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Endochrine disrupting chemicals
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Endochrine disrupting chemicals



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  • 1. ABOUT EDCs Natural or synthetic compounds Environmental or inappropriate developmental exposures Alter the hormonal and homeostatic systems
  • 2. What Do They Do?Interfere with endocrine modulation of neural and behavioral maturation. Synthesis Secretion Transport Binding Action Elimination
  • 3. Characteristics Of EDCs Potency ~ Natural Hormones >Half Lives Large [In human tissues] • Less potent-Active • Liver-More toxic compounds BIOMAGNIFICATION!
  • 4. How Do They Do It? Sexual development of brain- Androgens(male) and Estrogens(female) Mimic actions-Agonists Oppose-Antagonists
  • 5. Issues In EndocrineDisruption Age at exposure Latency from exposure Importance of mixtures Nontraditional dose-response dynamics Trans-generational epigenetic effects
  • 6. Types Of Endocrine Disruptors
  • 7. DDT
  • 8. THE DOWNSIDE Inhibit the proper development of female reproductive organs that adversely affects reproduction into maturity. Decrease in fertility in adult males DDT exposure in utero-childhood obesity.
  • 9.  Estrogen antagonism Androgen antagonism
  • 10. Polychlorinatedbiphenyls
  • 11.  Uses: Industrial coolants and lubricants. Are created by heating benzene, a byproduct of gasoline refining, with chlorine. Direct skin contact results in a severe acne-like condition called chloracne. . Exposure increases the risk of skin cancer, liver cancer, and brain cancer. Is toxic to the liver and thyroid. Increases childhood obesity in children exposed prenatally and may increase the risk of developing diabetes.
  • 12.  Affect Estrogen/Androgen/Thyroid Inhibits estrogen binding to the receptor- anti-estrogen Anti androgenic
  • 13. Bisphenol A (BPA)
  • 14. Low level exposure Diabetes Mammary and prostate cancers Decreased sperm count Early puberty Obesity Neurological problems
  • 15.  Estrogenic--- Binds to estrogen receptor
  • 16. Polybrominated diphenyl ethers Plastic cases of televisions and computers Electronics Textiles
  • 17.  Disrupt thyroid hormone balance Interfere with thyroxine (T4) binding with transthryetin Variety of neurological and developmental deficits, including low intelligence and learning disabilities
  • 18. Phthalates
  • 19.  Birth defects of the male reproductive system Estrogen Effecting Class--- Inhibit binding to the estrogen receptor Androgen Effecting--- anti-androgenic
  • 20. Alkyl phenols Nonylphenol Endocrine disruptor; Mimics estrogen
  • 21. Butylatedhydroxyanisole(BHA) Food antioxidant Estrogen--- Inhibits binding to the estrogen receptor.
  • 22. What we CAN do Educate yourself about endocrine disruptors, and educate your family and friends. Buy organic food whenever possible. Avoid using pesticides in your home or yard, or on your pet Find out if pesticides are used in your childs school or day care center and campaign for non-toxic alternatives. Avoid fatty foods such as cheese and meat whenever possible.
  • 23.  If you eat fish from lakes, rivers, or bays, check with your state to see if they are contaminated. Avoid heating food in plastic containers, or storing fatty foods in plastic containers or plastic wrap. Do not give young children soft plastic teethers or toys, since these leach potential endocrine disrupting chemicals. Support efforts to get strong government regulation of and increased research on endocrine disrupting chemicals.
  • 24. Prachee Sharma2010B1A3616H