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UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
UTI - III
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UTI - III

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This presentation is a continuation of UTI - Part I and Part II. It discusses Novel drugs from plants approved by German Commission E. for Urinary Tract Infections.

This presentation is a continuation of UTI - Part I and Part II. It discusses Novel drugs from plants approved by German Commission E. for Urinary Tract Infections.

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  • 1. Novel drugs from Plants approved by German Commission E. for UTI (UTI – III) - Ref: Bluementhal et. al. (1998) Presented by Dr. Sudhakar Kokate Director PPRC, India
  • 2. Angelica archangelica – Fruit Asparagus officinalis – Rhizome root Phaseolus vulgaris – Bean pod Taraxacum officinale Armoracia rusticana Orthosiphon spicatus Levisticum officinale
  • 3. Angelica archangelica
  • 4. Asparagus officinalis
  • 5. Phaseolus vulgaris
  • 6. Taraxacum officinale
  • 7. Armoracia rusticana
  • 8. Orthosiphon spicatus
  • 9. Levisticum officinale
  • 10. Tropaeolum majus Santalum album – Sandalwood Ononis spinosa Agropyron repens …. Above phyto drugs are approved by German Commission E. for UTI Ref: (Blumenthal et. al. 1998)
  • 11. Tropaeolum majus
  • 12. Santalum album
  • 13. Ononis spinosa
  • 14. Agropyron repens
  • 15. Botanicals with anti-nephrotoxic activity
  • 16. Rheum palmatum
  • 17. Rheum palmatum (Chinese rhubarb) Used for treatment of chronic renal failure in ancient times Active compounds: tannins Tannins reduce levels of uremic toxins and to improve glomercular filtration and blood flow to the kidneys (Yokozawa et. al. 1991)
  • 18. In rats with diabetic nephropathy showed that this extract speeded nitrogen excretion and alleviated hyper lipidemia (Yokozawa et. al. 1997) Several clinical trials in China Rheum palmatum (Chinese rhubarb)
  • 19. Findings – effect on symptoms blood urea nitrogen serum creatinine levels in chronic renal failure patients (Yarnell E. 2000) Rheum palmatum (Chinese rhubarb)
  • 20. Lespedeza capitata
  • 21. Lespedeza capitata Chemicals:  Flavonoids  Procyanidins  Pentacosane n-hexacosane  n-hentriacontane  n-tritriacontane
  • 22. Lespedeza capitata Preliminary clinical trials in patients with renal failure of various types suggest that extracts reduce azotemia uremia and cholesterol Procyanidins inhibited angiotension: converting enzyme (Wagner & Elbl. 1992) Phytoingredients to relieve the symptoms of benign prostatic hyperplasia (BPH)
  • 23.  Phytosterols  Terpenoids  Lectins  Plant oils  Phytoestrogens  Flavonoids  Polysaccharides  Aliphatic alcohols  Fatty acids (Lowe et. al. 1998)
  • 24. Serenoa repens, Sabal serrulata
  • 25. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Used in the treatment of genitourinary tract disturbances since 1899 It increases the function of the testicles and relieves irritation in mucous membranes of genitourinary tract and prostate (D’elos et. al. 1994)
  • 26. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Compounds: Carpic, Captylic, Lauric, Cis-linoleic, Myristic, Palmitic and Stearic acid Steroids: Beta-sitosterol, Campestrol, Cycloartenol, Lupeol, Lupenone, Stigmasterol
  • 27. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Aliphatic alcohols, polyprenic compounds (Arabinose, flavonoids, galactose, uronic acid, antranilic acid, carotenes, lipase and tannins (Van Coppenolle et. al. 2000)
  • 28. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Liposterolic extract of Serenoa repens showed:  Anti-androgenic  Anti-estrogenic  Anti-inflammatory effects (Lowe & Fagelman 1999)
  • 29. Pygeum africanum
  • 30. Pygeum africanum Bark extract (Tadenan®) is widely used in France and throughout Europe Other formulations like prostate are available in health food and nutrition shops in US (Lowe and Fagelman 1999)
  • 31. Pygeum africanum Bark contains waxes, triterpenes, fatty acids and their esters and ferulic acid Known to be anti-inflammatory and anti-edematous (Miller 1996)
  • 32. Effects of Pygeum extracts Reduction in Nocturia Improve peak flow rate Decrease residual urine and symptoms Inhibit androgen stimulation
  • 33. Effects of Pygeum extracts Suppresses prostatic growth factors Inflammation & cholesterol accumulation (McClure 2002)
  • 34. Urtica dioica
  • 35. Urtica dioica Root extracts widely used in Germany 16 different preparations available Major components:  Phenols  Lignans  Sterols  Polysaccharides  Lectins  Triterpene acids
  • 36. Utrica dioica Inhibits 5-alpha-reductase and aromatase activity (McQueen & Shields 2001) Extracts evaluated numerous multi-center open label and double-blind studies Significant improvement in peak flow rate & residual urinary volumes (Wagner et. al. 1994)
  • 37. Curcubita pepo
  • 38. Curcubita pepo Pumpkin seed oil for treating BPH kidney inflammation since 19th century Extracts have anti-androgenic, anti-inflammatory effects (Steenkamp 2003) Chemical: Phytosterols, Selen, Magnesium, Carotenoid
  • 39. Hypoxis rooperi
  • 40. Hypoxis rooperi (Harzol®) – extract of African star grass used in Germany Product contain > 70% Beta sitosterol dry weight (Lowe et. al. 1998) Effects: anti-inflammatory, stimulating Improved peak flow rate, residual urine volume (Dreikorn 2002)
  • 41. Secale cereale
  • 42. Secale cereale (Cernilton®) Rye grass pollen reported to be effective in symptoms of BPH Experimental studies suggest that the product contains: anti-inflammatory, inhibiting 5-ɑ-reductase activity
  • 43. Secale cereale No significant adverse effect It lowers urethral pressure, relax external muscles, decrease swelling in prostate
  • 44. Opuntia ficus-indica
  • 45. Opuntia ficus-indica Cactus flower extract for treatment of Prostatic hypertrophy …. British Herbal pharmacopoeia Anti-oxidant activity Inhibits reductase, aromatase activity (Jonas et. al. 1998)
  • 46. Epilobium sp.
  • 47. Epilobium sp. Historically used to treat prostate disorders, cancer, hypertrophy, prostatis, gastro-intestinal disorders Active compound – Oenotheis B
  • 48. Lepidium latifolium
  • 49. Lepidium latifolium This plant used as anti-escrobte stomach tonic, aperitif and diuretic Anti-inflammatory, anti-oxidant Steroid activity and inhibition of aromatase due to presence of flavonoids (Martinez caballero et. al. 2004)
  • 50. Botanical derivatives for Prostate cancer
  • 51. Camellia sinensis
  • 52. Camellia sinensis (Green tea) Effective compound: Epigallocatechin-3-gallate (Eaca) Prevent the initiation, promotion and progression of Prostate cancer
  • 53. Camellia sinensis (Green tea) Inhibit cell proliferation, decrease contact of carcinogenic with cells, blocking cancer initiation, slowing cancer progression Prevent DNA strand breaks (Liao et. al. 1995, Ahmad 1997)
  • 54. Silybum marianum
  • 55. Silybum marianum (Milk thistle) Seeds contain Silymarin inhibit prostate tumour growth in animal models In lab, Silibinin prevents cancer initiation, promotion, progression by altering signalling mols. & adaptor factor receptor (Zi et. al. 1998)
  • 56. Curcuma longa
  • 57. Curcuma longa “Curcumin” major active anti-oxidant component Effects: Inhibition of prostate cancer cell growth Induction of apoptosis (McClure 2002)
  • 58. Allium sativum
  • 59. Allium sativum Garlic diminishes LNcap cell growth on human prostate carcinoma (Pinto et. al. 1997) Active compound: S-allylmercaptocysteine Decrease prostate: specific antigen (PSA) Secretions & decreasing trophic effects (Steenkamp 2003)
  • 60. Thank You!! “BE WITH US”

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