ABOUT EDCs Natural or synthetic compounds Environmental or inappropriate developmental exposures Alter the hormonal and homeostatic systems
What Do They Do?Interfere with endocrine modulation of neural and behavioral maturation. Synthesis Secretion Transport Binding Action Elimination
Characteristics Of EDCs Potency ~ Natural Hormones >Half Lives Large [In human tissues] • Less potent-Active • Liver-More toxic compounds BIOMAGNIFICATION!
How Do They Do It? Sexual development of brain- Androgens(male) and Estrogens(female) Mimic actions-Agonists Oppose-Antagonists
Issues In EndocrineDisruption Age at exposure Latency from exposure Importance of mixtures Nontraditional dose-response dynamics Trans-generational epigenetic effects
Types Of Endocrine Disruptors
THE DOWNSIDE Inhibit the proper development of female reproductive organs that adversely affects reproduction into maturity. Decrease in fertility in adult males DDT exposure in utero-childhood obesity.
Estrogen antagonism Androgen antagonism
Uses: Industrial coolants and lubricants. Are created by heating benzene, a byproduct of gasoline refining, with chlorine. Direct skin contact results in a severe acne-like condition called chloracne. . Exposure increases the risk of skin cancer, liver cancer, and brain cancer. Is toxic to the liver and thyroid. Increases childhood obesity in children exposed prenatally and may increase the risk of developing diabetes.
Affect Estrogen/Androgen/Thyroid Inhibits estrogen binding to the receptor- anti-estrogen Anti androgenic
Bisphenol A (BPA)
Low level exposure Diabetes Mammary and prostate cancers Decreased sperm count Early puberty Obesity Neurological problems
Estrogenic--- Binds to estrogen receptor
Polybrominated diphenyl ethers Plastic cases of televisions and computers Electronics Textiles
Disrupt thyroid hormone balance Interfere with thyroxine (T4) binding with transthryetin Variety of neurological and developmental deficits, including low intelligence and learning disabilities
Birth defects of the male reproductive system Estrogen Effecting Class--- Inhibit binding to the estrogen receptor Androgen Effecting--- anti-androgenic
Butylatedhydroxyanisole(BHA) Food antioxidant Estrogen--- Inhibits binding to the estrogen receptor.
What we CAN do Educate yourself about endocrine disruptors, and educate your family and friends. Buy organic food whenever possible. Avoid using pesticides in your home or yard, or on your pet Find out if pesticides are used in your childs school or day care center and campaign for non-toxic alternatives. Avoid fatty foods such as cheese and meat whenever possible.
If you eat fish from lakes, rivers, or bays, check with your state to see if they are contaminated. Avoid heating food in plastic containers, or storing fatty foods in plastic containers or plastic wrap. Do not give young children soft plastic teethers or toys, since these leach potential endocrine disrupting chemicals. Support efforts to get strong government regulation of and increased research on endocrine disrupting chemicals.