Biology 4003 Genetics Course Syllabus Fall 2008
Meeting time and place: Monday Wednesday Friday, 1:55 - 2:45 P.M.
B35 Classroom-Office Building
Instructor: Dr. Jane Glazebrook
Rm 324 Cargill Laboratory of Plant and Microbial Genomics
Office hours: Monday 10:00-11:00 Rm 324 Cargill
Thursday 1:00-2:00 Rm 324 Cargill
Teaching assistant: Wei-Shan Hsu
(612) 624-4966 e-mail: firstname.lastname@example.org
Office hours: Monday 4:00-5:00 MCB 6-118
Wednesday 11:00-12:00 MCB 6-118
Course website: http://cbs.umn.edu/courses/glazebrook
Text: Principles of Genetics Snustad and Simmons, 4th edition (Wiley). NOTE: Almost
all of the figures to be used during lecture will come from the text. You might find it
helpful to bring the text to class.
Optional text: Study Guide and Problems Work Book. H. James Price (Wiley). This
paperback book has expanded problem sets and the answers to all problems in the book.
Reserve: The required and optional texts are on reserve in the McGrath library in St. Paul
and the biomedical library in Minneapolis.
DEFINITIONS OF GRADES & ACADEMIC WORKLOAD EXPECTATIONS
A: achievement that is outstanding relative to the level necessary to meet course
B: achievement that is significantly above the level necessary to meet course
C: achievement that meets the course requirements in every respect.
D: achievement that is worthy of credit even though it fails to meet fully the course
F: Represents failure and signifies that the work was either (1) completed but at a level of
achievement that is not worthy of credit or (2) was not completed and there was no
agreement between the instructor and the student that the student would be awarded an I .
Incompletes: The grade of "I" will be given only in response to extreme hardship,
usually medical emergencies, preventing completion of course requirements. A request
for an "I" grade must be made in writing before the last day of class. There is an official
form, available from the CBS Student Services Office, which must be filled out to apply
for an incomplete. If an "I" is assigned the student and instructor must reach agreement
on the nature of the incomplete work and the specific actions to be taken to complete the
course. University policy specifies that an "I" grade lapses automatically to "F" or "N" if
the work is not completed by the end of the next semester.
Course grading: There will be three in-class exams during the semester, and a final
exam. Each exam will consist of problems along with multiple choice and short answer
questions. There will be no opportunities for extra credit work. Your grade will be
determined entirely by your performance on these examinations.
Mid-term 1 - 100 points Friday, September 26
Mid-term 2 - 125 points Friday, October 24
Mid-term 3 - 125 points Friday, November 21
Final exam - 150 points 1:30pm-3:30pm Saturday, December 13
The weighting on the final exam will be 40 points for material taught after the 3rd mid-
term and 110 points for material taught in the rest of the course.
Exams are designed to be finished during one class period (mid-terms) or two hours
(final). Provided that there is no class using our room immediately after us, 30 minutes
of extra time will be allowed for students who want it.
Course grades will be determined based on the number of points earned out of the 500
Guaranteed curve: Grading will not be more severe than shown below. Depending in
part on the performance of the class as a whole, it may be more lenient. Last year, it was
very close to this:
above 425: A
above 375: at least a B
above 300: at least a C
above 225: at least a D
Grades of A-, B+, B-, and C+ will also be assigned. The points required for these grades
will be determined after all the exams are over, and will be based on the distribution of
student point totals.
Missed exams: If you do not take an exam, a grade of zero will be assigned for that
exam. If you miss an exam for a medical emergency, you will be asked to document the
emergency. If you anticipate missing an exam for any other reason, you must prearrange
the absence with the instructor at least one week ahead of the scheduled time for the
exam. Make-up exams may be oral or written, at the discretion of the instructor.
Academic dishonesty: academic dishonesty in any portion of the academic work for a
course shall be grounds for awarding a grade of F or N for the entire course. For this
course academic dishonesty would involve any attempt to copy information from another
student during examinations; to fraudulently request a re-grade by altering an exam after
it is returned; or to consult notes, texts or other material not provided by the instructor
Workload: For undergraduate courses, one credit is defined as equivalent to an average
of three hours of learning effort per week (over a full semester) necessary for an average
student to achieve an average grade in the course. For Biology 4003, a three credit course
that meets for 2.5 hours a week, a student should expect to spend an additional five to six
hours a week on coursework outside the classroom.
HELP! There will be scheduled help sessions with the TA and the instructor before each
examination. Office hours for the instructors and TA are listed above, and we are always
available by e-mail. Questions submitted by e-mail will be answered either by e-mail or
in class if they are of general interest. The instructors will usually remain after class to
answer any questions.
RECOMMENDED METHOD TO MASTER GENETICS AND ACHIEVE AN “A”
Before each lecture: Read the assigned text book pages in a casual manner to become
familiar with the topic. Do not try to master it all. Exams will cover only material
discussed in lecture, and many details in the text will be omitted.
Attend the lecture: This is VERY IMPORTANT. The lecture discussions are the basis
for exams. The instructor will demonstrate how to solve important problems that are
VERY SIMILAR to exam questions. During and after lectures, you have opportunities to
ask questions about any aspects of the course material that are unclear to you.
After each lecture: Work the assigned homework problems to test your understanding.
Review your notes and the textbook to make sure you have mastered the topic. If there is
something you don’t understand, GET HELP SOON! To master genetics, you have to
practice solving genetics problems. The course builds on itself over the course of the
semester. If you get lost in the beginning, it will be very difficult to catch up.
Before each exam: Work the problems on the practice exams. These are ACTUAL
EXAMS from last year! Your exams will be VERY SIMILAR! Come to the special
help sessions before each exam. These will consist entirely of the instructor and the TA
answering homework and practice exam problems on request. Note that you should have
worked the practice exams before going to the help sessions.
Date Topic Text references
September 3 Introduction. Mitosis, meiosis, Chapter 2: pp. 17-33
gametes. Chapter 3: pp. 42-46
September 5 Mendel's principles; monohybrid Chapter 3: pp. 46-53
and dihybrid crosses and beyond
September 8 Human pedigrees Chapter 3: pp.53-57
Extensions of Mendelian Chapter 4: pp. 65-68
genetics: allelic variation
September 10 Extensions of Mendelian Chapter 4: pp. 70-80
September 12 Chromosomal basis of Mendel’s Chapter 5 pp. 85-100
rules. Sex linkage; sex
September 15 Variation in chromosome number Chapter 6 pp. 100-122
and structure; cytogenetics;
September 17 Linkage and recombination: Two- Chapter 7 pp. 129-137
September 19 Linkage and recombination: Chapter 7 pp. 137-142
Three-point test crosses and
September 22 Genetic mapping in humans Chapter 7 pp. 142-151
September 24 Fungal genetics: Tetrad analysis Chapter 8 pp. 190-199
and centromere mapping
September 26 First Exam
September 29 DNA and chromosome structure Chapter 9 pp. 210- 214, 220-
October 1 DNA replication Chapter 10 pp. 241-273
October 3 Transcription Chapter 11 pp. 279-291
October 6 RNA processing Chapter 11 pp. 291-307
October 8 Translation and the Genetic Code Chapter 12 pp. 311-338
October 10 Mutation Chapter 13 pp. 342-362
October 13 Repair and recombination Chapter 13 pp. 362-374
October 15 Bacterial Genetics Chapter 8 pp. 163-190
October 17 Bacterial Genetics II
October 20 The Complementation Test and Chapter 14 pp. 380-398
the definition of the gene
October 22 The Complementation Test and Chapter 14 pp. 398-408
the definition of the gene II
October 24 Second Exam
October 27 Transposons Chapter 18 pp. 524-545
October 29 Dr. Nathan Springer: Chapter 15 pp. 417-428
Restriction enzymes and
October 31 Dr. Nathan Springer: Chapter 15 pp. 430-434,
Genomic and cDNA libraries, 438-448
hybridization, and DNA
November 3 PCR Chapter 15 pp. 438-439
November 5 Genome mapping and map- Chapter 16 pp. 453-470
November 7 Genome sequencing and Chapter 16 pp. 470-483
November 10 Molecular genetics in humans Chapter 17 pp. 492-506
November 12 Transgenic organisms. Reverse Chapter 17 pp. 506-517
November 14 Regulation of bacterial gene Chapter 20 pp. 569-580
expression I: Catabolite
repression and the lac operon
November 17 Regulation of bacterial gene Chapter 20 pp. 580-595
expression II: Attenuation;
regulation of lysogeny
November 19 Eukaryotic gene expression Chapter 21 pp. 599-612
November 21 Third Exam
November 24 Eukaryotic gene expression II Chapter 21 pp. 612-628
November 26 No class?
November 28 Thanksgiving-No Class
December 1 miRNAs and RNAi Chapter 21 pp. 612-614 and
December 3 Topic to be determined if we have
time at this point
December 5 Topic to be determined if we have
time at this point
December 8 Population genetics Chapter 26 pp. 737-755
December 10 Genetic analysis in model Supplemental materials
FINAL EXAM 1:30pm-3:30pm Saturday, December 13