Genetics Syllabus                                                Dr. Suzanne Gollery – Spring 2007

Course Code & No. - Se...
Genetics Syllabus                                                   Dr. Suzanne Gollery – Spring 2007

    -   Students ar...
Genetics Syllabus                                                 Dr. Suzanne Gollery – Spring 2007

Grading Policy: Sinc...
Genetics Syllabus                                                 Dr. Suzanne Gollery – Spring 2007

      format instruct...
Genetics Syllabus                                              Dr. Suzanne Gollery – Spring 2007

      Note: This syllabu...
Genetics Syllabus                                                         Dr. Suzanne Gollery – Spring 2007

Genetics Syllabus                                                          Dr. Suzanne Gollery – Spring 2007

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BIOL 410-1


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BIOL 410-1

  1. 1. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 Course Code & No. - Section: BIOL 410 and BIOL 415 – Sections 1 Course Title (Credits): Genetics (3) and Lab (1) Term & Year: Spring / 2007 Course Ref. No. (CRN): 10049 and 10050 Instructor: Dr. Suzanne W. Gollery Phone(s): x7456 or 775-832-0747 (7 a.m. - 9 p.m.) Email: Office: TCES, Second floor cubicle (by Jim Mullaney’s office) Office Hours: MWR 11:00 a.m. to 12:00 noon, and by appointment Class Meeting Time: MWF 12:00 noon – 1:55 p.m. (BIOL 410) F 2:00 – 4:50 p.m. (BIOL 415) Location: TCES, Room 206 (Biology Lab) Prerequisites (from Catalog): BIOL 101, BIOL 102, and MATH 215 (Statistics) Co-requisites (from Catalog): BIOL 410 and BIOL 415 are co-requisites Course Description: BIOL 410: Introduction to the transmission and expression of genetic material as it occurs in nucleate organisms from yeast to man. The genetic biology of eukaryotes is considered on the molecular, cellular, developmental, familial and population levels, with emphasis on inferences drawn from experimental observations. BIOL 415: Introduction to modern molecular genetic techniques, including recombinant DNA technology, restriction mapping, Southern blotting, PCR, DNA sequencing, and bioinformatics. Student Outcomes: - Students mastering the material of Genetics will demonstrate sufficient understanding and recall of the transmission and expression of genetic material of eukaryotes to be successful in graduate level biology and health science courses. - Students will demonstrate skill at reading and comprehending science texts. - Students will demonstrate ability to answer questions about eukaryotic genetics like those on standardized exams (such as the GRE, MCAT, or senior exit exams). - Students will communicate about and critique scientific concepts in paragraph form. - Students will demonstrate skill at critical analysis, logic, and problem solving relating to the transmission and expression of eukaryotic genetic material. - Students will demonstrate competence in basic molecular genetics techniques. - Students will demonstrate competence in presenting and analyzing scientific data in the format used by peer-reviewed scientific journals Methods of Assessing Student Outcomes: Mastery of Genetics material, writing, and laboratory skills will be assessed through: - Homework assignments coordinated with each text chapter - Exams (covering 4 to 6 chapters) in multiple choice, matching, true or false, and short answer format - A comprehensive final exam in multiple choice, matching, true or false, and short answer format - Written laboratory reports in the format of scientific papers Instructional Strategies: In order to communicate a body of knowledge, concepts, and skills in genetics, Genetics and Lab will utilize: - Lectures and lecture discussions - Laboratory exercises coordinated with lecture topics - Written homework assignments coordinated with lecture topics to encourage prompt and thorough reading of the text - Quizzes to provide feedback to students about their understanding of material before the exams. 1
  2. 2. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 - Students are encouraged to use the publisher’s companion web site to accompany the text, including tutorials, quizzes, and links to related sites. - Student study groups outside of class time are greatly encouraged! - Course material and resources will be available on a Moodle page. Required Texts and Materials: (The two required texts are packaged together under ISBN: 9780131593503) 1) Klug, Cummings, and Spencer, Essentials of Genetics, 6/e, Pearson/Prentice Hall, 2007. ISBN: 0-13-224127-7 2) Mertens and Hammersmith, Genetics Laboratory Investigations, 13/e, Pearson/Prentice Hall, 2007. ISBN: 0-13-174252-3 3) Internet access. A lap-top computer is recommended, as some laboratory exercises will include on-line activities. Students can complete the course using internet access available in SNC’s Prim Library. Supplemental Materials: 1) The course syllabus, handouts, and other material will be posted on a Moodle site at . 2) The publisher supports an anatomy and physiology web site ( to accompany the text. This well-designed resource includes animations, tutorials, quizzes, and links to related web sites. A fast internet connection is recommended. Students will learn how to access the companion web site during the first class period. 3) Current articles related to class topics from highly readable sources such as Science News or Scientific American may be assigned as supplemental reading. These will be distributed in class and posted on the course Moodle site. Attendance: Success in Genetics and Lab is largely dependent on faithful attendance at class and lab periods. Thus, laboratory reports will be accepted only from students who have attended and performed the laboratory exercise. Students MAY NOT be allowed to make up missed labs and exams. Since life happens, students may seek to excuse an absence and have an opportunity to do make up work for missed points. Absences will be excused for illness (of the student or a dependent) with a physician’s excuse, military duty, a family bereavement, or at the instructor’s discretion. Excused absences will NOT be granted for employment conflicting with class times, vacations, or oversleeping. Sanctions for Cheating and/or Plagiarism Plagiarism is “passing off a source’s information, ideas, or words as one’s own by omitting to acknowledge the sources.” This refers to all sources of information, including the Internet, the text, the instructor, and classmates. The following policy regarding cheating and plagiarism has been established: • First offense: Student receives a failing grade for that assignment; the instructor notifies the advisor and the Vice President of Academic Affairs. Students identified as committing an act of plagiarism will be referred to Student Services. • Second offense in the same class or any other class that semester or subsequent semesters: Student receives a failing grade for the class where the second offense takes place; the instructor notifies the advisor and the Vice President of Academic Affairs. • Third offense: The student is expelled from Sierra Nevada College. The instructor notifies the advisor and the Vice President of Academic Affairs. Mandatory Special Accommodations (ADA) Statement “Academic Accommodations: In accordance with the Americans with Disabilities Act and Section 504 of the Rehabilitation Act of 1973, students with a documented disability are eligible for support services and accommodations. If a student wishes to request an accommodation, contact the Director of Student Services (Prim Library room 323) at (775) 831-1314 x7534 within the first week of the semester.” 2
  3. 3. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 Grading Policy: Since BIOL 410 and 415 are co-requisites, and the material of each is so integral to the other, assignments from each will contribute to an overall point total and the same letter grade will be awarded to both courses. The grading curve is based on a 1000-point scale, with 77.5% of points from BIOL 410 and 22.5% from BIOL 415. Sierra Nevada College awards half grades (e.g., A– or B+), so a student with a point total within 1.5% of the cutoff for the letter grade will earn the appropriate half grade. Grading Curve Students may earn points in the following ways: A 90 – 100% 900 – 1000 BIOL 410 (77.5%): points Homework – 20 (of 23) at 10 points each 200 points B 80 – 89 % 800 – 899 Genetics Ethics presentation 75 points points Exams – 5 at 60 points each 300 points C 65 – 79% 650 – 799 Final Exam 200 points points D 50 – 65% 500 – 649 BIOL 415 (22.5%): points Lab Reports – 9 (of 10) at 25 points each 225 points F <50% <500 points Total 1000 points Homework: Students are assigned homework to encourage prompt reading of the text and review of class material, and to provide feedback about students’ understanding of important concepts before the exams. Assigned chapter problems and due dates are posted in the syllabus packet and on the moodle site, and will usually be posted on the whiteboard in class before homework is due. A student’s 20 best homework scores will count toward the grade. Homework may be hand-written (if legible) or typed (hard copy or e-mailed file). Exams: Five exams will cover material from the previous four to six chapters. Exams include multiple choice questions, since this format is used on standardized exams, such the GRE and MCAT. Other questions may include genetics problems, short answer, matching, essay, or true-false formats. Make-up exams will not be given without an excused absence. Students will have hard copy exams. Quizzes: Five hard copy quizzes covering material from two or three chapters will be given at the beginning of class periods indicated on the running schedule of classes for BIOL 410. The purpose of the quizzes is to encourage students to keep up on reading and studying, and to provide feedback about students’ understanding of the material before the exams. Quizzes will NOT count toward a student’s grade. HOWEVER, a student may substitute the cumulative quiz score for a lower exam score. (This will be most important if a student misses an exam.) Students will NOT be given extra time for a quiz if tardy, and make-up quizzes will NOT be scored. Final Exam: A comprehensive final exam with a format similar to the five exams will be given at the time scheduled by the SNC registrar. The final exam date, day, and time will be announce in class and posted on the Moodle site as soon as the SNC Spring 2007 final exam schedule is published. The entire SNC final exam schedule will be posted on the SNC web site at Academics/Registrar/Spring 2007 Schedules/Final Exam Schedule. Lab Reports: Students will compose lab reports in the style of scientific research reports, including introduction, materials and methods, data/results, discussion/conclusion, and citations. Lab report 3
  4. 4. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 format instructions will be discussed in detail during the first lab session. The 9 best lab report scores will count toward the student’s grade. Midterm grades: Midterm grades will be calculated using all work due through Monday, March 5, 2007. Due dates and late work: Homework and laboratory assignments are designed to help students learn the material and provide feedback before periodic examinations. Thus, work completed in a rush at the end of the semester serves little purpose. Accordingly, the instructor will adhere strictly to following late work policy: - Assignments are due at the BEGINNING of the class period assigned as the due date. Work turned in after class on the due date will be considered one day late. - Due dates are listed on the running schedule of classes for BIOL 410 and 415, and on any handouts describing the assignments. The running schedule and all assignment handouts are posted on the class Moodle site. - Late work will be accepted, HOWEVER, 10% of the possible points will be deducted for each CALENDAR day that the work is late. (Work handed in at the end of the class period will be considered late by one calendar day.) - Work that is more than seven calendar days late will NOT be accepted. - If a student anticipates an absence on a date that work is due, it is the student’s responsibility to get the work to the instructor on or before the due date. - Extra credit will NOT be accepted late after Friday, April 20, 2007. - Students may submit work in hard copy or by e-mail, and are encouraged to use e-mail in order to avoid penalties for late work. It is the student’s responsibility to ensure that e- mailed work has been received by the instructor; students should contact the instructor if a reply to e-mailed assignments is not returned. - Early or late work may be placed on the instructor’s office chair, in her faculty mailbox, or e-mailed. Extra credit: The content of extra credit assignments is designed to provide additional information related to course topics. Extra credit assignments may be used to make up points lost due to absences and to supplement a student’s point total to earn the next higher grade. Students may earn up to 50 points in extra credit (5% of total points possible). There are several options for earning extra credit, with point values assigned commensurate with the amount of work involved. These are listed on the Extra Credit handout in the syllabus packet, which is also posted on the class Moodle site. If more than 50 points of extra credit are accrued, the maximum of 50 points will be assigned to a student’s score. CAUTION! Most regular assignments and exams are worth more points than most extra credit assignments, so time should be devoted first to preparing regular assignments. All extra credit is due by Friday, April 20, 2007, and will NOT be accepted as late work after that time. Some extra credit options have earlier due dates. Schedule of classes: The following schedule is the instructor’s best estimate of which topics will be started on which dates, assignments due dates, and quiz and exam dates and coverage. The schedule is subject to change at the instructor’s discretion. A most current schedule for two or three upcoming class periods will be posted on the whiteboard during each class. If the actual class schedule will deviate permanently from the published one, the instructor will post and distribute a revised class schedule for the remainder of the semester. 4
  5. 5. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 Note: This syllabus is intended to provide students with a clear and accurate outline of course content, student outcomes, class topics, assignments and due dates, and exam dates. Students should keep and refer to the syllabus regularly, and learn how to access it on the course Moodle page. The instructor reserves the right to make announced changes to the syllabus and class schedule at her discretion if it is in the best interest of the students to do so. Major changes, such as changes to exam dates or coverage and permanent changes to the schedule, will be posted on the Moodle site and students will be e-mailed about such postings. 5
  6. 6. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 Schedule of classes for Genetics (BIOL 410) and Genetics Lab (BIOL 415) Spring Semester 2007 Work Date Day Reading Topics Begun Due Lab Exercises Lab Due 15-Jan M Martin Luther King Holiday 17-Jan W Syllabus Introduction to Genetics and Lab Introduce genetics ethics topics 19-Jan F Chapter 1 Genetics background assessment Class Begin Lab 1: Drosophila work dihybrid crosses 22-Jan M Chapter 2 Cell cycle, mitosis, and meiosis Ch 1 24-Jan W Chapter 3 Mendelian postulates and modern terminology 26-Jan F Chapter 3 Forked line method, χ2 test, and human Ch 2 Lab Supplement 3: Human pedigree pedigree analysis analysis; Gather Drosophila data 29-Jan M Chapter 4 Allele symbols, parital dominance, and Genetics ethics topic idea due multiple alleles Quiz on Chapters 1 - 3 31-Jan W Chapter 4 Gene interaction, X-linked, and sex-linked Ch 3 inheritance Gather Drosophila data Human 2-Feb F Chapter 4 Phenotypic expression and extranuclear Lab 2: Principles of probability pedigree inheritance Lab 3: χ2 test on Drosophila data analysis 5-Feb M Exam 1: Chapters 1 - 4 Ch 4 7-Feb W Chapter 5 Sex determination and sex chromosomes Non-disjunction, aneuploidy, and Lab 11: Linkage Analysis (crosses) Drosophila 9-Feb F Chapter 6 polyploidy Lab 9: Sex chromatin in human cells dihybrid cross 12-Feb M Chapter 6 Chromosomal rearrangements Ch 5 Chapter 7 Linkage and mapping 14-Feb W Chapter 7 More linkage and mapping 16-Feb F Chapter 9 DNA and RNA structure Ch 6 Lab 12: Tetrad Analysis (crosses) Sex chromatin 19-Feb M Presidents' Day Holiday DNA replication 21-Feb W Ch. 10 Quiz on Chapters 5 - 7 Ch 7 Gather/analyze linkage data 23-Feb F Ch. 10 DNA recombination Ch 9 Lab 7: Polytene chromosomes 26-Feb M Exam 2: Chapters 5, 6, 7, 9, and 10 Ch 10 Chromosome structure and DNA 28-Feb W Ch. 11 organization Start DNA digestions at noon Restriction mapping Polytene 2-Mar F Ch. 12 Ch 12: Transcription More linkage analysis? chromosomes 5-Mar M Ch. 13 Translation Ch 11 Ch. 13 Protein structure, domains, and exon Ch 12 7-Mar W Ch. 14 shuffling; Mutations Genetics ethics presentation outline due Lab 19: Chromatographic DNA repair and transposition characteriz- 9-Mar F Ch. 14 Midterm grades due to registrar Ch 13 ation of Drosophila mutants Linkage 12-Mar M SNC spring break to 16-Mar 6
  7. 7. Genetics Syllabus Dr. Suzanne Gollery – Spring 2007 Work Date Day Reading Topics Begun Due Lab Exercises Lab Due Ch. 15 Quiz on Chapters 11 - 14 (pp. 330, Regulation of eukaryotic gene expression 19-Mar M 338-352) Advising begins Ch 14 Ch. 15 More regulation of gene expression 21-Mar W Ch. 16 Cell Cycle Regulation Recombinant DNA: cut DNA, Cut DNA for recombinant DNA lab electro- Restriction 23-Mar F Ch. 16 Cancer Ch 15 phoresis, set up ligations mapping 26-Mar M Exam 3: Chapters 11 - 16 Ch 16 Lab: Transform E. coli with ligations 28-Mar W Ch. 17 Recombinant DNA and DNA libraries Recomb. DNA: Inoculate cultures to 30-Mar F Ch. 17 PCR, analysis of recombinant DNA, and prepare cloned DNAs Drosophila DNA sequencing Lab 26: NCBI and genome data mutants Last day to drop any SNC course!! mining Genomics Registration begins/Dec. Grad. Petitions 2-Apr M Ch. 18 due Ch 17 4-Apr W Ch. 18 Proteomics Recomb. DNA: Isolate plasmid DNA, Genome 6-Apr F Ch. 20 Developmental genetics set up restriction digests mining Quiz on Chapters 17 - 18 9-Apr M Ch. 20 More developmental genetics Ch 18 11-Apr W Ch 19 Genetics Ethics Presentations Electrophoresis of clone DNA; 13-Apr F Ch 19 Genetics Ethics Presentations Ch 20 Identifying GM crops (may start lab at noon and lecture in afternoon) 16-Apr M Exam 4: Chapters 17 - 20 Ch 19 18-Apr W Ch. 21 Quantitative genetics Ch. 21 More quantitative genetics Recomb DNA 20-Apr F Ch. 22 Population genetics Lab 22: Fingerprint ridge count GM crops 23-Apr M Ch. 22 More population genetics Ch 21 25-Apr W Ch. 23 Evolutionary genetics Quiz on Chapters 21 and 22 Ch 22 Quantitative & populations genetics Fingerprint 27-Apr F Ch. 24 Conservation genetics Ch 23 problems study session ridge count 30-Apr M Exam 5: Chapters 21 - 24 Ch 24 2-May W Review session for final exam through Final exam week - date and time of 4-May F 9-May Genetics Final Exam TBA 12-May Sat SNC commencement - 10:00 a.m. 7