BIOGRAPHICAL SKETCH
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    BIOGRAPHICAL SKETCH BIOGRAPHICAL SKETCH Document Transcript

    • Principal Investigator/Program Director (Last, First, Middle): Jefferson, Angela L. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE Angela Lee Jefferson Assistant Professor eRA COMMONS USER NAME angelaj@bu.edu Department of Neurology EDUCATION/TRAINING DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Lynchburg College, Lynchburg, VA B.A. 8/93-5/97 Psychology Loyola College, Baltimore, MD M.A. 8/99-1/00 Clinical Psychology Drexel University, Philadelphia, PA Ph.D. 9/99-6/03 Clinical Neuropsychology Brown Medical School, Providence, RI Internship 7/02-6/03 Neuropsychology Brown Medical School, Providence, RI Fellowship 7/03-7/04 Neuropsychology Boston University School of Medicine, Boston, MA Fellowship 7/04-6/05 Neuropsychology A. Positions and honors Positions and Appointments 07/05 - present Assistant Professor, Department of Neurology, Boston University School of Medicine 07/05 - present Director, Pre-Doctoral Clinical Research Training, Alzheimer’s Disease Clinical Research Program, Boston University School of Medicine 07/06 - present Associate Director, Education & Information Transfer Core, Alzheimer’s Disease Core Center, Boston University School of Medicine 08/06 - present American Psychological Association Division 40 (Neuropsychology) Liaison to the American Psychological Association Committee on Aging, Washington, DC Awards and Honors 1993-1997 Involving Leader Stipend Award, Lynchburg College, Lynchburg, VA 1994 Phi Eta Sigma National Honor Society, Lynchburg College, Lynchburg, VA 1995 Cardinal Key Honor Society, Lynchburg College, Lynchburg, VA 1995 Psi Chi National Psychology Honor Society, Lynchburg College, Lynchburg, VA 1995-1997 All-American Scholar Collegiate Award, Lynchburg College, Lynchburg, VA 1996-1997 Outstanding Psychology Major Award, Lynchburg College, Lynchburg, VA 2000 Francis Fields Memorial Research Award, Philadelphia Neuropsychological Society 2000 National Academy of Neuropsychology Student Poster Award, San Francisco, CA 2001 Francis Fields Memorial Research Award, Philadelphia Neuropsychological Society 2002 Advances in Clinical Practice Research Award, MCP & Drexel University, Philadelphia, PA 2003 Young Investigator Travel Scholarship, Vas-Cog, Gothenberg, Sweden 2003 Advances in Clinical Practice Research Award, Drexel University, Philadelphia, PA 2003-2005 National Research Service Award (F32), NIH/National Institute on Aging, Bethesda, MD 2004 Invited Attendee of NIA Summer Institute on Aging Research, Queenstown, MD 2005-2007 Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar 2005 Young Investigator Travel Scholarship, Vas-Cog, Florence, Italy 2006 Travel Fellowship, International Conference on Alzheimer’s Disease, Madrid, Spain 2006 International Travel Award, American Psychological Association B. Selected peer review publications (from 26 original reports and 1 chapter). 1. Jefferson AL, Paul RH, Poppas A, Cohen RA. Systemic hypoperfusion is associated with executive dysfunction in geriatric cardiac patients. Neurobiol Aging. (In press). 2. Jefferson AL, Cahn-Weiner D, Boyle P, Paul RH, Gordon N, Moser D, Cohen RA. Cognitive predictors of functional decline in vascular dementia. Internat J Geri Psych. (In press). 3. Jefferson AL, Wong S, Gracer TS, Green RC, Stern RA. Geriatric performances on the Boston Naming Test-30 item even version. App Neuropsych. (In press). PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page
    • Principal Investigator/Program Director (Last, First, Middle): 4. Jefferson AL, Wong S, Bolen E, Ozonoff A, Green RC, Stern RA. Cognitive predictors of HVOT performance differ between individuals with mild cognitive impairment and normal controls. Arch of Clin Neuropsych. (In press). 5. Jefferson AL, Barakat LP, Glosser G, Giovannetti T, Paul, RH. Object perception impairments predict instrumental activities of daily living in Alzheimer’s disease. J Clin Exper Neuropsych, 2006; 28(6):884-897. 6. Jefferson AL, Paul RH, Ozonoff A, Cohen RA. Evaluating elements of executive functioning as predictors of instrumental activities of daily living (IADLs). Arch Clin Neuropsych, 2006; 21(4):311-320. 7. Gunstad J, Poppas A, Smeal S, Paul RH, Tate DF, Jefferson AL, Forman D, Cohen RA. Relation of brain natriuretic Peptide levels to cognitive dysfunction in adults >55 years of age with cardiovascular disease. Amer J Card, 2006; 98(4):538-540. 8. Gunstad J, Bausserman L, Paul RH, Tate D, Hoth K, Poppas A, Jefferson AL, Cohen RA. C-reactive protein, but not homocysteine, is related to cognitive dysfunction in older adults with cardiovascular disease. J Clin Neurosci, 2006; 13(5): 540-546. 9. Jefferson AL, Glosser G, Detre JA, Sinson G, Liebeskind DS. Neuropsychological and perfusion MRI correlates of revascularization in a case of moyamoya syndrome. Amer J Neuroradiology, 2006; 27(1):98-100. 10. Gunstad J, Cohen RA, Tate D, Paul R, Poppas A, Hoth K, MacGregor K, Jefferson AL. Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease. Blood Pressure, 2005; 14(6):353-358. 11. Price CC, Jefferson AL, Merino JG, Heilman KM, Libon DJ. Subcortical vascular dementia: Integrating neuropsychological and neuroradiological data. Neurology, 2005; 65(3):376-382. 12. Paul RH, Gunstad J, Poppas A, Tate DF, Foreman D, Brickman AM, Jefferson AL, Hoth K, Cohen RA. Neuroimaging and cardiac correlates of cognitive function among patients with cardiac disease. Cerebrovascular Diseases, 2005; 20(2):129-133. 13. Paul RH, Haque O, Gunstad J, Tate DF, Grieve SM, Hoth K, Brickman AM, Cohen RA, Lange K, Jefferson AL, MacGregor K, Gordon E. Subcortical hyperintensities impact cognitive function among a select subset of healthy elderly. Arch Clin Neuropsych, 2005; 20(6):697-704. 14. Paul RH, Flanigan TP, Navia B, Makris N, Hinkin C, Jefferson AL, Malloy PF, Cohen RA. Apathy is associated with volume of the nucleus accumbens in patients infected with HIV. J Neuropsych Clin Neurosci, 2005; 17:167-171. 15. Brickman AM, Paul RH, Cohen RA, Williams LM, MacGregor KL, Jefferson AL, Tate DF, Gunstad J, Gordon E. Semantic and phonemic verbal fluency across the adult lifespan: Relationship to EEG theta power. Arch Clin Neuropsych, 2005; 20:561-573. 16. Gunstad J, MacGregor KL, Paul RH, Poppas A, Jefferson AL, Todaro J, Cohen RA. Cardiac rehabilitation improves cognitive performance: A preliminary examination. J Cardiopulm Rehab, 2005;25:173-176. 17. Jefferson AL, Brickman AS, Aloia M, Paul RH. The cognitive profile of vascular dementia (VaD). In: Paul RH, Cohen RA, Ott BR, Salloway S, eds. Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management. Totawa, NJ: Humana Press, 2005: 131-143. 18. Cosentino SA, Jefferson AL, Carey ME, Price CC, Davis KL, Swenson R, Libon DJ. An analysis of different diagnostic criteria for vascular dementia. Clin Neuropsych, 2004;18(1): 6-21. 19. Cosentino SA, Jefferson AL, Kaplan E, Libon DJ. Clock drawing errors in dementia: Neuropsychological and neuroanatomical considerations. Behav Cog Neuro, 2004;17(2):74-83. 20. Crews WD Jr, Jefferson AL, Broshek DK, Rhodes RD, Williamson J, Brazil A, Barth JT, Robbins MK. Neuropsychological dysfunction in patients with end-stage pulmonary disease: Lung transplant evaluation. Arch Clin Neuropsych, 2003;18(4):353-362. 21. Jefferson AL, Crews WD Jr, Broshek DK, Barth JT, Robbins MK. An examination of the neuropsychological sequelae associated with end-stage pulmonary disease secondary to alpha-1-antitrypsin deficiency. Adv Med Psychotherapy Psychodiagnostics, 2002;11:35-43. 22. Jefferson AL, Cosentino SA, Ball SK, Bogdanoff B, Leopold N, Kaplan E, Libon DJ. Errors produced on the Mini-Mental State Exam (MMSE) and neuropsychological test performance among patients with AD, Ischaemic Vascular Dementia, and Parkinson’s disease. J Neuropsych Clin Neurosci, 2002;14(3):311-320. 23. Kabat MH, Kane RL, Jefferson AL, Dipino RK. Construct validity of selected Automated Neuropsychological Assessment Metrices (ANAM) battery sub-tests utilizing factor analysis. Clin Neuropsych, 2002;15(4):498-507. 24. Crews WD Jr, Jefferson AL, Bolduc T, Elliott JB, Ferro NM, Broshek DK, Barth JT, Robbins MK. Neuropsychological dysfunction in patients suffering from end-stage chronic obstructive pulmonary disease. Arch Clin Neuropsych, 2001;16(7):643-652. 25. Jefferson AL, Powers DV, Pope M. Beck Depression Inventory-II (BDI-II) and the Geriatric Depression Scale (GDS) in older women. Clin Geron, 2001;22(3/4):3-12. PHS 398/2590 (Rev. 05/01) Page Continuation Format Page
    • Principal Investigator/Program Director (Last, First, Middle): 26. Crews WD Jr, Jefferson AL, Broshek DK, Barth JT, Robbins MK. Neuropsychological sequelae in a series of patients with end-stage cystic fibrosis: Lung transplant evaluation. Arch Clin Neuropsych, 2000;15(1):59-70. 27. Crews WD Jr, Jefferson AL, Barth JT. Longitudinal neuropsychological evaluation of a case of pineal tumor occurring in an adolescent female. App Neuropsych, 1999;6(2):108-114. C. Research Support Active Research Support Title: Inflammatory markers as a risk factor for Alzheimer’s disease in women Type: Boston University BIRCWH Scholars Program (K12-HD043444) Agency: Boston University/NIH Period: 7/01/05-6/30/07 Project Role: Co-I Specific Aims: The goal of this study is to determine whether inflammatory biomarkers are associated with Alzheimer’s disease and white matter hyperintensities. We also seek to identify if sex modifies the relationship between inflammatory markers and Alzheimer’s disease and white matter hyperintensities. Title: Boston University Alzheimer’s Disease Core Center (ADCC) Type: P30-AG13846 Agency: NIA Period: 7/01/96-6/30/11 Project Role: Co-I, Clinical Core Specific Aims: The major goal of this project is to build a broad-based research program in Alzheimer’s disease to better understand the phenomenology and pathophysiology of the disease and to facilitate treatment and prevention. Title: Mild cognitive impairment and decisional capacity Type: R03-AG026610 Agency: NIA Period: 5/01/06-4/30/08 Project Role: PI Specific Aims: The goal of this study is to assess the decisional capacity of patients with mild cognitive impairment and the cognitive correlates of informed consent for research participation among patients with mild cognitive impairment. Title: Neurogenetics of mild cognitive impairment Type: R03-AG027480 Agency: Boston University ADCC/NIA Period: 9/01/08-8/31/10 Project Role: PI Specific Aims: The purpose of this study is to longitudinally examine the relationship between apolipoprotein E (ApoE) polymorphisms and cognitive functioning among individuals with mild cognitive impairment (MCI). Pending Research Support Title: Multi-Institutional Research in Alzheimer’s Genetic Epidemiology Type: R01 AG09029 (L. Farrer, PI) Agency: NIA Period: pending Project Role: Co-I Specific Aims: This project seeks to evaluate the interaction of Alzheimer’s and vascular genetic factors with non- genetic risks for AD and relations with cognitive progression among AD cases and their first degree relatives. Title: Cardiac structure & function: Implications for cognitive aging & brain MRI Type: K23- AG030035 Agency: NIA Period: 7/01/07-6/30/12 Project Role: PI Specific Aims: The goal of this study is to determine whether cardiac structure and function is related to cognitive function and brain MRI measures cross-sectionally and longitudinally. Completed Research Support Title: Mild cognitive impairment and decisional capacity: A pilot study Type: Boston University Clinical Research Feasibility Funds Program Agency: Boston University GCRC/NIH Period: 6/01/05-5/31/06 Project Role: PI Specific Aims: The goal of this pilot study was to assess the decisional capacity of patients with mild cognitive impairment and the cognitive correlates of informed consent for research participation among patients with mild cognitive impairment. Title: Neurogenetics of mild cognitive impairment: A pilot study Type: Alzheimer’s Disease Core Center Pilot Program Agency: Boston University ADCC/NIA Period: 7/01/05-6/30/06 Project Role: PI PHS 398/2590 (Rev. 05/01) Page Continuation Format Page
    • Principal Investigator/Program Director (Last, First, Middle): Specific Aims: The purpose of this pilot study was to longitudinally examine the relationship between apolipoprotein E (ApoE) polymorphisms and cognitive functioning among individuals with mild cognitive impairment (MCI). PHS 398/2590 (Rev. 05/01) Page Continuation Format Page
    • Principal Investigator/Program Director (Last, First, Middle): Jefferson, Angela L. Title: Cardiovascular disease and neurocognition in the elderly Type: F32-AG022773 Agency: NIA Period: 7/15/03-6/30/05 Project Role: PI Specific Aims: The goal of this study was to examine the relationship between two echocardiogram measures of systemic perfusion, cardiac output and ejection fraction, and performances on neuropsychological tests among older outpatients with stable cardiovascular disease with specific emphasis on components of executive function. PHS 398/2590 (Rev. 09/04) Page 1 Continuation Format Page