• Save
Hormone seminar (3 24 10).key,bio-identical hormone replacement,Professional Village Pharmacy,compounding pharmacy
Upcoming SlideShare
Loading in...5
×
 

Hormone seminar (3 24 10).key,bio-identical hormone replacement,Professional Village Pharmacy,compounding pharmacy

on

  • 2,234 views

hormone replacement seminar, compounding pharmacy,Professional Village Pharmacy

hormone replacement seminar, compounding pharmacy,Professional Village Pharmacy

Statistics

Views

Total Views
2,234
Views on SlideShare
2,204
Embed Views
30

Actions

Likes
0
Downloads
0
Comments
1

5 Embeds 30

http://professionalvillagerx.blogspot.com 13
http://www.slideshare.net 11
http://site.mawebcenters.com 2
http://www.professionalvillagerx.com 2
http://www.slashdocs.com 2

Accessibility

Categories

Upload Details

Uploaded via as Apple Keynote

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />
  • <br /> <br />

Hormone seminar (3 24 10).key,bio-identical hormone replacement,Professional Village Pharmacy,compounding pharmacy Hormone seminar (3 24 10).key,bio-identical hormone replacement,Professional Village Pharmacy,compounding pharmacy Presentation Transcript

  • “The compounding specialists” W elc o me
  • Hormones
  • Hormones  Powerful chemical messengers
  • Hormones  Powerful chemical messengers  Derived from cholesterol
  • Hormones  Powerful chemical messengers  Derived from cholesterol  Made in the brain, ovaries, testicles, adrenal glands and body fat
  • Hormones  Powerful chemical messengers  Derived from cholesterol  Made in the brain, ovaries, testicles, adrenal glands and body fat  Affect every tissue in the body
  • Hormones  Powerful chemical messengers  Derived from cholesterol  Made in the brain, ovaries, testicles, adrenal glands and body fat  Affect every tissue in the body  Overall effect depends on the balance between various hormones
  • Hormones  Powerful chemical messengers  Derived from cholesterol  Made in the brain, ovaries, testicles, adrenal glands and body fat  Affect every tissue in the body  Overall effect depends on the balance between various hormones  Duration of exposure is as important as dose
  • Bio-Identical Hormones
  • Bio-Identical Hormones  Bio-Identical Hormones are chemically identical to those in the human body  Derived from cholesterol-like molecules called saponins (extracted from soybeans and yams)  Plants do not make hormones (only precursors)  Some available without prescription (ProGest)  Others require prescription  a few manufactured products (eg: Vivelle, Estrace, Prometrium)  custom compounded medications
  • Estrogens Estriol, Estradiol, Estrone
  • Estrogens Estriol, Estradiol, Estrone  Exert a stimulating effect on breast, uterus and brain
  • Estrogens Estriol, Estradiol, Estrone  Exert a stimulating effect on breast, uterus and brain  Prevent bone loss by osteoclasts
  • Estrogens Estriol, Estradiol, Estrone  Exert a stimulating effect on breast, uterus and brain  Prevent bone loss by osteoclasts  Involved in vasodilation and improved blood flow
  • Estrogens Estriol, Estradiol, Estrone  Exert a stimulating effect on breast, uterus and brain  Prevent bone loss by osteoclasts  Involved in vasodilation and improved blood flow  Promote fat storage at hips
  • Estrogens Estriol, Estradiol, Estrone  Exert a stimulating effect on breast, uterus and brain  Prevent bone loss by osteoclasts  Involved in vasodilation and improved blood flow  Promote fat storage at hips  Maintain integrity of urogenital tract
  • Progesterone
  • Progesterone  There is only ONE progesterone
  • Progesterone  There is only ONE progesterone  Works synergistically with estrogens  Balances effect of estrogens in many cases  slows cell growth  normalizes blood clotting  enhances estrogen’s cardiovascular benefits  decreases fluid retention (bloating)  improved fat metabolism
  • Progesterone  There is only ONE progesterone  Works synergistically with estrogens  Balances effect of estrogens in many cases  slows cell growth  normalizes blood clotting  enhances estrogen’s cardiovascular benefits  decreases fluid retention (bloating)  improved fat metabolism  Progesterone levels drop at peri-menopause
  • Testosterone
  • Testosterone  Anabolic hormone  builds and strengthens tissue, bone, urogenital tract, muscle
  • Testosterone  Anabolic hormone  builds and strengthens tissue, bone, urogenital tract, muscle  Declines with age
  • Testosterone  Anabolic hormone  builds and strengthens tissue, bone, urogenital tract, muscle  Declines with age  Vasodilator
  • Testosterone  Anabolic hormone  builds and strengthens tissue, bone, urogenital tract, muscle  Declines with age  Vasodilator  Balances effects of estrogen and cortisol
  • Testosterone  Anabolic hormone  builds and strengthens tissue, bone, urogenital tract, muscle  Declines with age  Vasodilator  Balances effects of estrogen and cortisol  Important for sex drive/sexual response
  • Dehydroepiandrosterone (DHEA)
  • Dehydroepiandrosterone (DHEA)  Made in the adrenal glands
  • Dehydroepiandrosterone (DHEA)  Made in the adrenal glands  Declines steadily with age
  • Dehydroepiandrosterone (DHEA)  Made in the adrenal glands  Declines steadily with age  Has important roles in immune function, ability to handle stress, and glucose disposal
  • Dehydroepiandrosterone (DHEA)  Made in the adrenal glands  Declines steadily with age  Has important roles in immune function, ability to handle stress, and glucose disposal  Balances cortisol
  • Dehydroepiandrosterone (DHEA)  Made in the adrenal glands  Declines steadily with age  Has important roles in immune function, ability to handle stress, and glucose disposal  Balances cortisol  Can convert into testosterone and estradiol
  • Cortisol
  • Cortisol  Made in the adrenal glands
  • Cortisol  Made in the adrenal glands  Catabolic hormone: breaks down tissue (part of the normal cycle of remodeling)
  • Cortisol  Made in the adrenal glands  Catabolic hormone: breaks down tissue (part of the normal cycle of remodeling)  Balances testosterone
  • Cortisol  Made in the adrenal glands  Catabolic hormone: breaks down tissue (part of the normal cycle of remodeling)  Balances testosterone  Stress hormone: modulates immune function, raises blood glucose, stores fat for energy
  • Cortisol  Made in the adrenal glands  Catabolic hormone: breaks down tissue (part of the normal cycle of remodeling)  Balances testosterone  Stress hormone: modulates immune function, raises blood glucose, stores fat for energy  In excess: osteoporosis, muscle wasting, obesity, brain neuron atrophy
  • Thyroid Hormone
  • Thyroid Hormone  Determines metabolic rate  nutrient utilization by tissue  fats, carbs, and protein)  affect protein synthesis  regulate bone growth  heat generation
  • Thyroid Hormone  Determines metabolic rate  nutrient utilization by tissue  fats, carbs, and protein)  affect protein synthesis  regulate bone growth  heat generation  Interacts with cortisol, progesterone, testosterone and estradiol
  • Female Hormone Patterns Menarche to Menopause
  • Female Hormone Patterns Menarche to Menopause  Teens  Anovulatory cycles are common  Low Progesterone  Estrogen Dominance
  • Female Hormone Patterns Menarche to Menopause
  • Female Hormone Patterns Menarche to Menopause  20 to 30 years old  May have regular monthly bleeding but may not be ovulating  if stressed: PMS  unbalanced hormone levels affect fertility and pregnancy
  • Female Hormone Patterns Menarche to Menopause
  • Female Hormone Patterns Menarche to Menopause  40 to 50 years old  Peak progesterone level declines  Total progesterone output throughout the luteal phase declines  Average estradiol level increases  may lead to estrogen dominance  Ovaries may secrete more testosterone instead of progesterone  Anovulatory cycles with irregular bleeding
  • Female Hormone Patterns Menarche to Menopause
  • Female Hormone Patterns Menarche to Menopause  40 to 50 years old  Estrogen dominance  Functional hypothyroidism  Normal TSH, but classic symptoms of under-active thyroid  Weight gain  Feeling cold  Dry skin, thinning scalp hair  Aching muscles  Fatigue  Low sex drive
  • Female Hormone Patterns Menarche to Menopause
  • Female Hormone Patterns Menarche to Menopause  50+ & Menopause  Estradiol level drops  Estrone level stays the same or rises  Ovary stops making progesterone and testosterone
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Estrogen Excess  Tender, swelling, and/or fibrocystic breasts  water retention  irritability  weight gain at hips  sometimes increased headaches or migraines  hypothyroid symptoms
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Estrogen Deficiency  Hot flashes & night sweats  vaginal dryness (also lips, skin, eyes...)  “brain fog” & memory problems  urinary incontinence (stress incontinence)  depression  bone loss
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Estrogen Deficiency  Low percent of body fat = at risk for low estrogen  estrogen CAN be made in body fat...if you have enough!  women with enough body fat may not need estrogen supplementation for menopause  women with low body fat may need extra estrogen
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Progesterone Deficiency  Irregular periods (teens and pre-menopause)  Tender and/or fibrocystic breasts  water retention  irritability  anxiety/depression  weight gain at hips  migraines  hypothyroid symptoms
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Androgen (Testosterone) Excess  Acne, oily skin  Facial hair growth  Weight gain at waist  High triglycerides  Seen in insulin resistance, polycystic ovary syndrome, obesity
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Androgen (testosterone) Deficiency  Depression  fatigue  vaginal dryness  low sex drive  bone loss  decreased sense of well being
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Cortisol (Stress Hormone) Excess  Irritability, anxiety, feel “burned out”  “brain fog” & memory problems  bone loss  insomnia & fatigue  low sex drive  weight gain at waist (“apple” profile)
  • Symptoms of Hormone Imbalance
  • Symptoms of Hormone Imbalance  Cortisol Deficiency “Adrenal Fatigue”  Usually preceded by prolonged stress/ chronic illness  Fatigue, feel “flat” or “burned out”  Allergies; immune function low  Feel cold all the time  Can’t get started in the morning  Low sex drive  Depression  Unstable blood sugar
  • Approach to Female Hormone Imbalances
  • Approach to Female Hormone Imbalances  The solution isn’t always HRT  Stress reduction (good diet, sleep, exercise, relaxation training)  Weight loss  Address insulin resistance  Nutrients  Herbs
  • Male Hormone Patterns
  • Male Hormone Patterns  Young Males  High testosterone  Low estradiol  Low progesterone
  • Male Hormone Patterns
  • Male Hormone Patterns  35 + years old
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year  Estradiol and estrone may rise; Prog stays low
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year  Estradiol and estrone may rise; Prog stays low  Gain weight around middle
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year  Estradiol and estrone may rise; Prog stays low  Gain weight around middle  Sleep problems associated with excess weight may lead to increased cortisol
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year  Estradiol and estrone may rise; Prog stays low  Gain weight around middle  Sleep problems associated with excess weight may lead to increased cortisol  Abdominal fat converts testosterone to estradiol under the influence of cortisol
  • Male Hormone Patterns  35 + years old  Testosterone drops about 1% per year  Estradiol and estrone may rise; Prog stays low  Gain weight around middle  Sleep problems associated with excess weight may lead to increased cortisol  Abdominal fat converts testosterone to estradiol under the influence of cortisol  Cortisol and estradiol directly oppose the action of testosterone
  • Approach to Male Hormone Imbalances
  • Approach to Male Hormone Imbalances  Weight loss
  • Approach to Male Hormone Imbalances  Weight loss  Weight training
  • Approach to Male Hormone Imbalances  Weight loss  Weight training  Reduce dietary estrogen burden
  • Approach to Male Hormone Imbalances  Weight loss  Weight training  Reduce dietary estrogen burden  Testosterone supplementation
  • Approach to Male Hormone Imbalances  Weight loss  Weight training  Reduce dietary estrogen burden  Testosterone supplementation  Aromatase inhibitors
  • Solving Hormone Problems
  • Solving Hormone Problems  History 85%
  • Solving Hormone Problems  History 85%  Physical examination 10%
  • Solving Hormone Problems  History 85%  Physical examination 10%  Lab tests 5%
  • Solving Hormone Problems  History 85%  Physical examination 10%  Lab tests 5%  Respect individual differences
  • Solving Hormone Problems  History 85%  Physical examination 10%  Lab tests 5%  Respect individual differences  Endocrinology will always be somewhat of an art, not an exact science
  • Role of Testing
  • Role of Testing  Symptoms help us reach a tentative diagnosis
  • Role of Testing  Symptoms help us reach a tentative diagnosis  Lab testing confirms or refutes the diagnosis
  • Role of Testing  Symptoms help us reach a tentative diagnosis  Lab testing confirms or refutes the diagnosis  Need to do comprehensive testing
  • Thank You John C. Richards Pharm.D. Barbara Dace Pharm.D. Debby DeJager Pharm.D. P ro f es s i o n al Village Pharmacy 91 6 - 4 8 3 - 3 4 5 5 www.professionalvillagerx.com