Medical Biochemistry
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Medical Biochemistry






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Medical Biochemistry Medical Biochemistry Document Transcript

  • Page i of x 1 ******************************************************** MEDICAL BIOCHEMISTRY 2009 ********************************************************
  • Page i of x MEDICAL BIOCHEMISTRY COURSE I. DESCRIPTION/Goals and Objectives: 1. Medical Biochemistry is the study of how fundamental biological processes work at the chemical level and how they are regulated. To help students develop an appropriate mastery of the field, the structure and function of biomolecules, molecular biology, and metabolism are presented using a combination of large- group lectures, small-group conferences, and self-studies. The emphasis is on clinical relevance, and the underlying assumption is that knowledge of biochemistry is essential for understanding the causes of manifestations of human illness, as well as the rationale of therapeutic strategies. By the completion of the course, it is expected that students will A. Achieve competency in their understanding of 1. The chemistry of aqueous solutions, selected aspects of thermodynamics, structure/function of macromolecules with emphasis on proteins as catalysts, structure/function of membranes, signal transduction 2. Nucleotide metabolism, DNA replication and repair, RNA transcription and processing, protein synthesis/processing/ targeting/degradation, regulation of gene expression (with cancer as a pathology of altered gene expression), the techniques (and their application) of genetic engineering. 3. The metabolism of glucose and glycogen, fatty acids and ketone bodies, amino acids (with emphasis on the branched-chain, aromatic, and sulfur-containing families), and sugars other than glucose; the regulation and integration of metabolism including fed/fasted/starved transitions and the hormones involved, and aerobic/anaerobic transitions 4. The metabolism of complex lipids containing or derived from fatty acids, cholesterol and its derivatives, lipoproteins 5. The structure/function of hemoglobin, the metabolism of heme, and the process of blood coagulation B. Recognize the interrelatedness of biochemistry, nutrition, genetics, microanatomy, and physiology C. Be prepared for the work of Year Two and for the NBME examinations
  • Page ii of x II. STRUCTURE: The material (85.5 hrs) of the Medical Biochemistry course has been mapped to the Fundamentals Module (16.0 hrs) and to seven symptom modules: Abnormal Amniocentesis (21.5 hrs), Muscle Weakness (11.5 hrs), Weight Loss (16.5 hrs), Chest Pain (10 hrs), Suspicious Lump (3.5 hrs), Shortness of Breath (2 hrs), Failure to Thrive (4.5 hrs). A. Location: Lectures, including Clinical Correlations, will be given in Auditorium A and simulcast to Seminar Room 7 at the Queen Lane Medical Campus and to Lecture Hall B on the Center City Hahnemann Campus. For medical students, Small Group sessions will take place in Seminar Rooms in the A wing, and in Interdisciplinary Laboratory B. Each student will be assigned to a particular group for case discussions (CI or CII) and for exam reviews (RI or RII). Assignments will be posted on the course web page, in the back of Auditorium A and across from Lab B prior to the first (and all subsequent) group meeting. For Professional Studies students, refer to the materials provided by the Office of Professional Studies. B. Recommended Textbooks: * Devlin, Thomas M. (ed) Textbook of Biochemistry with Clinical Correlations 6th ed. Wiley-Liss, Inc. NY 2006 Lehninger, Nelson and Cox Principles of Biochemistry 5th ed. W.H. Freeman and Co. NY 2008 Marks’ Basic Medical Biochemistry: A Clinical Approach. Lippincott, Williams & Wilkins Philadelphia, PA 2009 Murray et al Harper's Biochemistry 27th ed. Appleton and Lange Norwalk, CT 2006 Stryer, L. (Berg, Tymoczko and Stryer) Biochemistry 6th ed. W.H. Freeman Co., NY 2007 Voet, D. And Voet, J. Biochemistry 3rd ed. Wiley & Sons, Inc., NJ 2004
  • Page iii of x Review Books * Champe, Harvey and Ferrier Lippincott's Illustrated Review of Biochemistry 4th ed. J.B. Lippincott, Williams & Wilkins, Phila, PA 2008 * highly recommended Books in Specialized Areas Alberts et al Molecular Biology of The Cell 5th ed. Garland Publishing NY 2008 Lodish et al Molecular Cell Biology 6th ed. Freeman NY 2008 Thompson and Thompson Genetics in Medicine 7th ed. Saunders, Phila. 2007 Lewin, Benjamin Genes IX Oxford University Press New York, New York 2007 We thank Wiley-Liss and Lippincott, Williams & Wilkins for their permission to use figures from the Devlin text and from the Champe, Harvey and Ferrier review book for our educational purpose. C. Course Materials: Outlines of lecture, clinical correlation, self-study, and small group materials for Medical Biochemistry will be included in the appropriate module manuals. Please bring these materials to class since additional copies will not be available at the lecture. As outlines, the handouts are not complete and will need to be supplemented by notes taken in class and/or from readings. D. Small Group Conferences: Opportunities to consolidate and apply your learning to a clinical problem, to research and present a disease, and to prepare and present answers to assigned questions are provided through small group sessions. At the start of the course each student is assigned to a particular conference (C) group. Please go to that group, as they are balanced for number. While your group assignment will not change, the locations where the groups meet will change. It is expected that students will attend (and participate in) these activities. For medical students: Attendance is one way that professionalism will be assessed. Contact the course director prior to the due date for any scheduling problem that may arise. More than one unexcused absence will result in an Unprofessional Behavior form being sent to the Dean for Student Affairs. For Professional Studies students: Your conference schedule is separate from that for medical students, and will be made available to you by the Professional Studies Office, and also will be on the Biochemistry course web page. For both groups conferences are not taped.
  • Page iv of x E. Self-studies and Independent Explorations of Biochemistry (IEB): Opportunities for you to independently acquire information on selected topics are provided several times over the course. Questions on these topics will be part of the appropriate module exam. NOTE: For sections D and E use of materials prepared by previous classes is a violation of the Honor Code. F. Practice Questions: Questions similar in form and scope to those that will be in the examinations are provided for each module in which Medical Biochemistry participates. They are designed to give students practice with multiple choice questions. G. Examinations: All material, whether presented in lecture or small group, or assigned as a self- study or independent exploration, is subject to examination. Related material from previous modules may be included in subsequent module exams. All examinations are of the multiple choice question-type, with ~ 3-5 questions/ lecture hour. Each examination will be scored, and the score will be sent via e-mail by the Office of Medical Education. The test booklets are retained by the Department. For medical students: Times during which students may review their exam booklets and answer sheets will be posted after the exam. We encourage you to participate in this learning experience. For Professional Studies students there is a separate post-exam process and schedule; the schedule is distributed by the Professional Studies Office and also will be on the Biochemistry course web page. Medical students who cannot take an examination on schedule must notify the Associate Dean for Student Affairs, Dr. Sam Parrish, as quickly as possible. If Dean Parrish agrees that the absence is appropriate, the examination will be rescheduled. If a student misses an exam without the Dean's permission, a grade of zero may be given. Professional Studies students will follow the procedure outlined by that program. Students late to an examination will not be given additional time. Correct interpretation of questions is an integral part of the examination process and requires an understanding of the subject matter. Therefore, questions from individual students concerning the meaning of an exam question should not be asked. Alternative interpretations and/or answers will be considered after an examination has been graded and made available to students. H. Cumulative, Must-Pass Final Examination for medical students only: An examination covering the main concepts of the course will be given at the conclusion of the course. This examination (along with the course) must be passed to earn credit for Medical Biochemistry. The exam will contain ~ 110 questions and will constitute 10% of the course grade (see K). [Note: This exam is not required for Professional Studies students.]
  • Page v of x I. Exam Review Sessions: Faculty-led small group exam review sessions will be offered prior to each module examination. Each student is assigned to a particular review (R) group. Students are encouraged, but not required, to attend these sessions. Should additional review help be needed, please contact the Course Director. The exam review sessions are not taped. For Professional Studies students there is a separate pre-exam review schedule distributed by the Professional Studies Office, and available on the Biochemistry course web page. J. Quizzes: Biochemistry will participate in four (4) of the quiz periods; however, only three (3) scores will be included in calculating the final course grade. This means that the lowest quiz score will be dropped. Quizzes missed for any reason can NOT be made up and will be graded zero (0). Students late for a quiz session will not be given extra time. K. Grades: 1. For medical students a. As per college policy, grades recorded for transcript purposes are Honors, Highly Satisfactory, Satisfactory and Unsatisfactory. A grade of Marginally Unsatisfactory will be issued for failures that are permitted to be remediated by re-examination. Successful remediation converts an MU to an S; unsuccessful remediation converts MU to U. b. The final average of module-based activities in Biochemistry will be calculated by dividing the number of accrued points by the number of available points and multiplying by 100%. (Note: The APPROXIMATE number of quiz and module exam questions will be 280). Ninety percent of this value plus ten percent of the cumulative exam score added together will be the numerical course grade. (Note: 0.5 and above get rounded up while 0.4 and below get rounded down.) c. A course average of 70 or above is guaranteed to be a passing grade (providing the cumulative final also is passed, see section H.) Honors will be issued for course averages >91, Highly Satisfactory for course averages of 89-90, and Marginally Unsatisfactory for course averages of 68-69. Course averages below 68 will result in a grade of Unsatisfactory. The Department reserves the right, however, to lower the numerical score required for a grade. For example, based on the distribution of final averages for the course, Highly Satisfactory might also be issued for an average of 88. 2. For Professional Studies students a. The APPROXIMATE number of quiz and module exam questions in Biochemistry I will be 250, and 30 in Biochemistry II. b. A course average of 70 or above is guaranteed to be a passing grade. Course averages of 100-90 are considered to be in the A to A- range, with approximately the upper 50% of students in that range receiving an A. The medical student mean is the minimum score for
  • Page vi of x a B, and B- extends from just below the mean to 80. Course averages of 79-70 are considered to be in the C+ to C range, with approximately the upper 50% of students in that range receiving a C+. Course averages below 70 are considered to be unsatisfactory. How far below 70 will determine if the grade is a D or an F. A grade of D is remediable by reexamination for Biochemistry I but not for Biochemistry II. (Note: 0.5 and above get rounded up while 0.4 and below get rounded down.) L. Academic Support Services: Services for medical students whose performance does not reach a satisfactory level are offered both by the Biochemistry Department and by the institution. Within the Department students may be invited to meet with the Course Director to review their examinations, and/or they may be invited to special review sessions that will focus on understanding the material to be tested in the next exam. Additionally students may be referred to the Program for Support Services for tutoring or other assistance as needed. Professional Studies students should consult their handbook for academic support services. M. Remediation: For medical students: Remediation policies are set by the Evaluations and Promotions Committee. In general: 1. Students who fail the course final, but have an average in the course of >70, will be issued a course grade of Marginally Unsatisfactory. With permission of the Promotions Committee, these students will be given a departmental remediation exam. Successful completion of this examination converts the MU to no higher than a Satisfactory. 2. Students who receive a failing grade (Unsatisfactory) in the course must take and pass an approved summer course in Biochemistry or repeat the Drexel University College of Medicine course the following year. 3. Students who receive a grade of Marginal Unsatisfactory must take and pass a departmental remediation exam no later than two weeks before the start of the next academic year. For Professional Studies students, a D in Biochemistry I is remediable (highest grade attainable is C), while a D in Biochemistry II is not. Grades of U are not remediable. N. Exemptions: 1. For medical students entering Year 1 Students who, within the last two years, have earned a "B" or better in Bio- chemistry at an AAMC-accredited medical school may petition the Course Director for an exemption. Such a petition must be received by the end of the first week of the course. Exemption will require successful completion of a departmental exam. Until a decision on the petition is made, students must continue to meet all course expectations. Once exempted, students are excused from course-specific examination questions but are required to answer all integrated/multidisciplinary questions.
  • Page vii of x 2. For medical students entering Year 2 Transfer students will need to meet with the Course Director to have their credentials evaluated. O. Course Web Page: P. BIOCHEMISTRY LECTURERS AND CONFERENCE LEADERS: Room Campus Phone E-mail Dr. Jane.Clifford (Chair) 11108 NCB 215-762-4446 Dr. Michael Bouchard 11319 NCB 215-762-1898 Dr. Irwin Chaiken 11106 NCB 215-762-4917 Dr. Thomas Devlin * Dr. Denise Ferrier 163 QL 215-991-8292 Dr. Bradford Jameson 10128 NCB 215-762-6088 Dr. Marilyn Jorns 10318 NCB 215-762-7495 Dr. Patrick Loll 10106 NCB 215-762-7706 Dr. Alex Mazin 10103 NCB 215-762-7195 Dr. Robert McKenzie 4103 NCB 215-762-4096 Dr. Eishi Noguchi 11315 NCB 215-762-4825 Dr. Mauricio Reginato 11117 NCB 215-762-3554 Dr. Gerald Soslau 4122-28 NCB/PS 215-762-7831 Dr. John Swaney 139 QL 215-991-8285 Dr. Keith Vosseller 10118 NCB 215-762-8789 Dr. Michael White 10111 NCB 215-762-2355 Room Campus Phone DEPARTMENT OFFICES: Biochemistry 172 QL 215-991-8300 (Medical Education Office) Chair's Office 11108 NCB 215-762-4446 COURSE DIRECTOR: * Dr. Denise Ferrier 163 QL 215-991-8292 Course Coordinator: Mrs. Barbara Engle 172 QL 215-991-8272 * Dr. Ferrier is responsible for the course; therefore, all questions concerning the course should be directed to her. QL = Queen Lane Medical Campus, 2900 Queen Lane NCB = New College Building, 235 N. 15th Street, Center City Hahnemann Campus, MS497 NCB/PS = New College Building, 235 N. 15th Street, Center City Hahnemann Campus, MS344 Information about the Department and its members can also be found on the World Wide Web
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  • Interesting URL’s IFM Interdisciplinary Foundations of Medicine BASIC SCIENCE: BIOCHEMISTRY NetBiochem BioChemLinks On-line courses Pathways On-line supports Clinical Case Computer Tutorials in Biochemistry NIH Home Page BASIC SCIENCE: OTHER Genes and Disease Online Mendelian Inheritance in Man Office of Rare Diseases Gene Clinics
  • CLINICAL Karolinska Institute Medical Consult Medical Matrix Medical Tutor MEDICAL US.National Library of Medicine (NLM) National Library of Medicine Search Service Eccles Health Sciences Library Association of American Medical Colleges MDConsult MEDICAL TERMINOLOGY Short, web-based course from Des Moines University ANIMATIONS They also have animations for glycolysis, the TCA cycle, and the electron transport chain.