We know that many of the common drugs used today are effective because of their effect on prostaglandin synthesis and inhibition of the AA cascade. This schematic represents some of the known effects of drugs on this inflammatory process Review the slide However, drugs may adversely effect other systems/side effects Steroids-prednisone NSAIDS-Naproxin, ibuprofen, piroxicam----kidney damage, GI bleeding, abdominal pain, indigestion, N/V, ibuprofen Aspirin-may adversely effect glycination, GI Acetominophen-depletes inorganic sulfate (required) for sulfation/Phase II detox of drugs, xenobiotics, and steroid hormones, amine neurotransmitters. Soon to hit the arthritis market is another anti-inflammatory drug (Celebra) by Monsanto Corp.’s Searle unit--expected to ask the FDA for an expedited review by Sept, 1998. If so, it will hit the market early next year with sales expected to top $ 4 billion. (COX2 inhibitor) Global market for prescription painkillers, not including OTC sales is currently $ 5 billion However, ignoring the underlying imbalance does nothing more than treat the symptom
Additionally, there are a number of botanical medicines that can affect these pathways as well. Wintergreen, meadowsweet(filpendulamia ulmaria), Baikal skullcap(aryuvedic) hammamalis, white oak bark
20 The events of inflamm that underlie Sx of pain, swelling, loss of function are induced and regulated by a large number of chemical mediators (including eicosanoids..also kinins, histamine, monokines). The regulation of eicosanoid synthesis is a classic mechanism for controlling inflammation. Eicosanoids (hormone-like substances present in tissues throughout the body) function as mediators of a variety of physiological responses such as inflammation, blood clotting, vascular dilation, and immunity. Eicosanoids can be divided into 4 classes: Prostaglandins, Leukotrienes, thromboxanes, and prostacyclins. A large part of the inflammatory process is regulated by the prostaglandins and leukotrienes. Eicosanoids are produced from omega 6 and omega 3 poly fats present in cell membrane phospholipids. They are also released from cell membranes by the action of phospholipases . LA (seeds/vegetables) Is the predominant omega 6. Converts to AA, the direct precursor of pro-inflam mediators--prostaglandin series 2 (PGE2) and leukotrienes of the 4 series (LTB4). AA also comes directly from the diet (meat/dairy/peanuts). AA is the major fatty acid released in response to injury. Review LA to GLA to DGLA to AA. DGLA leads to (PGE1--anti-inflam). Little DGLA in body compared with AA. But diet (GLA, Borage/Black Current, EPO) can change this. (ALA) Alpha linolenic-also Essential. Goes to EPA to DHA. Harder to find it in diet--flax, pumpkin, walnut, fish. Eicosan oids produced from this fat form PGE3--anti-inflam and leukotrienes of the 5 series. The final conversion of fatty acids to their respective eicosanoids occurs with the help of cycloox and lipooxyg. Enzymatic pathways. As these two pathways use some of the same enzyme systems, there is substrate competition. In some cases there is direct inhibition of enzyme activity. This also means that a relative excess of one fatty acid will dominate an enzyme system , resulting in decreased conversion of the other fatty acids-see previous point Delta 6 desaturase is particularly susceptible to inhibition. This can create a bottleneck in pathway activity, and may be related to chronic inflammatory conditions in certain susceptible individuals. Estimates are that 10% of the population may be deficient in EFAs -this is because we have excessive consumption of AA, low consumption of EPA and ALA, and destruction of EFAs in general by hydrogenation, cooking and oxidation of vegetable oils.
However, it is also known that nutrients can have a significant modulatory affect on this specific pathway-- In developing UIX, we wanted to address nutrients that modulated these same pathways and enzymes. Vit E, C. glutathione peroxidase--NAC, glutathione, EPA
Thermography is a painless, non invasive, state of the art clinical test without any exposure to radiation and is used as part of an early detection program which gives women of all ages the opportunity to increase their chances of detecting breast disease at an early stage. It is particularly useful for women under 50 where mammography is less effective.
Thermography's role in breast cancer and other breast disorders is to help in early detection and monitoring of abnormal physiology and the establishment of risk factors for the development or existence of cancer. When used with other procedures the best possible evaluation of breast health is made.
This test is designed to improve chances for detecting fast-growing, active tumors in the intervals between mammographic screenings or when mammography is not indicated by screening guidelines for women under 50 years of age.
Uses new ultra-sensitive, high resolution digital infrared cameras.
Thermography demonstrates heat patterns that are strongly indicative of breast abnormality. The test can detect subtle changes in breast temperature that indicate a variety of breast diseases and abnormalities. Once abnormal heat patterns are detected in the breast, follow-up procedures including mammography are necessary to rule out or properly diagnose cancer and a host of other breast diseases such as fibrocystic syndrome.
Canadian researchers recently found that infrared imaging of breast cancers could detect minute temperature variations related to blood flow and demonstrate abnormal patterns associated with the progression of tumors. These images or thermograms of the breast were positive for 83% of breast cancers compared to 61% for clinical breast examination alone and 84% for mammography .
“ The frontier of COX inhibition in breast cancer prevention and treatment is being probed by several lines of evidence. Epidemiologic research demonstrates a 40% to 50% decrease in the risk of breast cancer among women who are chronic users of NSAIDs.”
Nutritional and Botanical Modulation of the Inflammatory Cascade—Eicosanoids, Cyclooxygenases, and Lipoxygenases— As an Adjunct in Cancer Therapy Jeanne M. Wallace, PhD, CNC
Balance out the affects of omega 6 fatty acid (linoleic acid). Omega 6 fats produce pro-inflammatory compounds which promote tumor growth, foster angiogenesis, and suppress immune function.
Omega-3’s compete w/Omega-6’s for enzymes needed for cancer-promoting metabolites.
Make cancer cells more vulnerable to free-radical attack by making membranes less saturated.
Promote cancer cell self destruction, increasing their rate of die-off and slowing tumor growth.
Dietary Fish Oil and Breast Cancer Progression
The growth of breast cancer cells in culture and in mice is inhibited by omega-3 fatty acids, scientists report in a fast track article in the November 10th International Journal of Cancer.
According to Dr. Rafat A. Siddiqui from the Methodist Research Institute, Clarian Health Partners in Indianapolis, "Omega-3 fatty acids activate an enzyme called sphingomyelinase, which generates the release of ceramide, a compound that ultimately causes cancer cell death.“
Breast tissue is very susceptible to fat soluble toxins. In a National Government (EPA) human adipose study published in 1990 involving 1377 individuals, 100 % of adipose tissue samples contained dioxin, dichlorobenzene, styrene, xylene, and ethylphenol. 76% of samples had PCB’s, benzene and a host of other chemicals.
Many chemicals act as xenoestrogens and many are just plain carcinogenic. DDT derivatives DDE, PCBs and organochlorenes have been found concentrated in cancer tissue.
Detoxification needs to be a primary focal point in the prevention of cancer.
Phase 2 liver detoxification is essential for removal of excess circulating estrogens and xenobiotics as well.
Sugar in all forms, hormones in meat and dairy products, pesticides, non-organic foods, food additives and preservatives (nitrates, nitrites), white flour, iron-fortified cereals, safflower, sunflower, corn oils, margarine, fried foods, processed and refined foods, commercial cereals, soda, fruit juice, alcohol, isolated soy protein and other processed soy products, reduced fat and nonfat dairy products (plain full fat yogurt in small quantities okay).
Protocol for Breast Cancer Nutritional Support
Supplement Recommendations :
Twice Daily Essential Packets
1 packet twice a day (both multi vitamins in the am)
A recent study reported that most Americans weren’t even getting the Recommended Daily Intake 1 (RDI) of vitamins and minerals , much less the optimal levels of them and that this suboptimal intake of vitamins and minerals is a risk factor for many chronic diseases (breast cancer, osteoporosis, heart disease, diabetes, …).
A summary of current research clearly shows that those who don’t supplement with a high quality multivitamin/ mineral and antioxidant formula are at risk for deficiencies 2 .
1 RDI is the recommended amount to avoid diseases of deficiency like scurvy or pellagra, NOT the amount needed for optimal health and to avoid the major diseases of aging like heart disease, osteoporosis, cancer and diabetes.
2 Medical Professionals and Health Care Practitioners looking for more information on the research supporting the above program can contact Designs for Health support and technical department at 800-847-8302 x 105 or via the website, www.designsforhealth.com .
In a study of 166 women undergoing treatment for breast cancer, nearly 70 percent had low levels of vitamin D in their blood, according to a study presented at the American Society of Clinical Oncology's Breast Cancer Symposium in San Francisco. The analysis showed women with late-stage disease and non-Caucasian women had even lower levels.
"Vitamin D is essential to maintaining bone health, and women with breast cancer have accelerated bone loss due to the nature of hormone therapy and chemotherapy. It's important for women and their doctors to work together to boost their vitamin D intake," said Luke Peppone, Ph.D., research assistant professor of Radiation Oncology, at Rochester's James P. Wilmot Cancer Center. Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency.
Women with breast cancer have low vitamin D levels
Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism.
Biochim Biophys Acta. 2002 Apr 15;1581(3):89-99
Conjugated Linoleic Acid (CLA) is a dietary fatty acid that has received considerable attention due to its unique properties in rodent models including anti-cancer, anti-atherogenic and anti-diabetic effects.
Anti-Inflammatory Properties as well as Immune Enhancing Properties
Epidemiological studies demonstrate that too much folic acid may promote the growth of precancerous cells.
Folic acid (synthetic) and folate (natural) has a “U” shaped relationship to the incidence of cancer. Too little folate presents risk for cancer due to deficient methylation, genetic expression and cell differentiation. Too much folate can promote the growth of tumor lesions. The correct
Research is suggesting that the use of folic acid (synthetic) in fortified foods and most nutritional supplements may pose much higher risk than natural folate found in foods and some supplements.
The synthetic folic acid must be converted (reduced) in the body. Many individuals cannot effectively convert the amount of folic acid they are now being exposed to since the introduction of food fortification in the US in 1998, and due to the increased use of nutritional supplements containing folic acid. This may result in a build-up of “unmetabolized” synthetic folic acid in many individuals.