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David ewing duncan   open science 7-30-10
 

David ewing duncan open science 7-30-10

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    David ewing duncan   open science 7-30-10 David ewing duncan open science 7-30-10 Presentation Transcript

    • Open Science Meets Personalized Health
      David Ewing Duncan
      Director, Center for Life Science Policy, UC Berkeley
    • Two Great Movements
      Citizen patients
      Citizen scientists
    • Historical Moment
    • People
      + Technology
      = Empowerment
    • “With great power comes great responsibility...”- Ben Parker (Spiderman’s Uncle)
    • Why DIY?
      • Curiosity
      • Feel it coming: early adopters
      • Outmoded paradigms
      • Tired of hearing no
      • Bad customer service
      • Change the world
    • THEEXPERIMENTAL
      MAN PROJECT
    • Age of Personalized Health
      • 10 million genetic markers
      • 9,366 genotypes
      • 320 environmental toxins
      • 22 hours of MRI brain scans
      • ~ 2 liters of blood
      • ~ $150,000
      The Experiment
    • Healthy
    • Not Just Genes...
      Environment
      Brain
      Body
    • Experimental Family
      Alzheimer’s (rs4420638)
      Father Mother
      AG AA
      David Brother
      AA AG
      Daughter
      AA
      Heart Attack (rs1075728)
      Father Mother
      AG AG
      David Brother
      GGAA
      Daughter
      AG
    • Favorite Genetic Marker
      CYP1A2
      Caffeine Fast Metabolizer
    • Mercury and Me
    • Mercury andMe
    • Mercury and Me
      Halibut (lunch) Swordfish (dinner)
    • Mercury Before: 4 ppb
      Mercury After: 13 ppb
    • My genetic sensitivity to mercury(Envirogenomics)
    • High Anxiety
    • Fear and Anxiety
      Emotional incongruence (emotional conflict)
      Emotional conflict resolution
      (emotion regulation)
    • (Don’t) Be Still My Beating Heart
    • First Add Genomics
      Copyright 2008 Entelos, Inc.
    • Biomarkers (Chemistry)
      Copyright 2008 Entelos, Inc.
    • Scans: Ultrasound and CT
      Copyright 2008 Entelos, Inc.
    • Genes + Environment +
      Biomarkers + Ultrasound + CT Scan
      Entelos Project
      Combine Risk Factors
    • Prediction of my future… ?
      Copyright 2008 Entelos, Inc.
    • Lost 10 pounds
    • Still work to be done
      • Science needs validating
      • Skeptical public
      • Resistance from traditional medicine
      • Expensive
      • Shift from old to new
    • Orwellian Possibilities
      • Big Brother
      • The Obama Effect
      • Discrimination
      • Genetic thrallism (Gattaca)
      • Unleashing monsters
      • Fear
    • Personalized Health Project
      • Coordinated effort to validate
      • Integration is key
      • Get creative with law, policy, education, ethics, media
      • Private sector and early adopters
      • Encourage (demand?) a paradigm shift
    • Thoughts on DIY
      • Dangers need to be taken seriously (credo of Ben Parker)
      • Be proactive with government and law enforcement
      • Work with Big Science – they need you, you need them
      • Do something wonderful
    • Coming this fall…
      The Linkage Project:
      A Manifesto
    • Still going… more tests
    • www.ExperimentalMan.com