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Biology 4003 Genetics Course Syllabus Fall 2008
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Biology 4003 Genetics Course Syllabus Fall 2008



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  • 1. Biology 4003 Genetics Course Syllabus Fall 2008 Meeting time and place: Monday Wednesday Friday, 1:55 - 2:45 P.M. B35 Classroom-Office Building Instructor: Dr. Jane Glazebrook Rm 324 Cargill Laboratory of Plant and Microbial Genomics (612) 624-5194 e-mail: Office hours: Monday 10:00-11:00 Rm 324 Cargill Thursday 1:00-2:00 Rm 324 Cargill Teaching assistant: Wei-Shan Hsu (612) 624-4966 e-mail: Office hours: Monday 4:00-5:00 MCB 6-118 Wednesday 11:00-12:00 MCB 6-118 Course website: Text: Principles of Genetics Snustad and Simmons, 4th edition (Wiley). NOTE: Almost all of the figures to be used during lecture will come from the text. You might find it helpful to bring the text to class. Optional text: Study Guide and Problems Work Book. H. James Price (Wiley). This paperback book has expanded problem sets and the answers to all problems in the book. Reserve: The required and optional texts are on reserve in the McGrath library in St. Paul and the biomedical library in Minneapolis. DEFINITIONS OF GRADES & ACADEMIC WORKLOAD EXPECTATIONS A: achievement that is outstanding relative to the level necessary to meet course requirements. B: achievement that is significantly above the level necessary to meet course requirements. C: achievement that meets the course requirements in every respect. D: achievement that is worthy of credit even though it fails to meet fully the course requirements. F: Represents failure and signifies that the work was either (1) completed but at a level of achievement that is not worthy of credit or (2) was not completed and there was no agreement between the instructor and the student that the student would be awarded an I . Incompletes: The grade of "I" will be given only in response to extreme hardship, usually medical emergencies, preventing completion of course requirements. A request for an "I" grade must be made in writing before the last day of class. There is an official
  • 2. form, available from the CBS Student Services Office, which must be filled out to apply for an incomplete. If an "I" is assigned the student and instructor must reach agreement on the nature of the incomplete work and the specific actions to be taken to complete the course. University policy specifies that an "I" grade lapses automatically to "F" or "N" if the work is not completed by the end of the next semester. Course grading: There will be three in-class exams during the semester, and a final exam. Each exam will consist of problems along with multiple choice and short answer questions. There will be no opportunities for extra credit work. Your grade will be determined entirely by your performance on these examinations. Mid-term 1 - 100 points Friday, September 26 Mid-term 2 - 125 points Friday, October 24 Mid-term 3 - 125 points Friday, November 21 Final exam - 150 points 1:30pm-3:30pm Saturday, December 13 The weighting on the final exam will be 40 points for material taught after the 3rd mid- term and 110 points for material taught in the rest of the course. Exams are designed to be finished during one class period (mid-terms) or two hours (final). Provided that there is no class using our room immediately after us, 30 minutes of extra time will be allowed for students who want it. Course grades will be determined based on the number of points earned out of the 500 points possible. Guaranteed curve: Grading will not be more severe than shown below. Depending in part on the performance of the class as a whole, it may be more lenient. Last year, it was very close to this: above 425: A above 375: at least a B above 300: at least a C above 225: at least a D Grades of A-, B+, B-, and C+ will also be assigned. The points required for these grades will be determined after all the exams are over, and will be based on the distribution of student point totals. Missed exams: If you do not take an exam, a grade of zero will be assigned for that exam. If you miss an exam for a medical emergency, you will be asked to document the emergency. If you anticipate missing an exam for any other reason, you must prearrange the absence with the instructor at least one week ahead of the scheduled time for the exam. Make-up exams may be oral or written, at the discretion of the instructor.
  • 3. Academic dishonesty: academic dishonesty in any portion of the academic work for a course shall be grounds for awarding a grade of F or N for the entire course. For this course academic dishonesty would involve any attempt to copy information from another student during examinations; to fraudulently request a re-grade by altering an exam after it is returned; or to consult notes, texts or other material not provided by the instructor during examinations. Workload: For undergraduate courses, one credit is defined as equivalent to an average of three hours of learning effort per week (over a full semester) necessary for an average student to achieve an average grade in the course. For Biology 4003, a three credit course that meets for 2.5 hours a week, a student should expect to spend an additional five to six hours a week on coursework outside the classroom. HELP! There will be scheduled help sessions with the TA and the instructor before each examination. Office hours for the instructors and TA are listed above, and we are always available by e-mail. Questions submitted by e-mail will be answered either by e-mail or in class if they are of general interest. The instructors will usually remain after class to answer any questions. RECOMMENDED METHOD TO MASTER GENETICS AND ACHIEVE AN “A” Before each lecture: Read the assigned text book pages in a casual manner to become familiar with the topic. Do not try to master it all. Exams will cover only material discussed in lecture, and many details in the text will be omitted. Attend the lecture: This is VERY IMPORTANT. The lecture discussions are the basis for exams. The instructor will demonstrate how to solve important problems that are VERY SIMILAR to exam questions. During and after lectures, you have opportunities to ask questions about any aspects of the course material that are unclear to you. After each lecture: Work the assigned homework problems to test your understanding. Review your notes and the textbook to make sure you have mastered the topic. If there is something you don’t understand, GET HELP SOON! To master genetics, you have to practice solving genetics problems. The course builds on itself over the course of the semester. If you get lost in the beginning, it will be very difficult to catch up. Before each exam: Work the problems on the practice exams. These are ACTUAL EXAMS from last year! Your exams will be VERY SIMILAR! Come to the special help sessions before each exam. These will consist entirely of the instructor and the TA answering homework and practice exam problems on request. Note that you should have worked the practice exams before going to the help sessions.
  • 4. COURSE OUTLINE Date Topic Text references September 3 Introduction. Mitosis, meiosis, Chapter 2: pp. 17-33 gametes. Chapter 3: pp. 42-46 Mendel’s principles September 5 Mendel's principles; monohybrid Chapter 3: pp. 46-53 and dihybrid crosses and beyond September 8 Human pedigrees Chapter 3: pp.53-57 Extensions of Mendelian Chapter 4: pp. 65-68 genetics: allelic variation September 10 Extensions of Mendelian Chapter 4: pp. 70-80 genetics;dominance and recessiveness, epistasis September 12 Chromosomal basis of Mendel’s Chapter 5 pp. 85-100 rules. Sex linkage; sex determination; dosage compensation. September 15 Variation in chromosome number Chapter 6 pp. 100-122 and structure; cytogenetics; chromosome rearrangements September 17 Linkage and recombination: Two- Chapter 7 pp. 129-137 point testcrosses September 19 Linkage and recombination: Chapter 7 pp. 137-142 Three-point test crosses and genetic mapping September 22 Genetic mapping in humans Chapter 7 pp. 142-151 September 24 Fungal genetics: Tetrad analysis Chapter 8 pp. 190-199 and centromere mapping September 26 First Exam September 29 DNA and chromosome structure Chapter 9 pp. 210- 214, 220- 231 October 1 DNA replication Chapter 10 pp. 241-273 October 3 Transcription Chapter 11 pp. 279-291 October 6 RNA processing Chapter 11 pp. 291-307 October 8 Translation and the Genetic Code Chapter 12 pp. 311-338 October 10 Mutation Chapter 13 pp. 342-362 October 13 Repair and recombination Chapter 13 pp. 362-374 October 15 Bacterial Genetics Chapter 8 pp. 163-190 October 17 Bacterial Genetics II October 20 The Complementation Test and Chapter 14 pp. 380-398 the definition of the gene October 22 The Complementation Test and Chapter 14 pp. 398-408 the definition of the gene II October 24 Second Exam October 27 Transposons Chapter 18 pp. 524-545 October 29 Dr. Nathan Springer: Chapter 15 pp. 417-428 Restriction enzymes and recombinant DNA October 31 Dr. Nathan Springer: Chapter 15 pp. 430-434, Genomic and cDNA libraries, 438-448 hybridization, and DNA sequencing November 3 PCR Chapter 15 pp. 438-439
  • 5. November 5 Genome mapping and map- Chapter 16 pp. 453-470 based cloning November 7 Genome sequencing and Chapter 16 pp. 470-483 functional analysis November 10 Molecular genetics in humans Chapter 17 pp. 492-506 November 12 Transgenic organisms. Reverse Chapter 17 pp. 506-517 genetics November 14 Regulation of bacterial gene Chapter 20 pp. 569-580 expression I: Catabolite repression and the lac operon November 17 Regulation of bacterial gene Chapter 20 pp. 580-595 expression II: Attenuation; regulation of lysogeny November 19 Eukaryotic gene expression Chapter 21 pp. 599-612 November 21 Third Exam November 24 Eukaryotic gene expression II Chapter 21 pp. 612-628 November 26 No class? November 28 Thanksgiving-No Class December 1 miRNAs and RNAi Chapter 21 pp. 612-614 and supplemental materials December 3 Topic to be determined if we have time at this point December 5 Topic to be determined if we have time at this point December 8 Population genetics Chapter 26 pp. 737-755 December 10 Genetic analysis in model Supplemental materials organisms FINAL EXAM 1:30pm-3:30pm Saturday, December 13