Biology 201 … GENETICS … Spring 1998 … Lecture Schedule

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Biology 201 … GENETICS … Spring 1998 … Lecture Schedule

  1. 1. Biology 201 – GENETICS –Spring 2004 Dr. Alice G. Lee Lecture: M, W, F 1:00- 2:05 p.m. Dieter Porter 208 Dieter-Porter 309 Lab: Tuesday, 2:30 - 5:30 p.m., Dieter-Porter 102 223-5283 aglee@washjeff.edu Blackboard: BIO201 Outcomes: Students who have a basic understanding of genetics from General Biology will further their knowledge of Mendelian, Molecular and Population genetics. Students will be able to quantitatively study the genetics of different organisms, to collect and analyze data from various organisms, to use different statistical and mathematical methods, to write scientific reports of their findings, and will have an appreciation of the technical bioethical considerations of current genetic research and applications. Lecture Schedule: Date Topic Pages in Text W 2/4/04 Chapter 1: Introduction 9-20 MENDELIAN GENETICS F 2/6/04 Chapter 2: Fundamentals of Mendelian Genetics 21-44 M 2/9/04 W 2/11/04 Chapter 3: Extensions and Applications of Mendelian Genetics 45-74 F 21/13/04 M 2/16/04 W 2/18/04 Quiz I ♣Water Plants in lab on 2/18 after class 75-104 and on 2/19 outside of class F 2/20/04 Chapter 4: Chromosomes and Heredity ♣Thin Plants in lab after class M 2/23/04 Chapter 5: Genetic Linkage 105-130 W 2/25/04 F 2/27/04 Exam I (Covers Mendelian Genetics) MOLECULAR GENETICS M 3/1/04 Chapter 6: Chemistry of Genes 131-152 W 3/3/04 ♣Cross-Pollinate in lab (also need to do on 3/4/04) F 3/5/04 NO CLASS: HHMI Mtg. on campus all day. Please visit poster session in afternoon. M 3/8/04 Chapter 7: Replication and Recombination of Genes 153-180 W 3/10/04 Chapter 8: Transcription and Its Control in Prokaryotes 181-202 F 3/12/04 Quiz II Chapter 9: Eukaryotic Gene Structure and Expression 203-236 M 3/15/04 W 3/17/04 F 3/19/04 Chapter 10: Translation 237-268 M 3/29/04 W 3/31/04 Exam II (Covers Molecular Genetics through Translation) F 4/2/04 Chapter 11: Gene Mutation I: DNA Damage and Repair 269-294 M 4/5/04 W 4/7/04 Chapter 12: Gene Mutation II: Transposable Elements and Cancer 295-310 F 4/9/04 M 4/12/04 Chapter 13: Genetics of Bacteria and Phages 311-336 W 4/14/04 F 4/16/04 GUEST SPEAKER: Andy Lepisto, “Cancer Immunology”-tent. date Chapter 14: Developmental Genetics M 4/19/04 ♣Count Seedlings--in lab during class 337-362 W 4/21/04 and recount on 4/22/04 outside of class F 4/23/04 Chapter 15: Gene Cloning and Manipulation 362-404 M 4/26/04 W 4/28/04 Quiz III F 4/30/04 Bioinformatics Handout POPULATION GENETICS M 5/3/04 Chapter 16: An Introduction to Population Genetics 405-430 W 5/5/04 F 5/7/04 Chapter 17: Extensions and Applications of Population Genetics 431-453 M 5/10/04 M 5/17/04, 2-5 p.m. Final Exam (Gene Mutation through Pop. Genetics and Laboratory) 201-Genetics
  2. 2. Biology 201 – GENETICS –Spring 2004– Dr. Alice G. Lee Laboratory Schedule: Tuesday, 2:30-5:30 p.m., Dieter-Porter 102 Assistant: Brooke Helfer Date Investigation 2/10/04 Safety Video (1 hour) 3 Principles of Probability 4 The Chi-Square Test (Parts IA and ID) (You are responsible for doing part IC on your data from Investigations 2 and 3.) 2/17/04 2 ♣Plant Brassica rapa, F1 seeds. Drosophila Dihybrid Crosses (Adult flies will be removed in the morning so that virgin females can be obtained during lab.) 2/18/04, ♣Water B. rapa with pipette from above—mandatory. 2/19/04, 2/20/04 2/20/04 ♣Thin to one plant per cell—after lecture-- mandatory. 2/24/04 ♣Check plants and reservoir levels. Check F1 from Drosophila crosses. Remove parent flies (P1) from crosses. 11 Human Chromosomes 3/2/04 Mate F1's to produce F2. ♣Cross-pollinate B. rapa. 3/3/04 ♣Cross-pollinate B. rapa. –during lecture time. 1:00 p.m. 3/4/04 ♣Cross-pollinate B. rapa and remove any unopened flower buds—outside of class-- mandatory. 3/9/04 8 Polytene Chromosomes from Drosophila Salivary Glands Check F2 Drosophila. Remove F1 parents. 3/16/04 Determine phenotypes and sex of F2 from Drosophila crosses and record in Table 2.1. **Report on Karyotype (Investigation 11) is due. Note: Assistant will cross Sordaria next week (Part I or Investigation 13). 3/30/04 13 Genetics of Ascospore Color in Sordaria. An Investigatino of Linkage and Crossing Over (Parts II, III, IV) **Report on Investigation 2 (with Chi-Square analysis) is due. ♣Remove plants from watering system and allow pods to dry in paper bags on lighting apparatus. 4/6/04 handout Chromosome 8: Gene Amplification of the Alu-TPA Gene by PCR (Prepare samples and amplify) ♣Remove bags of pods from light bank. 4/13/04 handout Chromosome 8: Gene Amplification of the Alu-TPA Gene by PCR (Electrophoresis and determine genotype for Alu insertion) (Hardy-Weinberg Analysis of class data) 4/20/04 ♣Harvest seeds and sprout on filter paper. Hand out PTC paper. 4/21/04 ♣Count seedlings—during lecture time. 1:00 p.m. 4/22/04 ♣Recount seedlings-mandatory Time TBD (Dr. Lee will arrange a time for you to come to the lab and work.) 4/27/04 24 Population Genetics: The Hardy-Weinburg Law **♣B. rapa Chi-Square analysis and workbook due. 5/4/04 23 Polygenic Inheritance: Fingerprint Ridge Count. **Questions from Chromosome 8 Gene Amplification are due. 5/11/04 **Gene Frequencies and Chi-Square on ABO data (Investigation 24) are due. Review for Final Exam 201-Genetics
  3. 3. Biology 201 – GENETICS –Spring 2004 (cont.) Text: Weaver, R. F. and Hedrick, P.W. 1995. Basic Genetics. 2nd ed. William C. Brown Publishers, Dubuque, IA. Problems Book: Zwicker, K.2003. Student Study Guide in Genetics. 7th ed. William C. Brown Publishers, Dubuque, IA. Laboratory Manual: Mertens, T.R. and R.L. Hammersmith. 2001 Genetics Laboratory Investigations, 12th ed., Prentice-Hall, Upper Saddle River, N.J. Attendance: is expected in lecture and is required in lab. There will be no make up laboratories. Ten points will be deducted from a student’s grade for every unexcused absence from lab. If a laboratory activity is scheduled during lecture time and you miss class, it will be considered a laboratory absence. Laboratory Reports: You are responsible for completing all assigned investigations. Please read the laboratory exercise before coming to lab. You should take notes during the laboratory in your notebook and/or lab manual and use them for calculations and for studying. Reports of many of the investigations will be turned in for a grade. Unless otherwise specified, you will complete forms for data, answer questions and do calculation specified in the lab manual, rather than turning in a full lab report. Please type onto the forms or word-process new tables onto another sheet of paper. Grading: Exam I 100 points Exam II 100 points Final Exam 200 points Quiz I 10 points Quiz II 10 points Quiz III 10 points Report on Investigation 2 25 points Report on Investigation 11 25 points Questions from Alu lab 25 points Report on Investigation 24 25 points B. rapa analysis 25 points Total: 555 points 201-Genetics
  4. 4. Other References Dr. Alice G. Lee 2004 Journals Received by W&J Library: Genetics Journal of Heredity Nature Science Scientific American Cell Journal of Biological Chemistry Books at W&J Library: Drlica. Understanding DNA & Gene Cloning: A Guide for the Curious. Tudge. The Engineer in the Garden: Genes and Genetics: From the Idea of Heredity to the Creation of Life. Lewin. Genes IV. Bollag and Edelstein. Protein Methods. Coombs. Dictionary of Biotechnology. 2nd ed. Berg. Dealing with Genes. McGrayne. Nobel Prize Women in Science. Hoy. Insect Molecular Genetics. Corcos. Gregor Mendel’s Experiments on Plant Hybrids. Johnson. How Scientists Think. Weismann. Democracy and DNA. Kitcher. The Lives to Come: The Genetic Revolution and Human Possibility. Vaughan. How Life Begins: The Science of Life in the Womb. Aldridge. The Thread of Life: The Story of Genes Books of Dr. Lee’s: Lewin. Genes VII. Maniatis. Molecular Cloning. Watson. Recombinant DNA Technology, 2nd. ed. Alberts. Molecular Biology of the Cell, 4th ed. Bolsolver. From Genes to Cells. Weaver. Molecular Biology, 2nd ed. Campbell and Heyer. Genomics, Proteomics and Bioinformatics. Videos of Dr. Lee’s: Discovering Women (in Science) Murder, Rape and DNA Recombinant DNA Technology The Building Blocks of Life Genetic Engineering The Double Life of RNA (HHMI) The Secret of Life (Biology Department) The Immune System (HHMI) Making Babies (PBS) Clockwork Genes (HHMI) A Harvest of Fear (PBS-NOVA) CD-ROMS of Dr. Lee’s: Explorations in Cell Biology and Genetics Hyper Cell An Electronic Companion to Genetics Cells and Genes 201-Genetics
  5. 5. Web Sites: Genetics Science Learning Center Experiments and background information Go to "Basic Genetics" at http://gslc.genetics.utah.edu/ Mendel Web: Experiments in Plant Hybridization e-mail rblum@netspace.org/MendelWeb/ or use Yahoo to search for “MendelWeb” or http://morgan.harvard.edu BioMolecules in the Classroom: Educational Molecular Visualization with Chime & RasMol http://klaatu.oit.umass.edu/microbio/rasmol/rasclass.htm EXTOXNET - The Extension TOXicology NETwork (pl of 3) http://ace.orst.edu/info/extoxnet/ The National Center for Biotechnology Information http://www.ncb.nlm.nih.gov/ BioChemNet. . . a directory of biology and chemistry educational resources http://schmidel.com/bionet.htm Medscape Home Page http://www.medscape.com Virtual FlyLab http://vflylab.calstatela.edu/edesktop/VirtApps/VflyLab/IntroVflyLab.html Virtual Cell http://ampere.scale.uiuc.edu/~m-lexa/cell/cell.html CellsAlive! http://www.cellsalive.com/ Biology Place (Benjamin-Cummings) http://www.biology.com Inheritance Patterns Analysis: Cotrix http://www.rrz.uni-hamburg.de/OeKoGenetik/welcome.htm The Biology Project (tutorials, animations and “Test Yourself”) http://www.biology.arizona.edu The National Biotechnology Information Facility (tutorials and information, including ABO Blood Group tutorial) http://www.nbif.org/course/course.html The Darwin Awards (for your amusement) http://www.darwinawards.com/ 201-Genetics

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