What will happen to the frequency of A and a, assuming that both alleles are neutral and each toad subpopulation is finite?
Toads and roads Subpopulations can diverge in allele frequencies even if there is random mating within each subpopulation . This population differentiation is due to random genetic drift. The result of population subdivision is reduced heterozygosity and deviation from HWE among subpopulations .
Wright’s Fixation Index ( F ST ) Sewall Wright 1889-1988
From Hartl & Clark, Principles of Population Genetics 0.076 Horseshoe crab 0.109 Drosophila equinoxialis 0.676 Jumping rodent 0.113 House mouse 0.077 Yanomamo villages 0.069 Human ‘races’ F ST Organism
Price Evans DA. N-acetyltransferase in pharmacogenetics of drug metabolism. In Kalow W, ed. Pharmacogenetics of drug metabolism. International encyclopedia of pharmacology and therapeutics. New York: Pergamon Press, 1992: 43:95-178. From Anne Chung www.apamsa.org/files/APAMSA%20presentation-general.ppt
Why is this observation interesting to evolutionary biologists?
Why is this observation interesting to physicians and drug companies?
Why is this observation interesting (and contentious) to society?
What evolutionary and non-evolutionary mechanisms could explain this observation?
American Anthropological Association (Am Anthropol 1998; 100: 712-713)
It has become clear that human populations are not unambiguous, clearly demarcated, biologically distinct groups. . . . Throughout history whenever different groups have come into contact, they have interbred. The continued sharing of genetic materials has maintained humankind as a single species. . . . Any attempt to establish lines of division among biological populations is both arbitrary and subjective.