• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Find out about the Pharmacokinetics Module
 

Find out about the Pharmacokinetics Module

on

  • 584 views

The new Pharmacokinetics Module provides:...

The new Pharmacokinetics Module provides:
-unprecedented access to preclinical and clinical exposure data extracted from the entire history of FDA Approval Packages and EMEA documents
-Hundreds of thousands of PK, preclinical and clinical exposure, and drug safety data searchable and filterable in one platform

Statistics

Views

Total Views
584
Views on SlideShare
584
Embed Views
0

Actions

Likes
0
Downloads
15
Comments
0

0 Embeds 0

No embeds

Accessibility

Categories

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Find out about the Pharmacokinetics Module Find out about the Pharmacokinetics Module Document Transcript

    • Pharmacokinetics Module In depth
    • What can I do with the Pharmacokinetics Module? “Access to this new source of pharmacokinetic data will allow us to better assess our drug projects and make more informed decisions, resulting in better outcomes.” Development partner Better inform your decision-making With access to this wealth of data, you can: when prioritizing and directing Create modeling sets: e.g. model therapeutic candidates for development. windows on new drug projects earlier and more effectively than ever before and model the effects Gain competitive advantages: e.g. find of different chemical substructures or active groups on exposure properties. out how to deliver a drug better than your competitors, learn where the bar Make drug development project risk assessments: e.g. can this drug be properly delivered at a has been set and identify competitive safe dose? opportunities for any drug class Understand potential pharmacokinetic based on your proprietary delivery responses: e.g. food effects, concomitant drugs, methods or formulations. co-morbidities and demographic effects. Compare internally generated exposure data with drugs sharing similarities in class, chemistry or targets. “Show me all the food effect data for drugs in my class with a T1/2 over 5 hours.” Search example
    • What kind of information can I find there? “If this has the same level of data that you have shown on thousands of drugs, then it stands alone as a resource for pharmacokinetics data. There is no other resource like this.” Beta tester The new Pharmacokinetic All of these PK parameters can be searched, filtered, or sorted under multiple experimental Module provides: conditions, for example: Unprecedented access to preclinical and clinical Drug name exposure data extracted from the entire history of FDA Approval Packages and EMEA documents. Concomitant drugs Hundreds of thousands of pharmacokinetic, Dose preclinical and clinical exposure, and drug-safety Route data searchable and filterable in one platform. Value (normalized in searching) Extracted data from more than 1.5 million Standard dose pages, from: Disease states FDA Approval Packages (1992 to present) Demographic differences FDA Classic Collection (1938 to 1991) Species EMEA EPARS (1995 to present) Study group (population) Enantiomers Metabolites Tissue-specific studies
    • What does a typical search look like? “Access to this new source of pharmacokinetic data will allow us to better assess our drug projects and make more informed decisions, resulting in better outcomes.” Development partner Find the right answer We know that it can take great amounts of time to find all the right data, even on a single drug PK parameter. The Pharmacokinetics Module can help you answer the kind of research questions that you deal with on a daily basis, saving potentially months of painstaking research. The Pharmacokinetics Module helps you find all the relevant data on your drug candidate, which means you can make better informed assessments and decisions. Example Can I find a drug in any class with T1/2 of more than five hours and food-effect data? Step 1: Searching for anticonvulsants that have a T1/2 of more than five hours and filtering for food-effect data returns from FDA Approval Packages and EMEA documents. NB. The screen shots illustrate the beta product. The final product may differ.
    • Step 2: You can then click through from the search results to view the full study that you are interested in. In this example, we have clicked “View Full Study” for carbamazepine. Step 3: You can then refine your search using parameter filters, such as “species”. NB. The screen shots illustrate the beta product. The final product may differ.
    • Technical Support/E-Customer Service Americas Tel: +1 888 615 4500 (+1 212 462 1978, if calling from outside the USA and Canada) Fax: +1 212 462 1974 Email: usinfo@pharmapendium.com Europe, Middle East and Africa Tel: +49-69-5050 4268 Fax: +49-69-5050 4213 Email: nlinfo@pharmapendium.com Asia-Pacific Tel: +81 3 5561 5034 Fax: +81 3 5561 5047 Email: jpinfo@pharmapendium.com www.info.pharmapendium.com Copyright © 2010 Elsevier Properties SA. All rights reserved. PharmaPendiumTM trademark is owned and protected by Elsevier Properties SA and used under licence