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Transcript

  • 1. Lecture 7 BIOL L100 Indiana University Southeast David Partin, Instructor
  • 2. Today’s Agenda
    • Announcements/Questions
    • Lecture 7: Mendelian Genetics and beyond
    • Practice Punnett Squares
    • One Minute Paper
    • Lab
    • Introduce Case Study #1
  • 3. Chapter 11
    • Mendelian Genetics (and beyond)
  • 4.
    • Gregor Mendel:
    • Austrian monk
    • Scientist
    • Pea farmer
    • Snazzy dresser
  • 5. Most traits are inherited independently. Mendel’s experiments refuted the “blending” concept of inheritance.
  • 6. Genotype- Phenotype- Homozygous- Heterozygous-
  • 7. Punnett Square Capital letters are always used to represent dominant traits. Dominant trait- Recessive trait-
  • 8. Alleles -alternate forms of a gene. Locus -alleles can be found on homologous chromosomes at a particular location called a gene locus.
  • 9. Let’s draw both parents’ chromosomes to make this concept clearer.
  • 10. Phenotype of offspring can reveal genotype of parents.
  • 11. Connection: Mendel’s Laws and Meiosis Instead of 1 trait at a time, let’s look at how 2 traits can be passed together.
  • 12. Dihybrid cross- Could you draw the parents’ chromosomes? Homozygous dominant Homozygous recessive
  • 13.  
  • 14. Heterozygous for both traits Homozygous recessive
  • 15. Let’s take a break…
    • Thanks for your attention!
    • When we return:
      • Human pedigrees
      • Beyond Mendelian Genetics
  • 16. Obviously, it wouldn’t be ethical to do ‘test-crosses’ on humans! We record human genetic information in a pedigree . KEY Square- Circle- Shaded- Unshaded- Horizontal line- Vertical line-
  • 17. Examples: Tay-Sachs Disease, Cystic Fibrosis, Phenylketonuria (PKU)
  • 18. Huntington Disease and Neurofibromatosis, for example
  • 19. Incomplete Dominance-
  • 20. Co-Dominance- Multiple alleles-
  • 21. Polygenic inheritance-
  • 22.  
  • 23. Environmental effects on genetics
  • 24. Any questions?
  • 25. Take a short break if you need one!
    • What’s next?
    • Practice Punnett Squares
    • One-Minute Paper
    • Lab
    • Introduce Case Study #1
  • 26. Punnett Squares
    • Let’s do some practice problems…
  • 27. Overview of today’s lab
    • In this exercise, you will observe and record the results of the offspring produced in a dihybrid heterozygous cross of two corn phenotypes.
    • The corn kernel phenotypes are:
      • Purple & starchy (purple & nonwrinkled)
      • Purple & sweet (purple & wrinkled)
      • Yellow & starchy (yellow & nonwrinkled)
      • Yellow & sweet (yellow & wrinkled)
    • Each team will count 3 ears of corn & record the total number of each type of kernel. Don’t remove the kernels. Use pins to mark the counted rows.
    • Record your results & answer the questions on pp55-56.
    • It could be useful to work through some of the questions at the end of Ch11 (pp201-202) and the “Practice Problems” found throughout the chapter. They won’t be turned in or graded, but some questions on the exam may look similar…
  • 28. Case Study #1
    • “ Sometimes it IS all in the Genes”
    • Mendelian genetics, Punnett squares
    • Cystic fibrosis: autosomal recessive disorder
  • 29. Preparation for Lecture 8
    • Study today’s lecture materials (and Ch. 11 & 12), so that Lecture 8 will be more useful to you.
    • Read Ch. 13