acne.ppt

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acne.ppt

  1. 1. Acne VulgarisAcne Vulgaris
  2. 2. Acne OverviewAcne Overview  Acne Vulgaris: “a chronic acne involving mainly the face, chest, and shouldersAcne Vulgaris: “a chronic acne involving mainly the face, chest, and shoulders that is common in adolescent humans and various domestic animals and isthat is common in adolescent humans and various domestic animals and is characterized by the intermittent formation of discrete papular or pustularcharacterized by the intermittent formation of discrete papular or pustular lesions often resulting in considerable scarring”lesions often resulting in considerable scarring”  Common & Limited to the SkinCommon & Limited to the Skin  Effects prepubescent individuals, teenagers, & adultsEffects prepubescent individuals, teenagers, & adults  Inflammatory lesions & scarring = social damageInflammatory lesions & scarring = social damage  Compliance is essentialCompliance is essential
  3. 3. The Compliance StudyThe Compliance Study  Examination with completion of questionnaireExamination with completion of questionnaire  Re-examined after 3 monthsRe-examined after 3 months  Derived the Objective Medication AdherenceDerived the Objective Medication Adherence (Med Ad)(Med Ad)  Discovered factors that influence complianceDiscovered factors that influence compliance  Treatments include: topical, oral antibiotics,Treatments include: topical, oral antibiotics, hormonal, & oral retinoidhormonal, & oral retinoid
  4. 4. Measurement of ComplianceMeasurement of Compliance  ““Compliance with treatment regimen is anCompliance with treatment regimen is an essential element in overall effectiveness ofessential element in overall effectiveness of therapy”therapy”  Objective-examine how patients complied withObjective-examine how patients complied with the studythe study  Important for patients to comply in order for theImportant for patients to comply in order for the results to be accurateresults to be accurate
  5. 5. Measurement of Compliance cont.Measurement of Compliance cont.  Measure the amount of the prescribed drug inMeasure the amount of the prescribed drug in the patientthe patient  Testers have to be cautious of patient realizingTesters have to be cautious of patient realizing what is being testedwhat is being tested  In examining compliance: measured pill count,In examining compliance: measured pill count, outcome of the process (DLQI) and clinicoutcome of the process (DLQI) and clinic attendanceattendance
  6. 6. Study DesignStudy Design  This study was an open, prospective study of 687This study was an open, prospective study of 687 consecutive patients, all between the ages of 12 and 48.consecutive patients, all between the ages of 12 and 48.  The study included patients with different demographicThe study included patients with different demographic features and with different degrees of severity of acnefeatures and with different degrees of severity of acne vulgaris.vulgaris.  Each patient was given a QOL assessment, whichEach patient was given a QOL assessment, which questioned the quality of the physical, emotional, social,questioned the quality of the physical, emotional, social, and role-or-function-associated life situation of anand role-or-function-associated life situation of an individual (i.e. how badly each patient’s acne wasindividual (i.e. how badly each patient’s acne was affecting his/her emotional, physical, and social states).affecting his/her emotional, physical, and social states).  The assessment contained 10 questions, with a score rangeThe assessment contained 10 questions, with a score range from 0 to 3 per question.from 0 to 3 per question.
  7. 7. Patient DemographicsPatient Demographics smokers nonsmokers female male employed students unemployed married unmarried
  8. 8. Treatment StatisticsTreatment Statistics isotretinoin conventional 1 Zaghloul
  9. 9. Inclusion CriteriaInclusion Criteria  Male or female patients with a firm diagnosis ofMale or female patients with a firm diagnosis of acne.acne.  Able to give informed consent.Able to give informed consent.  Each patient was prescribed an oral, topical, orEach patient was prescribed an oral, topical, or combined treatmentcombined treatment
  10. 10. Topical and Oral TreatmentsTopical and Oral Treatments  Topical Treatments:Topical Treatments:  The amount of topical treatment per patient was estimated by measuringThe amount of topical treatment per patient was estimated by measuring the surface area of the face, using the Rule of Hand.the surface area of the face, using the Rule of Hand.  FTU’s (Fingertip Units) were calculated for each patient to manage theirFTU’s (Fingertip Units) were calculated for each patient to manage their treatment application (for example, 1 FTU= 0.5g= 2% surface area)treatment application (for example, 1 FTU= 0.5g= 2% surface area)  Oral Treatments:Oral Treatments:  Tablets were prescribed by calculating the daily number of tabletsTablets were prescribed by calculating the daily number of tablets prescribed divided by the number of days that the study lasted.prescribed divided by the number of days that the study lasted.  Each patient was directly asked questions about his/herEach patient was directly asked questions about his/her treatment application/consumption. Each interview lasted fortreatment application/consumption. Each interview lasted for about 30-60 minutes.about 30-60 minutes.
  11. 11. Work CitedWork Cited  Zaghloul S.S., W.J Cunliffe and M.J.D.Zaghloul S.S., W.J Cunliffe and M.J.D. Goodfield. “Objective Assessment ofGoodfield. “Objective Assessment of Compliance withCompliance with Treatments in Acne.”Treatments in Acne.” British Journal of DermatologyBritish Journal of Dermatology vol. 152 May 2005: 1015.vol. 152 May 2005: 1015.

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