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Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
Protein
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Protein

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Transcript

  • 1. Central Dogma of Molecular Biology
  • 2. Universal Genetic Code
  • 3. Transfer RNA
  • 4. Ribosome
  • 5. Structure of E.coli Ribosome
  • 6. Ribosome Binding Site
  • 7. Ribosome Binding Site
  • 8.  
  • 9.  
  • 10. Translation Elongation
  • 11. Translation Termination
  • 12. THE ART OF GENETIC ENGINEERING <ul><li>Cut out a gene from humans or viruses or any other organism (donor) and attach to an appropriate switch in an acceptor eg. Bacteria. </li></ul>
  • 13.  
  • 14. Action of a Restriction Enzyme
  • 15. Blue-White Screening
  • 16. Mouse and Supermouse
  • 17. Ornamental Plant Luciferin + ATP Light Luciferase
  • 18. Genome Sequencing Initiative <ul><li>Genome-the DNA of the organism. </li></ul><ul><li>1990 to present </li></ul><ul><li>Genomes of 60 organisms sequenced </li></ul><ul><li>HGP initiated in 1996 (DOE, NIH & Wellcome Trust) </li></ul><ul><li>HGP completed in April, 2003 </li></ul>
  • 19. What have we learnt from the Human Genome Sequence <ul><li>30,000 genes in Human Genome corresponding to 1-2% of entire DNA. </li></ul><ul><li>Vast majority of DNA of unknown function. </li></ul><ul><li>98% sequence similarity with the Chimpanzee genome </li></ul><ul><li>Many Genes in Humans common with lower organisms* </li></ul>
  • 20. What can we do with the Human Genome Sequence? <ul><li>Identify function: Comparative Genomics </li></ul><ul><li>Functional Complementation </li></ul><ul><li>Map position of Genes </li></ul><ul><li>Global Gene Expression: Drug Targets </li></ul><ul><li>Personalized Medicine </li></ul>
  • 21. CHALLENGES OF THE HGP <ul><li>Functions of the 98% non-coding regions of the genome </li></ul><ul><li>Interaction of non-coding with coding regions. </li></ul><ul><li>Deciphering relationship between multi-gene and genetic diseases as well as complex traits of the individual*. </li></ul><ul><li>By 2013, an individual GENETIC BLUEPRINT </li></ul>
  • 22. C. elegans

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