Toxoplasma

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Toxoplasma

  1. 1. Toxoplasma (Toxoplasma gondii) Www.RCVetS.com
  2. 2. Introduction: Toxoplasma gondii. 1908 • Toxoplasma gondii intestinal epithelium and muscle. • It blood and peritoneal exudate
  3. 3. Site of infection:
  4. 4. Toxoplasma oocyst fecal floatation.
  5. 5. Host : • Intermediate host: • Human, cattle, birds, rodents, pigs, and sheep. • Definitive host: • Mainly domestic and wild cats.
  6. 6. Classification: • Phylum: Apicomplexa • Class: Conoidasida • Subclass: Coccidiasina • Order: Eucoccidiorida • Family: Sarcocystidae • Genus: Toxoplasma • Species: T.gondii
  7. 7. Geographical distribution: warm climates France and C. America
  8. 8. Signs & symptoms: • Body aches • Swollen lymph nodes • Headache • Fever • Fatigue • Occasionally, a sore throat People with weakened immune system • Headache • Confusion • Poor coordination • Blurred vision caused by severe inflammation of your retina (ocular toxoplasmosis).
  9. 9. Life cycle of Toxoplasama gondii
  10. 10. The protozoa multiplies sexually in the cat’s intestine and asexually in a many mammals and even birds. Cats are infected by eating infected rodent.the zoitocyst which contains bradyzoites travel to the intestine via digestive tract.
  11. 11. Cont. life cycle Bradyzoites are released in the intestine. Bradyzoites infect cells and become trophozoites. Fertilization occurs in the intestine and immature oocyst are passed in the cat’s feces. The Oocyst are contaminated with water, food and soil are ingested by intermediate host.
  12. 12. Merozoites:
  13. 13. Diagnosis: • Biopsy of humans. • (ELISA) Enzyme-Linked Immunoabsorbent Assays. • (IFAT) Indirect Fluorescent Antibody tests.
  14. 14. Treatment: • Sulphonamides • Pyrimethamine • Spiramycine • Atovaquone • Clindamycin • Spiramycin during pregnancy • Antibiotics and steroid tablets during an infection
  15. 15. Pathogenesis: immunocompetent persons asymptomatic infection. is benign and self-limited central nervous system (CNS) disease retinochoroiditis, or pneumonitis AIDS toxoplasma encephalitis intracerebral mass lesions by reactivation of chronic infection.
  16. 16. Lymphadenitis is the most common in humans. Children exhibit Hydrocephalous, retinochoroiditis, convulsion and intracerebral calsifications. Congenital neurological defects in infants.
  17. 17. Control: • Pets should be checked and cured. • Wash hands thoroughly with soup • Cats should be kept indoors and litter boxes changed daily. • Better cook your meat well. • Cat feces should be flashed down the toilet or burned.

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