DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers and A Scanner for Hereditary Defects: New Possibilities in Genetic Damage
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DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers and A Scanner for Hereditary Defects: New Possibilities in Genetic Damage

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DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers and A Scanner for Hereditary Defects: New Possibilities in Genetic Damage DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers and A Scanner for Hereditary Defects: New Possibilities in Genetic Damage Presentation Transcript

  • DNA-Repairing Protein May Be Key to Preventing Recurrence of SomeCancers and A Scanner for Hereditary Defects: New Possibilities in Genetic Damage Recognition for Improving Cancer Treatment Paula E. Montoya Medical student III semester Lina María Martínez Sánchez Molecular Biology
  • INTRODUTION • When the cell have a faulty system to repair damaged DNA is when we start to have a serious problems like cancer . • Also the repair system when cell become in cancer cell as well have a repair system that against treatment
  • A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FORIMPROVING CANCER TREATMENT (JAN. 24, 2013) • Our DNA are constantly repair himself for all the things that attack him, how from outside (UV light and toxins) and inside ( metabolic process) • This repair system is a process that have a lot importance for the normal functionality of the cell View slide
  • A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITIONFOR IMPROVING CANCER TREATMENT (JAN. 24, 2013)• When this system don’t recognized and repair damage genetic material can cause cancer or genetic disorders.• Hanspeter Nägeli and his team discovered protein XPD find damage genetic material , what makes this protein very important in the study of DNA. Find Mark Repair View slide
  • A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT (JAN. 24, 2013) • XPD protein as scanner: The genetic information is stored on DNA double helix. This protein works like a scanner looking signs of damage. When find this protein stop and“The XPD scanner (green)is in close contact with marks where needs repaira damaged point (red) on the DNA double helix.The damaged DNA strand lies in a deep pock etof the protein to enable a ferrous sensor (Fe) to the DNAcome into contact with the damaged point,thereby halting the protein as it moves along theDNA. (Credit: Picture:UZH)”
  • A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT (JAN. 24, 2013)Basis for possible courses of therapy• This mechanism is very important because protect healthy tissue and repair the DNA.• But have a impact in substances against cancer it, this helps , cause can stimulate or suppress this protein depends of requirements (used in therapy)
  • A SCANNER FOR HEREDITARY DEFECTS: NEW POSSIBILITIES IN GENETIC DAMAGE RECOGNITION FOR IMPROVING CANCER TREATMENT (JAN. 24, 2013)• PERSONAL OPINION :Every body cell has specific functions,but they all have a lot in common process,cellular repair is one of them, with veryimportant because I think its crucial tohave a functional balance of the cell; findthese proteins and know their functionwithin the I think the process is a majorbreakthrough in the field, but whatfollows so you can take one beyond whatyou will find will set the pace for thefunctionality of this protein as a cancertherapy.
  • DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers (Jan. 28, 2013) Antibiotics , University of methods of killing Central Florida cancer tumors - professor has body resistant found a protein present in several Like breast and types ovarian cancer This is important KLF8 protein cause can (appears to preventing tumors coming back protect tumor cells)
  • DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers ( Jan. 28, 2013)• All our cells can repair her DNA by important mechanisms ; thanks that the DNA can face constants damage threats.• The KLF8 is in specific cancers : such breast and ovarian cancer.• If they can stop his activity maybe they can stop cancer recurrence and use this as therapy against the cancer.
  • DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers ( Jan. 28, 2013)• The therapy that damage of DNA of cancer cells depends the capacity of this cells of repair himself . High levels of DNA repair Increase resistance of the cells to such therapies Increase improper DNA repair- mediated Increase the malignancy of the cells
  • DNA-Repairing Protein May Be Key toPreventing Recurrence of Some Cancers ( Jan. 28, 2013) KLF8-promoted DNA repair to the cell resistance to doxorubicin-induced cell death KLF8 have a role: repairing DNA damage cause by other types of genotoxic. This protein do a disturbing genomic integrity and contribute aggressive progression.
  • DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers ( Jan. 28, 2013)• PERSONAL OPINION: Not only know the properties of our cells as therapy isthe key but , if not that, to know who we are fightingagainst, it is very important to improve the waytreatment it , which is why I find this news importantbecause it deals with every day situations whichincrease in our society as the news says "There areBetween 2.5 million and 2.7 million Women who HaveBreast Cancer in the United States and 10 to 20percent will experience a recurrence" a percentage thatsuch research may decrease.
  • MEDICAL UTILITY• Research and update always will be very important in the area of ​medicine, as this can be at the forefront on issues is increasingly boom in the middle regarding diseases and treatment of these.
  • MEDICAL UTILITY• the importance of knowing how work our body , understand and thus achieve better treatment.
  • MEDICAL UTILITY• Our body is constantly changing and sometimes can not keep up and that is where we improve this adaptation.
  • MEDICAL UTILITY• XPD protein as scanner and KLF8 protein, that help us better understand the system of cellular DNA repair and use it in this adaptation .
  • BIBLIOGRAFIA1. Martínez Sánchez LM, Vargas Grisales N, Toro Montoya AE. Biología molecular. 7 ed. Medellín: UPB. Fac. de Medicina, 2012. p 85-101.2. A Scanner for Hereditary Defects: New Possibilities in Genetic Damage Recognition for Improving Cancer Treatment ,Jan. 24, 2013 from [internet] http://www.sciencedaily.com.3. DNA-Repairing Protein May Be Key to Preventing Recurrence of Some Cancers, Jan. 28, 2013, from [internet] http://www.sciencedaily.com.
  • THANKS• “If we knew what it was we were doing, it would not be called research, would it?”• ― Albert Einstein