Observing the brain to know ourselves                        Sara A. Solla                  Northwestern University
The human brain
The human brain
NeuronsAbout 85 billion neurons,of which about 15 billionare in the cortex.
Neurons
Neurons electrode
Spikes: action potentials
Spikes: from single neurons    to multiple neurons
Multi Electrode Arrays (MEAs)
Reaching tasks
Center out task
MEA recordings: center out task
MEA recordings: multiple targets
Converting thoughts into actions           Nicolelis, Nature Reviews Neuroscience (2003)
Brain machine interfacesIdea first proposed by Edward M. Schmidt in 1980: `Singleneuron recording from motor cortex as a p...
Multi Electrode Arrays (MEAs)    Truccolo, Hochberg, Donoghue, Nature Neuroscience (2009)
Activity: multiple neurons                  110 neurons, M1, hS3
Brain machine interfaces
NeuroprosthesisHochberg, Serruya, Friehs, Mukand, et al, Nature (2006)
Neuroprosthesis
MEA recordings: center out task
Target-dependent population activity             ni   Here ni is the number of spikes        fi =      emitted by neuron i...
Decoding direction of motion    for center out task
Predicting motion from neural activity  Simultaneous recordings of population activity provide insight on the activity of...
Bidirectional Brain Machine Interface • Incorporate realistic limb dynamics into forward pathway • Incorporate propriocept...
Upcoming SlideShare
Loading in...5
×

OBC | Observing the brain to know ourselves

586

Published on

Sara A. Solla, Northwestern University, Chicago, USA
Observing the brain to know ourselves

http://obc2012.outofthebox.si/

Published in: Education, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
586
On Slideshare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
1
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

OBC | Observing the brain to know ourselves

  1. 1. Observing the brain to know ourselves Sara A. Solla Northwestern University
  2. 2. The human brain
  3. 3. The human brain
  4. 4. NeuronsAbout 85 billion neurons,of which about 15 billionare in the cortex.
  5. 5. Neurons
  6. 6. Neurons electrode
  7. 7. Spikes: action potentials
  8. 8. Spikes: from single neurons to multiple neurons
  9. 9. Multi Electrode Arrays (MEAs)
  10. 10. Reaching tasks
  11. 11. Center out task
  12. 12. MEA recordings: center out task
  13. 13. MEA recordings: multiple targets
  14. 14. Converting thoughts into actions Nicolelis, Nature Reviews Neuroscience (2003)
  15. 15. Brain machine interfacesIdea first proposed by Edward M. Schmidt in 1980: `Singleneuron recording from motor cortex as a possible source ofsignals for control of external devices’. Schmidt, Annals of Biomedical Engineering (1980)
  16. 16. Multi Electrode Arrays (MEAs) Truccolo, Hochberg, Donoghue, Nature Neuroscience (2009)
  17. 17. Activity: multiple neurons 110 neurons, M1, hS3
  18. 18. Brain machine interfaces
  19. 19. NeuroprosthesisHochberg, Serruya, Friehs, Mukand, et al, Nature (2006)
  20. 20. Neuroprosthesis
  21. 21. MEA recordings: center out task
  22. 22. Target-dependent population activity ni Here ni is the number of spikes fi = emitted by neuron i during a time D bin of duration D .
  23. 23. Decoding direction of motion for center out task
  24. 24. Predicting motion from neural activity  Simultaneous recordings of population activity provide insight on the activity of networks of neurons and its relation to function.  The mathematical analysis of neural activity associated with arm reaches allows us to predict motion trajectory.  The ability to simultaneously record and decode the activity of large populations of neurons provides a tool for the restoration of function.
  25. 25. Bidirectional Brain Machine Interface • Incorporate realistic limb dynamics into forward pathway • Incorporate proprioception in feedback pathway
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×