Cytopenias result due to increased distruction of RBC, WBC & Platelets secondary to reduced flow of blood through enlarged and congested cords ( congestive splenomegaly ) or can be due to immune mediated mechanisms as the enlarged spleen has abundant phagocytes
Due to Rh incompatibility of the materno fetal blood groups.
The increased use of allogenic transplantation for renal, hepatic, cardiac and bone marrow diseases has led to the recognition of alloimmune hemolytic anemia resulting from the production of red cell antibodies in the recipient by donor lymphocytes transferred in the allograft.
As the antibody is of IgG type,spherocytosis and splenic destruction may occur.
Other drugs like quinine,quinidine, sulfonamides, sulfonylureas, phenacetin etc do not adhere tightly to the RBC surface and the drug antibody complexes are removed during the washing steps of the coombs reactions.
PowerPoint* Lecture slide Presentation By Dr.P.L.John Israel , Professor & Head of the Department of Internal Medicine Prathima Institute of Medical Sciences, Nagunur-Karimnagar Dist. Andhra Pradesh - INDIA HEMOLYTIC ANAEMIA THANK YOU ACQUIRED