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311lecturesf2006.doc

  1. 1. Biology 311 Human Genetics Fall 2006 Instructor Dr. Nancy J. Bachman Office 35 Denison Hall Office Hours MWF 11 am-12 noon Phone 436-3061 email bachman@oneonta.edu Web Page http://employees.oneonta.edu/bachman/human%20genetics/biology_311web.htm Lectures MWF 9-9:50 am HECO 127 Lecture Schedule week date lecture topic text Other assignments assignment 1 8/23 DNA/RNA/proteins (review) Chap. 1 Study questions 8/25 Chromosomes Chap. 2 Methods topic 2 8/28 Chromosome defects " " Article #1 8/30 Pedigree analysis Chap. 4 9/1 Complex traits " " Problem set 3 9/4 Hardy-Weinberg equilibrium " " 9/6 Recombinant DNA Chap. 5 Methods presentations 9/8 Recombinant DNA " " 4 9/11 Recombinant DNA Chap. 6 9/13 Recombinant DNA " " 9/15 Recombinant DNA Chap. 7 5 9/18 Recombinant DNA " " 9/20 Recombinant DNA " " 9/22 Human genome project Chap. 8 to p. 226 6 9/25 Bioinformatics “ “ 9/27 Model organisms Chap. 8 pp. First take home exam 226-235 due 9/29 mtDNA Chap. 9 to p. 244 7 10/2 Fall Break I--no class 10/4 Nuclear gene organization Skim Article #2 Chap. 9 pp. 244-272 10/6 Regulation of gene expression Chap. 10 8 10/9 Regulation of gene expression Chap. 10 10/11 Mutation and repair Chap. 11 10/13 Mutation and repair Chap. 11 1
  2. 2. 9 10/16 Comparing genes and Chap. 12 Problem Set #2 genomes 10/18 Gene mapping Chap. 13 10/20 Positional cloning Chap. 14 10 10/23 Complex diseases Chap. 15 10/25 Molecular pathology Chap. 16 10/27 Molecular pathology “ “ 11 10/30 Cancer genetics: oncogenes Chap. 17 Second take-home exam due 11/1 Cancer genetics: suppressors “ “ 11/3 DNA testing Chap. 18 12 11/6 DNA profiling “ “ Review paper topic 11/8 Functional genomics Chap. 19 11/10 Proteomics “ “ 13 11/13 Stem cells/cloning Chap. 20 11/15 Knock-outs/transgenics “ “ 11/17 RNAi " " 14 11/20 Fall Break III--no class 11/22 Fall Break III--no class 11/24 Fall Break III--no class 15 11/27 Gene therapy Chap. 21 11/29 Presentations Review papers due 12/1 Presentations 16 12/4 Presentations 12/6 Presentations 17 12/13 Final exam Final take-home 8 am-10:30 am Exam due Course Description: Biological basis for human heredity. Course will examine the transmission of traits in human lineages (pedigree analysis), the molecular basis for genetic disease (molecular genetics), chromosomal defects (cytogenetics), and genetic variation in populations (population genetics). Current topics such as the human genome project, cloning and stem cell research, DNA forensics, and gene therapy will be discussed. Course Objectives: 1. Review key concepts in molecular, Mendelian, and population genetics relevant to the study of human heredity. 2. Develop skills in critical thinking and problem solving based on aspects of genetics. 3. Highlight how the human genome project and new tools in molecular biology are impacting human genetic and reproductive technologies. 2
  3. 3. Required Text: Strachan, Tom and Read, Andrew P. (2004) Human Molecular Genetics 3, third edition. Garland Science, New York, NY. Required Readings: Research articles will be available on blackboard or in some cases can be downloaded directly from the web. Lecture and Exam Schedule: The class meets MWF 9-9:50 am in room 319 Science I. There will be three take-home exams. These will be handed out about a week before they are due. The third take-home will be due at the time scheduled for the final exam. Problem Sets: A major objective of this course is to encourage you to think critically about genetics. Problem sets will occasionally be assigned and worked in class. Several questions on the take-home exams will be problems. Methods Presentations: Early in the semester we will focus on a number of recombinant DNA methods. You will choose a particular method and investigate it further, including how it might be applied in human genetics. You will provide a class handout (paper or electronic) and brief presentation in class (10-15 min.) on the method. Images can be used from the text to illustrate your presentation and are available on blackboard. Research Articles: During the semester, we will be reading and discussing as a group two research articles. You will hand in a review of major points from the paper using the format in an upcoming class handout. For extra credit (up to 20 points), you can choose to review an additional research article you obtain from the instructor. Review paper and presentation: Details of this assignment will be given in an upcoming class handout. Identify early in the semester a topic in human genetics to research. The review paper will involve selecting a focus paper, which must be a published review or research article and additional related references including articles, books and internet sources. You will summarize major points of the article and provide additional background relevant to the topic. You will also give about a ten minute power point presentation to the class on your topic. The paper will be due Nov. 29, 2006 and presentations will be given during the last five class periods. Grading: Take-home exams (3 @ 80 pts. each) 240 pts. Problems and study questions 60 pts. Methods presentation 20 pts. Article reviews (2) 40 pts. (+ extra credit option) Review paper and presentation 80 pts. Course total 440 pts. 3
  4. 4. Grades will be assigned based on the following % of the course point totals: A 93-100% C 73-76% A- 90-92% C- 70-72% B+ 87-89% D+ 67-69% B 83-86% D 63-66% B- 80-82% D- 60-62% C+ 77-79% E <60% 4

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