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    • Danielle A. Garsin, Ph.D. October 2006 Name: Danielle A. Garsin, Ph.D. Present Title: Assistant Professor Address: University of Texas Health Sciences Center at Houston Department of Microbiology and Molecular Genetics 6431 Fannin St., MSB 1.168 Houston, TX 77030 Tel: (713) 500-5454 Fax: (713) 500-5499 Danielle.A.Garsin@uth.tmc.edu Citizenship: USA Undergraduate education: Cornell University, 1990-1993 B.S., Biological Sciences, 8/1993 Graduate education: Harvard University, 1994-1999 Ph.D., Biochemistry, 6/1999 Postdoctoral training: Massachusetts General Hospital/Harvard Medical School, 1999-2003 Irvington Institute for Immunological Research Post-Doctoral Fellow Academic Appointments: University of Texas Health Science Center at Houston Department of Microbiology and Molecular Genetics Assistant Professor, 12/29/2003-present Professional Organizations: American Society for Microbiology (ASM) The Genetics Society of America (GSA) Honors and Awards: •Travel Award to the 1st International ASM Conference on Enterococci, 2/2000 •Irvington Institute for Immunological Research Postdoctoral Fellow, 1/1/2000-12/31/2002 •Ellison Medical Foundation New Scholar Award in Global Infectious Disease, 8/1/2004-7/31/2008 •UTHSC Committee on the Status of Women Mentor Award Nominee, 11/2006 Editorial Positions: •Ad hoc reviewer for Science, PNAS, PLoS, Genetics, MCB Service on National Grant Review Panels, Study Sections, Committees: •Invited Participant of the National Academies, New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation Workshop, Washington DC, 4/27-29/2005. Service on the University of Texas Health Science Center at Houston Committees: •Association of Women Faculty (AWF), Medical School Representative at Large, 1/2005-present Service on Departmental Committees: •Texas Branch ASM Organizing Committee, 2004 •Microbiology and Molecular Genetics Seminar Program Coordinator, 2005-present •Microbiology and Molecular Genetics Retreat Organizer, 2006-present Service to the Community: •Community associate, Rice University, 2004 – present •Organizer, National Youth Leadership Forum (NYLF) visit to the department, 2005 1
    • Danielle A. Garsin, Ph.D. October 2006 Sponsorship of graduate students: Violeta Chavez, 2004- Kristina Fox, 2005- Sponsorship of postdoctoral fellows: Akiko Mohri, 2005- Sponsorship of undergraduates: Luis Vega (Rice University) 5/2004-6/2005 Sponsorship of graduate student tutorials: Violeta Chavez, 2004 Kate Pfluoghet, 2004 Toni Greene, 2004 Daneen Grossman, 2005 Kristina Fox, 2005 Jennifer Dale, 2005 Member of advisory/supervisory committees: Student Advisory/Supervisory Degree Melanie Hargrove A N/A Melissa Ramirez A/S Amy Courtney A Violeta Chavez A Kristina Fox A Member of Ph.D. candidacy examination committees: Student Chair Date Marenda Wilson 12/15/2004 Cana Ross 12/7/2005 Melanie Hargrove 1/6/2006 Amy Courtney 3/29/2006 Melissa Ramirez 4/13/2006 Daneen Grossman 11/15/2006 Current Teaching Responsibilities: •Microbiology and Molecular Genetics Core course, 7 lectures, 10.5 contact hours •Molecular Basis of Microbial Pathogenesis, 5 lectures, 5 contact hours •Medical Microbiology Laboratory, 9 contact hours •Medical Microbiology Course, 1 lecture, 1 contact hour •Problem Based Learning, 24 sessions, 48 contact hours Current Grant Support: Title: C. elegans as a Model Host for Understanding Innate Immune Response to Infectious Disease Principal Investigator: Danielle Garsin Source: Ellison Medical Foundation Period of Support: 8/1/2004 - 7/31/2008 Total Direct Costs: $185,184 Total Costs: $200,000 Title: Genomic Comparison of Infectious Strains of E. faecalis Principal Investigator: George Weinstock (Baylor College of Medicine) Source: National Institute of Allergy and Infectious Disease 1 R21 AI064470 Period of Support: 4/1/2005 - 3/31/2007 Total Direct Costs (to Dr. Garsin): $34,148 2
    • Danielle A. Garsin, Ph.D. October 2006 Total Costs (to Dr. Garsin): $49,983 Publications: A. Abstracts Garsin, D.A., Paskowitz, D.M., Duncan, L. and Losick, R.: Point Mutants of the Antisigma Factor SpoIIAB that Prevent Activation of σF. 9th International Conference on Bacilli, Lausanne, Switzerland, 7/1997. Garsin, D.A., Paskowitz, D.M., Duncan, L. and Losick, R.: The Kinase Activity of the Antisigma Factor SpoIIAB is Required for Activation as well as Inhibition of Transcription Factor σF during Sporulation in Bacillus subtilis. Boston Bacterial Meeting, Cambridge, MA, 6/1998. Garsin, D.A. and Losick, R.: A Proteolytic Switch Locking on the Activity of σF during Sporulation in Bacillus subtilis. Boston Bacterial Meeting, Cambridge, MA, 6/1999. Garsin, D.A., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Modeling Gram-Positive Pathogen-Host Interactions Employing Enterococcus faecalis and C. elegans. 1st International Conference on Enterococci, Banff, Alberta, Canada, 2/2000. Garsin, D.A., Sifri, C.D., Mylonakis, E., Calderwood, S.B. and Ausubel, F.M.: Modeling Gram-Positive Pathogen-Host Interactions Employing Enterococcus faecalis and C. elegans. Boston Bacterial Meeting, Boston, MA, 6/2000. Garsin, D.A., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Modeling Gram-Positive Pathogen-Host Interactions Employing Enterococcus faecalis and C. elegans. Keystone Symposium on Microbe Interactions with their Environments: Genome Perspectives. Taos, New Mexico, 2/2001. Garsin, D.A., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Identifying Enterococcus faecalis Virulence Factors by Screening for Avirulent Mutants in Caenorhabditis elegans. American Society for Microbiology General Meeting, Salt Lake City, Utah, 5/2002. Garsin, D.A.,Villaneuva, J.M., Begun, J., Kim, D.H., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Long- lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Boston Bacterial Meeting, Boston, MA, 6/2003. Garsin, D.A., Urbach, J., Huguet-Tapia, J.C., Peters, J.E. and Ausubel, F.M.: Tn917 Inserts Preferentially into the Replication Terminus, Keystone Symposium on Bacterial Chromosomes, Santa Fe, NM, 2/2004. Garsin, D.A.,Villaneuva, J.M., Begun, J., Kim, D.H., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Long- lived C. elegans daf-2 mutants are resistant to bacterial pathogens. American Society for Microbiology General Meeting, New Orleans, LA, 5/2004. Chavez, V. and Garsin, D.A.: DAF-16 Regulated Genes Mediate Resistance to Pathogens. West Coast Worm Meeting, Santa Barbara, CA, 6/2004. Chavez, V. and Garsin, D.A.: DAF-16 Regulated Genes Mediate Resistance to Pathogens. 10th Annual Research Day, Houston, TX, 10/2004. Chavez, V. and Garsin, D.A.: DAF-16 Regulated Genes Mediate Resistance to Pathogens. Texas Branch American Society for Microbiology, Houston, TX, 11/2004. Chavez, V. and Garsin, D.A.: C. elegans Pathogen Defense Mechanisms. 15th Biennial International C. elegans Conference. Los Angeles, CA, 6/2005. 3
    • Danielle A. Garsin, Ph.D. October 2006 Chavez, V., Maadani, A., Vega, L. and Garsin, D.A.: Attenuated E. faecalis Mutants Isolated in C. elegans reveal a Conserved Host Defense Mechanism. International ASM-FEMS Conference on Enterococci. Ellsinore, Denmark, 8/2005. Chavez, V., Maadani, A., Vega, L. and Garsin, D.A.: C. elegans Produces ROS in Response to Bacterial Pathogens. Society for Free Radical Biology 12th Annual Meeting. Austin, TX, 11/2005. Chavez, V., Maadani, A., Vega, L. and Garsin, D.A.: C. elegans Produces ROS in Response to Bacterial Pathogens. Drugs, Bugs and Vaccines. Galveston, TX, 4/2006. Garsin, D.A., Xiang, Q., Jiang, H., Murray, B.E. and Weinstock, G.M.: The Genome Sequence of E. faecalis OG1RF Reveals Significant Differences Compared to OG1RF. ASM Conference on Streptococcal Genetics. St. Malo, France, 6/2006. Garsin, D.A., Xiang, Q., Jiang, H., Murray, B.E. and Weinstock, G.M.: The Genome Sequence of E. faecalis OG1RF Reveals Significant Differences Compared to OG1RF. National Conference on Gram-Positive Pathogens. Omaha, NE, 10/2006. Fox, K.A., Maadani, A., Garsin, D.A.: Regulation of Etanolamine Utilization by Enterococcus faecalis. National Conference on Gram-Positive Pathogens. Omaha, NE, 10/2006. Bourgogne, A., Fox, K.A., Garsin, D.A., Murray, B.E.: An AtxA-like Protein Regulates Experssion of the Enteroccus faecalis Genes, epbABC, Encoding the Pilus Components, but not srtC, in OG1RF. National Conference on Gram-Positive Pathogens. Omaha, NE, 10/2006. B. Refereed Original Articles in Journals Alper, S., Dufour, A., Garsin, D.A., Duncan, L. and Losick R.: Role of adenosine nucleotides in the regulation of a stress-response transcription factor in Bacillus subtilis. J. Mol. Biol. 260:165-177, 1996. Garsin, D. A., Duncan, L., Paskowitz, D.M. and Losick R.: The kinase activity of the antisigma factor SpoIIAB is required for activation as well as inhibition of transcription factor σF during sporulation in Bacillus subtilis. J. Mol. Biol. 284:569-578, 1998. Garsin, D.A., Paskowitz, D.M., Duncan, L. and Losick, R.: Evidence for common sites of contact between the antisigma factor SpoIIAB and its partners SpoIIAA and the developmental transcription factorσF in Bacillus subtilis. J. Mol. Biol. 284:557-568, 1998. Pan, Q.,* Garsin, D.A.* and Losick, R.: Self-reinforcing activation of a cell-specific transcription factor by proteolysis of an antisigma factor in B. subtilis. Mol. Cell. 8:873-883, 2001. Garsin, D.A., Sifri, C.D., Mylonakis, E., Qin, X., Singh, K.V., Murray, B.M., Calderwood S.B. and Ausubel F.M.: A simple model host for identifying Gram-positive virulence factors. Proc. Natl. Acad. Sci. 98:10892-10897, 2001. Kim, D. A.,* Feinbaum, R.,* Alloing, G., Emerson, F.E., Garsin, D.A., Inoue, H., Tanaka-Hino, M., Hisamoto, N., Matsumoto, K., Tan, M.W. and Ausubel, F.M.: Requirement for p38 MAP kinase signaling pathway in Caenorhabditis elegans immunity. Science. 297:623-626, 2002. Sifri, C.D., Mylonakis, E., Singh, K.V., Qin, X., Garsin, D.A. Murray, B.E., Ausubel, F.M. and Calderwood, S.B.: Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice. Infection and Immunity. 70:5647-5650, 2002. 4
    • Danielle A. Garsin, Ph.D. October 2006 Garsin, D.A.,Villaneuva, J.M., Begun, J., Kim, D.H., Sifri, C.D., Calderwood, S.B. and Ausubel, F.M.: Long- lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 300:1921. 2003. Garsin, D.A., Urbach, J., Huguet-Tapia, J.C., Peters, J.E. and Ausubel, F.M.: Construction of an Enterococcus faecalis Tn917-mediated gene disruption library offers insight into Tn917 insertion patterns. Journal of Bacteriology. 186:7280-7289. 2004. Nallapareddy, S. R., Singh, K.V., Sillanpaa, J., Garsin, D.A., Hook, M., Murray B.E.: Endocarditis and biofilm-associated pili of Enterococcus faecalis. The Journal of Clinical Investigation. 116:2799. 2006. *These authors contributed equally. C. Invited Articles in Journals Garsin, D. A.: Microbiology. Peptide signals sense and destroy target cells. Science. 306:2202-3, 2004. F. Other Professional Communications 1. Invited seminars/presentations •New England Spores Conference, Cambridge, MA, 11/1996 •9th International Conference on Bacilli, Lausanne, Switzerland, 7/1997 •New England Spores Conference, Cambridge, MA, 11/1997 •New England Spores Conference, Cambridge, MA, 11/1998 •The 5th Annual Boston Bacterial Meeting, Cambridge, MA, 6/1999 •FASEB conference on Prokaryotic Transcription Initiation, Saxtons River, VT, 7/1999 •The 6th Annual Boston Bacterial Meeting, Cambridge, MA, 6/2000 •Keystone Symposia on Microbe Interactions with their Environments: Genome Perspectives. Taos, NM, 3/2001 •Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO, 1/2002 •Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO, 2/2002 •Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA, 3/2002 •Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, 3/2002 •Department of Microbiology, Cornell University, Ithaca, NY, 4/2002 •Center for Oral Biology, University of Rochester, Rochester, NY, 5/2002 •The 9th Annual Boston Bacterial Meeting, Cambridge, MA, 6/2003 •Department of Genetics, University of Melbourne, Melbourne, Australia, 7/2003 •Department of Biochemistry, University of Sydney, Sydney, Australia, 7/2003 •Department of Microbiology and Molecular Genetics, University of Texas Health Sciences Center, Houston, TX, 10/2003 •West Coast Worm Meeting, Santa Barbara, CA, 8/2004 •Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 10/2004 •10th Annual Research Day, University of Texas Health Science Center, Houston, TX, 10/2004 •Texas Branch American Society for Microbiology Meeting, Houston, TX, 11/2004 •Medical School Retreat, University of Texas Health Science Center, Houston, TX, 3/2005 •International ASM-FEMS Conference on Enterococci. Ellsinore, Denmark, 8/2005 •Fred Hutchinson Cancer Center, Seattle, WA, 9/2005 •Department of Pathology, University of Texas Health Science Center, Houston, TX, 1/2006 •Gordon Conference on Aging, Ventura, CA, 1/2006 •Burroughs Wellcome Fund Summer Conference, Vancouver, Canada, 8/2006 •Baylor College of Medicine, Huffington Center on Aging, Houston, TX, 11/2006. 3. Letters to the Editor 5
    • Danielle A. Garsin, Ph.D. October 2006 Bolm, M., Chhatwal, G.S., Jansen, W.T.M.; Ausubel, F.M., Begun, J., Kim, D.H., Moy, T., Ruvkun, G., Calderwood, S.B., Sifri, C.D. and Garsin, D.A. Bacterial resistance of daf-2 mutants. Science. 303:1976, 2004. 6. Other “Resistance to Food Poisoning Seems Factor in Worm Longevity,” Focus, News from Harvard Medical, Dental & Public Health Schools, July 11, 2003. “Microbiologist Garsin Wins Ellison Foundation Honor,” Distinctions, The University of Texas Health Science Center at Houston, December 2004. “Examining Pathogenesis in Roundworms,” ASM News, February 2005. “Collaboration Will Decipher Bacterium Strains,” The Scoop, The University of Texas Medical School at Houston, March 18, 2005. 6