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“ Manic-depression distorts moods and thoughts, incites dreadful behaviors, destroys the basis of rational thought, and too often erodes the desire and will to live It is an illness that is biological in its origins, yet one that feels psychological in the experience of it; an illness that is unique in conferring advantage and pleasure, yet one that brings in its wake almost unendurable suffering and, not infrequently, suicide.
if one parent has bipolar illness, chances are 1:7 that their child will
however, there are relatively few studies of the heritability of bipolar disorder
numerous subtypes of the disorder
categorical distinction between major depression and bipolar disorder (the presence of one manic episode) that confounds all genetic studies of depression since the disorders seem to be clearly related at some level