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Postmortem Screening Algorithm
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Postmortem Screening Algorithm

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  • 1. Postmortem Screening Algorithm Sudden and unexpected death—autopsy performed Risk factors present* No risk factors present* Contact Biochemical Genetics Laboratory 800-533-1710 ■ Order #81931 Postmortem Screening, Bile and Blood Spots ■ Collect appropriate specimens ■ Order #81931 Postmortem Screening, Bile and Blood Spots ■ Collect appropriate specimens Specimens collected and sent to Mayo Medical Laboratories • Blood and bile spots on filter paper card • Request newborn screening card be sent to Mayo Medical Laboratories from screening laboratory, when Specimens sent to Mayo Medical Laboratories possible • Blood and bile spots on filter paper card Specimen collected and held at client site • Urine on filter paper card • Skin biopsy • Urine on filter paper card; Store at ambient temperature Send or Fax clinical information and autopsy report to • Request newborn screening card be sent to Mayo Biochemical Genetics Laboratory** Medical Laboratories from screening laboratory, when possible Send or Fax clinical information and autopsy report to Biochemical Genetics Laboratory** Negative Positive No additional testing ■ Report provided Negative Positive ■ Consultation with Biochemical Genetics Laboratory (BGL) regarding additional information No additional testing ■ Report provided ■ Send urine specimen to Mayo ■ Refer family for review of test Medical Laboratories for analysis results and genetic consultation as requested by BGL DNA confirmatory testing and biochemical genetic testing of asymptomatic parents ■ Revised report issued that and siblings, if appropriate includes urine test results ■ Refer family for review of test results and genetic consultation * Risk factors • Family history of sudden infant death syndrome (SIDS) or sudden DNA confirmatory testing and unexplained deaths at any age biochemical genetic testing of • Family history of Reye syndrome asymptomatic parents and siblings, • Maternal complications of pregnancy (acute fatty liver of pregnancy, HELLP if appropriate syndrome [hemolysis, elevated liver enzymes, and low platelet count]) • Lethargy, vomiting, or fasting in the 48 hours prior to death • Allegation of child abuse (excluding obvious cases of trauma, physical harm) • Macroscopic autopsy finding • Fatty infiltration of the liver and/or other organs • Dilated or hypertrophic cardiomyopathy • Autopsy evidence of infection that routinely would NOT represent a life- threatening event * *Biochemical Genetics Laboratory Fax: 1-507-266-2888 © Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. MAYO, Mayo Medical Laboratories and the triple-shield Mayo logo are trademarks and/or service marks of MFMER. 07/09 Reviewed 2010

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