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THE UNIVERSITY OF NOTTINGHAM
SCHOOL OF MOLECULAR MEDICAL SCIENCES
Lecturer in Human Molecular Genetics
Candidates are invited to apply for a lectureship in Human Molecular Genetics in the School of
Molecular Medical Sciences (MOL), which is located within the Faculty of Medicine and Health
Sciences at the University of Nottingham. The aims of the post is to co-ordinate and teach
the new MSc course in Molecular Diagnostics and to develop a competitive, externally-funded,
research programme in and of human genetics that fit in with the research activities of the
Institute of Genetics. The appointee will be expected to have research interests that
complement those in the area of human genetic.
Teaching in the School at undergraduate level involves lectures (both at Queen’s Medical
Centre (QMC) and the Graduate Entry Medical course at Derby) and project supervision of
medical students. The School runs five successful MSc courses in Clinical Oncology, Cancer
Immunotherapy, Molecular Immunology, Molecular Medical Microbiology and in Clinical
Microbiology which attract over 100 students per year. The main remit of the new lecturer is
to take charge of co-ordinating and running the newly created MSc course in Molecular
Diagnostics, with the assistance of a research technician, the school’s postgraduate teaching
administrator and MSc course secretaries. This will include the teaching and supervision of
students, student recruitment, building a network of project supervisors and utilizing the
existing MSc database administration system.
Recently there has been a major administrative reorganisation within the Faculty in order to
establish a sustainable and expanding research base. MOL incorporates the Divisions of
Clinical Chemistry, Clinical Oncology, Haematology, Immunology, Microbiology and Infectious
Diseases and Pathology. Research in the Faculty is focused in five institutes, namely the
Institutes of i) Genetics ii) Infection, Immunity and Inflammation iii) Neuroscience, iv)
Pharmaceutical Sciences and Experimental Therapeutics and (v) Clinical Research. Also, a
number of clusters have been established, configured around technology platforms and
human resources, including Post Genomic Technologies, Gastroenterology/ Gastrointestinal
Research, Imaging Technologies, Stem Cells, Cancer Research, Population Sciences,
Respiratory Medicine, Centre of Integrated Systems Biology & Medicine and Centre for
Reproduction and Early Life.
The majority of academic staff in the School are associated with the Institute of Infection,
Immunity & Inflammation (III) and staff in the Division of Clinical Chemistry are all in the
Institute of Genetics. Information of on-going research can be found at the following website
http://www.nottingham.ac.uk/genetics. There is considerable scope for interactions with
strong research groups in the Institute of Genetics and in the School of Molecular Sciences
and other units within the University.
Human Genetics and Plus other areas
Within the Human Genetics group there is an emphasis on the role of repetitive DNA
sequences in health and disease, and in chromosome stability. Research includes: the
molecular basis of myotonic dystrophy and the identification of genes involved in cardiac
development; human genetic diversity, copy number analysis; molecular genetics of muscle
disease; mouse models of muscle disorders; molecular genetic approaches to anthropology
and human population genetics; human genetic variation and susceptibility to complex
• John Armour investigates variation in the human genome, focusing on changes in
copy number (DNA deletions and duplications). His group investigates both normal
variation in copy number and changes that can lead to genetic diseases.
• David Brook works on the molecular genetics of inherited human disorders, in
particular, conditions affecting the neuromuscular system and the development of
the heart. These studies range from mutation detection in families, to basic
molecular analyses that aim to understand fundamental aspects of disease
• Beth Coyle is investigating normal apoptosis during cerebellum development and
how this has been subverted in tumours. Apoptosis is a key process in development
particularly in the cerebellum where 70% of granule cells (the most abundant type of
neuron) die during maturation and in medulloblastoma tumours where cells have
overcome this response.
• Jane Hewitt studies the molecular mechanisms underlying inherited muscle disease.
Her group focuses on muscular dystrophies caused by mutations in genes encoding
glycosylation enzymes and a dominant disorder, facioscapulohumeral muscular
dystrophy, which is caused by a deletion in a tandem DNA repeat.
• Noor Kalsheker studies humoral control of genes of the serine proteinase inhibitor
family which regulate key biological pathways and how functional genetic variants
contribute to complex diseases such as Alzheimer's disease and chronic lung disease.
• Kevin Morgan aims to identify genetic factors that influence susceptibility to
Alzheimer's or lung disease, thereby possibly highlighting areas suitable for
therapeutic intervention. Genomic and proteomic approaches are being used to
identify new candidate genes and biomarkers.
• Linda Morgan is investigating the genetic basis of two related disorders of
pregnancy - pre-eclampsia and fetal growth restriction. Identification of susceptibility
genes provides valuable insights into the mechanism of disease leading to
preventative or therapeutic strategies.
THE UNIVERSITY OF NOTTINGHAM
SCHOOL OF MOLECULAR MEDICAL SCIENCES
Job Title: Lecturer in Human Molecular Genetics
Salary: £28,009 - £37,643 per annum, depending on qualifications and
experience. Salary can progress to £43,638 per annum, subject
Location: School of Molecular Medical Sciences/Institute of Genetics
Responsible to: Head of School
The aim of the post is to take charge of co-ordinating, running and lecturing on the newly
created MSc course in Molecular Diagnostics within the School of Molecular Medical Sciences
and to develop a competitive, externally-funded, research programme in an area of human
• Co-ordinating, running and teaching on the MSc course in Molecular Diagnostics.
• Contributing to the administration of the school and its teaching programme.
• Establishing an independent, internationally competitive research programme.
Qualifications/ PhD or equivalent in a relevant
Skills/Training Experience in advanced molecular Further bioinformatics skills.
biology skills including cloning, cell
transfection, high throughput
genotyping and basic bioinformatics
Experience Excellent publication record. Evidence of attracting external
Ability to teach at both research funding.
undergraduate and postgraduate Evidence of collaboration across
Experience of higher education
Experience of developing new
methods within the research
Experience of developing new methods within the research environment.Personal
AttributesCommunication skills, both oral and written.OtherFlexible approach to new
methods in teaching and research.
Informal enquiries may be addressed to Professor R James, Head of School, tel: 0115
8467952, Email: Richard.James@Nottingham.ac.uk or Professor N Kalsheker, Co-Director of
the Institute of Genetics, tel: 0115 823 0720, Email: Noor.Kalsheker@Nottingham.ac.uk
Please quote ref: TW/274. Closing date: 21 April 2006.
Peer Reviewed Publications since 2001
1. Lehmann DJ, Wiebusch H, Marshall SE, Johnston C, Morgan K, Schappert K, Poirier
J, Kalsheker N, Welsh I, Smith AD (2001). HLA I, II, and III genes in confirmed
late-onset Alzheimer’s disease. Neurobiol. Aging, 22: 71-77
2. Henry M, Cave S, Morgan K, O’Connor C, Fitzgerald MX, Kalsheker N (2001). Am
alpha-1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary
outcome in cystic fibrosis. Eur. J. Hum. Genet. 9: 273-278.
3. Morgan K, Licastro F, Tilley L, Ritchie A, Pedrini S, Kalsheker N (2001).
Polymorphism in the alpha 1-antichymotrypsin (ACT) gene promoter: effect on
expression in tranfected glial and liver cell lines and plasma ACT concentrations.
Hum. Genet. 109: 303-310
4. Marsters P, Morgan K, Morley S, van Gent D, Hejazi A, Backy M, Thorpe ERG,
Kalsheker N (2002). Oncostatin M induced alpha-1-antitrypsin (AAT) gene
expression in Hep G2 cells is mediated by a 3' enhancer. Biochem. J. 2002 Jul.
15: 365 (pt 2): 555-60.
5. Plummer S, Morgan L, Kalsheker N. SNPs at the 3' end of the angiotensinogen
gene define two haplotypes associated with the common 235Met variant. Am. J.
Hum. Genet. 71(2): 443-4.
6. Kalsheker N, Morley S, Morgan K. Gene regulation of the serine proteinase
inhibitors alpha-1-antitrypsin and alpha-1-antichymotrypsin. Biochem. Soc. Trans.
(2002): 30: 93-98.
7. Brown A, Farmer K, MacDonald L, Kalsheker N, Pritchard D, Haslett C, Lamb J,
Sallenave J-M. House dust mite Der p1 down regulates defenses of the lung by
inactivating elastase inhibitors. Amer. J. Resp. Cell Mol. Biol. (2003) Vol 29,
8. Ling Y, Morgan K, Kalsheker N. Amyloid precursor protein (APP) and the biology of
proteolytic processing: relevance to Alzheimer’s disease. Int. J. Biochem. & Cell
Biol. (2003) 35: 1505-1535.
9. van Gent D, Sharp P, Morgan K, Kalsheker N. Serpins: structure, function and
molecular evolution. Int. J. Biochem. & Cell Biol. (2003) 35: 1536-1547.
10. Licastro F, Chiappelli M, Grimaldi L.M.E., Morgan K, Kalsheker N, et al. A
polymorphism in the promoter of alpha-1-antichymotrypsin gene is associated with
an increased risk of Alzheimer’s disease and cognitive decline. Neurobiol. Aging.
11. Plummer S, Tower C, Morgan L, Alonso P, Baker P, Broughton Pipkin F, Kalsheker
N. Haplotypes of the angiotensin II receptor genes in women with normotensive
pregnancy and women with pre-eclampsia. Hum. Mutat. (2004) 24: 14-20.
12. Plummer S, Guetta-Baranes T, Batowski K, Yiannakis E, Morgan K, O’Connor C,
MacNee W, Kalsheker N. Haplotypes of the alpha-1-antitrypsin gene in healthy
controls and Z deficient patients. Hum. Mutat. DOI002/Human (2004) 9294.
13. Ritchie A, Morgan K, Kalsheker N. Allele-specific over-expression in astrocytes of
an alpha-1-antichymotrypsin promoter polymorphism. Mol. Brain Res. (2004)
14. Morgan L et al. Disentangling fetal and maternal susceptibility for pre-eclampsia: A
British multicentre candidate gene study. AmerJ. of Hum. Genet. (2005) 77:
15.Tower, C; Chappell, S; Acharya, M; Crane, R; Szolin, S; Symonds, L; Chevins, H;
Kalsheker, N; Baker, P; Morgan, L. Altered Transmission of Maternal Angiotensin II
Receptor Haplotypes in Fetal Growth Restriction. Hum. Mutat. (2006) 27: 138-144.
16.Chappell, S; Daly, L; Morgan, K; Guetta-Baranes, T; Roca, J; Rabinovich, R; Millar,
A; Donnelly, S; Keatings, V; MacNee, W; Stolk, J; Hiemstra, P; Miniati, M; Monti, S;
O’Connor, C and Kalsheker, N. Cryptic haplotypes of SERPIN A1 confer
susceptibility to chronic obstructive pulmonary disease. Hum. Mutat. (2006) 27
17. Baker, C; Neilsen, HM; Minthon, L; Wright, HT; Chappell, S, O’Kyere, J; May, S;
Morgan, K; Kalsheker, N; Janciauskiene S. Effects of Alzheimer’s peptide and anti 1-
antichymotrypsin on astroyte gene expression. Neurobiol. Aging (in press).
18. Tower CL; Chappell, SL; Morgan, K; Kalsheker, N; Baker, PN; Morgan, L J.
Transforming growth factor β1 regulates angiotensin II type I receptor gene
expression on the extravillous trophoblast cell line SEHPL-4. Mol. Hum. Reprod, (in