Jounral club presentation on 22 march 2014 in NATIONAL INSTITUTE OF UNANI MEDICINE, BANGALORE
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  • 1. DR MOHD SHAHID DEPARTMENT OF MOLAJAT NIUM, BANGALORE
  • 2.  BMC Complementary and Alternative Medicine is an open access, peer-reviewed journal that considers articles on interventions and resources that complement or replace conventional therapies, with a specific emphasis on research that explores the biological mechanisms of action, as well as their efficacy, safety, costs, patterns of use and/or implementation  Impact Factor : 2.08  ISSN: 1472-6882
  • 3.  BioMed Central is an STM (Science, Technology and Medicine) publisher of 258 peer-reviewed open access journals.  BioMed Central Floor 6, 236 Gray's Inn Road London WC1X 8HB United Kingdom Email: info@biomedcentral.com Customer Services: Customers in the UK call free on 0800 389 8136 All other customers call +44 (0) 20 3192 2009 (weekdays 9am - 6pm UK time) Fax: +44 (0)20 3192 2010
  • 4.  Indexing services All articles published in BMC Complementary and Alternative Medicine are included in PubMed, the most widely used biomedical bibliographic database service, which is run by the US National Library of Medicine  Other bibliographic databases  Google Scholar  MEDLINE
  • 5.  PubMed Central  SOCOLAR  SpringerLink  Thomson Reuters (ISI) etc...
  • 6. Received: 16 Nov 2012 Accepted: 01 Nov 2013 Published: 13 Nov 2013
  • 7.  A randomized, controlled cross-over trial of dermally- applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia
  • 8.  Informative ?  Self Explanatory ?  Variables are Specific ?
  • 9.  Daniel W O’Connor*  Barbara Eppingstall  John Taffe  Eva S van der Ploeg  *Correspondence: Daniel.OConnor@monash.edu School of Psychology and Psychiatry, Monash University, Kingston Centre, Warrigal Road, Cheltenham, Victoria 3192, Australia
  • 10. Competent ? Degree and Designations ? E mail is mentioned
  • 11.  A progressive, irreversible decline in mental function, marked by memory impairment and, often, deficits in reasoning, judgment, abstract thought, registration, comprehension, learning, task execution, and use of language  In the U.S., 4.5 million people are afflicted by dementia. The prevalence is esp. high in the very elderly: about 20% to 40% of those over 85 are demented  Dementia is somewhat more common in women than in men
  • 12.  Synonym L. officinalis Chaix. L. spica Linn.  Family Labiatae; Lamiaceae.  Habitat Native to Mediterranean region; cultivated in Jammu and Kashmir  English name: Lavender
  • 13.  Action Herb—mildly sedative, antiflatulent and cholagogue. Essential oil— antiseptic, antibacterial, antispasmodic.  Major constituents of the essential oil are linalool and linalyl acetate.
  • 14.  Family Papilionaceae; Fabaceae.  Habitat Mediterranean region and Asia Minor. Dried plant and flowers are imported into Mumbai from Persian Gulf  English Arabian or French: Lavender  Unani: Ustukhuddus, Alfaajan  Folk: Dhaaru
  • 15.  Action Flowers— antidepressive, sedative, anticonvulsant, carminative, a ntispasmodic, antibacterial, antiseptic. Used in depression, nervous headache, sluggish circulation, physical and mental exhaustion, insomnia, epilepsy, neuralgia and rheumatic affections  Plant—used for the treatment of epilepsy and chronic sinusitis in Unani medicine.
  • 16.  BACKGROUND clearly mentioned  Objective is clearly stated (want to know efficacy of test drug )  It is a Randomized, single blind cross-over trial, mentioned in abstract  Study design is also given in abstract  Hypothesis is declare  Results also mentioned clearly that test drug is not significant against the conrol drug  Trial registration also stated (ACTRN)
  • 17.  Conclusion is comprehensible  Within the word limit  Purpose of study is well defined
  • 18. Within word limits Appropriate
  • 19.  Prevalence missing of dementia  More emphasis on Lavender  Wonderfully describe why they choose test drug with proper references.  One study quted, that describe the efficacy is equal to lorazepam0.5 mg  Literature review provided  Aim of study is mentioned  Astonishingly discussed about previous study
  • 20.  Need of study is mentioned  Purpose of study is mentioned but why they choose fore arm massage instead of head or any other part of the body, not declared
  • 21.  Palace of study point out, and also from where the participants enrolled (8 specialist Psychogeriatric nursing home and 3 private nursing home in Melbourne)  Diagnostic criteria is declare, with REFERENCE (CLINICAL DEMENTIA RATING SCALE)  Inclusion & Exclusion criteria Stated  Test drug & dosage are mentioned properly, WHY THIS DRUG---- REFERENCES given  Duration of study mentioned between 2009 and 2011)
  • 22.  Study protocol approved by IEC  Test drug choose after electrophysical analysis in Department of Pharmacology and Toxicology, Otago University, New Zealand  Not describe the control drug (just stated neutral control oil)  Follow up & total number of patient screened declared  Drop outs declared, with REASONS  Randomization done through Exel random number generator
  • 23.  Duration of protocol is also declared, that is both intervention comprised 3 exposures over a one week with 4 days washout period and the trial was limited to 2 week  Sample size declared  Group A: total allocated patients 38, number of patients complete the intervention are 37  Group B ; total allocated patients 28, number of patients complete the intervention are 27  Written consent was taken from the next of Kin or legal guardians  Study design mentioned
  • 24.  Subjective and Objective criteria point out  Tables are clearly defined, with Graphical representation  Analysis are made through 1. Two sided hypothesis test with Type I error rate 0.05 and power set to 90 2. Binomial regression test
  • 25.  Discussion about the result are justified  Mention the limitation of study 1. Product varialbility 2. Limited knowledge base of lavender’s pharmacological properties 3. Dosing strategies are based largely on traditional practice
  • 26.  Unambiguously declare that Studies of essential oils are constrained by their variable formulations and uncertain pharmacokinetics and so optimal dosing and delivery regimens remain speculative.  However this, topically delivered, high strength, pure lavender oil had no discernible effect on affect and behaviour in a well-defined clinical sample.
  • 27.  Acknowledgements are declare  Funding: By National Health and Medical Research Council and the Dementia Collaborative Reasearch Centre administered through the University of New South Wales. Neither funding body, nor the supplier of materials, played any part in analysing data and preparing this report.  Reference according to the journal guidelines
  • 28.  This is wonderful example that how to done and write a standard paper  For me, this is the way to approach a study before going to conduct it  They have given every answers before you raise any question  Wonderful paper
  • 29. Always welcome at drshahidkhan2005@gmail.com Thanks for your patience
  • 30. Open For Discussion