Cancer develops due to abnormal cell growth and proliferation. The immune system normally identifies and eliminates cancerous cells, but cancer occurs when the immune system fails to do so, allowing abnormal cells to multiply and form tumors. Later stages of cancer are more difficult to treat as the cancer has already spread. While current treatments can target cancer cells, they do not address the underlying defect in cell production that allows cancer to relapse. Dendritic cell therapy is a type of immunotherapy that aims to revive the immune system's ability to recognize and fight cancer by producing dendritic cells, which help the immune system identify cancerous cells as threats.

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2. Contd..
Cancer is a global problem. The disease develops within us due to abnormal cell production
and collection of these cells, according to Dr Jamal A Khan, a medical microbiologist who
specializes in dendritic cell therapy in cancer. He says, “Our body is composed of tiny
structural units called cells, and old cells wither to give rise to new ones. The cell
production helps in growth and repair and maintains life.The massive rate of cell
production also gives rise to a small number of abnormal cells that need identification and
elimination for the body to carry on with its normal functions. Our immune system
identifies the abnormal (cancerous) cells and crushes them out of the system. Each day we
face a potential cancer threat but do not develop it, thanks to our immune system. A
person turns into a cancer patient when hisher immune system has primarily failed in
identifying a cancer cell and has allowed it to multiply till it forms a detectable tumour. The
cancer causes significant damage by the time it produces identifiable symptoms. In a
developing world, most patients are diagnosed at stage IV of the disease, meaning the
cancer has already spread to another distant organ. A stage I is a small and just detectable
lesion with no signs of it spreading. Stage II and III come in between as the cancer
progresses. Whatever may be the stage of cancer, treatment cannot assure cure. The
treatment helps in clearing cancer cells, but cannot stop the defect in cancer cell
production. As a result of which, can cer can relapse.“ Brought to you by
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3. Contd..
“The conventional treatment of surgery , chemotherapy and radiation is done only
for cancer and not to revive sleeping immunology . No drug can bring about this
change either. Dendritic cells (DC) are the master cells of the immune system. They
help in identifying an object (mutation cancer cells) as dangerous and create a large
pool of soldier cells (T cells) to combat it. Their discovery has added a new
dimension to cancer treatment, which comes under the heading of cancer
immunotherapy .It is primarily the lack in either their number or their complete
absence that determines the fate of cancer patient. The DC can be made to order in
the lab.When we know the cancer, it is easy to develop DC accordingly . This
additional treatment helps patients achieve long periods of remission. Being made
from the patient's own cells, it is a non-toxic way of treating cancers. We have been
doing DC therapy for a decade now,“ adds Dr Khan, who introduced this treatment
in India ten years ago. He has published articles on dendritic cell therapy , is a
member of ASCO and AACR, and has presented his work at various national and
international conferences, including the NIH, US. He is also the recipient of some
social awards in India.
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