Alimentary Pharmacology & Therapeutics 2000;14(4):413-420. 6. Conway, S. P., Morton, A. M., Oldroyd, B., Truscott, J. G., White, H., Smith, A. H., Haigh, I. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 2000;55(9):798-804. 7. Conway, S. P., Etherington, C., Munday, J., Goldman, M. H., Strong, J. J., Wootton, M. Safety and tolerability of bolus intravenous colistin in acute respiratory exacerbations in adults with cystic fibrosis. Annals of Pharmacotherapy 2000;34(11):1238-1242. 8. Doring, G., Conway, S. P., Heijerman, H. G., Hodson, M. E., Hoiby, N., Smyth, A., Touw, D. J. Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus. European Respiratory Journal 2000;16(4):749-767. 10

LTHT Publications 2000 9. Fear, N. T., McKinney, P. A., Parslow, R. C., Patterson, C. C., Bodansky, H. J. Childhood type 1 diabetes and parental occupation involving social mixing and infectious contacts. Diabetic Medicine 2000;17:487-491. 10. Feely, M. P. Intermittent use of Benzodiazepines in epilepy. Eds. M.R.Trimble and I.Hindmarch. In: Benzodiazepines. 2000; Wrightson Biomedical Publishing Ltd. 11. Feltbower, R. G., McKinney, P. A., Bodansky, H. J. Rising incidence of childhood diabetes is seen at all ages and in urban and rural settings in Yorkshire, United Kingdom. Diabetologia 2000;43:682-684. 12. Gee, L., Abbott, J., Conway, S. P., Etherington, C., Webb, A. K. Development of a disease specific health related quality of life measure for adults and adolescents with cystic fibrosis. Thorax 2000;55(11):946-954. 13. Hafeez, I., Muers, M. F., Murphy, S. A., Evans, E. G., Barton, R. C., McWhinney, P. Non-tuberculous mycobacterial lung infection complicated by chronic necrotising pulmonary aspergillosis. Thorax 2000;55(8):717-719. 14. Hull, M. A., Fenwick, S. W., Chapple, K. S., Scott, N. , Toogood, G. J., Lodge, J. P. Cyclo oxygenase-2 expression in colorectal cancer liver metastases. Clinical & Experimental Metastasis 2000;18:21-27. 15. Law, G. R., Bodansky, H. J., McKinney, P. A. When do environmental factors initiate islet cell damage in children with type 1 diabetes mellitis? Diabetic Medicine 2000;17:167-168. 16. McKinney, P. A., Okashat, M., Parslow, R. C., Law, G. R., Gurney, K. A., Williams, D. R. R., Bodansky, H. J. Early social mixing and childhood type 1 diabetes mellitus: a case control study in Yorkshire, UK. Diabetic Medicine 2000;17:236-242. 17. McWhinney, P. H., Ragunathan, P. L., Rowbotham, T. J. Failure to produce detectable antibodies to Legionella pneumophila by an immunocompetent adult. Journal of Infection 2000;41(1):91-92. 18. Moncur, P. H. and Heatley, R. V. Safety of proton-pump inhibitors: the acid test. European Journal of Gastroenterology & Hepatology 2000;12(2):145-147. 19. Padmore, E. Higher level nursing 1: competency and context for the higher level nurse. Journal of Diabetes Nursing 2000;4(2):40-43. 20. Padmore, E. DSN prescribing under patient group directions: clarity needed. Journal of Diabetes Nursing 2000;4(6 ):171-174. 21. Padmore, E. Higher level nursing 2: influencing care at all levels of the organisation. Journal of Diabetes Nursing 2000;4(3):74-77. 22. Scott, E. M., Greenwood, J. P., Stoker, J. B., Gilbey, S. G., Mary, D. A. Water drinking and sympathetic activation. The Lancet 2000;356(9246):2013. 23. Scott, E. M., Gaywood, I, Scott, B. B. Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut 2000;46(Suppl 1):i1-i8. 24. Ward, F., Bodger, K., Daly, M. J., Heatley, R. V. Medical managment of inflammatory bowel disease. Eds. K.Bodger, M.J.Daly, and R.V.Heatley. In: Clinical Economics in Gastroenterology 2000; 1st edition:116-132. Oxford, Blackwell Science Ltd. Medicine for the Elderly 1. Corrado, O. J. Caring for older hospital at home patients. Age & Ageing 2000;29(2):97-98. 2. Greenwood, J. P., Scott, E. M., Stoker, J. B., Mary, D. A. Chronic I1-imidazoline agonism : sympathetic mechanisms in hypertension. Hypertension 2000;35(6):1264-1269. 11

LTHT Publications 2000 3. Harkins, K. J. What's the use of cranberry juice? Age & Ageing 2000;29(1):9-12. 4. Harraf, F., Fergusson, N., Cartwright, P., Thompson, J., Corrado, O. J. A survey of the use of mechanical restraint. Age & Ageing 2000;29(Suppl 2):39. 5. Lowe, C. J., Raynor, D. K., Teale, C., Luban, G. Can practice nurses identify medication problems using the over-75 health check? Journal of Clinical Nursing 2000;9:816-817. 6. Molinari, C., Battaglia, A., Bona, G., Grossini, E., Mary, D. A., Vacca, G. The role of nitric oxide in the coronary vasoconstriction caused by growth hormone in anaesthetized pigs. Experimental Physiology 2000;85(2):203-208. 7. Molinari, C., Grossini, E., Mary, D. A., Vacca, G. The effect of distension of the gallbladder on plasma renin activity in anesthetized pigs. Circulation 2000; 101(21):2539-2545. 8. Mulley, G. P. Depression in older people with medical illness. Curran, Wattis and Lynch. The Practical Management of Depression in Older People. 2000; 9. Mulley, G. P. The evolution of age and ageing [editorial]. Age & Ageing 2000;1-2. 10. Phelan, F. and Teale, C. Tuberculosis in older people - is it on the increase? Trends in notifications in Leeds from 1976 to 1996. Age & Ageing 2000;29:319-323. 11. Ruggeri, P., Cogo, C. E., Picchio, V., Ermirio, R., Mary, D. A. Reflex cardiovascular responses to somatic stimulation in spontaneously hypertensive rats. Journal of Hypertension 2000;18(5):595-600. 12. Ruggeri, P., Battaglia, A., Ermirio, R., Grossini, E., Molinari, C., Mary, D. A., Vacca, G. Role of nitric oxide in the control of the heart rate within the nucleus ambiguus of rats. NeuroReport 2000;11(3):481-485. 13. Scott, E. M., Greenwood, J. P., Stoker, J. B., Gilbey, S. G., Mary, D. A. Water drinking and sympathetic activation. The Lancet 2000;356(9246):2013. 14. Teale, C. Respiratory disease in old age: RIA workshop. Tuberculosis infection in old age. Age & Ageing 2000;29:281-282. 15. Tolan, D., Dolben, J., Ferguson, M. Case report - Minerva. BMJ 2000;320:1218-1218. Psychiatry 1. Blenkiron, P., House, A., Milnes, D. The timing of acts of deliberate self-harm: is there any relation with suicidal intent, mental disorder or psychiatric management? Journal of Psychosomatic Research 2000;49(1):3-6. 2. Cameron, I., Curran, S., Newton, P., Petty, D., Wattis, J. Use of Donepezil for the treatment of mild- moderate Alzheimer's disease: an audit of the assessment and treatment of patients in routine clinical practice. International Journal of Geriatric Psychiatry 2000;15:887-891. 3. Carson, A. J., MacHale, S., Allen, K., Lawrie, S. M., Dennis, M., House, A., Sharpe, M. Depression after stroke and lesion location: a systematic review. The Lancet 2000;356(9224):122-126. 4. Chuck, A. J., Swannell, A. J., House, A., Pownall, R. The effects of Dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology 2000;39:1425-1426. 5. Cox, J. F., Banks, S., Stone, J. L. Counting the mentally ill in jails and prisons. Psychiatric Services 2000;51(4):533-534. 12

LTHT Publications 2000 6. Hawton, K., Townsend, E., Arensman, E., Gunnell, D., Hazell, P., House, A., van Heeringen, K. Psychosocial versus pharmacological treatments for deliberate self harm. Cochrane Database of Systematic Reviews [computer file] 2000;(2): CD001764. 7. Healy, D., Donoghue, J., Lecrubier, Y., Geddes, J., House, A. Debate "The new generation antidepressants are the most effective first-line treatment for depression". Eds. A.Dawson and A.Tylee. In: Depression: Social and Economic Timebomb. 2000;157-176. London, BMJ Books. 8. Holmes, J and House, A. Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study. Psychological Medicine 2000;30(4):921. 9. Holmes, J. D and House, A. O. Psychiatric illness in hip fracture. Age & Ageing 2000;29(6):537-546. 10. House, A. Management of depression and related disorders after stroke. Ed. W.Holland. In: Stroke: The Past, Present and Future. 2000;(10):45-49. Oxford University Press. 11. House, A and Mitchell, A. Antidepressants as a cause of hypertension. Prescribers Journal 2000;40(2):169-174. 12. Knapp, P., Young, J., House, A., Forster, A. Non-drug strategies to resolve psycho-social difficulties after stroke. Age & Ageing 2000;29(1):23-30. 13. Mitchell, A and House, A. Adjustment to illness and handicap, and to bereavement. Eds. M.Gelder, N.Andreasen, and J.Lopez-Ibor. New Oxford Textbook of Psychiatry. 2000;(5.3):1139-1147. Oxford University Press. 14. Ness, G. J., House, A., Ness, A. R. Aggression and violent behaviour in general practice: population based survey in the north of England. BMJ 2000;320(7247):1447-1448. 15. Peveler, R and House, A. Developing services in liaison psychiatry: making the case of need. Planning Special Services for Liaison Psychiatry. 2000;(1):1-13. London, Gaskell. 16. Ramchandani, P., Murray, B., Hawton, K., House, A. Deliberate self poisoning with antidepressant drugs: a comparison of the relative hospital costs of cases of overdose of tricyclics with those of selective-serotonin re-uptake inhibitors. Journal of Affective Disorders 2000;60(2):97-100. 17. Rosenheck, R. A., Banks, S., Pandiani, J., Hoff, R. Bed closures and incarceration rates among users of veterans affairs mental health services. Psychiatric Services 2000;51(10):1282-1287. 18. Ross-McGill, H., Hewison, J., Hirst, J., Dowswell, T., Holt, A., Brunskill, P., Thornton, J. G. Antenatal home blood pressure monitoring: a pilot randomised controlled trial. BJOG 2000;107(2):217-221. 19. Sharpe, M., Protheroe, D., House, A. Joint working with physicians in out-patient and in-patient hospital settings. In: Planning Special Services for Liaison Psychiatry. 2000;(16):195-206. London, Gaskell. 20. Stark, D. P and House, A. Anxiety in cancer patients. British Journal of Cancer 2000;83(10):1261-1267. 21. Steadman, H. J., Silver, E., Monahan, J., Appelbaum, P. S., Robbins, P. C., Mulvey, E. P., Grisso, T., Roth, L. H., Banks, S. A classification tree approach to the development of actuarial violence risk assessment tools. Law & Human Behavior 2000;24(1):83-100. 22. Sundaramurthy, D., Pieri, L. F., Gape, H., Markham, A. F., Campbell, D. A. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa. American Journal of Medical Genetics 2000;96(1):53-55. 23. Williams, C and Harkin, P. Directions. Multi-media mental health training. Mental Health Care & Learning Disabilities 2000;3(5):169-171. 13

LTHT Publications 2000 Respiratory Medicine 1. Allan, J. M., Hardie, L. J., Briggs, J. A., Davidson, L. A., Watson, J. P., Pearson, S. B., Muers, M. F., Wild, C. P. Genetic alterations in bronchial mucosa and plasma DNA from individuals at high risk of lung cancer. International Journal of Cancer 2000;91:359-365. 2. Elliott, M. W. Non-invasive ventilation during sleep. Sleep, 2000; 23(Suppl 4):S209-S212. 3. Elliott, M. W. Long term mechnical ventilation in severe COPD. Ed. N.Hill. In: Long-term Mechanical Ventilation. 2000;(Vol 152):151-175. New York, Marcel Dekker. Lung Biology in Health and Disease. 4. Elliott, M. W. Non-invasive ventilation in COPD patients with chronic respiratory failure-con. Monaldi Archives for Chest Disease 2000;55(1):58-61. 5. Hafeez, I., Muers, M. F., Murphy, S. A., Evans, E. G., Barton, R. C., McWhinney, P. Non-tuberculous mycobacterial lung infection complicated by chronic necrotising pulmonary aspergillosis. Thorax 2000;55(8):717-719. 6. Hill, K. M and Muers, M. F. Palliative care for patients with non-malignant end stage respiratory disease. Thorax 2000;55(12):979-981. 7. Lightowler, J. V and Elliott, M. W. Predicting the outcome from NIV for acute exacerbations of COPD. Thorax 2000;55(10):815-816. 8. Muers, M. F. British Thoracic Society and Society of Cardiothoracic Surgeons of Great Britain and Ireland Working Party. BTS Guidelines on the selection of patients with lung cancer for surgery. Thorax 2000;56:89-108. 9. Muers, M. F. and Robertson, R. J. Diagnosis of lung cancer: FOB before CT or CT before FOB? Thorax 2000;55(5):350-351. 10. Palmer, K and Pearson, S. B. Respiratory disorders. Eds. R.A.F.Cox., F.C.Edwards., and K.Palmer. In: Fitness for Work the Medical Aspects. 2000; 3rd edition, 371-398. Oxford University Press. 11. Plant, P. K., Owen, J. L., Elliott, M. W. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. The Lancet 2000;355(9219):1931-1935. 12. Plant, P. K., Owen, J. L., Elliott, M. W. One year period prevalence study of respiratory acidosis in acute exacerbations of COPD: implications for the provision of non-invasive ventilation and oxygen administration. Thorax 2000;55(7):550-554. 13. Turkington, P. M. and Elliott, M. W. Rationale for the use of non-invasive ventilation in chronic ventilatory failure. Thorax 2000;55(5):417-423. Vascular Medicine/Surgery 1. Ahmed, I. M., Uddin, J., Scott, D. J. A life-threatening case of a left upper quadrant mass. European Journal of Vascular & Endovascular Surgery 2000;20(2):207-208. 2. Ariens, R. A., Philippou, H., Nagaswami, C., Weisel, J. W., Lane, D. A., Grant, P. J. The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure. Blood 2000;96(3):988-995. 3. Ashcroft, A. E., Grant, P. J., Ariens, R. A. A study of human coagulation factor XIII A-subunit by electrospray ionisation mass spectrometry. Rapid Communications in Mass Spectrometry 2000;14(17):1607-1611. 14

LTHT Publications 2000 4. Barnett, N., Collyer, T. C., Weston, M., Spark, J. I., Scott, D. J. Pulsatile varicose veins. Journal of the Royal Society of Medicine 2000;93(1):29-30. 5. Beardsmore, D., Spark, J. I., MacAdam, R., Macdonald, D., Scott, D. J. A psoas ganglion causing obstruction of the iliofemoral arteries. European Journal of Vascular & Endovascular Surgery 2000;19(5):554-555. 6. Berridge, D. C., Kessel, D., Robertson, I. Surgery versus thrombolysis for acute limb ischaemia: Initial management (Cochrane Review). Cochrane Database of Systematic Reviews [computer file], 2000;4:CD002784. 7. Carter, A. M., Catto, A. J., Kohler, H. P., Ariens, R. A., Stickland, M. H., Grant, P. J. α-Fibrinogen Thr312Ala polymorphism and venous thromboembolism. Blood 2000;96(3):1177-1179. 8. Catto, A. J., McCormack, L. J., Mansfield, M. W., Carter, A. M., Bamford, J. M., Robinson, P., Grant, P. J. Apolipoprotein E polymorphism in cerebrovascular disease. Acta Neurologica Scandinavica 2000;101(6):399-404. 9. Catto, A. J. Cryptogenic stroke and genetics (invited review). Neurologia 2000;15(Suppl 3):92-95. 10. Eyers, P., Ashley, S., Scott, D. J. Tourniquets in arterial bypass surgery. European Journal of Vascular & Endovascular Surgery 2000;20(2):113-117. 11. Grant, P. J. The Edinburgh artery study: is lytic activity bad for the heart? European Heart Journal 2000;21(19):1566-1567. 12. Kibria, S. M. G., Leveson, S. H., Homer-Vanniasinkam, S. Spontaneous dissection of the abdominal aorta: a case report. Journal of the Royal College of Surgeons of Edinburgh 2000;45:408-410. 13. Kim, J., Richards, S., Kent, P. J. Clinical examination of varicose veins - a validation study. Annals of the Royal College of Surgeons of England 2000;82(3):171-175. 14. Lane, D. A. and Grant, P. J. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000;95(5):1517-1532. 15. Parry, D. J., Parikh, A., Robertson, I., Kessel, D., Scott, D. J. Case report: arterial haemorrhage from a chronic venous ulcer - pseudoaneurysm formation of the posterior tibial artery. European Journal of Vascular & Endovascular Surgery 2000;20(5):489-491. 16. Parry, D. J., Giles, M., Souka, H., Aldoori, M. I. Epidural abscess formation as a complication of femoropopiteal bypass graft infection. European Journal of Vascular & Endovascular Surgery 2000;19(6):671-672. 17. Parry, D. J., Waterworth, A., Scott, D. J. Case report: post-traumatic clavicular pseudo-arthrosis - an unusual case of venous thoracic outlet syndrome. European Journal of Vascular & Endovascular Surgery 2000;20(4):403-404. 18. Phipp, L. H., Scott, D. J., Kessel, D., Robertson, I. Stent implantation for mesenteric bypass graft stenosis. Journal of Endovascular Therapy: Official Journal of the International Society of Endovascular Specialists 2000;7(4):320-323. 19. Rowlands, T. E., Norfolk, D., Homer-Vanniasinkam, S. Chronic disseminated intravascular coagulopathy cured by abdominal aortic aneurysm repair. Cardiovascular Surgery 2000;8(4):292-294. 20. Turton, E. P., Scott, D. J., Delbridge, M., Snowden, S., Kester, R. C. Ruptured abdominal aortic aneurysm: a novel method of outcome prediction using neural network technology. European Journal of Vascular & Endovascular Surgery 2000;19(2):184-189. 15

LTHT Publications 2000 21. Warner, D., Catto, A., Kunz, G., Ireland, H., Grant, P. J., Lane, D. A. The thrombomodulin gene mutation G127-A (Ala25Thr) and cerebrovascular disease. Cerebrovascular Diseases 2000;10(5):359-363. 22. Wilson, M. H., Grant, P. J., Hardie, L. J., Wild, C. P. Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. FASEB Journal 2000;14(5):791-796. 23. Winkelmann, B. R., Hager, J., Kraus, W. E., Merlini, P., Keavney, B., Grant, P. J., Muhlestein, J. B., Granger, C. B. Genetics of coronary heart disease: current knowledge and research principles. American Heart Journal 2000;140(4):11-26. 16

LTHT Publications 2000 Division of Head, Neck and Musculoskeletal Services Dentistry 1. Aaron, J. E., Shore, P. A., Shore, R. C., Kanis, J. A. , Beneton, M. M. Trabecular architecture in women and men of similar bone mass with and without vertebral fracture: II three-dimensional histology. Bone 2000;27(2):277-282. 2. Arai, K., Kato, K., Nakagaki, H., Robinson, C. Plaque fluoride released from the glass ionomer cement and remineralization of neighbouring enamel in vivo. Caries Research 2000;34(4):340. 3. Arai, K., Kato, K., Nakagaki, Y., Toyama, A., Nagai, N., Noguchi, T., Kirkham, J., Robinson, C., Thu Thuy, T., Nguyen, T. T. Fluoride profiles in dental plaque in vivo formed on fluoride pre-treated human enamel. Caries Research 2000;34:254-259. 4. Ball, S. K., Backman, B., Brookes, S. J., Kirkham, J., Robinson, C., Shore, R. C. A scanning electron microscope investigation of hypoplastic amelogenesis imperfecta. Journal of Dental Research 2000;79(5):1185. 5. Bonass, W. A., Marsh, P. D., Devine, D. A., Percival, R. S., Aduse-Opoku, J., Hanley, S., Curtis, M. A. Identification of temperature-regulated antigens of porphyromonas gingivalis. Journal of Dental Research 2000;79(5):1186. 6. Bonass, W. A., Marsh, P. D., Percival, R. S., Aduse-Opoku, J., Hanley, S. A., Devine, D. A., Curtis, M. A. Identification of ragAB as a temperature-regulated operon of Porphyromonas gingivalis W50 using differential display of randomly primed RNA. Infection & Immunity 2000;68(7):4012-4017. 7. Brookes, S. J., Kirkham, J., Strafford, S. M., Shore, R. C., Wood, S. R., Robinson, C. Effect of calcium and magnesium ions on erosion of human enamel. Caries Research 2000;34(4):343. 8. Brookes, S. J., Kirkham, J., Wood, S. R., Shore, R. C., Robinson, C. Heterogeneity of the 20KDa major amelogenin component in developing enamel. Journal of Dental Research 2000;79(5):1184. 9. Brookes, S. J., Kirkham, J., Shore, R. C., Wood, S. R., Robinson, C. Concerning the lipophilic and lipophobic duality of enamel proteins. Journal of Dental Research 2000;79:513. 10. Brookes, S. J., Kirkham, J., Lyngstadaas, S. P., Shore, R. C., Wood, S. R., Robinson, C. Spatially related amelogenin interactions in developing rat enamel as revealed by molecular cross-linking studies. Archives of Oral Biology 2000;45:937-943. 11. Ching, E., Cook, P. A., Bubb, N. L., Wood, D. L. The effect of early static loading on the "in-vitro" shear/peel bond strength of a "no-mix" orthodontic adhesive. European Journal of Orthodontics 2000;22:555-559. 12. Devine, D. A., High, A. S., Owen, P. J., Poulsom, R., Bonass, W. A. Trefoil factor expression in normal and diseased human salivary glands. Human Pathology 2000;31(4):509-515. 13. Farmer, I., Freysdottir, J., Fortune, F. Expression of adhesion and activation molecules in human buccal epithelial cell lines and normal human buccal epithelium in situ. Journal of Oral Pathology & Medicine 2000;30(2):113-120. 14. Haixiang, J., Nakagaki, H., Hayashizaki, J., Tsuboi, S., Kato, K., Toyama, A., Arai, K., Thu Thuy, T., Thanh Ha, T., Kameyama, Y., Kirkham, J., Robinson, C. Fluoride and magnesium concentrations in human dental calculus obtained from Japanese and Chinese patients. Archives of Oral Biology 2000;45:611-615. 15. Hogan, D., Bonass, W. A., Devine, D. A., Percival, R. S., Marsh, P. D. Isolation and differential display of streptococcus mutans RNA. Journal of Dental Research 2000;79(5):1186. 17

LTHT Publications 2000 16. Keech, A., Devine, D. A., Wood, D., Killington, R. A., Boyes, H., Doubleday, B., Marsh, P. D. Ultra-violet disinfection using a novel microwave powered device. Journal of Dental Research 2000;79(5):1201. 17. Kirkham, J., Shore, R. C., Wood, S. R., Zhang, J., Smith, D. A. M., Brookes, S. J., Robinson, C. Behaviour of ionisable groups at surfaces; implications with respect to caries. Caries Research 2000;34(4):330. 18. Kirkham, J., Robinson, C., Strafford, S. M., Shore, R. C., Bonass, W. A., Brookes, S. J. , Wright, J. T. The chemical composition of tooth enamel in junctional epidermolysis bullosa. Archives of Oral Biology 2000;45(5):377-386. 19. Kirkham, J., Zhang, J., Shore, R. C., Wood, S. R., Brookes, S. J., Smith, D. A. M., Wallwork, M. L., Robinson, C. Surface charge domains are sites for protein crystal binding in developing enamel. Journal of Dental Research 2000;79(5):1184. 20. Kirkham, J., Zhang, J., Brookes, S. J., Shore, R. C., Wood, S. R., Smith, D. A. M. Evidence for charge domains on developing enamel crystal surfaces. Journal of Dental Research 2000;79(12):1943-1947. 21. Kirkham, J., Zhang, J., Shore, R. C., Brookes, S. J., Wood, S. R., Smith, D. A. M., Wallwork, M. L., Robinson, C. Amelogenin-mineral binding is related to charge domains on crystal surfaces. Journal of Dental Research 2000;79:152. 22. Kowash, M. B., Pinfield, A., Smith, J., Curzon, M. E. Effectiveness on oral health of a long-term health education programme for mothers with young children. British Dental Journal 2000;188(4):201-205. 23. Kowash, M. B., Curzon, M. E. J., Hart, P., Devine, D. A. Effectiveness of dental health education programmes on streptococcus mutans and caries levels for mothers with young children. Journal of Dental Research 2000;79(5):1179. 24. Maycock, J., Brookes, S. J., Kirkham, J., Wood, S. R., Shore, R. C., Robinson, C. Identification of protease activity in Emdogain. Journal of Dental Research 2000;79(5):1181. 25. O'Sullivan, E. A. and Curzon, M. E. J. Salivary factors affecting dental erosion in children. Caries Research 2000;34(1):82-87. 26. O'Sullivan, E. A. and Curzon, M. E. J. A comparison of acidic dietary factors in children with and without dental erosion. ASDC Journal of Dentistry for Children 2000;67(3):186-192. 27. Pearce, M. A., Devine, D. A., Dixon, R. A., van Steenbergen, T. J. M. Genetic heterogeneity in prevptella intermedia, prevotella nigrescens, prevotella corporis and related species isolated from oral and non-oral sites. Oral Microbiology and Immunology 2000;15:89-95. 28. Percival, R. S., Marsh, P. D., Devine, D. A., Bonass, W. A., Aduse-Opoku, J., Curtis, M. A. Effect of pH changes on porphyromonas gingivalis growth and expression of virulence determinants. Journal of Dental Research 2000;79(5):1189. 29. Preson, A. J., Punekar, S., Gosney, M. A. Oral care of elderly patients - nurses knowledge and views. Postgraduate Medical Journal 2000;76:89-91. 30. Pullin, L., Devine, D. A., Bonass, W. A., Percival, R. S., Marsh, P. D. Effect of peroxide on porphyromonas gingivalis growth and gene expression. Journal of Dental Research 2000;79(5):1187. 31. Rafferty, A., Hill, R. G., Wood, D. J. Amorphous phase separation of ionomer glasses. Journal of Materials Science 2000;35:3863-3869. 32. Roberts-Harry, E. A., Clerehugh, V., Shore, R. C., Kirkham, J., Robinson, C. Morphology and elemental composition of subgingival calculus in two groups. Journal of Periodontology 2000;71(9):1401-1411. 33. Roberts-Harry, E. A. and Clerehugh, V. Subgingival calculus: where are we now? A comparative review. Journal of Dentistry 2000;28(2):93-102. 18

LTHT Publications 2000 34. Robinson, C., Zhang, J., Shore, R. C., Brookes, S. J., Wood, S. R., Smith, D. A. M., Wallwork, M. L., Kirkham, J. Ionisation behaviour of phosphate groups at surfaces: implications for biomineralisation. Journal of Dental Research 2000;79:152. 35. Robinson, C., Shore, R. C., Brookes, S. J., Strafford, S. M., Wood, S. R., Kirkham, J. The chemistry of enamel caries. Critical Reviews in Oral Biology and Medicine 2000;11(4):481-495. 36. Robinson, C., Zhang, J., Shore, R. C., Wood, S. R., Brookes, S. J., Smith, D. A. M., Wallwork, M. L., Kirkham, J. Phosphate group ionisation after surface immobilisation: significance in mineralised tissues. Journal of Dental Research 2000;79(5):1184. 37. Robinson, C., Ball, S. K., Backman, B., Brookes, S. J., Kirkham, J., Shore, R. C. Amelogenin content of local hypoplastic amelogenesis imperfecta-affected enamel. Caries Research 2000;34(4):331. 38. Shore, P. A., Shore, R. C., Aaron, J. E. A three-dimentional histological method for direct determination of the number of trabeccular termini in cancellous bone. Biotechnic and Histochemistry 2000;75(4):183-192. 39. Shore, R. C., Kirkham, J., Devine, D. A., Marsh, P. D., Nattress, B. R., Allison, C., Robinson, C. Immunohistochemical study of bacterial distribution within oral biofilms. Journal of Dental Research 2000;79:421. 40. Shore, R. C., Devine, D. A., Marsh, P. D., Nattress, B. R., Robinson, C., Kirkham, J. Penetration of mineralising ions into natural oral biofilms. Caries Research 2000;34(4):318-318. 41. Shore, R. C., Kirkham, J., Brookes, S. J., Wood, S. R., Robinson, C. Distribution of exogenous proteins in caries lesions in relation to the pattern of demineralisation. Caries Research 2000;34(2):188-193. 42. Shore, R. C., Backman, B., Wright, J. T., Brookes, S. J., Staines, A., Kirkham, J., Robinson, C. Structure and elemental composition of enamel affected by hypomaturation amelogenesis imperfecta. Journal of Dental Research 2000;79(5):1184. 43. Smalley, J. W., Birss, A. J., Percival, R. S., Marsh, P. D. Temperature elevation regulates iron protoporphyrin IX and hemoglobin binding by porphyromonas gingivalis. Current Microbiology 2000;41(5):328-335. 44. Smith, D. A. M., Wallwork, M. L., Zhang, J., Kirkham, J., Robinson, C., Marsh, A., Wong, M. Electrolyte concentration on the chemical force titration behaviour of omega functionalised SAMS: evidence for the formation of strong ionic hydrogen bonds. The Journal of Physical Chemistry.A: Molecules, Spectroscopy, Kinetics, Environment and General Theory 2000;(104):8862-8870. 45. Strafford, S. M., Kirkham, J., Brookes, S. J., Shore, R. C., Wood, S. R., Robinson, C. Intra-oral calibration of beetrode pH electrodes for measuring plaque pH in vivo. Caries Research 2000;34(4):322. 46. Tsuboi, S., Wood, S. R., Nattress, B. R., Nakagaki, H. , Kirkham, J., Robinson, C. Effect of glass ionomer cement on dental plaque fluoride accumulation in vivo. Caries Research 2000;34(4):339. 47. Tugnait, A., Clerehugh, V., Hirschmann, P. N. The usefulness of radiographs in diagnosis and management of periodontal diseases: a review. Journal of Dentistry 2000;28(4):219-226. 48. Tugnait, A., Clerehugh, V., Hirschmann, P. N. Survey of radiographic practices for periodontal disease in UK and Irish dental teaching hospitals. Dentomaxillofacial Radiology 2000;29(6):376-381. 49. Walker, J. T., Bradshaw, D. J., Bennett, A. M., Fulford, M. R., Martin, M. V., Marsh, P. D. Mircrobial biofilm formation and contamination of dental-unit water systems in general dental practice. Applied and Environmental Microbiology 2000;66(8):3363-3367. 50. Watson, C. J., Tinsley, D., Sharma, S. Implant complications and failures: the single-tooth restoration. Dental Update 2000;27(1):35-38. 19

LTHT Publications 2000 51. Williams, S. A., Kwan, S. Y. L., Parsons, S. Parental smoking practices and caries experience in pre-school children. Caries Research 2000;34(2):117-122. 52. Wood, S. R., Kirkham, J., Nattress, B. R., Shore, R. C., Brookes, S. J., Robinson, C. The effect of plaque age on biofilm architecture and density. Journal of Dentistry 2000;28:219-226. 53. Wood, S. R., Kirkham, J., Nattress, B. R., Shore, R. C., Brookes, S. J., Robinson, C. Changes in biofilm architecture with increasing plaque age. Journal of Dental Research 2000;79:422. 54. Wood, S. R., Shore, R. C., Brookes, S. J., Kirkham, J., Walker, J. T., Robinson, C. Bacteriolytic activity of lysozyme bound to tooth enamel surface in vitro. Caries Research 2000;34(4):347. 55. Wood, S. R., Kirkham, J., Marsh, P. D., Shore, R. C., Nattress, B., Robinson, C. Architecture of intact natural human plaque biofilms studied by confocal laser scanning microscopy. Journal of Dental Research 2000;79(1):21-27. 56. Youngson, C. C. and Barclay, C. W. A pilot study of intraoral temperature changes. Clinical Oral Investigations 2000;4:183-189. 57. Zamzam, N. and Luther, F. Comparison of lip competence by remote video surveillance and clinical observation in children with and without cerebral palsy. European Journal of Orthodontics 2000;23(1):75-84. 58. Zhang, J., Kirkham, J., Shore, R. C., Brookes, S. J., Wood, S. R., Smith, D. A. M. Hypochlorite treatment of developing enamel crystals promotes in vitro growth. Journal of Dental Research 2000; 79(5):1184. 59. Zhang, J., Kirkham, J., Robinson, C., Wallwork, M. L. , Smith, D. A. M., Wong, M. A determination of the ionisation state of 11-Thioundeccyl-1-Phosphate in self assembled monolayers by chemical force microscopy. Analytical Chemistry 2000;72(9):1973-1978. ENT 1. Buckley, J. G. The future of head and neck surgery. Journal of Laryngology & Otology 2000;114(5):327-330. 2. Buckley, J. G. and MacLennan, K. Cancer spread in the larynx: a pathologic basis for conservation surgery. Head & Neck 2000; 22(3):265-274. 3. Buckley, J. G. and MacLennan, K. Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution. Head & Neck 2000;22(4):380-385. 4. Coatesworth, A. P and Lalwani, A. Neurofibromatosis Type 2. Eds. R.Tackler and C.Driscoll. In: Tumours of the Ear and Temporal Bone. 2000;1st edition (24):405-416., Lippincott Williams & Wilkins. 5. Donne, A. J., Homer, J. J., Woodhead, C. J. Oculostapedial synkinesis following Bell's palsy. Journal of Laryngology & Otology 2000;114(2):135-136. 6. Homer, J. J., Sheard, C. E., Jones, N. J. Cognitive dissonance: the placebo effect and the evaluation of surgical results. Clinical Otolaryngology 2000;25(3):195-199. 7. Homer, J. J., Williams, B. T., Semple, P., Swanepoel, A., Knight, L. C. Tonsillectomy by guillotine is less painful than by dissection. International Journal of Pediatric Otorhinolaryngology 2000;52(1):25-29. 8. Sood, S., Anthony, R., Homer, J. J., Van Hille, P., Fenwick, J. D. Hypoglossal-facial nerve anastomosis: assessment of clinical results and patient benefit for facial nerve palsy following acoustic neuroma excision. Clinical Otolaryngology & Allied Sciences 2000;25(3):219-226. 20

LTHT Publications 2000 Neurology 1. Bamford, J. M. Antiplatelet therapy for the secondary prevention of stroke or transient ischaemic attack. In: Stroke; the Past, Present and Future. 2000;29-32., Oxford University Press. 2. Bamford, J. M. The role of the clinical examination in the subclassification of stroke. Cerebrovascular Diseases 2000;10(Suppl 4):2-4. 3. Bhakta, B. B., Cozens, J. A., Chamberlain, M. A., Bamford, J. M. Impact of Botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 2000;69(2):217-221. 4. Brunyee, P., Bamford, J., Wardman, G., Fear, J. How to set up a stroke register. Nursing Times 2000;96(40):40-42. 5. Catto, A. J., McCormack, L. J., Mansfield, M. W., Carter, A. M., Bamford, J. M., Robinson, P., Grant, P. J. Apolipoprotein E polymorphism in cerebrovascular disease. Acta Neurologica Scandinavica 2000;101(6):399-404. 6. Dorman, P. J., Dennis, M. S., Sandercock, P. A. G., Bamford, J. M., on behalf of the UK collaborators in the International Stroke Trial (IST). Are the modified "simple questions" a valid and reliable measure of health related quality of life after stroke? Journal of Neurology, Neurosurgery & Psychiatry 2000;69:487-493. 7. Ford, H. L and Boggild, M. Multiple sclerosis. 2000;Issue 4:725-735. 8. Ford, H. L and Boggild, M. Multiple sclerosis. Clinical Evidence - BMJ. 2000;Issue 3:585-594. 9. Lees, K. R., Asplund, K., Carolei, A., Davis, S. M., Diener, H-C, Kaste, M., Orgogozo, J-M., Whitehead, J., Bamford, J. M., for the Gain International investigators. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. The Lancet 2000;355:1949-1954. 10. Lewis, M. B., MacQuillan, G., Bamford, J. M., Howdle, P. D. Delayed myelopathic presentation of the acquired hepatocerebral degeneration syndrome. Neurology 2000;54(4):1011. 11. Lewis, M. B. Telesales neuropathy. Postgraduate Medical Journal 2000;76:793-794. 12. Lewis, M. B. and Bamford, J. M. Global aphasia without hemiparesis secondary to Kingella Kingae endocarditis. Archives of Neurology 2000;57(12):1774-1775. 13. Maddison, P., Southern, P., Johnson, M. Clinical and MRI discordance in a case of delayed radiation myelopathy. Journal of Neurology, Neurosurgery & Psychiatry 2000;69:563-564. 14. Maddison, P. Cervical subdural haematoma. Journal of Neurology, Neurosurgery & Psychiatry 2000;68(2): 245. 15. Reuber, M., Enright, S., Goulding, P. J. Postoperative pseudostatus: not everything that shakes is epilepsy. Anaesthesia 2000;55(1):74-79. 16. Reuber, M., Zeidler, M., Chataway, J., Sadler, M. Munchausen syndrome by phone. The Lancet 2000;356:1358. 17. Reuber, M., Hattingh, L., Goulding, P. J. Epileptological emergencies in accident and emergency: a survey at St James's University Hospital, Leeds. Seizure 2000;9(3):216-220. 18. Thomas, S. R., Jamieson, D. R. S., Muir, K. W. Randomised controlled trial of atraumatic versus standard needles for diagnosis lumbar puncture. BMJ 2000;321:989-990. 21

LTHT Publications 2000 19. Warlow, C. P., Dennis, M. S., van Gijn, J., Hankey, G. J., Sandercock, P. A. G., Bamford, J. M. Stroke - A Practical Guide to Management. Ed. J.Wardlaw. 2000; 2nd edition, Oxford, Blackwell Science. Neurosurgery 1. Chumas, P. D. The role of surgery in asymtomatic lumbosacral spinal lipomas. British Journal of Neurosurgery 2000;14(4):301-304. 2. Dominguez, C. J., Tyagi, A., Hall, G., Timothy, J., Chumas, P. D. Sub-galeal coiling of the proximal and distal components of a ventriculo-peritoneal shunt. An unusual complication and proposed mechanism. Childs Nervous System 2000;16(8):493-495. 3. Doonan, J., Murphy, P., Timothy, J., Marks, P. Acute neurologic deteriation following lumbar puncture in an epidural abscess occurring 14 months after epidural catheter placement. Journal of Neurosurgery and Anesthesiology 2000;12(4):364-365. 4. Phillips, N. I. and John, N. W. Web-based surgical simulation for ventricular catheterization. Neurosurgery 2000;46(4):933-936. 5. Rutherford, J., Chu, C. E., Charlton, R. S., Chumas, P., Taylor, G. R., Barnes, D., Camplejohn, R. A novel germline 7 base pair insertion in p53; a functional study of the resulting truncated protein. British Journal of Cancer 2000;83(Suppl 1):210. 6. Sood, S., Timothy, J., Anthony, R., Strachan, D. R., Fenwick, J. D., Marks, P. Extracranial internal caroid artery pseudoaneurysm. American Journal of Otolaryngology 2000;21(4):259-262. 7. Sood, S., Anthony, R., Homer, J. J., Van Hille, P., Fenwick, J. D. Hypoglossal-facial nerve anastomosis: assessment of clinical results and patient benefit for facial nerve palsy following acoustic neuroma excision. Clinical Otolaryngology & Allied Sciences 2000;25(3):219-226. 8. Timothy, J., Dominguez, C. J., Lafuente, D., Marks, P. Ruptured spinal arteriovenous malformation causing cauda equina syndrome: case report. Journal of Clinical Neuroscience 2000;7(5):460-462. 7. Timothy, J., Hall, G., Chumas, P. Minimalist placement of external ventricular drains. A quick, safe, cheap and cosmetic procedure. British Journal of Neurosurgery 2000;14(4):339-340. Ophthalmology 1. Booth, A. P., Anwar, R., Chen, H., Churchill, A. J., Jay, J., Polansky, J., Nguyen, T., Markham, A. F. Genetic screening in a large family with juvenile onset primary open angle glaucoma. British Journal of Ophthalmology 2000;84(7):722-726. 2. Cassidy, L., Stirling, R., May, K., Picton, S., Doran, R. Ophthalmic complications of childhood medulloblastoma. Medical & Pediatric Oncology 2000;34(1):43-47. 3. Chang, B. Y. P. and George, N. D. L. Early blindness due to retinopathy of infantile cystinosis. Eye 2000;14:804-805. 4. Churchill, A. J., Hanson, I. M., Markham, A. F. Prenatal diagnosis of aniridia. Ophthalmology 2000;107(6):1153-1156. 5. Churchill, A. J., Vize, C. J., Stewart, O. G., Backhouse, O. What factors influence cataract waiting list time? British Journal of Ophthalmology 2000;84(4):429-431. 6. Comer, M. B., Newman, D. K., George, N. D. L., Martin, K. R., Moore, A. T. Who should manage primary retinal detachments? Eye 2000;14:572-578. 22

LTHT Publications 2000 7. Dick, A., Meyer, P., James, T., Forrester, J. V., Hale, G., Waldmann, H., Isaacs, J. CAMPATH-1H therapy for refractory ocular inflammatory disease. British Journal of Ophthalmology 2000;84:107-109. 8. McKibbin, M., Clark, B., Lee, H., Isaacs, J. D., Gooi, H. C., Morrell, A. J. No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis. British Journal of Ophthalmology 2000;84(4):395-398. 9. Murton, N. J., Rehman, I., Black, G. C., Inglehearn, C. F., Churchill, A. J. A novel deletion (IVS11+3del4) identified in the human PAX6 gene in a patient with aniridia. Human Mutation 2000;15(6):582. 10. Perveen, R., Lloyd, I. C., Clayton-Smith, J., Churchill, A. J., van Heyningen, V., Hanson, I., Taylor, D., McKeown, C., Super, M., Kerr, B., Winter, R., Black, G. C. M. Phenotypic variability and asymmetry of Rieger syndrome assosiated with PITX2 mutations. Investigative Ophthalmology & Visual Science 2000;41:2456-2460. Orthopaedic Surgery 1. Beardsmore, D., Spark, J. I., MacAdam, R., Macdonald, D., Scott, D. J. A psoas ganglion causing obstruction of the iliofemoral arteries. European Journal of Vascular & Endovascular Surgery 2000;19(5):554-555. 2. Bell, J., Besong, A. A., Tipper, J. L., Ingham, E., Wroblewski, B. M., Stone, M. H., Fisher, J. Influence of gelatin and bovine serum lubricants on ultra-high molecular weight polyethylene wear debris generated in in vitro simulations. Procedures of the Institution of Mechanical Engineers 2000;214(H):513-518. 3. Boerger, T. and Limb, D. Suprascapular nerve injury at the spinoglenoid notch after glenoid neck fracture. Journal of Shoulder and Elbow Surgery 2000;9(3):236-237. 4. Boerger, T. O., Limb, D., Dickson, R. A. Does 'canal clearance' affect neurological outcome after thoracolumbar burst fractures? Journal of Bone & Joint Surgery - British Volume 2000;82(5):629-635. 5. Campbell, D. A. Open reduction and internal fixation of intra articular and unstable fractures of the distal radius using the AO distal radius plate. Journal of Hand Surgery - British & European Volume 2000;25B(6):528-535. 6. Carrington, N. C., Smith, R. M., Knight, S. L., Matthews, S. J. E. Ilizarov bone transport over a primary tibial nail and free flap: a new technique for treating Gustillo grade 3b fractures with large segmental defects. Injury 2000;31(2):112-115. 7. Chapple, K., Kelty, C, Irwin, L. R., Mohan, R., Millner, P. A. Traumatic abscess of pectoralis major. Archives of Orthopaedic Trauma Surgery 2000;120:479-481. 8. Cohen, A., Giannoudis, P. V., Conroy, J., Matthews, S. J. E., Smith, R. M. Impingement fracture of the posterior process of the talus - a case report. Acta Orthopaedica Scandinavica 2000;71(6):642. 9. Conroy, J., Cohen, A., Smith, R. M., Matthews, S. Triplane fracture of the proximal tibia. Injury 2000;31(7):546-548. 10. Fisher, J., Ingham, E., Stone, M. H., Wroblewski, B. M., Besong, A. A., Tipper, J. L., Firkins, P., Minakawa, H., Matthews, J. B., Green, T. Wear particle morphologies in artificial hip joints: particle size is critical in the response of macrophages. Eds. Claude Rieker, Markus Windler, and Urs Wyss. In: Metasul. A Metal-on-Metal Bearing. 2000;121-124. Hans Huber. 11. Giannoudis, P. V and Archer, I. A. Intra-articular dislocation of the patella. Journal of Trauma-Injury Infection & Critical Care 2000;49(2):360-361. 23

LTHT Publications 2000 12. Giannoudis, P. V., MacDonald, D. A., Matthews, S. J., Smith, R. M., Furlong, A. J., De Boer, P. Non-union of the femoral diaphysis: the influence of reaming and non-steroidal anti-inflammatory drugs (NSAIDS). Journal of Bone & Joint Surgery - British Volume 2000;82(5):655-658. 13. Giannoudis, P. V., Smith, R. M., Perry, S. L., Windsor, A. J., Dickson, R. A., Bellamy, M. C. Immediate IL-10 expression following major orthopaedic trauma: relationship to anti-inflammatory response and subsequent development of sepsis. Intensive Care Medicine 2000;26(8):1076-1081. 14. Giannoudis, P. V., Cohen, A., Hinsche, A., Stratford, T., Matthews, S. J., Smith, R. M. Simultaneous bilateral femoral fractures: systemic complications in 14 cases. International Orthopaedics 2000;24:264-267. 15. Giannoudis, P. V., Matthews, S. J., Smith, R. M. Exchange nailing for femoral nonunion. Journal of Orthopaedic Trauma 2000;14(7):522-523. 16. Gopal, S., Majumder, S., Batchelor, A. G., Knight, S. L., De Boer, P., Smith, R. M. Fix and flap, the radical treatment of open tibial fractures. Journal of Bone & Joint Surgery - British Volume 2000;82(B):959-966. 17. Green, T., Fisher, J., Matthews, J. B., Stone, M. H., Ingham, E. Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. Journal of Biomedical Materials Research 2000;53:490-497. 18. Hafez, M.A., Bawarish, M.A., Guvvala, R. Closed talar body fracture with talonavicular dislocation; a case report. Foot and Ankle International 2000;21(7):599-601. 19. Harrington, P., Bunola, J., Jennings, A. J., Bush, D. J., Smith, R. M. Acute compartment syndrome masked by intravenous morphine from a patient-controlled analgesia pump. Injury 2000;31(5):387-389. 20. Hawkins, A., Midwinter, K., MacDonald, D. A. Trochanteric non-union in revision total hip arthroplasty: does it matter? Annals of the Royal College of Surgeons of England 2000;82(1):39-42. 21. Ingham, E., Green, T. R., Stone, M. H., Kowalski, R. , Watkins, N., Fisher, J. Production of TNF-alpha and bone resorbing activity by macrophages in response to different types of bone cement particles. Biomaterials 2000;21(10):1005-1013. 22. Joseph, J., Giannoudis, P. V., Hinsche, A., Cohen, A., Matthews, S. J., Smith, R. M. Compartment syndrome following isolated ankle fracture: a case report and review of the literature. International Orthopaedics 2000;24(3):173-175. 23. Kelty, C., Stamer, J., Irwin, L. R., Limb, D. Subacromial impingement due to the locking bolt of a humeral nail. Orthopaedics 2000;23(11):1200. 24. Limb, D. and Collier, A. Impingement syndrome. Current Orthopaedics 2000;14:161-166. 25. Matthews, J. B., Green, T., Stone, M. H., Wroblewski, B. M., Fisher, J., Ingham, E. Comparison of the response of primary human peripheral blood mononuclear phagocytes from different donors to challenge with model polyethylene. Biomaterials 2000;21:2033-2044. 26. Matthews, J. B., Green, T. R., Stone, M. H., Wroblewski, B. M., Fisher, J., Ingham, E. Comparison of the response of primary murine peritoneal macrophages and the U937 human histiocytic cell line to challenge with in vitro generated clinically relevant UHMWPE particles. Bio-Medical Materials & Engineering 2000;10(3-4):229-240. 27. Matthews, J. B., Besong, A. A., Green, T. R., Stone, M. H., Wroblewski, B. M., Fisher, J., Ingham, E. Evaluation of the response of primary human peripheral blood mononuclear phagocytes to challenge with in vitro generated clinically relevant UHMWPE particles of known size and dose. Journal of Biomedical Materials Research 2000;52(2):296-307. 24

LTHT Publications 2000 28. McNie, C. M., Barton, D. C., Ingham, E., Tipper, J. L., Fisher, J., Stone, M. H. The prediction of polyethylene wear rate and debris morphology produced by microscopic asperities on femoral heads. Journal of Materials Science: Materials in Medicine 2000;11:163-174. 29. McNie, C. M., Barton, D. C., Fisher, J., Stone, M. H. Modelling of damage to articulating surfaces by third body particles in total joint replacements. Journal of Materials Science: Materials in Medicine 2000;11:567-578. 30. Nicolopoulos, C. S., Anderson, E. G., Solomonides, S. E., Giannoudis, P. V. Evaluation of the gait analysis FSCAN pressure system: clinical tool or toy? The Foot, The International Journal of Clinical Foot Science 2000;10:124-130. 31. Philips, R., Hafez, M. A., Mohsen, A. M., Sherman, K. P., Hewitt, J. R., Browbank, I., Bouazza-Marouf, K. Computer and robotic assisted osteotomy around the knee. Studies of Health Technology and Informatics 2000;70:265-271. 32. Smith, R. M. The classification of fractures [editorial]. Journal of Bone & Joint Surgery - British Volume 2000;82(B):625-626. 33. Smith, R. M. and Giannoudis, P. V. Fractures of the femoral shaft. Surgery 2000;18(5):110-111. 34. Smith, R. M., Giannoudis, P. V., Bellamy, M. C., Perry, S. L., Dickson, R. A., Guillou, P. J. Interleukin-10 release and monocyte human leukocyte antigen-DR expression during femoral nailing. Clinical Orthopaedics & Related Research 2000;(373):233-240. 35. Templeton, P. A., Farrah, M. J., Williams, H. R., Bruguera, J., Smith, R. M. Complications of tibial shaft soccer fractures. Injury 2000; 31:415-419. 36. Tipper, J. L., Besong, A. A., Minakawa, H., Stone, M. H. The metal/polyethylene interface. Ed. Ian D Learmonth. In: Interfaces in Total Hip Arthoplasty. 2000;(10):113-120, Springer-Verlag. 37. Tipper, J. L., Ingham, E., Hailey, J. L., Besong, A. A., Fisher, J., Wroblewski, B. M., Stone, M. H. Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Charnley hip prostheses. Journal of Materials Science: Materials in Medicine 2000;11:117-124. 38. Wilson, J. M., London, N. J., Limb, D. A new fracture of the forearm adjacent to a healing fracture. International Orthopaedics 2000;24(1):58-59. Otolaryngology 1. Sood, S., Anthony, R., Pease, C. T. Sjogren's syndrome. Clinical Otolaryngology & Allied Sciences 2000;25(5):350-357. Plastic Surgery 1. Bellew, M., Kay, S. P., Webb, F., Ward, A. Developmental and behavioural outcome in obstetric brachial plexus palsy. Journal of Hand Surgery - British Volume 2000;25(1):49-51. 2. Garrido, A., Humphrey, G., Squire, R., Nishikawa, H. Sialoblastoma: a case report. British Journal of Plastic Surgery 2000;53:697-699. 3. Kay, S. P., Gupta, A., Scheker, L. The Growing Hand. 2000. 25

LTHT Publications 2000 Rheumatology & Rehabilitation 1. Banks, S and Ostrov, B. E. Hip joint remodelling in systemic-onset juvenile rheumatoid arthritis. Arthritis & Rheumatism 2000;43(12):2856. 2. Bent, N., Rabbitt, P., Metcalfe, D. Diabetes mellitus and the rate of cognitive ageing. British Journal of Clinical Psychology 2000;39:349-362. 3. Beyeler, C., Banks, R. E., Bird, H. A. Polymorphonuclear elastase-α1-proteinase inhibitor (elastase- α1 antitrypsin) in patients with rheumatic diseases: influence of disease activity. Journal of Rheumatology 2000;27:15-19. 4. Bhakta, B. B., Rooney, C. M., Wyatt, S., Roussounis, S. H., Chamberlain, M. A. Transition from paediatric to adult care. Bridging the gaps or passing the buck? Archives of Disease in Childhood 2000;82(3):269. 5. Bhakta, B. B., Cozens, J. A., Chamberlain, M. A., Bamford, J. M. Impact of Botulinum toxin type A on disability and carer burden due to arm spasticity after stroke: a randomised double blind placebo controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 2000;69(2):217-221. 6. Bhakta, B. B. Management of spasticity in stroke. British Medical Bulletin 2000;56(2):476-485. 7. Bird, H. A. Editorial: Long-term safety monitoring in rheumatoid arthritis. A proposal from OMERACT. Journal of Rheumatology 2000;27:831-833. 8. Bird, H. A. Drugs used in rheumatic and bone diseases. Ed. C.R.Sirtori. In: European Textbook of Clinical Pharmacology. 2000; Milan, McGraw-Hill. 9. Bird, H. A and English, C. Rheumatological disorders. Eds. R.A.F.Cox, F.C.Edwards, and R.I.McCallum. In: Fitness for Work. 2000;3rd edition:274-288. Oxford Medical Publications. 10. Bird, H. A. Joint hypermobility. Patient Information Booklet for Arthritis Research Campaign. 2000. 11. Bird, H. A and Broggini, M. Paroxetine versus Amitriptyline for the treatment of depression associated with rheumatoid arthritis: a randomised, double-blind, parallel-group study. Journal of Rheumatology 2000;27(12):2791-2797. 12. Dick, A., Meyer, P., James, T., Forrester, J. V., Hale, G., Waldmann, H., Isaacs, J. CAMPATH-1H therapy for refractory ocular inflammatory disease. British Journal of Ophthalmology 2000;84:107-109. 13. Emery, P., Breedveld, F. C., Lemmel, E. M., Kaltwasser, J. P., Dawes, P. T., Gomor, B., Van, DenBoschF, Nordstrom, D., Bjorneboe, O., Dahl, R., Horslev-Petersen, K., Rodriguez De La Serna, A., et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford) 2000;Jun;39:655-665. 14. Emery, P. Leflunomide: a new DMARD for rheumatoid arthritis. Hospital Medicine (London) 2000;61:344-347. 15. Geddes, J. M. L., Tennant, A., Chamberlain, M. A. The Leeds assessment scale of handicap: its operationalisation, reliability, validity and responsiveness in in-patient rehabilitation. Disability & Rehabilitation 2000;22(12):529-538. 16. Grahame, R., Bird, H. A., Child, A., Dolan, L., Edwards-Fowler, A., Ferrell, W., Gurley-Green, S., Keer, R., Mansi, E., Murray, K. J., Smith, E. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). Journal of Rheumatology 2000;27:1777-1779. 17. Griffiths, B and Emery, P. The joints. Lupus: A GP Guide to Diagnosis. 2000;(11), Lupus UK. 26

LTHT Publications 2000 18. Griffiths, B., Situnayake, R. D., Clark, B., Tennant, A., Salmon, M., Emery, P. Racial origin and its effect on disease expression and HLA-DRB1 types in patients with rheumatoid arthritis: a matched cross-sectional study. Rheumatology (Oxford) 2000;39:857-864. 19. Helliwell, P. S., Hetthen, J., Sokoll, K., Green, M., Marchesoni, A., Lubrano, E., Veale, D., Emery, P. Joint symmetry in early and late rheumatoid and psoriatic arthritis: comparison with a mathematical model. Arthritis & Rheumatism 2000;43(4):865-871. 20. Huissoon, A. P., Emery, P., Bacon, P. A., Gordon, J., Salmon, M. Increased expression of CD23 in rheumatoid synovitis. Scandinavian Journal of Rheumatology 2000;29(3):154-159. 21. Hyman, N., Barnes, M., Bhakta, B. B., Cozens, A., Bakheit, A. M., Kreczy-kleedorfer, B., Poewe, W., Bain, P., Glickman, S., Sayer, A., Richardson, A., Dott, C., Cohen, H. Botulinum toxin (Dysport®) treatment of upper leg adductor spasticity in multiple sclerosis: A prospective, randomised, double blind, placebo controlled dose ranging study. Journal of Neurology, Neurosurgery & Psychiatry 2000;68(6):707-712. 22. le Gallez, P., Dimmock, S., Bird, H. A. Spiritual healing as adjunct therapy for rheumatoid arthritis. British Journal of Nutrition 2000;9:695-700. 23. Marzo-Ortega, H., McGonagle, D., Veale, D., Emery, P. Case definition of psoriatic arthritis. The Lancet 2000;356(9247):2095. 24. McGonagle, D., Pease, C., Marzo-Ortega, H., O'Connor, P., Emery, P. The case for classification of polymyalgia rheumatica and remitting seronegative symmetrical synovitis with pitting edema as primarily capsular/entheseal based pathologies [editorial]. Journal of Rheumatology 2000;27(4):837-840. 25. McGonagle, D. and Emery, P. Enthesitis, osteitis, microbes, biomechanics, and immune reactivity in ankylosing spondylitis. Journal of Rheumatology 2000;27(10):2302-2304. 26. McKibbin, M., Clark, B., Lee, H., Isaacs, J. D., Gooi, H. C., Morrell, A. J. No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis. British Journal of Ophthalmology 2000;84(4):395-398. 27. Morgan, A. W., Griffiths, B., Ponchel, F., Montague, B. M., Ali, M., Gardener, P. P., Gooi, H. C., Situnayake, R. D., Markham, A. F., Emery, P., Isaacs, J. D. Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. Arthritis & Rheumatism 2000;43(10):2328-2334. 28. Pease, C. T., Bhakta, B. B., Devlin, J., Emery, P. Does the age of onset of rheumatoid arthritis influence phenotype?: a prospective study of outcome and prognostic factors. Rheumatology 2000;39:112-113. 29. Pease, C. T and Bhakta, B. B. RS3PE syndrome: the relation with HLA B7. Annals of the Rheumatic Diseases 2000;59:239-240. 30. Phillips, N. I and Bhakta, B. B. Affect of deep brain stimulation on limb paresis after stroke. The Lancet 2000;356 (9225):222-223. 31. Proudman, S. M., Conaghan, P. G., Richardson, C., Griffiths, B., Green, M. J., McGonagle, D., Wakefield, R. J., Reece, R. J., Miles, S., Adebajo, A., Gough, A., Helliwell, P., Martin, M., Huston, G., Pease, C., Veale, D. J., Isaacs, J., van der Heijde, D. M., Emery, P. Treatment of poor-prognosis early rheumatoid arthritis: a randomised study of treatment with Methotrexate, Cyclosporin A, and intra-articular corticosteroids compared with Sulfasalazine alone. Arthritis & Rheumatism 2000;43(8):1809-1819. 32. Rayner, S. A., King, W. J., Comer, R. M., Isaacs, J. D., Hale, G., George, A. J. T., Larkin, D. F. P. Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation. Clinical & Experimental Immunology 2000;122:109-116. 33. Sood, S., Anthony, R., Pease, C. T. Sjogren's syndrome. Clinical Otolaryngology & Allied Sciences 2000;25(5):350-357. 27

LTHT Publications 2000 34. Stockwin, L. H., McGonagle, D., Martin, I. G., Blair, G. E. Dendritic cells: immunological sentinels with a central role in health and disease. Immunology & Cell Biology 2000;78(2):91-102. 35. Ubhi, T., Bhakta, B. B., Ives, H. L., Allgar, V., Roussounis, S. H. Randomised double blind placebo controlled trial of the effect of Botulinum toxin on walking in cerebral palsy. Archives of Disease in Childhood 2000;83(6):481-487. 36. Wakefield, R. J., Gibbon, W. W., Conaghan, P. G., O'Connor, P., McGonagle, D., Pease, C., Green, M. J., Veale, D. J., Isaacs, J. D., Emery, P. The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis. Arthritis & Rheumatism 2000;43(12):2762-2770. 37. Waxman, R., Tennant, A., Helliwell, P. A prospective follow-up study of low back pain in the community. Spine 2000;25(16):2085-2090. 38. Woodburn, J., Stableford, Z., Helliwell, P. S. Preliminary investigation of debridement of plantar callosities in rheumatoid arthritis . Rheumatology (Oxford) 2000;39:652-654. 28

LTHT Publications 2000 Division of Medicine, Surgery and Oncology Cancer Medicine 1. Achuthan, R., Bell, S. M., Leek, J. P., Roberts, P., Horgan, K., Markham, A. F., Selby, P. J., MacLennan, K. A. Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma. Genes, Chromosomes & Cancer, 2000;29(4):347-349. 2. Adams, J., Carder, P. J., Downey, S., Forbes, M. A., MacLennan, K., Allgar, V., Kaufman, S., Hallam, S., Bicknell, R., Walker, J. J., Cairnduff, F., Selby, P. J., Perren, T. J., Lansdown, M., Banks, R. E. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of Tamoxifen. Cancer Research 2000;60(11):2898-2905. 3. Alexandroff, A. B., Jackson, A. M., Paterson, T., Haley, J. L., Ross, J. A., Longo, D, Murphy, W., James, K., Taub, D. D. Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Molecular Immunology 2000;37:515-526. 4. Alison, D. L. Chemotherapy and hormonal manipulation. Eds. K.H.Simpson and K.Budd. In: Cancer Pain Management A Comprehensive Approach. 2000;(16):247-260. 5. Amir, Z., Haward, R. A., Barker, E. A., Lane, R. C. Recent trends in the place of death of cancer patient: A cancer registry based study in the Yorkshire region (1989-1996). Cancer Strategy 2000;2:55-60. 6. Amir, Z., Wright, A., Kernohan, E. E. M., Hart, G. Attitudes, beliefs and behaviour regarding the use of sunbeds amongst healthcare workers in Bradford. European Journal of Cancer Care 2000;9(2):76-79. 7. Ash, D., Flynn, A., Battermann, J., de Reijke, T., Lavagnini, P., Blank, L. ESTRO/EAU/EORTC recommendations fon permanent seed implantation for localized prostate cancer. Radiotherapy and Oncology 2000;57(3):315-321. 8. Banks, R. E. Measurement of cytokines in clinical samples using immunoassays: problems and pitfalls. Critical Reviews in Clinical Laboratory Sciences 2000;37(2):131-182. 9. Banks, R. E., Forbes, M. A., Patel, P. M., Storr, M., Hallam, S., Clarke, D., Novick, D., Ingham, E., Bowmer, C., Southgate, J., Trejdosiewicz, L. K., Illingworth, J., Perren, T. J., Selby, P. J. Subcutaneous administration of recombinant glycosylated interleukin 6 in patients with cancer: pharmacokinetics, pharmacodynamics and immunomodulatory effects. Cytokine 2000;12(4):388-396. 10. Banks, R. E., Dunn, M. J., Hochstrasser, D. F., Sanchez, J. C., Blackstock, W., Pappin, D. J., Selby, P. J. Proteomics: new perspectives, new biomedical opportunities. The Lancet, 2000;356(9243):1749-1756. 11. Barrett, J. H., Brennan, P., Fiddler, M., Silman, A. Breast-feeding and postpartum relapse in women with rheumatoid inflammatory arthritis. Arthritis & Rheumatism 2000;43:1010-1015. 12. Bennett, M., Adam, J., Alison, D., Hicks, F., Stockton, M. Leeds eligibility criteria for specialist palliative care services. Palliative Medicine 2000;14:157-158. 13. Buckley, J. G. and MacLennan, K. Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution. Head & Neck 2000;22(4):380-385. 14. Buckley, J. G. and MacLennan, K. Cancer spread in the larynx: a pathologic basis for conservation surgery. Head & Neck 2000; 22(3):265-274. 15. Burchill, S. A. and Selby, P. J. Molecular detection of low-level disease in patients with cancer. Journal of Pathology 2000;190(1):6-14. 16. Campbell, J., German, L., Lane, C., Dodwell, D. Radiotherapy outpatient review: a nurse-led clinic. Clinical Oncology (Royal College of Radiologists) 2000;12:104-107. 29

LTHT Publications 2000 17. Chester, J. D., Dent, J. T., Wilson, G., Ride, E., Seymour, M. T. Protracted infusional 5-fluorouracil (5-FU) with bolus mitomycin in 5-FU-resistant colorectal cancer. Annals of Oncology 2000;11( 2): 235-237. 18. da Gramont, A., Figer, A., Seymour, M., Homerin, M., Hmissi, A., Cassidy, J., Boni, C., Cortes-Funes, H., Cervantes, A., Freyer, G., Papamichael, D., Le Bail, N., Louvet, C., Hendler, D., de Braud, F., Wilson, C., Morvan, F., Bonetti, A. Leucovorin and Fluorouracil with or without Oxaliplatin as first-line treatment in advanced colorectal cancer. Journal of Clinical Oncology 2000;18:2038-2947. 19. Davies, F. E., Rawstron, A. C., Pratt, G., Coupe, R., Clarke, D., Lubenko, A., Short, K., Perren, T. J., Selby, P. J., Maclennan, S., Major, K., Woodhead, V., Robinson, F., Child, J. A., Smith, G. M., Johnson, P. W., Morgan, G. J. Current awareness. Hematological Oncology 2000;18(3):121-128. 20. Davies, F. E., Rawstron, A. C., Pratt, G., Coupe, R., Clarke, D., Lubenko, A., Short, K., Perren, T. J., Selby, P. J., Maclennan, S., Major, K., Woodhead, V., Robinson, F., Child, J. A., Smith, G. M., Johnson, P. W., Morgan, G. J. Positive and negative selection to reduce tumour contamination in peripheral blood stem cell harvests. Hematological Oncology 2000;18(3):111-120. 21. Delaney, B., Moayyedi, P., Soo, S., Deeks, J., Forman, D. This meta-analysis is potentially misleading. BMJ 2000;320:1208-1209. 22. Diggle, C. P., Pitt, E., Trejdosiewicz, L. K., Southgate, J. Effects of long-chain fatty acids on human urothelial cells in organ culture. Prostaglandins, Leukotrienes and Essential Fatty Acids 2000;62(4):249-252. 23. Diggle, C. P., Pitt, E., Roberts, P., Trejdosiewicz, L. K., Southgate, J. N-3 and N-6 polyunsaturated fatty acids induce cytostasis in human urothelia independent of p53 gene function. Journal of Lipid Research 2000; 41(9):1509-1515. 24. Feber, T. Head and Neck Oncology Nursing. Ed. T.Feber. 1st edition, 2000. 25. Foran, J. M., Gupta, R. K., Cunningham, D., Popescu, R. A., Goldstone, A. H., Sweetenham, J. W., Pettengell, R., Johnson, P. W. M., Bessell, E., Hancock, B., Summers, K., Hughes, J., Rohatiner, A. Z. S., Lister, T. A. A UK multicenter phase II study of Rituximab (chimeric anti-CD20 monoclonal antibody) in patients with follicular lymphoma, with PCR monitoring of molecular response. British Journal of Haematology 2000;109(1):81-88. 26. Foran, J. M., Rohatiner, A. Z. S., Cunningham, D., Popescu, R. A., Solal-Celigny, P., Ghielmini, M., Coiffier, B., Johnson, P. W. M., Gisselbrecht, C., Reyes, F., Radford, J. A., Bessell, E. M., Souleau, B., Benzohra, A., Lister, T. A. European phase II study of Rituximab (chimeric anti-CD20 monoclonal antibody) for patients with newly diagnosed mantle-cell lymphoma and previously treated mantle-cell lymphoma, immunocytoma and small B-cell lymphocytic lymphoma. Journal of Clinical Oncology 2000;18:317. 27. Gerrard, G. E. and Levy, D. Survey of UK oncologists' treatment of CNS tumours. Neuro-Oncology 2000;2:3. 28. Greenwood, D., Cade, J., Draper, A., Barrett, J. H., Calvert, C., Greenhalgh, A. Seven consumption patterns identified among women in the UK women's cohort study. European Journal of Clinical Nutrition 2000;54:314-320. 29. Harnden, P and Southgate, J. Revised classification of urothelial neoplasms. American Journal of Surgical Pathology 2000;24:160-161. 30. Haward, R. A and Amir, Z. Progress in establishing non-surgical oncology within English cancer units. British Journal of Cancer 2000;83(3):284-286. 31. James, R and Seymour, M. T. Chemotherapy for advanced colorectal cancer. Ed. J.Scholefield. In: Challenges in Colorectal Cancer. 2000;166-191.Oxford, Blackwell Science. 30

LTHT Publications 2000 32. Kiely, M. T. and Alison, D. L. Palliative care activity in a medical oncology unit: the implications for oncology training. Clinical Oncology 2000;12:179-181. 33. Kiltie, A. E., Elwell, C., Close, H. J., Ash, D. V. Iridium-192 implantation for node-negative carcinoma of the penis: the Cookridge Hospital experience. Clinical Oncology (Royal College of Radiologists) 2000;12:25-31. 34. Knowles, M. A., Moore, B., Hicks, R. Carcinogenesis studies using cultured human bladder. Ed. M.a.S.Webber, L. In: In Vitro Models for Cancer Research. 2000;(IV):21-61., CRC Press. 35. Kwok, M., Gerrard, G. E., Edwards, A. Palliative efficacy of whole brain radiotherapy in poor prognosis patients with multiple brain metastases. Clinical Oncology 2000;5:332. 36. Kwok, M. C., Adlard, J. W., Gerrard, G. E. The effect of radiotherapy waiting times on the treatment of glioblastoma. British Journal of Cancer 2000;83(Suppl):53. 37. Linch, D., Smith, P., Hancock, B., Hoskin, P., Cunningham, D., Newland, A., Milligan, D., Stevenson, P., Wood, J., MacLennan, K. A., Vaughan Hudson, B., Vaughan Hudson, G., Gregory, W. A randomised British National Lymphoma Investigation trial of CHOP vs a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma. Annals of Oncology 2000;11:87-90. 38. Lones, M., Raphael, M., McCarthy, K., Perkins, S., Terrier-Lacombe, M-J., MacLennan, K., Ramsay, A., Wotherspoon, A., Bayle, C., Cairo, M., Gerrard, M., Patte, C., Auperin, A. Mature B-cell lymphoma/leukemia in children and adolescents: Intergroup pathologist concensus with the revised European-American lymphoma classification. Annals of Oncology 2000;11:47-51. 39. MacLennan, K. A. Lymph nodes, thymus and spleen. In: U.JCE. General and Systematic Pathology. 2000;3rd edition:589-611. Churchill Livingstone. 40. Moayyedi, P., Soo, S., Deeks, J., Delaney, B., Harris, A., Innes, M., Oakes, R., Wilson, S., Roalfe, A., Bennett, C., Forman, D. Eradication of helicobacter pylori for non-ulcer dyspepsia. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD002096. 41. Prescott, S., Jackson, A. M., Hawkyard, S. J., Alexandroff, A. B., James, K. Mechanisms of action of intravesical bacille calmette-guerin: local immune mechanisms. Clinical Infectious Diseases 2000;31:S91-93. 42. Protheroe, A. S., Pickard, C., Johnson, P. W., Craddock, T., Shefta, J., Short, K., Lancaster, F., Selby, P. J., Henwood, J., Boylston, A. W. Persistence of clonal T-cell expansions following high-dose chemotherapy and autologous peripheral blood progenitor cell rescue: direct evidence for early reconstitution by mature T cells. British Journal of Haematology 2000;111(3):766-773. 43. Rapley, E. A., Crockford, G. P., Teare, D., Biggs, P., Seal, S., Barfoot, R., Edwards, S., Hamoudi, R., Heimdal, K., Fossa, S. D., Tucker, K., Donald, J., Collins, F., Friedlander, M., Hogg, D., Goss, P., Heidenreich, A., Ormiston, W., Daly, P. A., Forman, D., Oliver, R. T. D., Leahy, M., Huddart, R., Cooper, C. S., Bodmer, J. G., Easton, D. F., Stratton, M. R., Bishop, D. T. Localization to chromosome Xq27 of a susceptibility gene for testicular germ-cell tumours. Nature Genetics 2000;24:197-200. 44. Salem, C., Liang, G , Tsai, Y. C, Coulter, J., Knowles, M. A., Feng, A-C., Groshen, S., Nichols, P. W., Jones, P. A. Progressive increases in de novo methylation of CpG islands in bladder cancer. Cancer Research 2000;60:2473-2476. 45. Selby, P. Cancer therapy. Oncology Update 2000;295-304. 46. Seymour, M. T. Combination chemotherapy for advanced colorectal cancer. Eds. D.Cunningham, D.Haller, and A.Miles. In: The Effective Management of Colorectal Cancer. 2000;63-73. London, Aesculapius Medical Press. 31

LTHT Publications 2000 47. Sibley, K., Bell, S., Knowles, M. A. Redefining a critical region of LOH on 4p16.3 in bladder cancer. Genes, Chromosomes & Cancer 2000;29:378-379. 48. Silman, A and Barrett, J. H. Letter - Reply to Nelson. Arthritis & Rheumatism 2000;43:234. 49. Spencer, J. A., Crosse, B. A., Mannion, R. A., Sen, K. K., Perren, T. J., Chapman, A. H. Gastroduodenal obstruction from ovarian cancer: imaging features and clinical outcome. Clinical Radiology 2000;55(4):264-272. 50. Stark, D. P and House, A. Anxiety in cancer patients. British Journal of Cancer 2000;83(10):1261-1267. 51. Stenning, S., Brada, M., Thomas, D. G. T., Collins, P. , Cruickshank, G., Gerrard, G. E., Grant, R., Rampling, R., Wilkins, P. Prognostic indices for malignant glioma: matching form to function. Neuro- Oncology 2000;2:39. 52. Sturla, L. M., Westwood, G., Selby, P. J., Lewis, I. J., Burchill, S. A. Induction of cell death by basic fibroblast growth factor in Ewing's sarcoma. Cancer Research 2000;60(21):6160-6170. 53. Susol, E., MacGregor, A., Barrett, J. H., Wilson, H., Black, C., Welsh, K., Silman, A., Ollier, B., Worthington, J. A two stage genome-wide screen for susceptibility loci in primary Reynaud's phenomenon. Arthritis & Rheumatism 2000;43:1641-1646. 54. Taylor, R. E and Macdonald, R. Education and training of senior house officers in clinical oncology departments. Clinical Oncology (Royal College of Radiologists) 2000;12:42-47. 55. Thomas, E., Barrett, J. H., Donn, R., Thomson, W., Southwood, T., and British Paediatric Rheumatology Group. Subtyping of juvenile idiopathic arthritis using latent class analysis. Arthritis & Rheumatism 2000;43:1496-1503. Dermatology 1. Cunliffe, W. J., Holland, D. B., Clark, S. M., Stables, G. I. Comedogenesis: some new aetiological, clinical and therapeutic strategies. British Journal of Dermatology 2000;142(6):1084-1091. 2. Cunliffe, W. J and Goulden, V. Phototherapy and acne vulgaris. British Journal of Dermatology 2000;142(5):855-856. 3. Goodfield, M. J. D and Evans, E. G. V. Combined treatment with surgery and short duration oral antifungal therapy in patients with limited dermatophyte toe-nail infection. Journal of Dermatological Treatment 2000;11:259-262. 4. Goulden, V and Wilkinson, S. M. Evaluation of a contact allergy clinic. Clinical & Experimental Dermatology 2000;25(1):67-70. 5. Harland, M., Holland, E. A., Ghiorzo, P., Mantelli, M., Bianchi-Scarra, G., Goldstein, A. M., Tucker, M. A., Ponder, B. A., Mann, G. J., Bishop, D. T., Newton Bishop, J. Mutation screening of the CDKN2A promoter in melanoma families. Genes, Chromosomes & Cancer 2000;28(1):45-57. 6. McWhirter, J. M., Collins, M., Bryant, I., Wetton, N. M., Newton Bishop, J. A. Evaluating "safe in the sun": a curriculum programme for primary schools. Health Education Research 2000;15:203-217. 7. Newton Bishop, J. A., Bradburn, M., Bergman, W., Osterlind, A., Pinney, E., Rosdahl, I, Scerri, L., Weichenthal, M., Mant, D., Breitbart, E. W., Karlssons, P., Altman, D. G. Teaching non-specialist health care professionals how to identify the atypical mole syndrome phenotype: a multinational study. British Journal of Dermatology 2000;142(2):331-337. 32

LTHT Publications 2000 8. Newton Bishop, J. A., Wachsmuth, R. C., Harland, M., Bataille, V., Pinney, E., Mack, P., Baglietto, L., Cuzick, J., Bishop, D. T. Genotype/phenotype and penetrance studies in melanoma families with germline CDKN2A mutations. Journal of Investigative Dermatology 2000;114(1):28-33. 9. Newton Bishop, J. A. Melanoma. Hospital Medicine 2000;61:1-5. 10. Newton Bishop, J. A. Melanocytic naevi and melanoma. Eds. Harper, Oranje and Prose. In: Textbook of Pediatric Dermatology. 2000;937-951. UK, Blackwell Science. 11. Ravenscroft, J., Goodfield, M. J. D., Evans, E. G. V. Trichophyton tonsurans tinea capitis and tinea corporis: treatment and follow-up of four affected family members. Paediatric Dermatology 2000;17:407-409. 12. Sommer, S., Wilkinson, S. M., Merchant, W. J., Goulden, V. Sweet's syndrome presenting as palmoplantar pustulosis. Journal of the American Academy of Dermatology 2000;42(2 Pt 2):332-334. 13. Sommer, S., Wilkinson, S. M., Sheehan-Dare, R. A. Persistent telangiectasia following patch testing with topical corticosteroids. Contact Dermatitis 2000;43(5):306. 14. Sommer, S and Wilkinson, S. M. A series of 3 patients sensitised to reactive dyes during patch testing. Contact Dermatitis 2000;43:227-228. 15. Sommer, S and Sheehan-Dare, R. A. Pulsed dye laser treatment of port-wine stains in pigmented skin. Journal of the American Academy of Dermatology 2000;42(4):667-671. 16. Stables, G. I., Taylor, P. C., Highet, A. S. Scleredema associated with paraproteinaemia treated by extracorporeal photopheresis. British Journal of Dermatology 2000;142 (4):781-783. 17. Thomson, K. F and Cunliffe, W. J. Acne fulminans 'sine fulminans'. Clinical & Experimental Dermatology 2000;25(4):299-301. 18. Thomson, K. F and Wilkinson, S. M. Allergic contact dermatitis to plant extracts in patients with cosmetic dermatitis. British Journal of Dermatology 2000;142(1):84-88. 19. Thomson, K. F and Highet, A. S. Penile ulceration in fatal malignant atrophic papulosis (Degos' disease). British Journal of Dermatology 2000;143:1320-1322. 20. Thomson, K. F and Highet, A. S. Staphylococcal fissure of the upper lip. Clinical & Experimental Dermatology 2000;25:659-660. 21. Thomson, K. F., Sheehan-Dare, R. A., Wilkinson, S. M. Allergic contact dermatitis from topical carmustine. Contact Dermatitis 2000;42(2):112. 22. Till, A. E., Goulden, V., Cunliffe, W. J., Holland, K. T. The cutaneous microflora of adolescent, persistent and late-onset acne patients does not differ. British Journal of Dermatology 2000;142(5):885-892. 23. Wilkinson, S. M. Effects of infection control measures on skin of healthcare workers. Communicable Disease and Public Health 2000;4:305-306. 24. Wilkinson, S. M. Glass workers. Eds. L.Kanerva, P.Elsner, P, Wahlberg, J, and Maibach, H. I. In: Handbook of Occupational Dermatology. 2000;956-957. Berlin, Springer Verlag. 25. Wilkinson, S. M., Beck, M. H., Steel, I. Results of patch testing with hydrocortisone butyrate in different vehicles. Contact Dermatitis 2000;42(5):299-300. 26. Wilkinson, S. M and Beck, M. H. Patch testing for corticosteroid allergy using high and low concentrations. Contact Dermatitis 2000;42(6):350-351. 27. Wilkinson, S. M and Thomson, K. F. Foot dermatitis due to non-disperse azo dyes. Contact Dermatitis 2000;42(3):162-163. 33

LTHT Publications 2000 28. Wilkinson, S. M. Corticosteroid cross-reactions: an alternative view. Contact Dermatitis 2000;42(2):59-63. 29. Wilkinson, S. M. Patch test reactions to natural rubber latex: irritant or allergic? Contact Dermatitis 2000;42(3):179-181. Epidemiology 1. Alexander, F. E., Jarrett, R. F., Lawrence, D., Armstrong, A. A., Freeland, J., Gokhale, D. A., Kane, E., Taylor, G. M., Wright, D. H., Cartwright, R. A. Risk factors for Hodgkin's disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents. British Journal of Cancer 2000;82:1117-1121. 2. Badzioch, M., Eeles, R., Leblanc, G., Foulkes, W. D., Giles, G., Edwards, S., Goldgar, D., Hopper, J. L., Bishop, D. T., Moller, P., Heimdal, K., Easton, D., The CRC/BPG UK familial prostate cancer study coordinators & collaborators., The EC BIOMED familial prostate cancer study collaborators and Simard, J. Suggestive evidence for a site-specific early-onset prostate cancer gene on chromosome 1p36. Journal of Medical Genetics 2000;37:947-948. 3. Cartwright, R., Law, G., Roman, E., on behalf of the UKCCS investigators. Radon and terrestrial gamma radiation in the United Kingdom Childhood Cancer Study: objectives, materials and methods. British Journal of Cancer 2000;82:1073-1102. 4. Cartwright, R. A. and on behalf of the UKCCS investigators. Childhood cancer and residential proximity to power lines. British Journal of Cancer 2000;83:1573-1580. 5. Forrest, M. S., Edwards, S. S. M., Hamoud, R. A., Dearnaley, D. P., Arden-Jones, A., Dowe, A., Murkin, A., Kelly, J., Teare, M. D., Easton, D. F., Knowles, M. A., Bishop, D. T., Eeles, R. A., The CRC/BPG UK familial prostate cancer study collaborators., The EC BIOMED familial prostate cancer study collaborators. No evidence of germline PTEN mutations in familial prostate cancer. Journal of Medical Genetics 2000;37(3):210-212. 6. Hanby, A. M., Kelsell, D. P., Potts, H. W., Gillett, C. E., Bishop, D. T., Spurr, N. K., Barnes, D. M. Association between loss of heterozygosity of BRCA1 and BRCA2 and morphological attributes of sporadic breast cancer. International Journal of Cancer 2000;88(2):204-208. 7. Harland, M., Holland, E. A., Ghiorzo, P., Mantelli, M., Bianchi-Scarra, G., Goldstein, A. M., Tucker, M. A., Ponder, B. A., Mann, G. J., Bishop, D. T., Newton Bishop, J. Mutation screening of the CDKN2A promoter in melanoma families. Genes, Chromosomes & Cancer 2000;28(1):45-57. 8. Lakhani, S. R., Gusterson, B. A., Jacquemier, J., Sloane, J. P., Anderson, T. J., van de Vijver, M. J., Venter, D., Freeman, A., Antoniou, A., McGuffog, L., Smyth, E., Steel, C. M., Haites, N., Scott, R. J., Goldgar, D., Neuhausen, S., Daly, P. A., Ormiston, W., McManus, R., Scherneck, S., Ponder, B. A. J., Futreal, P. A., Peto, J., Stoppa-Lyonnet, D., Bignon, Y-J., Stuewing, J. P., Bishop, D. T., Klijn, J. G. M., Devilee, P., Cornelisse, C. J., Lasset, C., Lenoir, G., Barkardottir, R. B., Egilsson, V., Hamann, U., Chang-Claude, J., Sobol, H., Weber, B., Easton, D. F., Stratton, M. R. The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2. Clinical Cancer Research 2000;6:782-789. 9. Law, G. R., Kane, E. V., Roman, E., Smith, A., Cartwright, R. Residential radon exposure and adult acute leukaemia. The Lancet 2000;355:1888. 10. Mansur, A. H., Christie, G., Turner, A., Bishop, D. T., Markham, A. F., Helms, P., Morrison, J. F. Lack of linkage between chromosome 5q23-33 markers and IgE/bronchial hyperreactivity in 67 Scottish families. Clinical & Experimental Allergy 2000;30(7):954-961. 11. Mansur, A. H., Williams, G. A., Bishop, D. T., Markham, A. F., Lewis, S., Britton, J., Morrison, J. F. Evidence for a role of HLA DRB1 alleles in the control of IgE levels, strengthened by interacting TCR A/D marker alleles. Clinical & Experimental Allergy 2000;30(10):1371-1378. 34

LTHT Publications 2000 12. Mazoyer, S., Robinson, M., Taylor, G. R., Bishop, T., et al. The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations. American Journal of Human Genetics 2000;67(1):207-212. 13. Newton Bishop, J. A., Wachsmuth, R. C., Harland, M., Bataille, V., Pinney, E., Mack, P., Baglietto, L., Cuzick, J., Bishop, D. T. Genotype/phenotype and penetrance studies in melanoma families with germline CDKN2A mutations. Journal of Investigative Dermatology 2000;114(1):28-33. 14. Rapley, E. A., Crockford, G. P., Teare, D., Biggs, P., Seal, S., Barfoot, R., Edwards, S., Hamoudi, R., Heimdal, K., Fossa, S. D., Tucker, K. , Donald, J., Collins, F., Friedlander, M., Hogg, D., Goss, P., Heidenreich, A., Ormiston, W., Daly, P. A., Forman, D., Oliver, R. T. D., Leahy, M., Huddart, R., Cooper, C. S., Bodmer, J. G., Easton, D. F., Stratton, M. R., Bishop, D. T. Localization to chromosome Xq27 of a susceptibility gene for testicular germ-cell tumours. Nature Genetics 2000;24:197-200. 15. Robinson, M. D., Chu, C. E., Turner, G., Bishop, D. T., Taylor, G. R. Exon deletions and duplications in BRCA1 detected by semiquantitative PCR. Genetic Testing 2000;4(1):49-54. 16. Roddam, P. L, Rollinson, S., Kane, E., Roman, E., Moorman, A., Cartwright, R., Morgan, G. J. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Pharmacogenetics 2000;10(7):605-615. 17. Rollinson, S., Roddam, P., Kane, E., Roman, E., Cartwright, R., Jack, A., Morgan, G. J. Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia. Carcinogenesis 2000;21(1):43-47. 19. Singh, R., Bishop, D. T., and the ACTANE Consortium. No evidence of linkage to chromosome 1q42.2-43 in 131 prostate cancer families from the ACTANE Consortium. British Journal of Cancer 2000;83(12):1654-1658. 20. Smith, A. G., Dovey, G. J., Cartwright, R. A. Topical Cloramphenicol and the risk of acute lymphoblastic leukaemia. Pharmacoepidemiology and Drug Safety 2000;9:215-219. 21. RCA1 Exon 12 Duplication Screening Group, Mazoyer, S., Bishop, D. T., et al. The Exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations. American Journal of Human Genetics 2000;67:207-212. Gastroenterology 1. Aldersley, M. A., Hamlin, P. J., Jones, P. F., Markham, A. F., Robinson, P. A., Howdle, P. D. No polymorphism in the tissue transglutaminase gene detected in coeliac disease patients. Scandinavian Journal of Gastroenterology 2000;35(1):61-63. 2. Axon, A., Lambert, R., Robaszkiewicz, M., Rosch, T., Sonnenberg, A. The second European Endoscopy Forum (Sintra, Portugal, 17-18 June 1999): twenty questions on the esophagogastric junction. Endoscopy 2000;32(5):411-418. 3. Axon, A. T. R. Treatment of Helicobacter pylori: an overview. Alimentary Pharmacology & Therapeutics 2000;14(Suppl 3):1-6. 4. Axon, A. T. R., Malfertheiner, P., Megraud, F. Non-ulcer dyspepsia and patient management, including diagnosis and treatment: definitions and terminology. European Journal of Gastroenterology & Hepatology 2000;12(9):1053-1056. 5. Axon, A. T. R and O'Mahony, S. Quality assurance in endoscopy. World Gastroenterology News (OMGE) 2000;(Spring):31-32. 35

LTHT Publications 2000 6. Bani-Hani, K., Sue-Ling, H., Johnston, D., Axon, A. T. R., Martin, I. G. Barrett's oesophagus: results from a 13 year surveillance programme. European Journal of Gastroenterology & Hepatology 2000;12:649-654. 7. Bardhan, K. D., Dillon, J., Axon, A. T. R., Cooper, B. T., Tildesley, G., Wyatt, J. I., Gatz, G., Braun, W. Triple therapy for Helicobacter pylori eradication: a comparison of Pantoprazole once versus twice daily. Alimentary Pharmacology & Therapeutics 2000;14:59-67. 8. Bercik, P., Verdu, E. F., Armstrong, D., Idstrom, J. P. , Cederberg, C., Markert, M., Crabtree, J. E., Stolte, M., Blum, A. L. The effect of ammonia on omeprazole-induced reduction of gastric acidity in subjects with Helicobacter pylori infection. American Journal of Gastroenterology 2000;95(4):947-955. 9. Crabtree, J. E. Immune-mediated mucosal injury in Helicobacter pylori infection. Ed. L.Rodrigo. In: Treatment of Digestive Diseases. 2000;53-59. Madrid, Accion Medica. 10. Danielsson, D., Farmery, S. M., Blomberg, B., Perry, S., Rautelin, H., Crabtree, J. E. Co-expression in Helicobacter pylori of cagA and non-opsonic neutrophil activation enhances the association with peptic ulcer disease. Journal of Clinical Pathology 2000;53(4):318-321. 11. Delaney, B., Moayyedi, P., Soo, S., Deeks, J., Forman, D. This meta-analysis is potentially misleading. BMJ 2000;320:1208-1209. 12. Everett, S. M., White, K. L., Schorah, C. J., Calvert, R. J., Skinner, C., Miller, D., Axon, A. T. In-vivo DNA damage in gastric epithelial cells. Mutation Research 2000;468(1):73-85. 13. Fukada, S., Tanaka, M., Soma, Y., Shimoyama, T., Mikami, T., Crabtree, J. E., Saito, H., Munakata, A., Yoshida, Y. Histological analysis of gastritis and Helicobacter pylori infection in patients with early gastric cancer: a case control study. Journal of Gastroenterology and Hepatology 2000;15:1370-1376. 14. Hayat, M., Axon, A. T., O'Mahony, S. Diagnostic yield and effect on clinical outcomes of push enteroscopy in suspected small-bowel bleeding. Endoscopy 2000;32(5):369-372. 15. Howdle, P. D. Clinical evaluation of the patient with liver disease. Eds. J.G.O'Grady, J.R.Lake, and P.D.Howdle. In: Comprehensive Clinical Hepatology. 2000;4.1-16. London, Harcourt Publishers Ltd. 16. Jennings, J. S., Wyatt, J. I., Howdle, P. D. A new cause of "non-responsiveness" in coeliac disease? Postgraduate Medical Journal 2000;76(894):227-229. 17. Lake, J. R and Howdle, P. D. Gastrointestinal hemorrhage and portal hypertension. Eds. J.G.O'Grady. J.R.Lake and P.D.Howdle. In: Comprehensive Clinical Hepatology. 2000;6.1-14. London, Harcourt Publishers Ltd. 18. Lewis, M. B., MacQuillan, G., Bamford, J. M., Howdle, P. D. Delayed myelopathic presentation of the acquired hepatocerebral degeneration syndrome. Neurology 2000;54(4):1011. 19. Minhas, S., Cartledge, J., Eardley, I. The role of prostaglandins in penile erection. Prostaglandins Leukotrienes & Essential Fatty Acids 2000;62(3 ):137-146. 20. Moayyedi, P., Wason, C., Peacock, A., Walan, A., Bardhan, K., Axon, A. T. R., Dixon, M. F. Changing patterns of Helicobacter pylori gastritis in long-standing acid suppression. Helicobacter 2000;5:206-214. 21. Moayyedi, P., Forman, D., Braunholtz, D., Feltbower, R., Crocombe, W., Liptrott, M., Axon, A. The proportion of upper gastrointestinal symptoms in the community associated with Helicobacter pylori, lifestyle factors, and nonsteroidal anti-inflammatory drugs. Leeds HELP Study Group. American Journal of Gastroenterology 2000;95(6):1448-1455. 22. Moayyedi, P., Soo, S., Deeks, J., Delaney, B., Harris, A., Innes, M., Oakes, R., Wilson, S., Roalfe, A., Bennett, C., Forman, D. Eradication of helicobacter pylori for non-ulcer dyspepsia. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD002096. 36

LTHT Publications 2000 23. Moayyedi, P., Feltbower, R., Crocombe, W., Mason, S., Atha, P., Brown, J., Dowell, A. C., Richards, I. D., Axon, A. T. The effectiveness of Omeprazole, Clarithromycin and Tinidazole in eradicating Helicobacter pylori in a community screen and treat programme. Leeds HELP Study Group. Alimentary Pharmacology & Therapeutics 2000;14(6):719-728. 24. Moayyedi, P., Feltbower, R., Brown, J., Mason, S., Mason, J., Nathan, J., Richards, I. D. G., Dowell, A. C., Axon, A. T. R. Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial. The Lancet 2000;355(9216):1665-1669. 25. Moncur, P. H and Heatley, R. V. Safety of proton-pump inhibitors: the acid test. European Journal of Gastroenterology & Hepatology 2000;12(2):145-147. 26. Nelson, D. B., Murdoch, M., Sandozi, I. K., Dalmasso, A. P., Crabtree, J. E., Ho, S. B. Dyspepsia is associated with CagA-positive Helicobacter pylori. American Journal of Gastroenterology 2000;95(12):3412-3417. 27. O'Grady, J. G., Lake, J. R., Howdle, P. D. Comprehensive Clinical Hepatology. 2000; London, Harcourt Publishers Ltd. 28. O'Mahony, S., Naylor, G., Axon, A. Quality assurance in gastrointestinal endoscopy. Endoscopy 2000; 32(6):483-488. 29. Rembacken, B. J., Fujii, T., Cairns, A., Dixon, M. F., Yoshida, S., Chalmers, D. M., Axon, A. T. Flat and depressed colonic neoplasms: a prospective study of 1000 colonoscopies in the UK. The Lancet 2000;355(9211):1211-1214. 30. Roda, A., Musiani, M., Pasini, P., Baraldini, M., Crabtree, J. E. In situ hybridization and immunohistochemistry with enzyme-triggered chemiluminescent probes. Methods in Enzymology 2000;305:577-590. 31. Vaira, D., Malfertheiner, P., Megraud, F., Axon, A. T. R., Deltenre, M., Gasbarrini, G., O'Morain, C., Pajares Garcia, J. M. , Quina, M., Tytgat, G. N. J., and the European Helicobacter pylori HpSA Study Group. Noninvasive antigen-based assay for assessing Helicobacter pylori eradication: A European multicenter study. American Journal of Gastroenterology 2000;95:925. 32. Ward, F., Bodger, K., Daly, M. J., Heatley, R. V. Medical managment of inflammatory bowel disease. Eds. K.Bodger, M.J.Daly, and R.V.Heatley. In: Clinical Economics in Gastroenterology. 2000; 1st edition:116-132. Oxford, Blackwell Science Ltd. Genito-Urinary Medicine 1. Chodynicka, B., Serwin, A. G., Jan Czyo-Jankowska, M., Waugh, M. A. Epidemiology of syphilis and gonorrhoea in Eastern Poland in the years 1988 - 1997. Journal of Central and Eastern Europe Dermato- Venereology Association (CEEDVA) 2000;2(26):29. 2. Dencheva, R., Spirov, G., Niagolova, D., Pehlivanov, G., Tsankov, N., Waugh, M. A. Epidemiology of syphilis in Bulgaria 1990 - 1998. International Journal of STD & AIDS 2000;11:819-822. 3. Hextall, R and Wilson, J. Current primary care management of STDs. Prescribers Journal 2000;11:53-67. 4. Mammen-Tobin, A and Monteiro, E. F. Pneumocystis carinii pneumonia following discontinuation of primary prophylaxis despite highly active antiretroviral therapy. International Journal of STD & AIDS 2000;11(1):64-65. 5. Potocnik, M., Butina, M. R., Bartenjev, I., Waugh, M. A. Syphilis in Slovenia - on the threshold of the European Union. International Journal of STD & AIDS 2000;11:795-797. 37

LTHT Publications 2000 6. Reade, S and Wilson, J. Infections of the female genital tract. Update 2000;61:428-442. 7. Waugh, M. My choice: Medical professional secrecy with special reference to venereal diseases. Sexually Transmitted Infections 2000;76 (Suppl 1):S19-S20. 8. Waugh, M. A. Re-emergence of syphilis [editorial]. Hospital Medicine 2000;61(7):454-455. 9. Waugh, M. A. The fascinating development of sexually transmitted diseases. International Journal of STD & AIDS 2000;11:682-683. 10. Waugh, M. A. Sexually transmitted diseases and AIDS in the world and their consequences. Dermatologia Kliniczna l Zabiegowa 2000;2(Suppl 1):23. 11. Waugh, M. A. The international community. What are the problems: what are we doing, Where do we go from here? In: Sexually Transmitted Diseases in Changing Europe. 2000;5-5. Rotterdam NL, Department of Dermatology and Venereology, Academisch Ziehenhaus. 12. Waugh, M. A. Sexually transmitted diseases and AIDS in the world and their consequences. Dermato- Venerologie (Bucharest) 2000;45(3):43-44. 13. Waugh, M. A. The British Co-operative Clinical Group (BCCG) [editorial]. Sexually Transmitted Infections 2000;76(1):4-5. 14. Waugh, M. A. Choroby przenoszone droga piciowa l AIDS w swiecie oraz ich nastepstwa. (Sexually transmitted diseases and AIDS in the world and their consequences). Przeglad Dermatologiczny 2000;87(5):437-439. 15. Waugh, M. A. World trends in STIS/HIV/AIDS: what is coming up next for specialists in this field. Sexual Health Matters 2000;1(4):71-72. 16. Waugh, M. A. A global review of HIV infection, its interaction with other infections and establishment responses. Medico-Legal Journal 2000;68(3):81-88. 17. Waugh, M. A. Sexually transmitted diseases, migration and the sex trade in Europe 2000. Journal of the European Academy of Dermatology and Venereology 2000;14(Suppl):24. 18. Waugh, M. A. Syphilis 2000 - global problems and evidence based medicine. Magyar Venerologiai Archivum (Budapest) 2000;4(2-3):127. 19. Wilson, J. Bacterial vaginosis - an update. Sexual Health Matters 2000;1:86-87. 20. Wilson, J. D. and Hines, B. Nurse counselling for women with abnormal cervical cytology improves colposcopy and cytology follow-up attendance rates. Sexually Transmitted Infections 2000;76:322. General Surgery 1. Achuthan, R., Bell, S. M., Leek, J. P., Roberts, P., Horgan, K., Markham, A. F., Selby, P. J., MacLennan, K. A. Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma. Genes, Chromosomes & Cancer, 2000;29(4):347-349. 2. Adams, J., Carder, P. J., Downey, S., Forbes, M. A., MacLennan, K., Allgar, V., Kaufman, S., Hallam, S., Bicknell, R., Walker, J. J., Cairnduff, F., Selby, P. J., Perren, T. J., Lansdown, M., Banks, R. E. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of Tamoxifen. Cancer Research 2000;60(11):2898-2905. 3. Ainslie, W., Reed, J., Larvin, M., McMahon, M. J. Successful laparoscopic rescue of an impacted lithotriptor basket from the common bile duct. Endoscopy 2000;32(6):S34. 38

LTHT Publications 2000 4. Ainslie, W. B., Larvin, M., Martin, I. G., McMahon, M. J. Liver retraction techniques for laparoscopic cholecystectomy. Surgical Endoscopy 2000;14 (3):311-discussion 312. 5. Ammori, B. J., Conroy, J., Pollard, S. G. Roux-en-Y gastric bypass: a safe and effective operation in morbidly obese and superobese patients. British Journal of Surgery 2000;87(Suppl 1):33. 6. Ammori, B. J., Miller, G. V., Prasad, S., Gulieria, S., Furniss, S., Pollard, S. G., Lodge, J. P. A. Extensive surgery for hilar cholangiocarcinoma: early results. British Journal of Surgery 2000;87(Suppl 1):57. 7. Ammori, B. J., Birbas, K., Davides, D., Vezakis, A., Larvin, M., McMahon, M. J. Routine vs "on demand" postoperative ERCP for small bile duct calculi detected at intraoperative cholangiography. Clinical evaluation and cost analysis. Surgical Endoscopy 2000;14 (12):1123-1126. 8. Attia, M. S., Prasad, K. J., Bellamy, M. C., Lodge, J. P. A. Organ retrieval - fluids and techniques. Ed. J.L.R.Forsythe. In: A Companion to Surgical Practice: Transplantation Surgery. 2000;2nd edition. London, Balliere Tindall. 9. Bani-Hani, K., Sue-Ling, H., Johnston, D., Axon, A. T. R., Martin, I. G. Barrett's oesophagus: results from a 13 year surveillance programme. European Journal of Gastroenterology & Hepatology 2000;12:649-654. 10. Beardsmore, D., Spark, J. I., MacAdam, R., Macdonald, D., Scott, D. J. A psoas ganglion causing obstruction of the iliofemoral arteries. European Journal of Vascular & Endovascular Surgery 2000;19(5):554-555. 11. Botterill, I. D and Sagar, P. M. Intestinal obstruction. Surgery 2000;18:33-39. 12. Chapple, K. S., Cartwright, E. J., Hawcroft, G., Tisbury, A., Bonifer, C., Scott, N., Windsor, A. C., Guillou, P. J., Markham, A. F., Coletta, P. L., Hull, M. A. Localization of cyclo oxygenase-2 in human sporadic colorectal adenomas. American Journal of Pathology 2000;156(2):545-553. 13. Chapple, K. S., Spencer, J. A., Windsor, A. C., Wilson, D., Ward, J., Ambrose, N. S. Prognostic value of magnetic resonance imaging in the management of fistula-in-ano. Diseases of the Colon & Rectum 2000;43(4):511-516. 14. Corbett, E. J., Barry, B. N., Pollard, S. G., Lodge, J. P., Bellamy, M. C. Laser doppler flowmetry is useful in the clinical management of small bowel transplantation. Gut 2000;47(4):580-583. 15. Danielsson, D., Farmery, S. M., Blomberg, B., Perry, S., Rautelin, H., Crabtree, J. E. Co-expression in Helicobacter pylori of cagA and non-opsonic neutrophil activation enhances the association with peptic ulcer disease. Journal of Clinical Pathology 2000;53(4):318-321. 16. Dexter, S. P., Miller, G. V., Davides, D., Martin, I. G., Sue-Ling, H. M., Sagar, P. M. , Larvin, M., McMahon, M. J. Relaparoscopy for the detection and treatment of complications of laparoscopic cholecystectomy. American Journal of Surgery 2000;179(4):316-319. 17. Earnshaw, J. J., Farndon, J. R., Guillou, P. J., Johnson, C. D., Murie, J. A., Murray, G. D. A comparison of reports from referees chosen by authors or journal editors in the peer review process. Annals of the Royal College of Surgeons of England 2000;82(4 Suppl):133-135. 18. Guillou, P. J. and Earnshaw, J. J. Surgical Publishing: dealing with the rejected article. British Journal of Surgery 2000; 87(12):1603-1604. 19. Hull, M. A., Fenwick, S. W., Chapple, K. S., Scott, N., Toogood, G. J., Lodge, J. P. Cyclo oxygenase-2 expression in colorectal cancer liver metastases. Clinical & Experimental Metastasis 2000;18:21-27. 20. Jayne, D. G., Perry, S. L., Morrison, E., Farmery, S. M., Guillou, P. J. Activated mesothelial cells produce heparin-binding growth factors: implications for tumour metastases. British Journal of Cancer 2000;82(6):1233-1238. 39

LTHT Publications 2000 21. Kanwar, S., Windsor, A. C., Welsh, F., Barclay, G. R., Guillou, P. J., Reynolds, J. V. Lack of correlation between failure of gut barrier function and septic complications after major upper gastrointestinal surgery. Annals of Surgery 2000;231(1):88-95. 22. Konig, P., Ambrose, N. S., Scott, N. Hereditary internal anal sphincter myopathy causing proctalgia fugax and constipation: further clinical and histological characterization in a patient. European Journal of Gastroenterology & Hepatology 2000;12(1):127-128. 23. Lodge, J. P., Ammori, B. J., Prasad, K. R., Bellamy, M. C. Ex vivo and in situ resection of inferior vena cava with hepatectomy for colorectal metastases. Annals of Surgery 2000;231(4):471-479. 24. Macadam, R. C., Sarela, A. I., Farmery, S. M., Robinson, P. A., Markham, A. F., Guillou, P. J. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. British Journal of Cancer 2000;83(2):188-195. 25. Martin, I. G., Stark, P., Jolly, B. Benefiting from clinical experience: the influence of learning style and clinical experience on performance in an undergraduate objective structured clinical examination. Medical Education 2000;34(7):530-534. 26. Morris, J., Spencer, J. A., Ambrose, N. S. MR imaging classification of perianal fistulas and its implications for patient management. Radiographics 2000;20(3):623-635. 27. Pollard, S. G. Small intestinal transplantation. Eds. K.Bodger, M.Daly and R.V.Heatley. In: Clinical Economics in Gastroenterology. 2000;250-264. Oxford, Blackwell Science. 28. Prasad, R and Pollard, S. G. Small bowel transplantation. Current Opinion in Gastroenterology 2000;16(2):126-133. 29. Ramnarine, I. R., Mulpur, A. K., McMahon, M. J., Thorpe, J. A. C. Pleuro-biliary fistula from a ruptured choledochal cyst. European Journal of Cardio-Thoracic Surgery 2000;19(2) 30. Sagar, P. M. Operative mortality rates among surgeons [editorial comment]. Diseases of the Colon & Rectum 2000;43:1532-1534. 31. Sagar, P. M. and Pemberton, J. H. Surgical palliation of colorectal cancer. European Journal of Gastroenterology & Hepatology 2000;12(4):409-413. 32. Sarela, A. I., Macadam, R. C., Farmery, S. M., Markham, A. F., Guillou, P. J. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 2000;46(5):645-650. 33. Smith, R. M., Giannoudis, P. V., Bellamy, M. C., Perry, S. L., Dickson, R. A., Guillou, P. J. Interleukin-10 release and monocyte human leukocyte antigen-DR expression during femoral nailing. Clinical Orthopaedics & Related Research 2000;(373):233-240. 34. Sood, S., Anthony, R., Pease, C. T. Sjogren's syndrome. Clinical Otolaryngology & Allied Sciences 2000;25(5):350-357. 35. Stockwin, L. H., McGonagle, D., Martin, I. G., Blair, G. E. Dendritic cells: immunological sentinels with a central role in health and disease. Immunology & Cell Biology 2000;78(2):91-102. 36. Stojkovic, S., Ireland, I. W., Holmfield, J. H., Sagar, P. M., Finan, P. J. Interobserver variability on the reporting of dynamic evacuation proctography. Colorectal Disease 2000;2:355-358. 37. Vezakis, A., Davides, D., Birbas, K., Ammori, B. J., Larvin, M., McMahon, M. J. Laparoscopic treatment of Mirizzi syndrome. Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 2000;10(1):15-18. 38. Vezakis, A., Davides, D., Ammori, B. J., Martin, I. G., Larvin, M., McMahon, M. J. Intraoperative cholangiography during laparoscopic cholecystectomy. Surgical Endoscopy 2000;14(12):1118-1122. 40

LTHT Publications 2000 39. Ward, J., Chen, F. , Guthrie, J. A., Wilson, D., Lodge, J. P., Wyatt, J. I., Robinson, P. J. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 2000;214(1):159-166. 40. Williamson, M. E. R., Miller, A. S., Lewis, W. G., Sagar, P. M., Holdsworth, P. J., Johnston, D., Smith, A. The effect of pelvic ileal reservoir volume and antiperistaltic reflux on emptying efficiency. Diseases of the Colon & Rectum 2000;43:1368-1374. 41. Zbar, A. P., Aslam, M., Allgar, V. Faecal incontinence after internal sphincterotomy for anal fissure. Techniques in Coloproctolology 2000;4(1):25-28. Gynaecology 1. Batar, I., Gbolade, B. A., Wildemeersch, D. Immediate postabortal insertion of the frameless IUD: review of current experience. European Journal of Contraception & Reproductive Health Care 2000;5(1):96-98. 2. Bigrigg, A., Evans, M. E., Gbolade, B. A., Newton, J. , Pollard, L., Szarewski, A., Walling, M. Depo provera discussion paper on clinical care, effectiveness and side effects. British Journal of Family Planning, 2000;26(1):97-99. 3. Gbolade, B. A. Preventing repeat abortion through use of immediate post-abortion contraception. Sexual Health Matters 2000;1(1):9-10. 4. Gbolade, B. A. Women with other malignant diseases. Ed. E.Killick. In: Contraception in Practice. 2000;19-29. London, Martin Dunitz. 5. Gbolade, B. A. Teenage pregnancy rates and the age and sex of general practitioners. Record linkage analysis could have been used [letter]. BMJ 2000;321(7257):381-382. Haematology 1. Backhouse, O., Parapia, L., Mahomed, I., Lee, D. Familial thrombophilia and retinal vein occlusion. Eye 2000;14:13-17. 2. Child, J. A., Johnson, S. A., Rule, S., Smith, G. M., Morgan, G. J., Johnson, P. W., Prentice, A. G., Tollerfield, S. M., Wareham, E. FLUDAP: salvage chemotherapy for relapsed/refractory aggressive non- Hodgkin's lymphoma. Leukemia & Lymphoma 2000;37(3-4):309-317. 3. Connor, M. P., Bynoe, A. G., Redfern, N., Pokora, J., Clarke, J. Developing senior doctors as mentors: a form of continuing professional development. Report of an initiative to develop a network of senior doctors as mentors: 1994-99. Medical Education 2000;34:747-753. 4. Davies, F. E., Rawstron, A. C., Pratt, G., Coupe, R., Clarke, D., Lubenko, A., Short, K., Perren, T. J., Selby, P. J., Maclennan, S., Major, K., Woodhead, V., Robinson, F., Child, J. A., Smith, G. M., Johnson, P. W., Morgan, G. J. Current awareness. Hematological Oncology 2000;18(3):121-128. 5. Davies, F. E., Rawstron, A. C., Pratt, G., Coupe, R., Clarke, D., Lubenko, A., Short, K., Perren, T. J., Selby, P. J., Maclennan, S., Major, K., Woodhead, V., Robinson, F., Child, J. A., Smith, G. M., Johnson, P. W., Morgan, G. J. Positive and negative selection to reduce tumour contamination in peripheral blood stem cell harvests. Hematological Oncology 2000;18(3):111-120. 6. Davies, F. E., Rawstron, A. C., Owen, R. G., Morgan, G. J. Controversies surrounding the clonogenic origin of multiple myeloma. British Journal of Haematology 2000;110(1):240-241. 41

LTHT Publications 2000 7. Davies, F. E., Rollinson, S. J., Rawstron, A. C., Roman, E., Richards, S., Drayson, M., Child, J. A., Morgan, G. J. High-producer haplotypes of tumor necrosis factor alpha and lymphotoxin alpha are associated with an increased risk of myeloma and have an improved progression-free survival after treatment. Journal of Clinical Oncology 2000;18(15):2843-2851. 8. Evans, M., Cottrell, D., Shiach, C. Emotional and behavioural problems and family functioning in children with haemophilia: a cross-sectional survey. Haemophilia 2000;6(6):682-687. 9. Follows, G. A., McVerry, B. A., Owen, R. G. Precursor B-lymphoblastic transformation of grade I follicle centre lymphoma following Rituximab therapy. American Journal of Clinical Pathology 2000;114:982-983. 10. Hillmen, P. and Richards, S. J. Implications of recent insights into the pathophysiology of paroxysmal nocturnal haemoglobinuria. British Journal of Haematology 2000;108(3):470-479. 11. Kilbride, J., Baker, T. G., Parapia, L. A., Khoury, S. A. Incidence of iron-deficiency anaemia in infants in a prospective study in Jordan. Haemophilia 2000; 64(4):231-236. 12. Kottaridis, P. D., Milligan, D. W., Chopra, R., Chakraverty, R. K., Chakrabarti, S., Robinson, S., Peggs, K., Verfuerth, S. Pettengell R, Marsh, J. C., Schey, S. , Mahendra, P., Morgan, G. J., Hale, G., Waldmann, H., de Elvira, M. C., Williams, C. D., Devereaux, S., Linch, D. C., Goldstone, A. H., Mackinnon, S. In vivo CAMPATH-1H prevents graft-versus-host disease following non-myeloablative stem cell transplantation. Blood 2000;96(7):2419-2425. 13. Love, E. M., Williamson, L. M., Cohen, H., Jones, H., Todd, A., Soldan, K., Revill, J., Norfolk, D. R., Barbara, J., Atterbury, C., Asher, D. Serious Hazards of Transfusion (SHOT). Annual Report 1998/99. 2000;April. London, Royal College of Pathologists. 14. Millar, D. S., Kemball-Cook, G., McVey, J. H., Tuddenham, E. G., Mumford, A. D., Attock, G. B., Reverter, J. C., Lanir, N., Parapia, L. A., Reynaud, J., Meile, E., von Felton, A., Martinowitz, U., Prangnell, D. R., Krawczak, M., Cooper, D. N. Molecular analysis of the genotype-phenotype relationship in factor VII deficiency. Human Genetics 2000;107(4):327-342. 15. Norfolk, D. R. Ultraviolet and gamma-irradiated platelets. Eds. J.Seghatchian, E.L.Snyder and P.Krailadsiri. In: Platelet Therapy - current status and future trends. 2000;415-437. Amsterdam, Elsevier. 16. Norfolk, D. R and Seghatchian, J. Pharmacological therapies to minimise platelet transfusion. Transfusion Science 2000;22:149-153. 17. O'Connor, S. J., Su'ut, L., Morgan, G. J., Jack, A. S. The relationship between typical and atypical B-cell chronic lymphocytic leukemia. A comparative genomic hybridization-based study. American Journal of Clinical Pathology 2000;114(3):448-458. 18. Owen, R. G., Johnson, S. A., Morgan, G. J. Waldenstrom's macroglobulinaemia: laboratory diagnosis and treatment. Hematological Oncology 2000;18(2):41-49. 19. Owen, R. G., Parapia, L. A., Higginson, J., Misbah, S. A., Child, J. A., Morgan, G. J., Jack, A. S. Clinicopathological correlates of IgM paraproteinemias. Clinical Lymphoma 2000;1(1):39-43. 20. Rawstron, A. C., Fenton, J. A., Ashcroft, J., English, A., Jones, R. A., Richards, S. J. , Pratt, G., Owen, R., Davies, F. E., Child, J. A., Jack, A. S., Morgan, G. J. Interleukin 6 (IL-6) receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood 2000;96(12):3880-3886. 21. Richards, S. J., Morgan, G. J., Hillmen, P. Immunophenotypic analysis of B cells in PNH: insights into the generation of circulating naive and memory B cells. Blood 2000;96(10):3522-3528. 22. Richards, S. J., Rawstron, A. C., Hillmen, P. Application of flow cytometry to the diagnosis of paroxysmal nocturnal hemoglobinuria. Cytometry 2000;42(4):223-233. 42

LTHT Publications 2000 23. Roddam, P. L, Rollinson, S., Kane, E., Roman, E., Moorman, A., Cartwright, R., Morgan, G. J. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Pharmacogenetics 2000;10(7):605-615. 24. Rollinson, S., Roddam, P., Kane, E., Roman, E., Cartwright, R., Jack, A., Morgan, G. J. Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia. Carcinogenesis 2000;21(1):43-47. 25. Rowlands, T. E., Norfolk, D., Homer-Vanniasinkam, S. Chronic disseminated intravascular coagulopathy cured by abdominal aortic aneurysm repair. Cardiovascular Surgery 2000;8(4):292-294. 26. Simnett, S. J., Stewart, L. A., Sweetenham, J., Morgan, G., Johnson, P. W. Autologous stem cell transplantation for malignancy: a systematic review of the literature. Clinical and Laboratory Haematology 2000;22(2):61-72. 27. Tobal, K., Newton, J., Macheta, M., Chang, J., Morgenstern, G., Evans, P. A., Morgan, G., Lucas, G. S., Liu Yin, J. A. Molecular quantitation of minimal residual disease in acute myeloid leukaemia with t(8;21) can identify patients in durable remission and predict clinical relapse. Blood 2000;95(3):815-819. 28. Wechalekar, A. and Parapia, L. Hereditary haemorrhagic telangiectasia with protein S deficiency in a family: a case report. European Journal of Haematology 2000;64(1):59-60. Palliative Care 1. Alison, D. L. Chemotherapy and hormonal manipulation. K.H.Simpson. and K.Budd. Cancer Pain Management A Comprehensive Approach. 2000;(16):247-260. 2. Bennett, M., Adam, J., Alison, D., Hicks, F., Stockton, M. Leeds eligibility criteria for specialist palliative care services. Palliative Medicine 2000;14:157-158. 3. Franks, P. J and Kite, S. The level of need for palliative care: a systematic review of the literature. Palliative Medicine 2000;14(2):93-104. 4. Kiely, M. T and Alison, D. L. Palliative care activity in a medical oncology unit: the implications for oncology training. Clinical Oncology 2000;12:179-181. 5. Simpson, K. H and Lynch, L. Physiology and pharmacology of nausea and vomiting. Eds. Hemmings & Hopkins. In: Foundations of Anaesthesia. Basic & Clinical Sciences. 2000;623-631. Mosby-Wolfe. 6. Simpson, K. H and Russon, L. The use of intrathecal drug delivery systems in palliative care. CME Bulletin in Palliative Care 2000;2(1):17-21. 7. Simpson, K. H. Philosophy of cancer pain management. Eds. K.H.Simpson and K.Budd. In: Management of Cancer Pain. 2000; Oxford University Press. 8. Simpson, K. H. Cancer Pain Management, A Comprehensive Approach. Eds. K.H.Simpson and K.Budd. 2000; Oxford University Press. Renal & Liver Services 1. Asghar, R., Woodrow, G., Turney, J. H. A case of eosinophilic peritonitis treated with oral corticosteroids. Peritoneal Dialysis International 2000;20(5):579-580. 2. Ashmore, S. D., Jones, C. H., Newstead, C. G., Daly, M. J., Chrystyn, H. Ondansetron therapy for uremic pruritus in hemodialysis patients. American Journal of Kidney Diseases 2000;35(5):827-831. 43

LTHT Publications 2000 3. Kumar, A., Brownjohn, A. M., Turney, J. H. Congestive heart failure - can the nephrologist help? Journal of the Royal College of Physicians of London 2000;34(1):36-37. 4. Kumar, A and Turney, J. H. SLE, diabetes mellitus and emphysematous infections of the urinary tract. Lupus 2000;9:721-722. 5. Newstead, C. G. Cyclosporin-induced hypertension. Prescribers Journal 2000;40:165-168. 6. Newstead, C. G. Lymphoproliferative disease post-renal transplantation. Nephrology, Dialysis, Transplantation 2000;15:1913-1916. 7. Richardson, D., Bartlett, C., Will, E. J. Intervention thresholds and ceilings can determine the haemoglobin outcome distribution in a haemodialysis population. Nephrology, Dialysis, Transplantation 2000;15:2007-2013. 8. Schurmann, A., Mooney, A., Sanders, L., Sells, M. A., Wang, H. G., Reed, J. C., Bokoch, G. M. p-21 activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Molecular & Cellular Biology 2000;20:453-461. 9. Taylor, C. J., Newstead, C. G., Dyer, P. A. Unravelling the role of histocompatibility in liver transplantation. Transplantation 2000;69:1232-1233. 10. Than, N., Woodrow, G., Oldroyd, B., Gonzalez, C., Turney, J. H., Brownjohn, A. M. Effect of peritoneal fluid on whole body and segmental multiple frequency bioelectrical impedance in patients on peritoneal dialysis. European Journal of Clinical Nutrition 2000;54(5):450-451. 11. Than, N. and Turney, J. H. Continuous haemofiltration in acute renal failure. The Lancet 2000;356(9239):1441. 12. Turney, J H. Renal conservation for gas-forming infections. The Lancet 2000;355(9206):770-771. 13. Turney, J H. There's more inside the tablet. BMJ 2000;320(7250):1646. 14. Will, E. J. European guidelines for renal anaemia-predicting 85% compliance. Nephrology, Dialysis, Transplantation 2000;15:439-440. 15. Woodrow, G., Oldroyd, B., Stables, G., Gibson, J., Turney, J. H., Brownjohn, A. M. Effects of Icodextrin in automated peritoneal dialysis on blood pressure and bioelectrical impedance analysis. Nephrology, Dialysis, Transplantation 2000;15(6):862-866. 16. Wright, M. J., Woodrow, G., Young, G., Brownjohn, A. M., Turney, J. H. Biocompatible dialysis membranes do not reduce plasma leptin levels. Nephrology, Dialysis, Transplantation 2000;15(6):925-926. 17. Wright, M. J., Lindley, E. J., Swales, D., Brownjohn, A. M., Turney, J. H., Will, E. J., Woodrow, G. Consistent timing of the post-dialysis blood sample is necessary to prevent undertreatment in single needle dialysis. Nephrology, Dialysis, Transplantation 2000;15(4):554-555. Urology 1. Cartledge, J., Eardley, I., Morrison, J. F. Reply. British Journal of Urology 2000;86(6):757. 2. Cartledge, J., Lloyd, S. N., Joyce, A. D. The efficacy of different coupling media in the transmission of extracorporeal shockwaves. British Journal of Urology International 2000;857:54. 3. Cartledge, J., Eardley, I., Morrison, J. F. B. Aminoguanidine reverses the effects of diabetes on corpus cavernosal smooth muscle in vitro. British Journal of Urology International 2000;86:361. 44

LTHT Publications 2000 4. Cartledge, J., Eardley, I., Morrison, J. F. B. Advanced glycation end products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes. British Journal of Urology International 2000;88(55):41. 5. Cartledge, J., Eardley, I., Morrison, J. F. B. The effects of diabetes on corpus cavernosal smooth muscle invitro are reversed by Aminoguanidine. European Urology 2000;37 (52):42. 6. Cartledge, J. J., Eardley, I., Morrison, J. F. B. Impairment of corpus cavernosal smooth muscle relaxation by glycosylated human haemoglobin. British Journal of Urology 2000;85:735-741. 7. Cartledge, J. J., Minhas, S., Eardley, I., Morrison, J. F. Endothelial and neuronal-derived nitric oxide mediated relaxation of corpus cavernosal smooth muscle in a rat, in vitro, model of erectile function. International Journal of Impotence Research 2000;12(4):213-221. 8. Cartledge, J. J., Davies, A. M., Eardley, I. A randomised double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. British Journal of Urology 2000;85(4):421-426. 9. Curtis, S. P., Eardley, I., Boyce, M., Larson, P., Haesen, R., Gottesdiener, K., Gertz, B. J. Single dose methodology to assess the influence of an alpha1-adrenoceptor antagonist on uroflowmetric parameters in patients with benign prostatic hyperplasia. British Journal of Clinical Pharmacology 2000;49(3):269-273. 10. Eardley, I. and Kirby, R. S. Lower urinary tract obstruction. Ed. H.A.F.Dudley. In: Hamilton Bailey's Emergency Surgery. 2000;13th edition, Butterworths. 11. Joyce, A. D., Beerlage, H., Janetscheck, G. Urological laparoscopy for beginners. European Urology 2000;38(3):365-373. 12. Krane, R., Teloken, C., Eardley, I., Guiliano, F., Brock, G., Hutter, A. Oral therapy for erectile dysfunction. Eds. G.Wagner, S.Khoury, A.Jardin, F.Guiliano, and R.Rosen. In: Erectile Dysfunction. 1st International Consultation. 2000; Plymbridge. 13. Minhas, S., Cartledge, J., Eardley, I. The role of prostaglandins in penile erection. Prostaglandins Leukotrienes & Essential Fatty Acids 2000;62(3 ):137-146. 14. Minhas, S., Eardley, I., Joyce, A. D., Morrison, J. B. The effect of cyclic GMP on rabbit corporal smooth muscle tone and its modulation by cyclo-oxygenase products. Prostaglandins Leukotrienes & Essential Fatty Acids 2000;62(3):153-160. 15. Spencer, J. A., Tomlinson, A. J., Weston, M. J., Lloyd, S. N. Early report: comparisons of breath-hold MR excretory urography, Doppler ultrasound and isotope renography in evaluation of symptomatic hydronephrosis in pregnancy. Clinical Radiology 2000;55:446-453. 16. Thomas, D. F. M. Congenital diseases of the upper urinary tract. Eds. R.M.Weiss, N.J.R.George, and P.H.O'Reilly. In: Comprehensive Urology. 2000;185-201. London, Mosby. 17. Wilson, J. R., Weston, M. J., Singh, P., Eardley, I. Blue rubber bleb naevus syndrome: an unusual cause of urethral bleeding. British Journal of Dermatology 2000;143(3):677-678. 45

LTHT Publications 2000 Division of Laboratory, Radiology and Pharmacy Services Chemical Pathology 1. Barth, J. H. Should men still go bald gracefully? The Lancet 2000;355(9199):161-162. 2. Barth, J. H., Jones, R. G., Payne, R. B. Calculation of renal tubular reabsorption of phosphate: the algorithm performs better than the nomogram. Annals of Clinical Biochemistry 2000;37(Pt 1):79-81. 3. Carrigan, T. D., Field, H., Illingworth, R. N., Gaffney, P., Hamer, D. W. Toxicological screening in trauma. Journal of Accident & Emergency Medicine 2000;17(1):33-37. 4. Payne, R. B. Creatinine clearance and glomerular filtration rate. Annals of Clinical Biochemistry 2000;37(Pt 1):98-99. Clinical Genetics 1. Amor, D. J and Woods, C. G. Pseudotrisomy 13 syndrome in siblings. Clinical Dysmorphology 2000;9(2):115-118. 2. Crow, Y. J., Jackson, A. P., Roberts, E., van, BeusekomE, Barth, P., Corry, P., Ferrie, C. D., Hamel, B. C., Jayatunga, R., Karbani, G., Kalmanchey, R., Kelemen, A., King, M., Kumar, R., Livingstone, J., Massey, R., McWilliam, R., Meager, A., Rittey, C., Stephenson, J. B., Tolmie, J. L., Verrips, A., Voit, T., van, BokhovenH, Brunner, H. G., Woods, C. G. Aicardi-Goutieres syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21. American Journal of Human Genetics 2000;67(1):213-221. 3. Deeble, V. J., Roberts, E., Jackson, A., Lench, N., Karbani, G., Woods, C. G. The continuing failure to recognise Alstrom syndrome and further evidence of genetic homogeneity. Journal of Medical Genetics 2000;37(3):219. 4. Ellis, L. A., Taylor, G. R., Mueller, R. F. Rapid, reliable screening for connexin 26 mutations in nonsyndromic sensorineural hearing loss. Journal of Medical Genetics 2000;37(Suppl 1):646. 5. Ellis, L. A., Taylor, C. F., Taylor, G. R. A comparison of fluorescent SSCP and denaturing HPLC for high throughput mutation scanning. Human Mutation 2000;15(6):556-564. 6. Gardiner, C. A., Sharma, V., Rutherford, A. J., Balen, A. H., Flintoff, K. J., Taylor, G. R., Chu, C. E. Family history and molecular genetic investigations in men with oligospermia referred for intracytoplasmic sperm injection (ICSI). Journal of Medical Genetics 2000;37(Suppl 1):37. 7. Gardiner, C. A and Woods, C. G. High myopia, and mild mental retardation in three brothers. Clinical Dysmorphology 2000;9(1):43-46. 8. Hampson, K., Woods, C. G., Latif, F., Webb, T. Mutations in the MECP2 gene in a cohort of girls with Rett syndrome. Journal of Medical Genetics 2000;37(8):610-612. 9. Hanby, A. M., Kelsell, D. P., Potts, H. W., Gillett, C., Bishop, T., Barnes, D. M. The morphological attributes of sporadic breast cancer with LOH of the BRCA1 and BRCA2 loci: confounding observations and similarities to familial cases. International Journal of Cancer 2000;88(2):204-208. 10. Hodge, D., Misbah, S. A., Mueller, R. F., Glass, E. J. Proteus syndrome and immunodeficiency. Archives of Disease in Childhood 2000;82:234-250. 11. Hutchin, T. P., Parker, M. J., Young, I. D., Davis, A. C., Pulleyn, L. J., Deeble, J., Lench, N. J., Markham, A. F., Mueller, R. F. A novel mutation in the mitochondrial tRNASer(UCN) gene in a family with nonsyndromic sensorineural hearing impairment. Journal of Medical Genetics 2000; 37(Online):692-694. 46

LTHT Publications 2000 12. Mazoyer, S., Robinson, M., Taylor, G. R., Bishop, T., et al. The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations. American Journal of Human Genetics 2000;67(1):207-212. 13. McHale, D. P., Jackson, A. P., Campbell, D. A., Levene, M. I., Corry, P., Woods, C. G., Lench, N. J., Mueller, R. F., Markham, A. F. A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. European Journal of Human Genetics 2000;8(4):267-272. 14. Moynihan, L., Jackson, A. P., Roberts, E., Karbani, G. , Lewis, I., Corry, P., Turner, G., Mueller, R. F., Lench, N. J., Woods, C. G. A third novel locus for primary autosomal recessive microcephaly maps to chromosome 9q34. American Journal of Human Genetics 2000;66(2):724-727. 15. Mueller, R. F. and Lench, N. J. Mapping of the DFNB1 locus. Advances in Oto-Rhino-Laryngology 2000;56:116-123. 16. Parker, M. J., Fortnum, H. M., Young, I. D., Davis, A. C., Mueller, R. F. Population-based genetic study of childhood hearing impairment in the Trent Region of the United Kingdom. Audiology 2000;39(4):226-231. 17. Pattison, L., Crow, Y. J., Deeble, V. J., Jackson, A. P., Jafri, H., Rashid, Y., Roberts, E., Woods, C. G. A fifth locus for primary autosomal recessive microcephaly maps to chromosome 1q31. American Journal of Human Genetics 2000;67(6):1578-1580. 18. Reardon, W. and Mueller, R. F. Inherited deafness in childhood - the genetic revolution unmasks the clinical challenge. Archives of Disease in Childhood 2000;82:319-321. 19. Robinson, M. D., Chu, C. E., Turner, G., Bishop, D. T., Taylor, G. R. Exon deletions and duplications in BRCA1 detected by semiquantitative PCR. Genetic Testing 2000;4(1):49-54. 20. Rutherford, J., Chu, C. E., Charlton, R. S., Chumas, P., Taylor, G. R., Barnes, D., Camplejohn, R. A novel germline 7 base pair insertion in p53; a functional study of the resulting truncated protein. British Journal of Cancer 2000;83(Suppl 1):210. 21. Whatley, S. D., Roberts, A. G., Llewellyn, D. H., Bennett, C. P., Garrett, C., Elder, G. H. Non-erythroid form of acute intermittent porphyria caused by promoter and frameshift mutations distant from coding sequence of exon 1 of the HMBS gene. Human Genetics 2000;107:243-248. Cytogenetics 1. Diggle, C. P., Pitt, E., Roberts, P., Trejdosiewicz, L. K., Southgate, J. N-3 and N-6 polyunsaturated fatty acids induce cytostasis in human urothelia independent of p53 gene function. Journal of Lipid Research 2000; 41(9):1509-1515. Histopathology 1. Achuthan, R., Bell, S. M., Leek, J. P., Roberts, P., Horgan, K., Markham, A. F., Selby, P. J., MacLennan, K. A. Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma. Genes, Chromosomes & Cancer, 2000;29(4):347-349. 2. Adams, J., Carder, P. J., Downey, S., Forbes, M. A., MacLennan, K., Allgar, V., Kaufman, S., Hallam, S., Bicknell, R., Walker, J. J., Cairnduff, F., Selby, P. J., Perren, T. J., Lansdown, M., Banks, R. E. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of Tamoxifen. Cancer Research 2000;60(11):2898-2905. 3. Bani-Hani, K., Martin, I. G., Hardie, L. J., Mapstone, N., Briggs, J. A., Forman, D., Wild, C. P. Prospective study of cyclin D1 overexpression in Barrett's esophagus: association with increased risk of adenocarcinoma. Journal of the National Cancer Institute 2000;92(16):1316-1321. 47

LTHT Publications 2000 4. Bardhan, K. D., Dillon, J., Axon, A. T. R., Cooper, B. T., Tildesley, G., Wyatt, J. I., Gatz, G., Braun, W. Triple therapy for Helicobacter pylori eradication: a comparison of Pantoprazole once versus twice daily. Alimentary Pharmacology & Therapeutics 2000;14:59-67. 5. Buckley, J. G. and MacLennan, K. Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution. Head & Neck 2000;22(4):380-385. 6. Buckley, J. G. and MacLennan, K. Cancer spread in the larynx: a pathologic basis for conservation surgery. Head & Neck 2000; 22(3):265-274. 7. Cameron, D. A., Keen, J. C., Dixon, J. M., Bellamy, C., Hanby, A., Anderson, T. J., Miller, W. R. Effective Tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes. European Journal of Cancer 2000;36:845-851. 8. Dublin, E., Hanby, A., Patel, N. K., Liebman, R., Barnes, D. Immunohistochemical expression of uPA, uPAR, and PAI-1 in breast carcinoma. American Journal of Pathology 2000;157:1219-1227. 9. Duddy, P., Hanby, A., Barnes, D., Camplejohn, R. The Fasay: an effective method of identifying tumours that harbour p53 mutations. Journal of Molecular Diagnostics 2000;2(y2000):139-144. 10. Economopoulou, P., Hanby, A., Odell, E. W. Expression of E-cadherin, cellular differentiation and polarity in epithelial salvary neoplasms. Oral Oncology 2000;36:515-518. 11. Ghose, S. I., Squire, B. R., Stringer, M. D., Batcup, G., Crabbe, D. C. G. Hirschsprung's disease: problems of the transition-zone pull-through. Journal of Paediatric Surgery 2000;35(12):1805-1809. 12. Gillett, C. E., Springall, R. J., Barnes, D. M., Hanby, A. M. Multiple tissue core arrays in histopathology research: a validation study. Journal of Pathology 2000;192:549-553. 13. Given, H. F., Radbourne, R., Oag, H., Merritt, S., Barclay, E., Hanby, A. M., Lamlum, H., McGrath, J., Curran, C., Tomlinson, I. The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of age of presentation in breast cancer. European Journal of Cancer 2000;36:533-534. 14. Grobholtz, R., Verbeke, C. V., Schleger, C., Koehrmann, K. U., Hein, B. Expression of mage-antigens and analysis of the inflammatory T-cell infiltrate in human seminoma. Urological Research 2000;28:398-403. 15. Hamilton, A., Larsimont, D., Paridaens, R., Drijkoningen, M., van de Vijver, M., Bruning, P., Hanby, A., Houston, S., Treilleux, I., Guastalla, J-P., Van Vreckem, A., Sylvester, R., Piccart, M. A study of the value of p53, c-erbB2 and Bcl-2 in the prediction of response to Doxorubicin and Paclitaxel as single agents in metastatic breast cancer; a companion study to EORTC 10923. Translational Medicine 2000;3:233-240. 16. Hanby, A. M., Kelsell, D. P., Potts, H. W., Gillett, C., Bishop, D.T., Spurr,N.K., Barnes, D. M. The morphological attributes of sporadic breast cancer with LOH of the BRCA1 and BRCA2 loci: confounding observations and similarities to familial cases. International Journal of Cancer 2000;88(2):204-208. 17. Hanck, C., Verbeke, C., Storm, L., Junghanss, T., Singer, M. V. Intestinale bilharzione. Zeitschrift fuer Gastroenterologie 2000;38:799-802. 18. Hardie, L. J., Briggs, J. A., Davidson, L. A., Allan, J. M., King, R. F., Williams, G. I., Wild, C. P. The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer. Carcinogenesis 2000;21(2):167-172. 19. Harnden, P. and Southgate, J. Revised classification of urothelial neoplasms. American Journal of Surgical Pathology 2000;24:160-161. 20. Hayden, J. D., Cawkwell, L., Dixon, M. F., Pardal, F., Murgatroyd, H., Gray, S., Quirke, P., Martin, I. G. A comparison of microsatellite instability in early onset gastric carcinomas from relatively low and high incidence European populations. International Journal of Cancer 2000;85(2):189-191. 48

LTHT Publications 2000 21. Helliwell, T. R., Appleton, R. E., Mapstone, N., Davidson, J., Walsh, K. P. Dermatomyositis and Whipple's disease. Neuromuscular Disorders 2000;10(1):46-51. 22. Hull, M. A., Fenwick, S. W., Chapple, K. S., Scott, N. , Toogood, G. J., Lodge, J. P. Cyclo oxygenase-2 expression in colorectal cancer liver metastases. Clinical & Experimental Metastasis 2000;18:21-27. 23. Jennings, J. S., Wyatt, J. I., Howdle, P. D. A new cause of "non-responsiveness" in coeliac disease? Postgraduate Medical Journal 2000;76(894):227-229. 24. Konig, P., Ambrose, N. S., Scott, N. Hereditary internal anal sphincter myopathy causing proctalgia fugax and constipation: further clinical and histological characterization in a patient. European Journal of Gastroenterology & Hepatology 2000;12(1):127-128. 25. Lamlum, H., Papadopoulou, A., Llyas, M, Rowan, A, Gillett, C., Hanby, A., Talbot, I., Bodmer, W., Tomlinson, I. APC mutations are sufficient for the growth of early colorectal adenomas. PNAS 2000;97(5):2225-2228. 26. Leong, A. C. K., Hanby, A. M., Potts, H. W. W., Tan, T. S. P., Skilton, D., Ryder, K., Harris, W. H. Cell- cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast. International Journal of Cancer 2000;89 :26-31. 27. Linch, D., Smith, P., Hancock, B., Hoskin, P., Cunningham, D., Newland, A., Milligan, D., Stevenson, P., Wood, J., MacLennan, K. A., Vaughan Hudson, B., Vaughan Hudson, G., Gregory, W. A randomised British National Lymphoma Investigation trial of CHOP vs a weekly multi-agent regimen (PACEBOM) in patients with histologically aggressive non-Hodgkin's lymphoma. Annals of Oncology 2000;11:87-90. 28. Lones, M., Raphael, M., McCarthy, K., Perkins, S., Terrier-Lacombe, M-J., MacLennan, K., Ramsay, A., Wotherspoon, A., Bayle, C., Cairo, M., Gerrard, M., Patte, C., Auperin, A. Mature B-cell lymphoma/leukemia in children and adolescents: Intergroup pathologist concensus with the revised European-American lymphoma classification. Annals of Oncology 2000;11:47-51. 29. MacLennan, K. A. Lymph nodes, thymus and spleen. In: U.JCE. General and Systematic Pathology. 2000;3rd edition:589-611. Churchill Livingstone. 30. Mapstone, N. P. Pathology of oesophageal and gastric tumours. Surgery 2000;18(1):iii-vi. 31. Misbah, S. A and Mapstone, N. P. Whipple's disease revisited. Journal of Clinical Pathology 2000;53(10):750-755. 32. Niedergethmann, M., Verbeke, C., Wolf, G., Verbeke, C. V., Richter, A. Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection. International Journal of Pancreatology 2000;28(1):33-41. 33. Pera, M., Brito, M. J., Poulsom, R., Riera, E., Hanby, A., Wright, N. A. Duodenal-content reflux esophagitis induces the development of glandular metaplasia and adenosquamous carcinoma in rats. Carcinogenesis 2000;21:1587-1591. 34. Protheroe, A. S., Pickard, C., Johnson, P. W., Craddock, T., Shefta, J., Short, K., Lancaster, F., Selby, P. J., Henwood, J., Boylston, A. W. Persistence of clonal T-cell expansions following high-dose chemotherapy and autologous peripheral blood progenitor cell rescue. British Journal of Haematology 2000;111(3):766-773. 35. Rowan, A, Churchman, M., Jeffrey, R., Hanby, A., Poulsom, R., Tomlinson, I. In situ analysis of LKB1/stk11 mRNA expression in human normal tissues and tumours. Journal of Pathology 2000;192(2):203-206. 36. Sawyer, E., Hanby, A. M., Lakhani, S., Ellis, I., Boyle, S., Ellis, P., Tomlinson, I. Molecular analysis of phyllodes tumours reveals distinct changes in the epithelial and stromal components. American Journal of Pathology 2000;156:1093-1098. 49

LTHT Publications 2000 37. Schleger, C., Arens, N., Zentgraf, H., Bleyl, U., Verbeke, C. Identification of frequent chromosomal aberrations in ductal adenocarcinoma of the pancreas by comparative genomic hybridization (CGH). Journal of Pathology 2000;191(1):27-32. 38. Scott, N. Pathology of gastritis and gastro-oesophageal reflux disease. Eds. Heatley & Moncur. In: Dyspepsia. 2000;(4):47-59. 39. Stead, M. L., Brown, J. M., Bosanquet, N., Franks, P. J., Guillou, P. J., Quirke, P., Jayne, D., Monson, J. R., Webb, A. V. Assessing the relative costs of standard open surgery and laparoscopic surgery in colorectal cancer in a randomised controlled trial in the United Kingdom. Critical Reviews in Oncology-Hematology 2000;33(2):99-103. 40. Verbeke, C., Wenthe, U., Bergler, W. F., Zentgraf, H. Charaterisation of the expanded T-cell population in infection mononucleosis: apoptosis, expression of apoptosis-related genes, and Epstein-Barr virus (EBV) status. Clinical & Experimental Immunology 2000;120(2):294-300. 41. Ward, J., Guthrie, J. A., Scott, J., Atchley, J., Wilson, D., Davies, M. H., Wyatt, J. I., Robinson, P. J. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology 2000;216(1):154-162. 42. Ward, J., Chen, F., Guthrie, J. A., Wilson, D., Lodge, J. P., Wyatt, J. I., Robinson, P. J. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 2000;214(1):159-166. Immunology 1. Degg, T. J., Allen, K. R., Barth, J. H. Measurement of plasma 5-hydroxyindoleacetic acid in carcinoid disease: an alternative to 24-h urine collections? Annals of Clinical Biochemistry 2000;37(Pt 5):724-726. 2. Hodge, D., Misbah, S. A., Mueller, R. F., Glass, E. J. Proteus syndrome and immunodeficiency. Archives of Disease in Childhood 2000;82:234-250. 3. Marshall, S. M. and Barth, J. H. Standardisation of HBA1c measurements - a consensus statement. Annals of Clinical Biochemistry 2000;37:45-56. 4. McKibbin, M., Clark, B., Lee, H., Isaacs, J. D., Gooi, H. C., Morrell, A. J. No strong association between alleles of tumour necrosis factor alpha and interleukin-1 receptor antagonist and corneal melting associated with systemic vasculitis. British Journal of Ophthalmology 2000;84(4):395-398. 5. Morgan, A. W., Griffiths, B., Ponchel, F., Montague, B. M., Ali, M., Gardener, P. P., Gooi, H. C., Situnayake, R. D., Markham, A. F., Emery, P., Isaacs, J. D. Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. Arthritis & Rheumatism 2000;43(10):2328-2334. 6. Owen, R. G., Parapia, L. A., Higginson, J., Misbah, S. A., Child, J. A., Morgan, G. J., Jack, A. S. Clinicopathological correlates of IgM paraproteinemias. Clinical Lymphoma 2000;1(1):39-43. 7. Protheroe, A. S., Pickard, C., Johnson, P. W., Craddock, T., Shefta, J., Short, K., Lancaster, F., Selby, P. J., Henwood, J., Boylston, A. W. Persistence of clonal T-cell expansions following high-dose chemotherapy and autologous peripheral blood progenitor cell rescue. British Journal of Haematology 2000;111(3):766-773. 8. Stratford, G. A., Barth, J. H., Rutherford, A. J., Balen, A. H. Value of thyroid function tests in routine screening of women investigated in fertility. Human Fertility 2000;3:203-206. 50

LTHT Publications 2000 Medical Physics 1. Ash, D., Flynn, A., Battermann, J., de Reijke, T., Lavagnini, P., Blank, L. ESTRO/EAU/EORTC recommendations fon permanent seed implantation for localized prostate cancer. Radiotherapy and Oncology 2000;57(3):315-321. 2. Berry, E., Kelly, S., Hutton, J., Lindsay, H. S., Blaxill, J. M., Evans, J. A., Connelly, J., Tisch, J., Walker, G. C., Sivananthan, U. M., Smith, M. A. Intravascular ultrasound-guided interventions in coronary artery disease: a systematic literature review, with decision-analytic modelling, of outcomes and cost- effectiveness. Health Technology Assessment (South Hampton, NY), 2000;4:1-117. 3. Berry, E., Kelly, S., Hutton, J., Harris, K. M., Smith, M. A. Identifying studies for systematic reviews. An example from medical imaging. International Journal of Technology Assessment in Health Care 2000;Spring;16(2):668-672. 4. Brettle, D. S. Health informatics and computing: The future. Eds. P.F.Sharp and A.C.Perkins. In: Physics and Engineering in Medicine in the New Millenium. 2000;(6.1):47-48. 5. Brown, S. B., Gannon, M. J., Holroyd, J. A., Johnson, N., Stringer, M., Vernon, D. I. The use of ALA-PDT for endometrial ablation in the treatment of menorrhagia. Eds. P.Wyss, B.J.Tadir and U.Haller. In: Photomedicine in Gynecology and Reproduction. 2000;219-226. Basel, Karger. 6. Chapple, K. S., Spencer, J. A., Windsor, A. C., Wilson, D., Ward, J., Ambrose, N. S. Prognostic value of magnetic resonance imaging in the management of fistula-in-ano. Diseases of the Colon & Rectum 2000;43(4):511-516. 7. Conway, S. P., Morton, A. M., Oldroyd, B., Truscott, J. G., White, H., Smith, A. H., Haigh, I. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 2000;55(9):798-804. 8. Flynn, A and Weston, S. J. Brachytherapy physics considerations. Eds. C.Greco and M.J.Zelefsky. In: Radiotherapy of Prostate Cancer 2000;1(19):261-266. Amsterdam, Harwood Academic Publishers. 9. Gonzalez, C. H., Oldroyd, B., Evans, J. A., Smye, S. W., Holland, P. Standardized limb abduction for bioimpedance measurements using position restraints. Physiological Measurement 2000;21(2):263-270. 10. Graves, M. J., Berry, E., Avedisijan, A., Westhead, M., Black, R. T., Beacock, D. J., Kelly, S., Niemi, P. A multicenter validation of an active contour-based left ventricular analysis technique. Journal of Magnetic Resonance Imaging 2000;12:232-239. 11. Kiltie, A. E., Povall, J. M., Taylor, R. E. The need for the moving junction in craniospinal irradiation. British Journal of Radiology 2000;73(870):650-654. 12. Lindley, E. J., Lopot, F., Harrington, M., Elseviers, M. M., for the EDTNA/ERCA Collaborative Research Programme. Treatment of water for dialysis European survey. EDTNA ERCA Journal 2000;26( 4):34-40. 13. Marks, P. V., Belchetz, P. E., Saxena, A., Igbaseimokumo, U., Thomson, S., Nelson, M., Stringer, M. R., Holroyd, J. A., Brown, S. B. Effect of photodynamic therapy on recurrent pituitary adenomas: clinical phase I/II trial - an early report. British Journal of Neurosurgery 2000;14(4):317-325. 14. Moghissi, K., Dixon, K., Thorpe, J. A., Stringer, M., Moore, P. J. The role of photodynamic therapy in inoperable oesophageal cancer. European Journal of Cardio-Thoracic Surgery 2000;17(2):95-100. 15. Morgan, A. M., Aird, E. G. A., Aukett, R. J., Duane, S., Jenkins, N. H., Mayles, W. P. M., Moretti, C., Thwaites, D. I. IPEM guidelines on dosimeter systems for use as transfer instruments between the UK primary dosimetry standards laboratory (NPL) and radiotherapy centres. Physics in Medicine & Biology 2000;45:2445-2457. 51

LTHT Publications 2000 16. Nevett, G., Nagel, C., Elseviers, M. M., Lindley, E. J., for the EDTNA/ERCA Collaborative Research Programme . Provision of dietary advice in selected centres across Europe. EDTNA ERCA Journal 2000;26(4):22-27. 17. O'Riordan, E., Craven, C. M., Wilson, D., Robinson, P. J. Dual phase hepatic CT: influence of scanning direction on liver attenuation. AJR.American Journal of Roentgenology 2000;174(5):1417-1421. 18. Scott, J., Ward, J., Guthrie, J. A., Wilson, D., Robinson, P. J. MRI of liver: a comparison of CNR enhancement using high dose and low dose Ferumoxide infusion in patients with colorectal liver metastases. Magnetic Resonance Imaging 2000;18(3):297-303. 19. Simpson, S. The role of the vascular radiographer. Synergy 2000;12-6(3) 20. Stewart, S. P., Searle, P., Westmacott, C. F., Hay, A. W. M., Smith, A. H. Long term in vivo precision of lumbar spine DXA scans uring a lunar PDX-L absorptiometer. Osteoporosis International 2000;11 (Suppl 1):44. 21. Stringer, M. R. The physical parameters of photodynamic therapy. Eds. P.F.Sharp and A.C.Perkins. In: Physics and Engineering in Medicine in the New Millenium. 2000;68-75. Institute of Physics and Enginnering in Medicine. 22. Stubbs, B. Planning a radiotherapy centre. British Journal of Radiology 2000;73:1135-1137. 23. Tanner, S. F., Ramenghi, L. A., Ridgway, J. P., Berry, E., Saysell, M. A., Martinez, D., Arthur, R. J., Smith, M. A., Levene, M. I. Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants. American Journal of Roentgenology 2000;174 (6):1643-1649. 24. Tuohy, J., et al. The provision and replacement of radiotherapy equipment [report]. Royal College of Radiologists, London 2000. 25. Turton, E. P., Scott, D. J., Delbridge, M., Snowden, S., Kester, R. C. Ruptured abdominal aortic aneurysm: a novel method of outcome prediction using neural network technology. European Journal of Vascular & Endovascular Surgery 2000;19(2):184-189. 26. Van Waeleghem, J. P., Elseviers, M. M., Lindley, E. J., for the EDTNA/ERCA Collaborative Research Programme. Management of the vascular access in Europe. Part 1 - A study of centre based policies. EDTNA ERCA Journal 2000;26(4):28-33. 27. Ward, J., Guthrie, J. A., Scott, J., Atchley, J., Wilson, D., Davies, M. H., Wyatt, J. I., Robinson, P. J. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology 2000;216(1):154-162. 28. Ward, J., Chen, F., Guthrie, J. A., Wilson, D., Lodge, J. P., Wyatt, J. I., Robinson, P. J. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 2000;214(1):159-166. 29. Weston, S. J and MacDougall, N. D. Isocentric treatment of inclined volumes planned using coronal sections. Physics in Medicine & Biology 2000;45(5):N37-N41. 30. Wright, M. J., Lindley, E. J., Swales, D., Brownjohn, A. M., Turney, J. H., Will, E. J., Woodrow, G. Consistent timing of the post-dialysis blood sample is necessary to prevent undertreatment in single needle dialysis. Nephrology, Dialysis, Transplantation 2000;15(4):554-555. 52

LTHT Publications 2000 Microbiology 1. Ala'Aldeen, D. A., Neal, N. R., Ait-Tahar, K., Nguyen-Van-Tam, J. S., English, A., Falla, T. J., Hawkey, P. M., Slack, R. C. Dynamics of meningococcal long-term carriage among university students and their implications for mass vaccination. Journal of Clinical Microbiology 2000;38:2311-2316. 2. Ashbee, H. R and Evans, E. G. V. Fungi and skin. Microbiology Today 2000;27:132-134. 3. Beggs, C. B., Kerr, K. G., Donnelly, J. K., Sleigh, P. A., Mara, D. D., Cairns, G. The resurgence of tuberculosis in the tropics. An engineering approach to the control of mycobacterium tuberculosis and other airborne pathogens: a UK hospital based pilot study. Transactions of the Royal Society of Tropical Medicine & Hygiene 2000;94(2):141-146. 4. Chanawong, A., M'Zali, F. H., Heritage, J., Lulitanond, A., Hawkey, P. M. Characterisation of extended- spectrum beta-lactamases of the SHV family using a combination of PCR-single strand conformational polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (PCR-RFLP). FEMS Microbiology Letters 2000;184(1):85-89. 5. Dade, J., Wilcox, M. H., Kay, E. Hazards of multiple use of pharmaceutical solutions. The Lancet 2000;356:1684-1685. 6. Denton, M., Hall.M.J., Todd, N. J., Kerr, K. G., Littlewood, J. M. Improved isolation of stenotrophomonas maltophilia from the sputa of patients with cystic fibrosis using a selective medium. Clinical Microbiology and Infection 2000;6(7):397-398. 7. Denton, M., Mooney, L., Kerr, K. G. Faucet aerators: a source of patient colonization with stenotrophomonas maltophilia. American Journal of Infection Control 2000;28(4):323-324. 8. Duggan, P. S., Parker, S. D., Phillips-Jones, M. K. Characterisation of a Rrhodobacter sphaeroides gene that encodes a product resembling Eescherichia coli cytochrome b(561) and R. sphaeroides cytochrome b(562). FEMS Microbiology Letters 2000;189(2):239-246. 9. Eady, E. A., Coates, P., Ross, J. I., Ratyal, A. H., Cove, J. H. Antibiotic resistance patterns of aerobic coryneforms and furazolidone-resistant Gram-positive cocci from the skin surface of the human axilla and fourth toe cleft. Journal of Antimicrobial Chemotherapy 2000;46(2):205-213. 10. Ellis, D., Marriott, D., Hajjeh.R.A., Warnock, D. W., Meyer, W., Barton, R. C. Epidemiology: surveillance of fungal infections. Medical Mycology 2000;38(Suppl 1):33-40. 11. Evans, E. G. V., Bulmer, G. S., Aly, R., Coo-Barcelona, L., Chakrabarti, A., Elias-Costa, M. R. I. de., Gugnani, H. C. Training medical mycologists in developing countries. Medical Mycology 2000;38(Suppl 1):33-40. 12. Evans, E. G. V and Ashbee, H. R. New antifungal agents. Ed. M.H.Wilcox. In: Fast Facts: Infection Highlights 1999-2000. 2000;73-80. Oxford, Health Press. 13. Goodfield, M. J. D. and Evans, E. G. V. Combined treatment with surgery and short duration oral antifungal therapy in patients with limited dermatophyte toe-nail infection. Journal of Dermatological Treatment 2000;11:259-262. 14. Hafeez, I., Muers, M. F., Murphy, S. A., Evans, E. G., Barton, R. C., McWhinney, P. Non-tuberculous mycobacterial lung infection complicated by chronic necrotising pulmonary aspergillosis. Thorax 2000;55(8):717-719. 15. Hawkey, P. M. Mechanisms of resistance to antibiotics. Intensive Care Medicine 2000;26 (Suppl 1):S9-13. 16. Hawkey, P. M. Tropical and exotic infections: antibiotic resistence in the tropics. Journal of Medical Microbiology 2000;49:5-27. 53

LTHT Publications 2000 17. Hoy, C. M., Wood, C. M., Hawkey, P. M., Puntis, J. W. L. Duodenal microflora in very-low-birth-weight neonates and relation to nectrotizing enterocolitis. Journal of Clinical Microbiology 2000;68:4539-4547. 18. Ingham, E. and Fisher, J. Biological reactions to wear debris in total joint replacement. Proceedings of the Institution of Mechanical Engineers.Part H - Journal of Engineering in Medicine 2000;214(1):21-37. 19. Jackson, C. J., Barton, R. C., Kelly, S. L., Evans, E. G. V. Strain identification of Trichophyton rubrum by specific amplification of subrepeat elements in the ribosomal-DNA non-transcribed spacer (NTS). Journal of Clinical Microbiology 2000;38:4527-4534. 20. Kerr, K. G., Beggs, C. B., Sleigh, P. A., Cairns, G., Donnelly, J. K. Transmission of tuberculosis. Journal of Hospital Infection 2000;46(1):77-78. 21. Kite, P. and Wilcox, M. H. The diagnosis of central venous catheter-related blood stream infection. Current Medical Literature Clinical Nutrition 2000;9:57-61. 22. Landers, P., Kerr, K. G., Rowbotham, T. J., Tipper, J. L., Keig, P. M., Ingham, E., Denton, M. Survival and growth of burkholderia cepacia within the free-living amoeba acanthamoeba polyphaga. European Journal of Clinical Microbiology & Infectious Diseases 2000;19(2):121-123. 23. Longshaw, C. M., Farrell, A. M., Wright, J. D., Holland, K. T. Identification of a second lipase gene, gehD, in Staphylococcus epidermidis: comparison of sequence with those of other staphylococcal lipases. Microbiology 2000;146 (Pt 6):1419-1427. 24. M'Zali, F. H., Chanawong, A., Kerr, K. G., Birkenhead, D., Hawkey, P. M. Detection of extended-spectrum beta-lactamases in members of the family enterobacteriaceae: comparison of the MAST DD test, the double disc and the Etest ESBL. Journal of Antimicrobial Chemotherapy 2000;45(6):881-885. 25. Mohr O'Hara, C., Brenner, F. W., Steigerwalt, A. G., Hill, B. C., Holmes, B., Grimont, P. A. D., Hawkey, P. M., Penner, J. L., Miller, J. M., Brenner, D. J. Classification of Proteus vulgaris biogroup 3 with recognition of Proteus hauseri sp.nov., nom. Rev and unnamed Proteus genomospecies 4,5 and 6. International Journal of Systematic and Evolutionary Microbiology 2000;50:1869-1875. 26. Phillips-Jones, M. K. Use of a lux reporter system for monitoring rapid changes in alpha-toxin gene expression in Clostridium perfringens during growth. FEMS Microbiology Letters 2000;188(1):29-33. 27. Ravenscroft, J., Goodfield, M. J. D., Evans, E. G. V. Trichophyton tonsurans tinea capitis and tinea corporis: treatment and follow-up of four affected family members. Paediatric Dermatology 2000;17:407-409. 28. Sleigh, P. A., Beggs, C. B., Donnelly, J. K., Kerr, K. G. The use of engineering controls to disinfect mycobacterium tuberculosis and other airborne pathogens in hospital buildings. Indoor and Built Environment 2000;9(1):17-27. 29. Walker, P. P., Reynolds, M. T., Ashbee, H. R., Brown, C., Evans, E. G. V. Vaginal yeasts in the era of "over-the counter" antifungals. Sexually Transmitted Infections 2000;76:437-438. 30. Wilcox, M. H., Fitzgerald, P., Freeman, J., Denton, M. , Gill, A. B., Hoy, C., Parnell, P., Porter, C., Haspinall, L., Hawkey, P. A five year outbreak of methicillin-susceptible Staphylococcus aureus phage type 53,85 in a regional neonatal unit. Epidemiology & Infection 2000;124(1):37-45. 31. Wilcox, M. H. Infective antibiotic associated diarrhoea. Ed. M.H.Wilcox. In: Infection Highlights 1999. 2000; Oxford, Health Press. 32. Wilcox, M. H., Fawley, W. N., Parnell, P. Value of lysozyme agar incorporation and alkaline thioglycollate exposure for the environmental recovery of Clostridium difficile. Journal of Hospital Infection 2000;44(1):65-69. 54

LTHT Publications 2000 33. Wilcox, M. H., Reynolds, M. T., Hoy, C. M., Brayson, J. Combined cervical swab and urine specimens for PCR diagnosis of genital Chlamydia trachomatis infection. Sexually Transmitted Infections 2000;76(3):177-178. 34. Wilcox, M. H and Dave, J. The cost of hospital-acquired infection and the value of infection control. Journal of Hospital Infection 2000;45(2):81-84. 35. Wilcox, M. H. Infection Highlights 1999. Ed. M.H.Wilcox. 2000; Oxford, Health Press. 36. Wilcox, M. H and Fawley, W. N. Hospital disinfectants and spore formation by Clostridium difficile. The Lancet 2000;356:1324. 37. Wilcox, M. H. Respiratory antibiotic use and Clostridium difficile infection - is it the drugs or is it the doctors. Thorax 2000;55:633-634. 38. Wilcox, M. H and Modi, N. Management of meningococcal sepsis and risk of infection in healthcare workers. eBMJ 2000;http://www.bmj.com/cgi/eletters/319/7218/1147#EL4. 39. Wilcox, M. H., Fawley, W. N., Freeman, J., Stead, J. In vitro activity of new generation fluoroquinolones against genotypically distinct and indistinguishable Clostridium difficile isolates. Journal of Antimicrobial Chemotherapy 2000;46:551-555. 40. Wilcox, M. H. and Modi, N. Meningococcal disease in healthcare workers. BMJ 2000;320:247. Pharmacy 1. Ashmore, S. D., Jones, C. H., Newstead, C. G., Daly, M. J., Chrystyn, H. Ondansetron therapy for uremic pruritus in hemodialysis patients. American Journal of Kidney Diseases 2000;35(5):827-831. 2. Cameron, I., Curran, S., Newton, P., Petty, D., Wattis, J. Use of Donepezil for the treatment of mild- moderate Alzheimer's disease: an audit of the assessment and treatment of patients in routine clinical practice. International Journal of Geriatric Psychiatry 2000;15:887-891. 3. Dade, J., Wilcox, M. H., Kay, E. Hazards of multiple use of pharmaceutical solutions. The Lancet 2000;356:1684-1685. 4. Dade, J. Profile of prophylactic antibiotics. Ed. R.C.Kester. In: Handbook of Infections in Surgery. 2000;(6) London, Science Press. 5. Harcourt-Brown, N. H., Dawson, M. T., Judd, A. T. Dichloromethane poisoning in a dog: a case report. Veterinary Record 2000;146(2):48-49. 6. Howarth, A., D'Emanuele, A., Raynor, D. K. Developing a personal medicines information website. Pharmaceutical Journal 2000;265:R49-R49. 7. Knapp, P., Young, J., House, A., Forster, A. A review of non-drug strategies to resolve psycho-social difficulties after stroke. Age and Ageing 2000;29:23-30. 8. Knapp, P., Raynor, D. K., Forster, A., Henley, J. Written information about medicines for consumers (Protocol for a Cochrane Review). The Cochrane Library (Oxford) 2000; Oxford: Update Software(2) 9. Lowe, C. J and Raynor, D. K. Intentional non-adherence in the elderly: fact or fiction? Pharmaceutical Journal 2000;265:R19. 10. Lowe, C. J., Raynor, D. K., Teale, C., Luban, G. Can practice nurses identify medication problems using the over-75 health check? Journal of Clinical Nursing 2000;9:816-817. 55

LTHT Publications 2000 11. Lowe, C. J., Raynor, D. K., Purvis, J., Farrin, A. J., Hudson, J. Effects of a medicine review programme in an elderly general paractice population. British Journal of Clinical Pharmacology 2000;50:172-175. 12. Lowe, C. J., Petty, D., Zermansky, A., Raynor, D. K. Development of a method for clinical medication review by a pharmacist in general practice. Pharmacy World and Science 2000;22:121-126. 13. Petty, D. R., Zermansky, A. G., Lowe, C. J., Raynor, D. K. Pharmacists conducted clinical medication review: consultation generator or saver? Pharmaceutical Journal 2000;265:R29. 14. Raynor, D. K., Nicolson, M., Nunney, J., Petty, D., Vail, A., Davis, L. The development and evaluation of an extended support programme by community pharmacists for elderly patients at home. International Journal of Pharmacy 2000;8:157-164. 15. Raynor, D. K and Knapp, P. Do patients see read & retain the new mandatory medicines information leaflets? Pharmaceutical Journal 2000;264:268-270. 16. Raynor, D. K., Sharp, J. A., Rattenbury, H., Towler, R. J. Medicine information helplines: a survey of hospital pharmacy based services in the UK and their conformity with guidelines. Annals of Pharmacotherapy 2000;34:106-111. 17. Ward, F., Bodger, K., Daly, M. J., Heatley, R. V. Medical managment of inflammatory bowel disease. Eds. K.Bodger, M.J.Daly, and R.V.Heatley. Clinical Economics in Gastroenterology. 2000; 1st Edition:116-132. Oxford, Blackwell Science Ltd. Radiology 1. Barnett, N., Collyer, T. C., Weston, M., Spark, J. I., Scott, D. J. Pulsatile varicose veins. Journal of the Royal Society of Medicine 2000;93(1):29-30. 2. Bates, J. A and Irving, H. C. Renal transplants. Eds. H.B.Meire, D.O.C.Cosgrove, K.C.Dewbury. and Farrant. In: Clinical Ultrasound - Abdominal & General Ultrasound Vol 2. 2000;2nd edition. 3. Bates, J. A and Irving, H. C. Gallbladder and biliary tree. Eds. H.B.Meire, D.O.C.Cosgrove, K.C.Dewbury, and Farrant. In: Clinical Ultrasound - Abdominal & General Ultrasound Vol 1. 2000;2nd edition. 4. Bates, J. A and Irving, H. C. The biliary tract. Eds. H.B.Meire, D.O.C.Cosgrove, and K.C.Dewsbury. In: Clinical Ultrasound - A Comprehensive Text. 2000;2nd Edition. London, Churchill Livingstone. 5. Bates, J. A and Irving, H. C. The transplant kidney. Eds. H.B.Meire, D.O.C.Cosgrove, and K.C.Dewsbury. In: Clinical Ultrasound - A Comprehensive Text. 2000;2nd Edition. London, Churchill Livingstone. 6. Berridge, D. C., Kessel, D., Robertson, I. Surgery versus thrombolysis for acute limb ischaemia: Initial management (Cochrane Review). Cochrane Database of Systematic Reviews [computer file], 2000;4:CD002784. 7. Berry, E., Kelly, S., Hutton, J., Harris, K. M., Smith, M. A. Identifying studies for systematic reviews. An example from medical imaging. International Journal of Technology Assessment in Health Care 2000;Spring;16(2):668-672. 8. Blumenkranz, M. S., Woodburn, K. W., Qing, F., Verdooner, S., Kessel, D., Miller, R. Lutetium texaphyrin (Lu-Tex): a potential new agent for ocular fundus angiography and photodynamic therapy. American Journal of Ophthalmology 2000;129(3):353-362. 9. Bury, R. F., Cowen, A. R., Davies, A. G., Hawkridge, P., Bruijns, A. J. C., von Reth, E. Initial technical and clinical evaluation of a new universal image receptor system. European Radiology 2000;10:1983-1987. 56

LTHT Publications 2000 10. Chapple, K. S., Spencer, J. A., Windsor, A. C., Wilson, D., Ward, J., Ambrose, N. S. Prognostic value of magnetic resonance imaging in the management of fistula-in-ano. Diseases of the Colon & Rectum 2000;43(4):511-516. 11. Conway, S. P., Morton, A. M., Oldroyd, B., Truscott, J. G., White, H., Smith, A. H., Haigh, I. Osteoporosis and osteopenia in adults and adolescents with cystic fibrosis: prevalence and associated factors. Thorax 2000;55(9):798-804. 12. El-Khalili, N., Brodie, K., Kessel, D. WebSTer: a web-based surgical training system. Eds. J.D.Westwood., H.M.Hoffman., G.T.Mogel., R.A.Robb and D.Stredney. In: Medicine Meets Virtual Reality. 2000. 13. El-Khalili, N., Brodie, K., Kessel, D. WebSTer: a web-based surgical training system. Student Health Technology Information 2000;70:69-75. 14. England, R. E., Martin, D. F., Morris, J., Sheridan, M. B., Frost, R., Freeman, A., Lawrie, B., Deakin, M., Fraser, I., Smith, K. A prospective randomised multicentre trial comparing 10 fr teflon tannenbaum stents with 10 fr polyethylene cotton-leung stents in patients with malignant common duct strictures. Gut 2000;46:395-400. 15. Gibbon, W. W., Cooper, J. R., Radcliffe, G. S. Distribution of sonographically detected tendon abnormalities in patients with a clinical diagnosis of chronic Achilles tendinosis. Journal of Clinical Ultrasound 2000;28(2):61-66. 16. Goodfellow, J., Gibbon, W. W., Nokes, L. D. The Achilles heel of exercise. The Lancet 2000;355 (9218):1910. 17. Irving, H. C and Meire, H. B. Diffuse liver disease. Eds. H.B.Meire., D.O.C.Cosgrove and K.C.Dewsbury. In: Clinical Ultrasound - A Comprehensive Text. 2000;2nd Edition. London, Churchill Livingstone. 18. Kessel, D and Poretz, R. D. Sites of photodamage induced by photodynamic therapy with a chlorin e6 triacetoxymethyl ester (CAME). Photochemistry & Photobiology 2000;71(1 ):94-96. 19. Kessel, D., Luo, Y., Mathieu, P., Reiners, J. J. Jr. Determinants of the apoptotic response to lysosomal photodamage. Photochemistry & Photobiology 2000;71(2):196-200. 20. Kessel, D and Luo, Y. Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Letters 2000;151(1):25-29. 21. Liston, J. C. Are too many breast cancers missed at assessment? The Breast 2000;9(4):201-207. 22. Long, G and Gibbon, W. W. Postgraduate medical education: methodology. British Journal of Sports Medicine 2000;34(4):236-237. 23. Morris, J., Spencer, J. A., Ambrose, N. S. MR imaging classification of perianal fistulas and its implications for patient management. Radiographics 2000;20(3):623-635. 24. O'Riordan, E., Craven, C. M., Wilson, D., Robinson, P. J. Dual phase hepatic CT: influence of scanning direction on liver attenuation. AJR.American Journal of Roentgenology 2000;174(5):1417-1421. 25. Parry, D. J., Parikh, A., Robertson, I., Kessel, D., Scott, D. J. Case report: arterial haemorrhage from a chronic venous ulcer - pseudoaneurysm formation of the posterior tibial artery. European Journal of Vascular & Endovascular Surgery 2000;20(5):489-491. 26. Phipp, L. H., Scott, D. J., Kessel, D., Robertson, I. Stent implantation for mesenteric bypass graft stenosis. Journal of Endovascular Therapy: Official Journal of the International Society of Endovascular Specialists 2000;7(4):320-323. 57

LTHT Publications 2000 27. Rankine, J. J., Fourtune, D. G., Hutchinson, C. E., Hughes, D. G., Main, C. J. Pain drawings in the assessment of nerve root compression: a comparative study with lumbar spine MRI. Ed. D.J.Lawrence. In: Year Book of Chiropratice. 2000. 28. Rankine, J. J., Thomas, A. N., Fluechter, D. Diganosis of pneumothorax in critically ill adults. Postgraduate Medical Journal 2000;76:399-404. 29. Rankine, J. J., Nicholson, D. A., Driscoll, P. Radiological Assessment in ABC of Major Trauma. Eds. P.Driscoll and D.Skinner. 2000;3rd Edition, BMJ Books. 30. Richardson, D., Foster, J., Davison, A. M., Irving, H. C. Parvus tardus waveform suggesting renal artery stenosis-remember the more proximal stenosis. Nephrology, Dialysis, Transplantation 2000;15(4):539-543. 31. Robinson, P. J and Sheridan, M. B. Pancreatitis: computed tomography and magnetic resonance imaging. European Radiology 2000;10(3):401-408. 32. Robinson, P. J. Imaging liver metastases: current limitations and future prospects. British Journal of Radiology 2000;73(867):234-241. 33. Sandrasegaran, K., Robinson, P. J., Sprigg, A. Imaging of lymphoma. Eds. B.W.Hancock, P.J.Selby, K.MacLennan and J.O.Armitage. In: Malignant Lymphoma. 2000; Arnold. 34. Scott, J., Ward, J., Guthrie, J. A., Wilson, D., Robinson, P. J. MRI of liver: a comparison of CNR enhancement using high dose and low dose Ferumoxide infusion in patients with colorectal liver metastases. Magnetic Resonance Imaging 2000;18(3):297-303. 35. Spencer, J. A., Tomlinson, A. J., Weston, M. J., Lloyd, S. N. Early report: comparisons of breath-hold MR excretory urography, Doppler ultrasound and isotope renography in evaluation of symptomatic hydronephrosis in pregnancy. Clinical Radiology 2000;55:446-453. 36. Spencer, J. A., Crosse, B. A., Mannion, R. A., Sen, K. K., Perren, T. J., Chapman, A. H. Gastroduodenal obstruction from ovarian cancer: imaging features and clinical outcome. Clinical Radiology 2000;55(4):264-272. 37. Spencer, J. A. Magnetic resonance imaging of the pelvis. BMJ 2000;320:1419-1420. 38. Wainford, K. Paediatric trauma: a refresher. Synergy 2000;12-4(12 ref):8-10. 39. Ward, J., Chen, F., Guthrie, J. A., Wilson, D., Lodge, J. P., Wyatt, J. I., Robinson, P. J. Hepatic lesion detection after superparamagnetic iron oxide enhancement: comparison of five T2-weighted sequences at 1.0 T by using alternative-free response receiver operating characteristic analysis. Radiology 2000;214(1):159-166. 40. Ward, J., Guthrie, J. A., Scott, J., Atchley, J., Wilson, D., Davies, M. H., Wyatt, J. I., Robinson, P. J. Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis. Radiology 2000;216(1):154-162. 41. Webber, J., Herman, M., Kessel, D., Fromm, D. Photodynamic treatment of neoplastic lesions of the gastrointestinal tract. Recent advances in techniques and results. Langenbecks Archives of Surgery 2000;385(4):299-304. 42. Weston, M. J. Spinal abnormalities. Eds. P.Twining, J.M.McHugo and D.W.Pilling. In: Textbook of Fetal Abnormalities. 2000; London, Churchill Livingstone. 43. Willetts, I. E., Ayodeji, M., Ramsden, W. H., Squire, R. Venous patency after open central-venous cannulation. Pediatric Surgery International 2000;16(5-6):411-413. 44. Wilson, J. R., Weston, M. J., Singh, P., Eardley, I. Blue rubber bleb naevus syndrome: an unusual cause of urethral bleeding. British Journal of Dermatology 2000;143(3):677-678. 58

LTHT Publications 2000 Molecular Medicine 1. Achuthan, R., Bell, S. M., Leek, J. P., Roberts, P., Horgan, K., Markham, A. F., Selby, P. J., MacLennan, K. A. Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma. Genes, Chromosomes & Cancer, 2000;29(4):347-349. 2. Ahmed, I., Glynn, B. P., Perkins, A. V., Castro, M. G. , Rowe, J., Morrison, E., Linton, E. A. Processing of procorticotrophin-releasing hormone (proCRH): molecular forms of CRH in placentae from normal and pre-eclamptic pregnancies. Journal of Clinical Endocrinology & Metabolism 2000;85(2):755-764. 3. Aldersley, M. A., Hamlin, P. J., Jones, P. F., Markham, A. F., Robinson, P. A., Howdle, P. D. No polymorphism in the tissue transglutaminase gene detected in coeliac disease patients. Scandinavian Journal of Gastroenterology 2000;35(1):61-63. 4. Anwar, R., Gallivan, L., Miloszewski, K. J., Markham, A. F. Factor XIII deficiency causing mutation, Ser295Arg, in exon 7 of the factor XIIIA gene. Thrombosis & Haemostasis 2000;84(4):591-594. 5. Ardley, H. C., Rose, S. A., Tan, N., Leek, J. P., Markham, A. F., Robinson, P. A. Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. Cytogenetics & Cell Genetics 2000;89(1-2):137-140. 6. Ardley, H. C., Moynihan, T. P., Markham, A. F., Robinson, P. A. Promoter analysis of the human ubiquitin- conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. Biochimica et Biophysica Acta 2000;1491(1-3):57-64. 7. Askham, J. M., Moncur, P., Markham, A. F., Morrison, E. E. Regulation and function of the interaction between the APC tumour suppressor protein and EB1. Oncogene 2000;19(15):1950-1958. 8. Bamashmus, M. A., Downey, L. M., Inglehearn, C. F., Gupta, S. R., Mansfield, D. C. Genetic heterogeneity in familial exudative vitreoretinopathy; exclusion of the EVR1 locus on chromosome 11q in a large autosomal dominant pedigree. British Journal of Ophthalmology 2000;84(4):358-363. 9. Bonifer, C. Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required? Trends in Genetics 2000;16(7):310-315. 10. Bonthron, D. T., Hayward, B. E., Moran, V., Strain, L. Characterisation of TH1 and CTSZ, two non- imprinted genes downstream of GNAS1 in chromosome 20q13. Human Genetics 2000;107(2):165-175. 11. Booth, A. P., Anwar, R., Chen, H., Churchill, A. J., Jay, J., Polansky, J., Nguyen, T., Markham, A. F. Genetic screening in a large family with juvenile onset primary open angle glaucoma. British Journal of Ophthalmology 2000;84(7):722-726. 12. Chapple, K. S., Cartwright, E. J., Hawcroft, G., Tisbury, A., Bonifer, C., Scott, N., Windsor, A. C., Guillou, P. J., Markham, A. F., Coletta, P. L., Hull, M. A. Localization of cyclo oxygenase-2 in human sporadic colorectal adenomas. American Journal of Pathology 2000;156(2):545-553. 13. Churchill, A. J., Hanson, I. M., Markham, A. F. Prenatal diagnosis of aniridia. Ophthalmology 2000;107(6):1153-1156. 14. Clarke, D., Vegiopoulos, A., Crawford, A., Mucenski, M., Bonifer, C., Frampton, J. In vitro differentiation of c-myb(-/-) ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent. Oncogene 2000;19(30):3343-3351. 15. Craddock, T. P., Zumla, A. M., Ollier, W. E., Chintu, C. Z., Muyinda, G. P., Lancaster, F. C., Boylston, A. W. Predominance of one T-cell antigen receptor BV haplotype in African populations. Immunogenetics 2000;51(3):231-237. 59

LTHT Publications 2000 16. Crow, Y. J., Jackson, A. P., Roberts, E., van, BeusekomE, Barth, P., Corry, P., Ferrie, C. D., Hamel, B. C., Jayatunga, R., Karbani, G., Kalmanchey, R., Kelemen, A., King, M., Kumar, R., Livingstone, J., Massey, R., McWilliam, R., Meager, A., Rittey, C., Stephenson, J. B., Tolmie, J. L., Verrips, A., Voit, T., van, BokhovenH, Brunner, H. G., Woods, C. G. Aicardi-Goutieres syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21. American Journal of Human Genetics 2000;67(1):213-221. 17. Deeble, V. J., Roberts, E., Jackson, A., Lench, N., Karbani, G., Woods, C. G. The continuing failure to recognise Alstrom syndrome and further evidence of genetic homogeneity. Journal of Medical Genetics 2000;37(3):219. 18. Frolova-Jones, E. A., Ensser, A., Stevenson, A. J., Kinsey, S. E., Meredith, D. M. Stable marker gene transfer into human bone marrow stromal cells and their progenitors using novel herpesvirus saimiri-based vectors. Journal of Hematotherapy & Stem Cell Research 2000;9(4):573-581. 19. Goodwin, D. J., Hall, K. T., Giles, M. S., Calderwood, M. A., Markham, A. F., Whitehouse, A. The carboxy terminus of the herpesvirus saimiri ORF 57 gene contains domains that are required for transactivation and transrepression. Journal of General Virology, 2000;81(Pt 9):2253-2265. 20. Greig, E and Sandle, G. I. Diarrhoea in ulcerative colitis: the role of altered colonic sodium transport. Eds. J.D.Schilzke, M.Fromm, E.O.Riecken and H.J.Binder. In: Annals of the New York Academy of Sciences. 2000;915:327-332. 21. Hall, K. T., Giles, M. S., Goodwin, D. J., Calderwood, M. A., Markham, A. F., Whitehouse, A. Characterization of the herpesvirus saimiri ORF73 gene product. Journal of General Virology 2000;81(Pt 11):2653-2658. 22. Hall, K. T., Giles, M. S., Goodwin, D. J., Calderwood, M. A., Carr, I. M., Stevenson, A. J., Markham, A. F., Whitehouse, A. Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri. Journal of Virology 2000;74(16):7331. 23. Hardie, L. J., Briggs, J. A., Davidson, L. A., Allan, J. M., King, R. F., Williams, G. I., Wild, C. P. The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer. Carcinogenesis 2000;21(2):167-172. 24. Hargrave, M., James, K., Nield, K., Toomes, C., Georgas, K., Sullivan, T., Verzijl, H. T., Oley, C. A., Little, M., De Jonghe, P., Kwon, J. M., Kremer, H., Dixon, M. J., Timmerman, V., Yamada, T., Koopman, P. Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative to three congenital diseases. Human Genetics 2000;106(4):432-439. 25. Hayward, B. E and Bonthron, D. T. An imprinted antisense transcript at the human GNAS1 locus. Human Molecular Genetics 2000;9(5):835-841. 26. Hutchin, T. P., Parker, M. J., Young, I. D., Davis, A. C., Pulleyn, L. J., Deeble, J., Lench, N. J., Markham, A. F., Mueller, R. F. A novel mutation in the mitochondrial tRNASer(UCN) gene in a family with nonsyndromic sensorineural hearing impairment. Journal of Medical Genetics 2000; 37(Online):692-694. 27. Hutchin, T. P and Cortopassi, G. A. Mitochondrial defects in hearing impairment. Cellular & Molecular Life Sciences 2000;57:1927-1937. 28. Jayne, D. G., Perry, S. L., Morrison, E., Farmery, S. M., Guillou, P. J. Activated mesothelial cells produce heparin-binding growth factors: implications for tumour metastases. British Journal of Cancer 2000;82(6):1233-1238. 29. Judson, H., van Roy, N., Strain, L., Vandesompele, J., Van Gele, M., Speleman, F., Bonthron, D. T. Structure and mutation analysis of the gene encoding DNA fragmentation factor 40 (caspase-activated nuclease), a candidate neuroblastoma tumour suppressor gene. Human Genetics 2000;106(4):406-413. 60

LTHT Publications 2000 30. Kamiya, M., Judson, H., Okazaki, Y., Kusakabe, M., Muramatsu, M., Takada, S., Takagi, N., Arima, T., Wake, N., Kamimura, K., Satomura.K., Hermann, R., Bonthron, D. T., Hayashizaki, Y. The cell cycle control gene ZAC/PLAGL1 is imprinted - a strong candidate gene for transient neonatal diabetes. Human Molecular Genetics 2000;9(3):453-460. 31. Karayi, M. K., Neal, D. E., Markham, A. F. Current status of linkage studies in hereditary prostate cancer. British Journal of Urology 2000;86(6):659-669. 32. Kontaraki, J., Chen, H. H., Riggs, A., Bonifer, C. Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression. Genes & Development 2000;14(16):2106-2122. 33. Li, T., Vu, T. H., Zeng, Z. L., Nguyen, B. T., Hayward, B. E., Bonthron, D. T., Hu, J. F., Hoffman, A. R. Tissue-specific expression of antisense and sense transcripts at the imprinted GNAS locus. Genomics 2000;69(3):295-304. 34. Macadam, R. C., Sarela, A. I., Farmery, S. M., Robinson, P. A., Markham, A. F., Guillou, P. J. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. British Journal of Cancer 2000;83(2):188-195. 35. Mansur, A. H., Christie, G., Turner, A., Bishop, D. T., Markham, A. F., Helms, P., Morrison, J. F. Lack of linkage between chromosome 5q23-33 markers and IgE/bronchial hyperreactivity in 67 Scottish families. Clinical & Experimental Allergy 2000;30(7):954-961. 36. Mansur, A. H., Williams, G. A., Bishop, D. T., Markham, A. F., Lewis, S., Britton, J., Morrison, J. F. Evidence for a role of HLA DRB1 alleles in the control of IgE levels, strengthened by interacting TCR A/D marker alleles. Clinical & Experimental Allergy 2000;30(10):1371-1378. 37. Maraj, B. H., Leek, J. P., Carr, I. M., Markham, A. F. Identification of a novel microsatellite marker tightly linked to the KAI-1 gene for predicting prostate cancer progression. European Urology 2000;37(2):228-233. 38. McHale, D. P., Jackson, A. P., Campbell, D. A., Levene, M. I., Corry, P., Woods, C. G., Lench, N. J., Mueller, R. F., Markham, A. F. A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. European Journal of Human Genetics 2000;8(4):267-272. 39. McHale, J. C., McKie, A. B., Tarttelin, E. E., Inglehearn, C. F. Expression map of human chromosome region 17p13.3, spanning the RP13 dominant retinitis pigmentosa locus, the Miller-Dieker lissencephaly syndrome (MDLS) region, and a putative tumour suppressor locus. Cytogenetics & Cell Genetics 2000;88(3-4):225-229. 40. Mighell, A. J., Smith, N. R., Robinson, P. A., Markham, A. F. Vertebrate pseudogenes. FEBS Letters 2000;468(2-3):109-114. 41. Morgan, A. W., Griffiths, B., Ponchel, F., Montague, B. M., Ali, M., Gardener, P. P., Gooi, H. C., Situnayake, R. D., Markham, A. F., Emery, P., Isaacs, J. D. Fc gamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups. Arthritis & Rheumatism 2000;43(10):2328-2334. 42. Moynihan, L., Jackson, A. P., Roberts, E., Karbani, G. , Lewis, I., Corry, P., Turner, G., Mueller, R. F., Lench, N. J., Woods, C. G. A third novel locus for primary autosomal recessive microcephaly maps to chromosome 9q34. American Journal of Human Genetics 2000;66(2):724-727. 43. Mueller, R. F and Lench, N. J. Mapping of the DFNB1 locus. Advances in Oto-Rhino-Laryngology 2000;56:116-123. 44. Murton, N. J., Rehman, I., Black, G. C., Inglehearn, C. F., Churchill, A. J. A novel deletion (IVS11+3del4) identified in the human PAX6 gene in a patient with aniridia. Human Mutation 2000;15(6):582. 61

LTHT Publications 2000 45. Norris, A. L., Clissold, P. M., Askham, J. M., Morrison, E. E., Moncur, P., McCall, S. H., Coletta, P. L., Meredith, D. M., Markham, A. F. Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation. European Journal of Cancer 2000;36(4):525-532. 46. Pattison, L., Crow, Y. J., Deeble, V. J., Jackson, A. P., Jafri, H., Rashid, Y., Roberts, E., Woods, C. G. A fifth locus for primary autosomal recessive microcephaly maps to chromosome 1q31. American Journal of Human Genetics 2000;67(6):1578-1580. 47. Perveen, R., Lloyd, I. C., Clayton-Smith, J., Churchill, A. J., van Heyningen, V., Hanson, I., Taylor, D., McKeown, C., Super, M., Kerr, B., Winter, R., Black, G. C. M. Phenotypic variability and asymmetry of Rieger syndrome assosiated with PITX2 mutations. Investigative Ophthalmology & Visual Science 2000;41:2456-2460. 48. Praphanphoj, V., Goodman, B. K., Thomas, G. H., Nield, K. M., Toomes, C., Dixon, M. J., Geraghty, M. T. Molecular cytogenetic evaluation in a patient with a translocation (3:21) associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES). Genomics 2000;65(1):67-69. 49. Protheroe, A. S., Pickard, C., Johnson, P. W., Craddock, T., Shefta, J., Short, K., Lancaster, F., Selby, P. J., Henwood, J., Boylston, A. W. Persistence of clonal T-cell expansions following high-dose chemotherapy and autologous peripheral blood progenitor cell rescue. British Journal of Haematology 2000;111(3):766-773. 50. Pulleyn, L. J., Jackson, A. P., Roberts, E., Carradice, A., Muxworthy, C. A new locus for autosomal recessive non-syndromal sensorineural hearing impairment (DFNB27) on chromosome 2q23-q31 is not allelic to DFNA16. European Journal of Human Genetics 2000;8:991-993. 51. Sarela, A. I., Macadam, R. C., Farmery, S. M., Markham, A. F., Guillou, P. J. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Gut 2000;46(5):645-650. 52. Smith, M. L., Hawcroft, G., Hull, M. A. The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. European Journal of Cancer 2000;36(5):664-674. 53. Stevenson, A. J., Frolova-Jones, E., Hall, K. T., Kinsey, S. E., Markham, A. F., Whitehouse, A., Meredith, D. M. A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy. Cancer Gene Therapy 2000;7(7):1077-1085. 54. Stevenson, A. J., Giles, M. S., Hall, K. T., Goodwin, D. J., Calderwood, M. A., Markham, A. F., Whitehouse, A. Specific oncolytic activity of herpesvirus saimiri in pancreatic cancer cells. British Journal of Cancer 2000;83(3):329-332. 55. Stevenson, A. J., Clarke, D., Meredith, D. M., Kinsey, S. E., Whitehouse, A., Bonifer, C. Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro. Gene Therapy 2000;7(6):464-471. 56. Sundaramurthy, D., Pieri, L. F., Gape, H., Markham, A. F., Campbell, D. A. Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa . American Journal of Medical Genetics 2000;96(1):53-55. 57. Tan, N. G., Ardley, H. C., Rose, S. A., Leek, J. P., Markham, A. F., Robinson, P. A. Characterisation of the human and mouse orthologues of the Drosophila ariadne gene. Cytogenetics & Cell Genetics 2000;90(3-4):242-245. 58. Wedgwood, S., Lam, W. K., Pinchin, K. M., Markham, A. F., Cartwright, E. J., Coletta, P. L. Characterization of a brain-selective transcript of the Adenomatous polyposis coli tumor suppressor gene. Mammalian Genome 2000;11(12):1150-1153. 62

LTHT Publications 2000 Division of Childrens Services and Obstetrics Assisted Conception 1. Abushieka, N., Salha, O., Sharma, V., Brinsden, P. Monozygotic twinning and IVF/ICSI treatment: a report of 11 cases and review of literature. Human Reproduction Update 2000;6:396-403. 2. Abushieka, N., Salha, O., Brinsden, P. Extra-uterine pregnancy following assisted conception treatment. Human Reproduction Update 2000;6:80-92. 3. Gardiner, C. A., Sharma, V., Rutherford, A. J., Balen, A. H., Flintoff, K. J., Taylor, G. R., Chu, C. E. Family history and molecular genetic investigations in men with oligospermia referred for intracytoplasmic sperm injection (ICSI). Journal of Medical Genetics 2000;37(Suppl 1):37. 4. Rajkhowa, M., Allgar, V., Sharma, V. Factors influencing the cumulative conception rate and discontinuation of in-vitro fertilisation treatment of infertility. Journal of Reproduction & Fertility 2000; (Series 25):A194. 5. Rajkhowa, M., Glass, M. R., Rutherford, A. J., Balen, A. H., Sharma, V., Cuckle, H. S. Trends in the incidence of ectopic pregnancy in England and Wales from 1966 to 1996. BJOG: an International Journal of Obstetrics & Gynaecology 2000;107(3):369-374. 6. Salha, O. and Balen, A. H. New concepts in superovulation strategies for assisted conception treatments. Current Opinion in Obstetrics & Gynecology 2000;12(3):201-206. 7. Salha, O., Dada, T., Levett, S., Allgar, V., Sharma, V. The influence of supernumeracy embryos on the clinical outcome of IVF cycles. Journal of Assisted Reproduction & Genetics 2000;17(6):335-343. Midwifery 1. Donnelly, A., Renfrew, M. J., Woolridge, M. W., Martin, L. A., Snowden, H. M. The influence of hospital discharge packs on the duration and exclusivity of breastfeeding. Cochrane Database of Systematic Reviews, The Cochrane Library, Update Software 2000. 2. Donnelly, A., Snowden, H. M., Renfrew, M. J., Woolridge, M. W. Commercial hospital discharge packs for breastfeeding women. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD002075. 3. Drife, J. O. Influencing the future. Ed. D.Fraser. In: Professional Studies for Midwifery Practice. 2000;Box 13(12):226-226. London, Churchill Livingstone. 4. Escott, D., Spiby, H., Slade, P., Fraser, R. Identifying pre-existing coping strategies. Journal of Reproductive and Infant Psychology 2000;18(3):257. 5. Fairbank, L., O'Meara, S., Renfrew, M. J., Woolridge, M., Sowden, A. J., Lister-Sharp, D. A systematic review to evaluate the effectiveness of interventions to promote the initiation of breastfeeding. Health Technology Assessment (South Hampton, NY), 2000;4:1-171. 6. Green, J. M., Renfrew, M. J., Curtis, P. A. Continuity of carer: what matters to women? A review of the evidence. Midwifery 2000;16(3):186-196. 7. Greenhalgh, R., Slade, P., Spiby, H. Coping style, antenatal preparation and fathers experiences of labour and the postpartum. Birth 2000;27(3):177-184. 8. Harris, C., Woolridge, M. W., Hay, A. W. M. Factors affecting the transfer of organochlorine pesticide residues to breastmilk. Chemosphere 2000;43(2):243-256. 63

LTHT Publications 2000 9. Meddings, F. Fetal Doppler: the panacea for fetal heart monitoring. British Journal of Midwifery 2000;8(3):172. 10. Morrell, C. J., Spiby, H., Stewart, P., Walters, S., Morgan, A. Costs and effectiveness of community postnatal support workers: randomised controlled trial. BMJ 2000;321(7261):593-598. 11. Morrell, C. J., Spiby, H., Stewart, P., Walters, S., Morgan, A. Costs and benefits of community postnatal support workers: a randomised controlled trial. Health Technology Assessment (South Hampton, NY) 2000;4(South Hampton, NY):1-100. 12. Proctor, S and Renfrew, M. J. Linking Research and Practice in Midwifery: In: A Guide to Evidence Based Care. Harcourt Brace and Company. 2000; London. 13. Proctor, S and Renfrew, M. J. The reality of evidence-based practice in midwifery. Eds. S.Proctor and M.J.Renfrew. In: Linking Research and Practice in Midwifery. 2000;(11):185-193. Bailliere Tindall. 14. Renfrew, M. J and Smith, M. A. R&D in the NHS. Eds. S.Proctor and M.J.Renfrew. In: Linking Research and Practice in Midwifery. 2000;(3):55-70. Bailliere Tindall. 15. Renfrew, M. J., Lang, S., Martin, L., Woolridge, M. Interventions for influencing sleep patterns in exclusively breastfed infants. Cochrane Database of Systematic Reviews [computer file] 2000; (2):CD000113 . 16. Renfrew, M. J., Lang, S., Woolridge, M. Oxytocin for promoting successful lactation. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD000156. 17. Renfrew, M. J. Developing high-quality research in midwifery: lessons learned from the midwifery research database, MIRIAD. Midwifery 2000;16(3):229-236. 18. Renfrew, M. J and Woolridge, M. W. Enabling women to breastfeed. A structured review of interventions which support or inhibit breastfeeding. The Stationery Office (London) 2000. 19. Renfrew, M. J., Lang, S., Woolridge, M. W. Early versus delayed initiation of breastfeeding. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD000043. 20. Renfrew, M. J., Lang, S., Martin, L., Woolridge, M. W. Feeding schedules in hospitals for newborn infants. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD000090. 21. Slade, P., Escott, D., Spiby, H., Henderson, B., Fraser, R. B. Ante-natal preditors and use of coping strategies in labour. Psychology and Health 2000;15:555-569. 22. Steen, M. Product focus. Femé pad: out of the ice age and into the new millennium. British Journal of Midwifery 2000;8(5):312-315. 23. Steen, M., Cooper, K., Marchant, P., Griffiths-Jones, M., Walker, J. A randomised controlled trial to compare the effectiveness of ice-packs and Epifoam with cooling maternity gel pads at alleviating postnatal perineal trauma. Midwifery 2000;16(1):48-55. Obstetrics & Gynaecology 1. Adams, J., Carder, P. J., Downey, S., Forbes, M. A., MacLennan, K., Allgar, V., Kaufman, S., Hallam, S., Bicknell, R., Walker, J. J., Cairnduff, F., Selby, P. J., Perren, T. J., Lansdown, M., Banks, R. E. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of Tamoxifen. Cancer Research 2000;60(11):2898-2905. 64

LTHT Publications 2000 2. Balen, A. H. Mini-symposium on polycystic ovary syndrome. [editor]. Human Fertility 2000;3(2):73-115. 3. Balen, A. H. Ovulation induction. Ed. G.Kovacs. In: The Polycystic Ovary Syndrome. 2000;117-143. Cambridge University Press. 4. Balen, A. H and Genton, P. Valproate for girls with epilepsy. Annals of Neurology 2000;47(4):550-552. 5. Balen, A. H. Infertility 2000 - Postgraduate Update Series Journal. Editor-in-chief and author. 2000;(68 pages) The Netherlands, Excerpta Medica. 6. Balen, A. H and Jacobs, H. S. Polycystic ovaries and assisted conception. Ed. G.Kovacs. In: The Polycystic Ovary Syndrome. 2000;159-181. Cambridge University Press. 7. Balen, A. H. Prescribing in practice: polycystic ovary syndrome. The Prescriber 2000;11:31-39. 8. Balen, A. H. Surgical management of PCOS: pros and cons. The Obstetrician & Gynaecologist 2000;2:17-20. 9. Balen, A. H. Laparoscopic treatment of polycystic ovary syndrome. Ed. J.Bonnar. In: Recent Advances in Obstetrics & Gynaecology. 2000;111-122. Edinburgh, Churchill Livingstone. 10. Balen, A. H. Ovulation induction for polycystic ovary syndrome. Human Fertility 2000;3:106-111. 11. Bancroft, K., Tuffnell, D. J., Mason, G. C., Rogerson, L. J., Mansfield, M. A randomised controlled pilot study of the management of gestational impaired glucose tolerance. BJOG: an International Journal of Obstetrics & Gynaecology 2000;107(8):959-963. 12. Barber, D., Barlow, D., Balen, A. H. Fertility nurses doing embryo transfers - what is the impact on training? Human Fertility 2000;3:181-185. 13. Briggs, D. A., Power, N. J., Lamb, V., Rutherford, A. J., Gosden, R. G. Amplification of DNA sequences in polar bodies from human oocytes for diagnosis of mitochondrial disease [letter]. The Lancet 2000;355(9214):1520-1521. 14. Cuckle, H. Antenatal screening for chromosomal and genetic abnormalities. Ed. P.M.Shaugh O'Brien. In: The Yearbook of Obstetrics and Gynaecology. 2000;(Vol 8):74-85. London, RCOG. 15. Cuckle, H. Biochemical screening for Down syndrome. European Journal of Obstetrics, Gynecology, & Reproductive Biology 2000;92(1):97-101. 16. Cuckle, H. Screening for Down syndrome. Statistical modelling is best tool for formulating screening policy [letter]. BMJ 2000;321(7263):763-765. 17. Cuckle, H and Arbuzova, S. Maternal blood superoxide dismutase in Down syndrome. Prenatal Diagnosis 2000;20(4):354-355. 18. Cuckle, H. S and Wald, N. J. Principles of screening. N.Wald. and I.Leck. Antenatal and Neonatal Screening. 2000;2nd edition:3-22. Oxford University Press. 19. Curry, J. I., McKinney, P., Thornton, J. G., Stringer, M. D. The aetiology of gastroschisis. British Journal of Obstetrics and Gynaecology 2000;107(11):1339-1346. 20. de Graaf, I., Cuckle, H. S., Pajkrt, E., Leschot, N. J., Bleker, O. P., van Lith, J. M. Co-variables in first trimester maternal serum screening. Prenatal Diagnosis 2000;20(3):186-189. 21. Drife, J. O. Seven guidelines of wisdom. BMJ 2000;320(7245):1349A. 22. Drife, J. O. How to party. BMJ 2000;320(7238):881A. 65

LTHT Publications 2000 23. Drife, J. O. Student feedback. BMJ 2000;321(7252):59A. 24. Drife, J. O. Happy birthday, Ma'am. BMJ 2000;321(7257):391A. 25. Drife, J. O. Safer Childbirth and the CNST. NHSLA Review 2000;20:16-17. 26. Drife, J. O. Publish and be praised. BMJ 2000;320(7231):389A. 27. Drife, J. O. Influencing the future. Ed. D.Fraser. In: Professional Studies for Midwifery Practice. 2000;Box 13(12):226-226. London, Churchill Livingstone. 28. Drife, J. O. Maternal mortality: national and international perspectives. Ed. P.M.S.O'Brien. In: The Yearbook of Obstetrics and Gynaecology. 2000;Vol 8:86-96. London, RCOG Press. 29. Drife, J. O. The effect of hormones on the breast. Ed. J.Studd. In: Progress in Obstetrics and Gynaecology. 2000;Vol 14:372-385. Edinburgh, London, New York. Churchill Livingstone. 30. Drife, J. O. Cultural and historical perspectives. Eds. S.O'Brien, I.Cameron and A.MacLean. In: Disorders of the Menstrual Cycle. 2000;3-12. London, RCOG Press. 31. Drife, J. O. Maternal and perinatal mortality: the confidential enquiries. Eds. S.Campbell and C.Lees. In: Obstetrics by Ten Teachers. 2000;17th edition:19-32. London, Arnold. 32. Drife, J. O. My hero. BMJ 2000;321(7265):905A. 33. Drife, J. O. Auntie Pat. BMJ 2000;321(7272):1357A. 34. Drife, J. O. Risks and benefits of high- and low-dose oral contraceptive pills. Gynaecology Forum 2000;5(4):16-20. 35. Ferriman, E. L., Sehmi, I. K., Jones, R., Railton, A., Hilton, R. C., Cuckle, H. S. False-positive maternal serum screening in systemic lupus erythematosis: a case report. Prenatal Diagnosis 2000;20(10):851. 36. Gardiner, C. A., Sharma, V., Rutherford, A. J., Balen, A. H., Flintoff, K. J., Taylor, G. R., Chu, C. E. Family history and molecular genetic investigations in men with oligospermia referred for intracytoplasmic sperm injection (ICSI). Journal of Medical Genetics 2000;37(Suppl 1):37. 37. Garry, R., Clayton, R., Hawe, J. The effect of endometriosis and its radical laparoscopic excision on quality of life indicators. BJOG: an International Journal of Obstetrics & Gynaecology 2000;107(1):44-54. 38. Gosden, R. G. Low temperature storage and grafting of human ovarian tissue. Molecular & Cellular Endocrinology 2000;163(1-2):125-129. 39. Hayden, C and Balen, A. H. New approaches to therapy for PCOS. Topical Endocrinology 2000;14:4-8. 40. Hornbuckle, J., Vail, A., Abrams, K. R., Thornton, J. G. Bayesian interpretation of trials: the example of intrapartum electronic fetal heart rate monitoring. BJOG 2000;107(1):3-10. 41. Jarvis, G. J. Surgery for urinary incontinence. Best Practice & Research in Clinical Obstetrics & Gynaecology 2000;14(2):315-334. 42. Jenkins, C., Roberts, J., Wilson, R., MacLean, M. A. , Shillito, J., Walker, J. J. Evidence of a T(H) 1 type response associated with recurrent miscarriage. Fertility & Sterility 2000;73(6):1206-1208. 43. Kremer, C., Duffy, S., Moroney, M. Patient satisfaction with outpatient hysteroscopy versus day case hysteroscopy: randomised controlled trial. BMJ 2000;320(7230):279-282. 44. Kremer, C and Duffy, S. Endomerial ablation: the next generation. British Journal of Obstetrics and Gynaecology 2000;107(12):1443-1452. 66

LTHT Publications 2000 45. Kremer, C and Duffy, S. In vitro studies of cryoablation of the endometrium. American Journal of Obstetrics & Gynecology 2000;183(1):22-27. 46. Lumsden, M. A., Twaddle, S., Hawthorn, R., Traynor, I. , Gilmore, D., Davis, J., Deeny, M., Cameron, I. T., Walker, J. J. A randomised comparison and economic evaluation of laparoscopic-assisted hysterectomy and abdominal hysterectomy. BJOG 2000;107(11):1386-1391. 47. Maymon, R., Sehmi, I. K., Herman, A., Jones, R. G., Sherman, D., Cuckle, H. Serum inhibin A levels in pregnant women with systemic lupus erythematosus or antiphospholipid syndrome. Prenatal Diagnosis 2000;20(1):12-16. 48. Miller, D. Analysis and significance of messenger RNA in human ejaculated spermatozoa. Molecular Reproduction & Development 2000;56(Suppl 2):259-264. 49. Miller, H., Wilson, R., Jenkins, C., MacLean, M. A., Roberts, J., Walker, J. J. Glutathione levels and miscarriage. Fertility & Sterility 2000;74(6):1257-1258. 50. Moroz, C., Maymon, R., Jauniaux, E., Traub, L., Cuckle, H. Screening for trisomies 21 and 18 with maternal serum placental isoferritin p43 component. Prenatal Diagnosis 2000;20(5):395-399. 51. Moutsatsou, P., Liakou, K., Breen, K., Cuckle, H. Serum expression of sialyltransferase in normal and Down's syndrome-affected pregnancy. Annals of Clinical Biochemistry 2000;37(Pt 4):507-511. 52. Nugent, D., Vandekerckhove, P., Hughes, E., Arnot, M., Lilford, R. Gonadotrophin therapy for ovulation induction in subfertility associated with polycystic ovary syndrome . The Cochrane Library (Oxford) 2000; (4):16-ROM. 53. Oktay, K., Newton, H., Gosden, R. G. Transplantation of cryopreserved human ovarian tissue results in follicle growth initiation in SCID mice. Fertility & Sterility 2000;73(3):599-603. 54. Olsen, S. F., Secher, N. J., Tabor, A., Weber, T., Walker, J. J., Gluud, C. Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG 2000;107(3):382-395. 55. Perez, G. I., Trbovich, A. M., Gosden, R. G., Tilly, J. L. Mitochondria and the death of oocytes. Nature 2000;403(6769):500-501. 56. Pesso, R., Berkenstadt, M., Cuckle, H., Gak, E., Peleg, L., Frydman, M., Barkai, G. Screening for fragile X syndrome in women of reproductive age. Prenatal Diagnosis 2000; 20(8):611-614. 57. Picton, H. M., Kim, S., Gosden, R. G. Cryopreservation of gonadal tissue and cells. British Medical Bulletin 2000;56(3):603-615. 58. Picton, H. M and Gosden, R. G. Ovarian tissue banking and in vitro growth and maturation of human primordial follicles. Molecular & Cellular Endocrinology 2000;166(1):27-35. 59. Rajkhowa, M., Glass, M. R., Rutherford, A. J., Balen, A. H., Sharma, V., Cuckle, H. S. Trends in the incidence of ectopic pregnancy in England and Wales from 1966 to 1996. BJOG: an International Journal of Obstetrics & Gynaecology 2000;107(3):369-374. 60. Rajkhowa, M., Glass, M. R., Rutherford, A. J., Michelmore, K., Balen, A. H. Polycystic ovary syndrome: a risk factor for cardiovascular disease? BJOG 2000;107(1):11-18. 61. Rogerson, L., Hawe, J., Duffy, S. Modern approaches to management of menorrhagia. Hospital Medicine (London) 2000;61:90-92. 62. Rogerson, L., Mason, G. C., Roberts, A. C. Preliminary experience with twenty perineal repairs using Indermil tissue adhesive. European Journal of Obstetrics, Gynecology, & Reproductive Biology 2000;88(2):139-142. 67

LTHT Publications 2000 63. Rose, M. P., Gaines Das, R. E., Balen, A. H. Definition and measurement of follicle stimulating hormone. Endocrine Reviews 2000;21(1):5-22. 64. Ross-McGill, H., Hewison, J., Hirst, J., Dowswell, T., Holt, A., Brunskill, P., Thornton, J. G. Antenatal home blood pressure monitoring: a pilot randomised controlled trial. BJOG 2000;107(2):217-221. 65. Salha, O and Balen, A. H. New concepts in superovulation strategies for assisted conception treatments. Current Opinion in Obstetrics & Gynecology 2000;12(3):201-206. 66. Sehmi, I. K., Jones, R. G., Gordon, Y., Cuckle, H. S. Serum screening in a Japanese population. Prenatal Diagnosis 2000;20(5):437-439. 67. Sehmi, I. K., Jones, R. G., Gordon, Y., Cuckle, H. S. Current awareness in prenatal diagnosis. Prenatal Diagnosis 2000;20(5):441-447. 68. Shores, E. M., Picton, H. M., Hunter, M. G. Differential regulation of porcine theca cell steroidogenesis by LH, IGF-1and granulosa cells in serum-free culture. Journal of Reproduction & Fertility 2000;118(2):211-219. 69. Sparey, C and Robson, S. C. Oesophageal atresia. Prenatal Diagnosis 2000;20(3):251-253. 70. Steen, M., Cooper, K., Marchant, P., Griffiths-Jones, M., Walker, J. A randomised controlled trial to compare the effectiveness of ice-packs and Epifoam with cooling maternity gel pads at alleviating postnatal perineal trauma. Midwifery 2000;16(1):48-55. 71. Stratford, G. A., Barth, J. H., Rutherford, A. J., Balen, A. H. Value of thyroid function tests in routine screening of women investigated in fertility. Human Fertility 2000;3:203-206. 72. Tay, J. I., Moore, J., Walker, J. J. Ectopic pregnancy. Western Journal of Medicine 2000;173(2):131-134. 73. Tay, J. I., Moore, J., Walker, J. J. Clinical review. Regular review: ectopic pregnancy. BMJ 2000;320(7239):916-919. 74. Tay, J. I., Moore, J., Walker, J. J. Ectopic pregnancy [published erratum appears in BMJ 2000 Aug 12;321(7258):424]. BMJ 2000;320(7239):916-919. 75. Taylor, G. M. Reducing wound infection at Caesarean section: an audit of antibiotic prophylaxis. Health Bulletin 2000;58:38-44. 76. Taylor, G. M., McKenzie, C. A., Mires, G. J. The use of a computerised obstetric information system to improve clinical effectiveness: thromboprophylaxis at Caesarean section. Postgraduate Medical Journal 2000;76:354-356. 77. Taylor, G. M., Mires, G. J., Abel, E., Tsantis, S., Farrell, T., Chien, P. F. W., Lui, Y. The development and validation of an algorithm for real-time computerised fetal heart rate monitoring. British Journal of Obstetrics and Gynaecology 2000;107:1130-1137. 78. Thomas, J., Callwood, A., Brocklehurst, P., Walker, J. The national sentinel caesarean section audit. BJOG 2000;107(5):579-580. 79. Thornton, J. G. Prophylactic anticonvulsants for pre-eclampsia? BJOG 2000;107(7):839-840. 80. Tomlinson, A. J., Campbell, J., Walker, J. J., Morgan, C. Malignant primary hypertension in pregnancy treated with lisinopril. Annals of Pharmacotherapy 2000;34(2):180-182. 81. Wald, N. J., Hackshaw, A. K., Cuckle, H. S. Maternal serum alphafetoprotein screening for open neural tube defects: revised statistical parameters [letter; comment]. BJOG 2000;107(2):296-298. 82. Walker, J. J. Pre-eclampsia. The Lancet 2000;356(9237):1260-1265. 68

LTHT Publications 2000 83. Walker, J. J. Severe pre-eclampsia and eclampsia. Best Practice & Research in Clinical Obstetrics & Gynaecology 2000;14(1):57-71. 84. Weeks, A. D. Menorrhagia and hypothyroidism. Evidence supports association between hypothyroidism and menorrhagia. BMJ 2000;320(7235):649. 85. Weeks, A. D., Duffy, S. R., Walker, J. J. A double-blind randomised trial of leuprorelin acetate prior to hysterectomy for dysfunctional uterine bleeding. BJOG 2000;107(3):323-328. Paediatrics & Child Health 1. Cade, A., Walters, M. P., McGinley, N., Firth, J., Brownlee, K. G., Conway, S. P., Littlewood, J. M. Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis [see comments]. Pediatric Pulmonology 2000;29(3):172-176. 2. Cade, A., Brownlee, K. G., Conway, S. P., Haigh, D., Short, A., Brown, J., Dassu, D., Mason, S. A., Phillips, A., Eglin, R., Graham, M., Chetcuti, A., Chatrath, M., Hudson, N., Thomas, A., Chetcuti, P. A. Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis. Archives of Disease in Childhood 2000;82(2):126-130. 3. Ceylan, H., Puntis, J. W. L., Stringer, M. D. Ulcer in an ileocolic anastomosis treated with Ranitidine. Journal of Pediatric Surgery 2000;35:809-810. 4. Ceylan, H., Puntis, J. W., Abbott, C., Stringer, M. D. Recurrent peri-anastomotic ileo/jejunal-colic ulceration. Journal of Pediatric Gastroenterology & Nutrition 2000;30(4):450-452. 5. Conway, S. P., Morton, A., Wolfe, S. Enteral tube feeding for cystic fibrosis. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD001198. 6. Dear, P. R., Rennie, J. M., Newell, S. J., Rosenbloom, L. Response to the proposal of a template for defining a causal relation between acute intrapartum events and cerebral palsy. Clinical Risk 2000;6:137-142. 7. Dear, P. R and Newell, S. J. Establishing probable cause in cerebral palsy: how much certainty is enough? BMJ 2000;321:1075-1076. 8. Denton, M., Hall.M.J., Todd, N. J., Kerr, K. G., Littlewood, J. M. Improved isolation of stenotrophomonas maltophilia from the sputa of patients with cystic fibrosis using a selective medium. Clinical Microbiology and Infection 2000;6(7):397-398. 9. Elshimy, N., Gallagher, B., West, D., Stringer, M. D., Puntis, J. W. Outcome in children under 5 years of age with constipation: a prospective follow-up study. International Journal of Clinical Practice 2000;54(1):25-27. 10. Evans, D. J and Levene, M. I. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD001240. 11. Evans, D. J and Levene, M. I. Anticonvulsants for preventing mortality and morbidity in full term newborns with perinatal asphyxia. The Cochrane Library (Oxford) 2000;(3):5-ROM. 12. Frothingham, T. E., Hobbs, C. J., Wynne, J. M., Yee, L., Goyal, A., Wadsworth, D. J. Follow up study eight years after diagnosis of sexual abuse. Archives of Disease in Childhood 2000;83(2):132-134. 13. Godbole, P., Botterill, I., Newell, S. J., Sargar, P. M., Stringer, M. D. Solitary rectal ulcer syndrome in children. Journal of the Royal College of Surgeons of Edinburgh 2000;45:411-414. 14. Hancock, S. W., Newell, S. J., Brierly, J., Berry, A. Premedication for neonatal intubation - current practice in the UK and Australia. Archives of Disease in Childhood Fetal & Neonatal Edition 2000;83:F77. 69

LTHT Publications 2000 15. Hanks, H. G. I and Wynne, J. M. Sexual abuse of children by women - an approach to assessment. Ed. M.C.Calder. In: Complete Guide to Sexual Abuse Assessments. 2000. 16. Hodge, D and Chetcuti, P. A. J. RSV: management of the acute episode. Paediatric Respiratory Reviews 2000;1:215-220. 17. Hodge, D and Puntis, J. W. The use of expressed breast milk for the premature newborn. Clinical Nutrition 2000;19(2):75-77. 18. Hoy, C. M., Wood, C. M., Hawkey, P. M., Puntis, J. W. L. Duodenal microflora in very-low-birth-weight neonates and relation to nectrotizing enterocolitis. Journal of Clinical Microbiology 2000;68:4539-4547. 19. Kuruvatti, M. C and Puntis, J. W. L. Hospital design and miasmatist disease theory. Yorkshire Medicine 2000;12:49-52. 20. Levene, M. I., Tudehope, D. I., Thearle, M. J. Essentials of Neonatal Medicine. 2000;3. Oxford, Blackwell Science. 21. Littlewood, J. M., Koch, C., Lambert, P. A., Hoiby, N. , Elborn, J. S., Conway, S. P., Dinwiddie, R., Duncan-Skingle, F. A ten year review of colomycin. Respiratory Medicine 2000;94(7):632-640. 22. Lucock, M., Daskalakis, I., Briggs, D., Yates, Z., Levene, M. I. Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c-t methylenetetrahydrofolate reductase and 276a-g methionine synthase genotypes. Molecular Genetics and Metabolism 2000;70:27-44. 23. Lucock, M. Folic acid: nutritional biochemistry, molecular biology and role in disease processes. Molecular Genetics and Metabolism 2000;71:121-138. 24. Lucock, M and Daskalakis, I. New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions. British Journal of Biomedical Science 2000;57:254-260. 25. Mason, G. A and Gill, A. B. Obtaining informed consent to neonatal randomised controlled trials: interviews with parents and clinicians in the Euricon study group. The Lancet 2000;356:2045-2051. 26. McClure, R. J and Newell, S. J. Randomised controlled study of clinical outcome following trophic feeding. Archives of Disease in Childhood Fetal & Neonatal Edition 2000;82(1):F29-F33. 27. McHale, D. P., Jackson, A. P., Campbell, D. A., Levene, M. I., Corry, P., Woods, C. G., Lench, N. J., Mueller, R. F., Markham, A. F. A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. European Journal of Human Genetics 2000;8(4):267-272. 28. Meadow, R. Preface. Sudden Unexpected Deaths in Infancy. Eds. P.Fleming, P.Blair, C.Bacon, and J.Berry. 2000; London, The Sationery Office. 29. Meadow, R. The medical expert. Experts in the New Legal World. 2000;10-15. London, Expert Witness Institute. 30. Meadow, R. Winning the battle for a college. Ed. B.Valman. In: The Royal College of Paediatrics and Child Health at the Millennium. 2000;78-86. London, RCPCH. 31. Meadow, R. The dangerousness of parents who have abnormal illness behaviour. Child Abuse Review 2000;9:62-68. 32. Morgan, C., Dear, P. R., Newell, S. J. Effect of changes in oscillatory amplitude on PaCO(2) and PaO(2) during high frequency oscillatory ventilation. Archives of Disease in Childhood Fetal & Neonatal Edition 2000;82(3):F237-F242. 70

LTHT Publications 2000 33. Murdoch-Eaton, D. G. Undergraduate projects - do they have to be within the conventional medical environment? Medical Education 2000;34:95-100. 34. Newell, S. J. Constipation in childhood (contributing author). Drug and Therapeutics Bulletin 2000;38:57-60. 35. Newell, S. J. Enteral feeding of the micropremie. Clinics in Perinatology 2000;27(1):221-234. 36. Page, S., Abel, G., Stringer, M. D., Puntis, J. W. L. Management of septicaemic infants during longterm parenteral nutrition. International Journal of Clinical Practice 2000;54:147-150. 37. Peters, M., Beath, S. V., Puntis, J. W. L., John, P. Superior vena cava thrombosis causing respiratory obstruction successfully resolved by stenting in a small bowel transplantation candidate. Archives of Disease in Childhood 2000;83:163-164. 38. Puntis, J. W. L. Gastrointestinal problems in adolescents. International Journal of Gastroenterology 2000;5:5-8. 39. Puntis, J. W. L. Posseting. Professional Care of Mother and Child 2000;10:128-133. 40. Puntis, J. W. L. George Eliot: the Leeds connection. Yorkshire Medicine 2000;12:102-104. 41. Puntis, J. W. L. Gastrointestinal problems in infancy. The Phamaceutical Journal 2000;265:52-56. 42. Puntis, J. W. L. Infant colic. Professional Care of Mother and Child 2000;10:94-99. 43. Puntis, J. W. L. Feeding problems in infants. Eds. C.Holden and A.MacDonald. In: Nutrition and Child Health. 2000;103-119. Edinburgh, Bailliere Tindall. 44. Puntis, J. W. L. Cisapride was effective in the short term for constipation in children. Evidence-Based Medicine 2000;5:150. 45. Puntis, J. W. L. Cisapride was effective in the short term for constipation in children. American College of Physicians Journal Club 2000;133:64. 46. Puntis, J. W. L. Pharyngeal web. Journal of Pediatric Surgery 2000;35:1015. 47. Puntis, J. W. L., Thwaites, R., Abel, G., Stringer, M. D. Children with neurological disorders do not always need fundoplication concomitant with percutaneous endoscopic gastrostomy. Developmental Medicine & Child Neurology 2000;42(2):97-99. 48. Puntis, J. W. L. Maternal and fetal nutrition. Eds. C.Holden and A.MacDonald. In: Nutrition and Child Health. 2000;1-15. Edinburgh, Bailliere Tindall. 49. Smith, D. P and Meadow, S. R. Maternal understanding of the toxicity of substances used in non-accidental poisioning. Child Abuse Review 2000;9:257-263. 50. Stringer, M. D., Veysi, V. T., Puntis, J. W. L., Batcup, G., Dixon, M. F. Gastroduodenal ulcers in the Helicobacter pyori era. Acta Paediatrica 2000;89:1181-1185. 51. Swallow, J. E., Briggs, M., Semple, P. Pain at home: childrens' experience of tonsillectomy. Journal of Child Health Care 2000;4(3):93-98. 52. Tanner, S. F., Ramenghi, L. A., Ridgway, J. P., Berry, E., Saysell, M. A., Martinez, D., Arthur, R. J., Smith, M. A., Levene, M. I. Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants. American Journal of Roentgenology 2000;174 (6):1643-1649. 53. Thomas, A. J. Non accidental injury to children. Ed. M.Stark. In: A Physician's Guide to Clinical Forensic Medicine. 2000;5(5):117-134. 71

LTHT Publications 2000 54. Ubhi, T. Treatment of paediatric cerebral palsy with Dysport. Hospital Medicine 2000;61(London):718-721. 55. Ubhi, T., Bhakta, B. B., Ives, H. L., Allgar, V., Roussounis, S. H. Randomised double blind placebo controlled trial of the effect of Botulinum toxin on walking in cerebral palsy. Archives of Disease in Childhood 2000;83(6):481-487. 56. Ubhi, T., Reece, A., Craig, A. Congenital skull fracture as a presentation of Menkes disease. Developmental Medicine & Child Neurology 2000;42(5 ):347-348. 57. Veldtman, G. R., Matley, S. L., Kendall, L., Quirk, J., Gibbs, J. L., Parsons, J. M., Hewison, J. Illness understanding in children and adolescents with heart disease. Heart (British Cardiac Society: Online) 2000;84:395-397. 58. Wardley, B. S and Puntis, J. W. L. Handbook of Paediatric Nutrition. 2000; Spanish edition. Oxford, Oxford University Press. 59. Wilcox, M. H., Fitzgerald, P., Freeman, J., Denton, M., Gill, A. B., Hoy, C., Parnell, P., Porter, C., Haspinall, L., Hawkey, P. A five-year outbreak of methicillin-susceptible Staphylococcus aureus phage type 53,85 in a regional neonatal unit. Epidemiology & Infection 2000;124(1):37-45. 60. Wynne, J. M and Hobbs, C. J. Examination of children who may have been sexually abused. Archives of Disease in Childhood 2000;82(3):268. 61. Yeung, S., Ferrie, C. D., Murdoch-Eaton, D. G., Livingston, J. H. Topiramate for drug-resistant epilepsies. European Journal of Paediatric Neurology 2000;4(1):31-33. Paediatric Cardiology 1. Thomson, J. D., Veldtman, G. R., Uzun, O. Images in congenital heart disease. Transient intimal aneurismal formation during an aortogram using a pigtail catheter. Cardiology in the Young 2000;10(1):73-74. Paediatric Endocrinology 1. Westwood, M. E., Butler, G. E., McLellan, A. C., Barth, J. H. The combined pituitary function test in children: an evaluation of the clinical usefulness of TRH and LHRH stimulation tests through a retrospective analysis of one hundred and twenty six cases. Clinical Endocrinology 2000;52(6):727-733. Paediatric Neurology 1. Bhakta, B. B., Rooney, C. M., Wyatt, S., Roussounis, S. H., Chamberlain, M. A. Transition from paediatric to adult care. Bridging the gaps or passing the buck? Archives of Disease in Childhood 2000;82(3):269. 2. Childs, A. M., Meaney, J. F., Ferrie, C. D., Holland, P. C. Neurovascular compression of the trigeminal and glossopharyngeal nerve: three case reports. Archives of Disease in Childhood 2000;82(4):311-315. 3. Crow, Y. J., Jackson, A. P., Roberts, E., van, BeusekomE, Barth, P., Corry, P., Ferrie, C. D., Hamel, B. C., Jayatunga, R., Karbani, G., Kalmanchey, R., Kelemen, A., King, M., Kumar, R., Livingstone, J., Massey, R., McWilliam, R., Meager, A., Rittey, C., Stephenson, J. B., Tolmie, J. L., Verrips, A., Voit, T., van, BokhovenH, Brunner, H. G., Woods, C. G. Aicardi-Goutieres syndrome displays genetic heterogeneity with one locus (AGS1) on chromosome 3p21. American Journal of Human Genetics 2000;67(1):213-221. 4. Ubhi, T., Bhakta, B. B., Ives, H. L., Allgar, V., Roussounis, S. H. Randomised double blind placebo controlled trial of the effect of Botulinum toxin on walking in cerebral palsy. Archives of Disease in Childhood 2000;83(6):481-487. 72

LTHT Publications 2000 5. Yeung, S., Ferrie, C. D., Murdoch-Eaton, D. G., Livingston, J. H. Topiramate for drug-resistant epilepsies. European Journal of Paediatric Neurology 2000;4(1):31-33. Paediatric Oncology/Haematology 1. Cassidy, L., Stirling, R., May, K., Picton, S., Doran, R. Ophthalmic complications of childhood medulloblastoma. Medical & Pediatric Oncology 2000;34(1):43-47. 2. Coulson, S. and Phelan, L. Clinical research in paediatric oncology and the role of the research nurse in the UK. European Journal of Oncology Nursing 2000;4(3):154-161. 3. Freedman, M. H., Bonilla, M. A., Fier, C., Bolyard, A. A., Scarlata, D., Boxer, L. A., Brown, S., Cham, B., Kannourakis, G., Kinsey, S. E., Mori, P. G., Cottle, T., Welte, K., Dale, D. C. Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G-CSF therapy. Blood 2000;96(2):429-436. 4. Frolova-Jones, E. A., Ensser, A., Stevenson, A. J., Kinsey, S. E., Meredith, D. M. Stable marker gene transfer into human bone marrow stromal cells and their progenitors using novel herpesvirus saimiri-based vectors. Journal of Hematotherapy & Stem Cell Research 2000;9(4):573-581. 5. Glaser, A. W., Wilkey, O., Greenberg, M. Sperm and ova conservations: existing standards of practice in North America. Medical & Pediatric Oncology 2000;35:116-118. 6. Hann, I., Vora, A., Richards, S., Hill, F., Gibson, B., Lilleyman, J., Kinsey, S., Mitchell, C., Eden, O. B. Benefit of intensified treatment for all children with acute lymphoblastic leukaemia: results from MRC UKALL XI and MRC ALL97 randomised trials. UK Medical Research Council's Working Party on Childhood Leukaemia. Leukemia 2000;14(3):356-363. 7. Lewis, I. J., Weeden, S., Machin, D., Stark, D., Craft, A. W. Received dose and dose-intensity of chemotherapy and outcome in nonmetastatic extremity osteosarcoma. Journal of Clinical Oncology 2000;18(24):4028-4037. 8. Reid, U. Problems of infertility following cancer therapy in childhood and adolescence. European Journal of Oncology Nursing 2000;4(3):171-175. 9. Stevenson, A. J., Frolova-Jones, E., Hall, K. T., Kinsey, S. E., Markham, A. F., Whitehouse, A., Meredith, D. M. A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy. Cancer Gene Therapy 2000;7(7):1077-1085. 10. Stevenson, A. J., Clarke, D., Meredith, D. M., Kinsey, S. E., Whitehouse, A., Bonifer, C. Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro. Gene Therapy 2000;7(6):464-471. 11. Stiller, C. A., Bunch, K. J., Lewis, I. J. Ethnic group and survival from childhood cancer: report from the UK Children's Cancer Study Group. British Journal of Cancer 2000;82(7):1339-1343. 12. Sturla, L. M., Westwood, G., Selby, P. J., Lewis, I. J., Burchill, S. A. Induction of cell death by basic fibroblast growth factor in Ewing's sarcoma. Cancer Research 2000;60(21):6160-6170. 13. Thomas, H., Boddy, A. V., English, M. W., Hobson, R., Imeson, J., Lewis, I., Morland, B., Pearson, A. D., Pinkerton, R., Price, L., Stevens, M., Newell, D. R. Prospective validation of renal function-based Carboplatin dosing in children with cancer: A United Kingdom Cancer Group Trial. Journal of Clinical Oncology 2000;18(21):3614-3621. 73

LTHT Publications 2000 Paediatric Surgery 1. Ceylan, H., Puntis, J. W. L., Stringer, M. D. Ulcer in an ileocolic anastomosis treated with Ranitidine. Journal of Pediatric Surgery 2000;35:809-810. 2. Ceylan, H., Puntis, J. W., Abbott, C., Stringer, M. D. Recurrent peri-anastomotic ileo/jejunal-colic ulceration. Journal of Pediatric Gastroenterology & Nutrition 2000;30(4):450-452. 3. Curry, J. I., McKinney, P., Thornton, J. G., Stringer, M. D. The aetiology of gastroschisis. British Journal of Obstetrics and Gynaecology 2000;107(11):1339-1346. 4. Elshimy, N., Gallagher, B., West, D., Stringer, M. D., Puntis, J. W. Outcome in children under 5 years of age with constipation: a prospective follow-up study. International Journal of Clinical Practice 2000;54(1):25-27. 5. Farshi, Z., Atkinson, K. R., Squire, R. A study of clinical opinion and practice regarding circumcision. Archives of Disease in Childhood 2000;83:393-396. 6. Fraser, M. and Thomas, D. F. M. Management of urinary calculi in children. Dialogues in Pediatric Urology 2000;23 (2):4-5. 7. Garrido, A., Humphrey, G., Squire, R., Nishikawa, H. Sialoblastoma: a case report. British Journal of Plastic Surgery 2000;53:697-699. 8. Ghose, I, Mason, G. C., Martinez, D., Harrison, K. L. , Evans, J. A., Ferriman, E. L., Stringer, M. D. Hyperechogenic fetal bowel: a prospective analysis of sixty consecutive cases. British Journal of Obstetrics and Gynaecology 2000;107(3):426-429. 9. Ghose, S. I., Squire, B. R., Stringer, M. D., Batcup, G., Crabbe, D. C. G. Hirschsprung's disease: problems of the transition-zone pull-through. Journal of Paediatric Surgery 2000;35(12):1805-1809. 10. Godbole, P., Botterill, I., Newell, S. J., Sargar, P. M., Stringer, M. D. Solitary rectal ulcer syndrome in children. Journal of the Royal College of Surgeons of Edinburgh 2000;45:411-414. 11. Page, S., Abel, G., Stringer, M. D., Puntis, J. W. L. Management of septicaemic infants during longterm parenteral nutrition. International Journal of Clinical Practice 2000;54:147-150. 12. Puntis, J. W. L., Thwaites, R., Abel, G., Stringer, M. D. Children with neurological disorders do not always need fundoplication concomitant with percutaneous endoscopic gastrostomy. Developmental Medicine & Child Neurology 2000;42(2):97-99. 13. Stringer, M. D. Liver tumours. Seminars in Pediatric Surgery 2000;9:196-208. 14. Stringer, M. D and Willetts, I. E. John Hunter, Frederick Treves and intussusception. Annals of the Royal College of Surgeons of England 2000;82(1):18-23. 15. Stringer, M. D., Veysi, V. T., Puntis, J. W. L., Batcup, G., Dixon, M. F. Gastroduodenal ulcers in the Helicobacter pyori era. Acta Paediatrica 2000;89:1181-1185. 16. Thomas, D. F. M and Kapila, L. Children's surgery: a first class service [Report]. Royal College of Surgeons of England 2000. 17. Thomas, D. F. M. Congenital diseases of the upper urinary tract. Eds. R.M.Weiss, N.J.R.George, and P.H.O'Reilly. In: Comprehensive Urology. 2000:185-201.London, Mosby. 18. Willetts, I. E., Ayodeji, M., Ramsden, W. H., Squire, R. Venous patency after open central-venous cannulation. Pediatric Surgery International 2000;16(5-6):411-413. 74

LTHT Publications 2000 Division of Corporate Services Nursing 1. Cade, A., Walters, M. P., McGinley, N., Firth, J., Brownlee, K. G., Conway, S. P., Littlewood, J. M. Evaluation of fecal pancreatic elastase-1 as a measure of pancreatic exocrine function in children with cystic fibrosis [see comments]. Pediatric Pulmonology 2000;29(3):172-176. 2. Closs, S. J. Research for nursing: whose job is it anyway? Nurse Education Today 2000;20:423-425. 3. Closs, S. J. Sleep. Eds. M.Alexander, J.Fawcett and P.Runciman. In: Nursing Practice: Hospital and Home - the Adult. 2000:(25). Churchill Livingstone. 4. Closs, S. J., Baum, G., Bryar, R. M., Griffiths, J., Knight, S. Barriers to research implementation in two Yorkshire hospitals. Clinical Effectiveness in Nursing 2000;4(1):3-10. 5. Conway, S. P., Morton, A., Wolfe, S. Enteral tube feeding for cystic fibrosis. Cochrane Database of Systematic Reviews [computer file] 2000;(2):CD001198. 6. Cortis, J. D. Perceptions and experiences with nursing care: a study of Pakistani (Urdu) communities in the United Kingdom. Journal of Transcultural Nursing 2000;11(2):111-118. 7. Coulson, S and Phelan, L. Clinical research in paediatric oncology and the role of the research nurse in the UK. European Journal of Oncology Nursing 2000;4(3):154-161. 8. Dowswell, G., Lawler, J. A., Dowswell, T., Young, J., Forster, A., Hearn, J. Investigating recovery from stroke: a qualitative study. Journal of Clinical Nursing 2000;9(4):507-515. 9. Emsley, L. Why wear surgical face masks? Nursing Times 2000;96(27):38-39. 10. Fairley, D. Follow the leader?... strengthening the role of the ward leader. Nursing Times 2000;96(34):28-29. 11. Fairley, D. In my view: why I've turned into an old nark. Nursing Times 2000;96(27):25-12. 12. Feber, T. Head and Neck Oncology Nursing. Ed.T.Feber. 2000;1st Edition. 13. Greenwood, A. Mental health emergency. Nursing Standard 2000;14(37):14-15. 14. Hamer, S. Public health nursing: identifying priorities. Nursing Standard 2000;14(30):31-32. 15. Holdich, P. Pilot study of a novel approach to education: the Diabyte flyer. Journal of Diabetes Nursing 2000;4(4):116-120. 16. Hughes, N and Neal, R. D. Adults with terminal illness: a literature review of their needs and wishes for food. Journal of Advanced Nursing 2000;32(5):1101-1107. 17. Kendrick, K. Ethical issues. Ed. B.Dolan. In: Accident and Emergency: Theory into Practice. Bailliere Tindall (Philadelphia, PA) 2000:17. 18. Kendrick, K. You don't mean sex! Nursing Standard 2000;June:14(37):23. 19. Kendrick, K. D. and Costello, J. 'Healthy viewing?': experiencing life and death through a voyeuristic gaze. Nursing Ethics: an International Journal for Health Care Professionals 2000;7(1):15-22. 20. Knapp, P., Young, J., House, A., Forster, A. Non-drug strategies to resolve psycho-social difficulties after stroke. Age & Ageing 2000;29(1):23-30. 75

LTHT Publications 2000 21. Metcalfe, C. J., Lewin, R. J. P., Closs, S. J., Hughes, C., Perry, S., Wright, J. Research in the NHS: a survey of four therapies. British Journal of Therapy & Rehabilitation 2000;7(4):168-175. 22. Neal, R. D., Heywood, P. L., Morley, S. 'I always seem to be there' - a qualitative study of frequent attenders. British Journal of General Practice 2000;50(458):716-723. 23. Reid, U. Problems of infertility following cancer therapy in childhood and adolescence. European Journal of Oncology Nursing 2000;4(3):171-175. 24. Tanner, J and Timmons, S. Backstage in the theatre. Journal of Advanced Nursing 2000;32(4) : 975-980. 25. Tanner, J. Helping novice writers get published in the BJPN. British Journal of Perioperative Nursing 2000;10(12):628-631. 26. Tanner, J. A practice based approach to the selection of course content. Nurse Education Today 2000;20(2):141-146. 27. Williams, L. E and Coleman, S. B. Developing a framework to evaluate patient hoists. Professional Nurse 2000;15 (5):331-334. 28. Wright, B. Stress and distress. Ed. B.Dolan. In: Accident and Emergency: Theory into Practice Bailliere Tindall (Philadelphia, PA) 2000:27. Clinical Effectiveness 1. Farshi, Z., Atkinson, K. R., Squire, R. A study of clinical opinion and practice regarding circumcision. Archives of Disease in Childhood 2000;83:393-396. Research & Development 1. Berry, E., Kelly, S., Hutton, J., Lindsay, H. S., Blaxill, J. M., Evans, J. A., Connelly, J., Tisch, J., Walker, G. C., Sivananthan, U. M., Smith, M. A. Intravascular ultrasound-guided interventions in coronary artery disease: a systematic literature review, with decision-analytic modelling, of outcomes and cost- effectiveness. Health Technology Assessment (South Hampton, NY), 2000;4(South Hampton, NY):1-117. 2. Berry, E., Kelly, S., Hutton, J., Harris, K. M., Smith, M. A. Identifying studies for systematic reviews. An example from medical imaging. International Journal of Technology Assessment in Health Care 2000;Spring;16(2):668-672. 3. Renfrew, M. J and Smith, M. A. R&D in the NHS. Eds. S.Proctor and M.J.Renfrew. In: Linking Research and Practice in Midwifery. 2000;(3):55-70., Bailliere Tindall. 4. Salha, O., Dada, T. , Levett, S., Allgar, V., Sharma, V. The influence of supernumeracy embryos on the clinical outcome of IVF cycles. Journal of Assisted Reproduction & Genetics 2000;17(6):335-343. 5. Tanner, S. F., Ramenghi, L. A., Ridgway, J. P., Berry, E., Saysell, M. A., Martinez, D., Arthur, R. J., Smith, M. A., Levene, M. I. Quantitative comparison of intrabrain diffusion in adults and preterm and term neonates and infants. American Journal of Roentgenology 2000;174 (6):1643-1649. 6. Ubhi, T., Bhakta, B. B., Ives, H. L., Allgar, V., Roussounis, S. H. Randomised double blind placebo controlled trial of the effect of Botulinum toxin on walking in cerebral palsy. Archives of Disease in Childhood 2000;83(6):481-487. 76

LTHT Publications 2000 Statistics 1. Adams, J., Carder, P. J., Downey, S., Forbes, M. A., MacLennan, K., Allgar, V., Kaufman, S., Hallam, S., Bicknell, R., Walker, J. J., Cairnduff, F., Selby, P. J., Perren, T. J., Lansdown, M., Banks, R. E. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of Tamoxifen. Cancer Research 2000;60(11):2898-2905. 2. Hornbuckle, J., Vail, A., Abrams, K. R., Thornton, J. G. Bayesian interpretation of trials: the example of intrapartum electronic fetal heart rate monitoring. BJOG 2000;107(1):3-10. 3. Rajkhowa, M., Allgar, V., Sharma, V. Factors influencing the cumulative conception rate and discontinuation of in-vitro fertilisation treatment of infertility. Journal of Reproduction & Fertility 2000; (Series 25):A194. 4. Salha, O., Dada, T. , Levett, S., Allgar, V., Sharma, V. The influence of supernumeracy embryos on the clinical outcome of IVF cycles. Journal of Assisted Reproduction & Genetics 2000;17(6):335-343. 5. Watkins, E. J., Mitchell, S., Allgar, V., Brown, J. Failure of oral transmucosal Fentanyl as a premedicant for paediatric day case surgery. British Journal of Anaesthesia 2000;84(7). 6. Zbar, A. P., Aslam, M., Allgar, V. Faecal incontinence after internal sphincterotomy for anal fissure. Techniques in Coloproctolology 2000;4(1):25-28. 77

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