Cancer - II

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This presentation is a continuation of Cancer - I. It discusses anti-cancer phyto-drugs from natural plant origin.

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Cancer - II

  1. 1. Anti-Cancer Phyto-drugs (Cancer Part – II) Presented by Dr. Sudhakar Kokate Director PPRC, India
  2. 2. Dedication This presentation is dedicated to all Cancer patients across the globe and may our efforts, towards research in this area benefit those who are fighting the dangerous disease
  3. 3. Catharanthus roseus PPRC/INDIA 01
  4. 4. Catharanthus roseus  Family: Apocynaceae  Drugs: Vincristine, Vinblastine  Mode of action in cancer: 1. Lymphocytic leukaemia 2. Adult lymphoma 3. Testicular carcinoma PPRC/INDIA 02
  5. 5. Betula alba PPRC/INDIA 03
  6. 6. Betula alba  Family: Betulaceae  Drugs: Betulinic acid  Mode of action in cancer: 1. Melanoma PPRC/INDIA 04
  7. 7. Thalictrum minus, T. dasycarpum, T. glandulosissimum PPRC/INDIA 05
  8. 8.  Family: Ranunculaceae  Drugs: Hernandezine, Thalicarpine  Mode of action in cancer: 1. Leukaemia (Sarcoma cells affected) PPRC/INDIA 06 Thalictrum minus, T. dasycarpum, T. glandulosissimum
  9. 9. Camptotheca acuminata PPRC/INDIA 07
  10. 10. Camptotheca acuminata  Family: Nyssaceae  Drugs: Camptothecin  Mode of action in cancer: 1. Lymphoma 2. Leukaemia 3. Solid epithelial tumours PPRC/INDIA 08
  11. 11. Colchium speciosum PPRC/INDIA 09
  12. 12. Colchium speciosum  Family: Liliaceae  Drugs: Colchicine  Mode of action in cancer: 1. Breast cancer 2. Thyroid cancer 3. Oesophageal cancer PPRC/INDIA 10
  13. 13. Cephalotaxus harringtonia PPRC/INDIA 11
  14. 14. Cephalotaxus harringtonia  Family: Cephalotaxaceae  Drugs: Harringtonine, Homoharringtonine  Mode of action in cancer: 1. Leukaemia 2. Agranulocyte leukaemia 3. Myelocytic leukaemia PPRC/INDIA 12
  15. 15. Tripterygium wilfordii PPRC/INDIA 13
  16. 16. Tripterygium wilfordii  Family: Celastraceae  Drugs: Triptolide A, B, C, Tripdionide  Mode of action in cancer: 1. Leukaemia PPRC/INDIA 14
  17. 17. Brucea antidysenterica PPRC/INDIA 15
  18. 18. Brucea antidysenterica  Family: Simaroubaceae  Drugs: Bruceantin  Mode of action in cancer: 1. Breast cancer 2. Melanoma sarcoma PPRC/INDIA 16
  19. 19. Podophyllum peltatum PPRC/INDIA 17
  20. 20. Podophyllum peltatum  Family: Podophyllaceae  Drugs: Podophyllotoxin  Mode of action in cancer: 1. Lung metastatic tumours 2. Malignant lymphoma 3. Carcinoma of nasopharynx 4. Germ cell neoplasm PPRC/INDIA 18
  21. 21. Taxus brevifolia PPRC/INDIA 19
  22. 22. Taxus brevifolia  Family: Taxaceae  Drugs: Paclitaxel or Taxol  Mode of action in cancer: 1. Ovarian cancer 2. Breast cancer PPRC/INDIA 20
  23. 23. Crocus sativus PPRC/INDIA 21
  24. 24. Crocus sativus  Active principle: Provitamin  Anti-oxidant activity  Ref: Nair et. al. 1994 PPRC/INDIA 22
  25. 25. Curcuma longa PPRC/INDIA 23
  26. 26. Curcuma longa  Active principle: Curcumin  Strong anti-oxidant activity  Ref: Rao et. al. 1995 PPRC/INDIA 24
  27. 27. Alstonia boonei PPRC/INDIA 25
  28. 28. Alstonia boonei  Family: Apocynaceae  Inhibition of Lysosomal enzymes and glycoproteins  Ref: Saraswathi et. al. 1998 PPRC/INDIA 26
  29. 29. Ixora coccinea PPRC/INDIA 27
  30. 30. Ixora coccinea  Inhibited DNA synthesis  Ref: Latha and Panikkar 1998 PPRC/INDIA 28
  31. 31. Dictamnus dasycarpus PPRC/INDIA 29
  32. 32. Dictamnus dasycarpus  Active principle: Limonoid triterpene enhances cytotoxicity to microtubules suggesting the action site may be extract of Barringtonia racemosa  Anti-tumour activity against Dalton’s Lymphoma Ascitis (DLA) in mice  Ref: Thomas et. al. 2002 PPRC/INDIA 30
  33. 33. Brassica oleracea PPRC/INDIA 31
  34. 34. Brassica oleracea  Administration of allyl isothiocyanate (AITC) a naturally occurring Sulphur compound along with Cyclophosphamide (CYP) induced Urotoxicity, where glutathione in bladder and liver enhanced and also showed normal bladder morphology PPRC/INDIA 32
  35. 35. Punica granatum PPRC/INDIA 33
  36. 36. Punica granatum  The fruit rind powder elicited an increase in antibody titre, inhibited leukocyte migration and delayed hypersensitivity reaction confirming its stimulatory effect on humoral and cell mediated components of the immune system in rabbits  Ref: Gracious et. al. 2001 PPRC/INDIA 34
  37. 37. Withania somnifera PPRC/INDIA 35
  38. 38. Withania somnifera  Extracts of plant stimulated immunological activity in mice  Ref: Davis and Kultan 2000 PPRC/INDIA 36
  39. 39. Trigonella foenum-graecum PPRC/INDIA 37
  40. 40. Trigonella foenum-graecum  It exhibited a stimulatory effect on immune function in mice  Ref: Bin-Hafeez et. al. 2003 PPRC/INDIA 38
  41. 41. Silybum marianum PPRC/INDIA 39
  42. 42. Silybum marianum  Active principle: Silymarin  A plant flavanolignan mixture isolated from the seeds  Possesses antioxidant, anti-inflammatory, immuno-modulatory properties leading to prevention of different cancers PPRC/INDIA 40
  43. 43. Silybum marianum  “Silibinin” major active component inhibits Prostate tumour - Ref: Singh et. al. 2003  Inhibits chemically induced urinary bladder neoplasms and preneoplastic lesions – Vinh et. al. 2002  Reduces colon carcinogenesis in rats – Yanaida et. al. 2002 PPRC/INDIA 41
  44. 44. Tomatoes PPRC/INDIA 43
  45. 45. Lycopene PPRC/INDIA 42
  46. 46. Lycopene in Tomatoes  Lycopene, the major carotenoid in tomatoes is a protective compound against Prostate cancer  It affects Stomach, Colon, Oral, Lung and Breast cancer  Protects mice from bacterial infections and inhibits growth of Ascites tumours PPRC/INDIA 44
  47. 47. Lycopene in Tomatoes  Affects glioma cells  Suppresses orthotopic growth of human prostate tumours  Lycopene inhibits proliferation of Lung cancer – Levy et. al. 1995  Inhibits the growth of Leukaemia and malignant tumours PPRC/INDIA 45
  48. 48. Chilies PPRC/INDIA 47
  49. 49. Capsaicin PPRC/INDIA 46
  50. 50. Capsaicin  Family: Solanaceae  Capsaicin, active principle in hot red and chilli, peppers  Widely used as spices  Dual role in carcinogenic and mutagenic processes PPRC/INDIA 48
  51. 51. Capsaicin  Protective effect on stomach cancer  Affects metabolism of carcinogens  Represses the growth of Hela, Ovarian carcinoma, mammary adeno-carcinoma and P. leukaemia, HL 60 cells PPRC/INDIA 49
  52. 52. Zingiber officinale PPRC/INDIA 51
  53. 53. Gingerol PPRC/INDIA 50
  54. 54. Gingerol: Zingiber officinale  Possesses substantial antioxidant activity  Also possesses inhibitory effect on xanthine oxidase  Inhibits platelet aggression, formation of thromboxane and prostaglandin  Protects skin cancer, ear oedema PPRC/INDIA 52
  55. 55. Gingerol: Zingiber officinale  Prevents intestinal carcinogenesis in rats  Inhibits pulmonary metastasis in mice HL 60 cells – Lee and Surh 1998 PPRC/INDIA 53
  56. 56. Tabebuia avellanedae PPRC/INDIA 54
  57. 57. Tabebuia avellanedae  Extract from stem bark showed anti-tumour activity  Nowadays T. avellanedae extract is commercialized as a miracle drug in the treatment of cancer and other health problems in Japan – Nakamura 2000 PPRC/INDIA 55
  58. 58. Tabebuia avellanedae  Components from this extract: 1. Naphtho-quinone lapachol 2. Beta-lapachone showed strong anti-neoplastic properties PPRC/INDIA 56
  59. 59. Allium sativum PPRC/INDIA 57
  60. 60. Allium sativum  Garlic contains Diallyl sulfide (DAS) which showed potent antioxidant compound with anti-inflammatory, anti-mutagenic and cancer preventive properties  DAS imparts chemo-preventive effects against skin, mammary, lung, colon and liver cancers PPRC/INDIA 58
  61. 61. Thank You!! “BE WITH US”

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