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Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
Mohit Patel -- Disruptive Diner: Nano Possibilities
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Mohit Patel -- Disruptive Diner: Nano Possibilities

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Presentation from 10/15/13 on innovative startup producing cost effective nano particle kits to get large amounts of DNA into cells without damaging them. Genetix Fusion LLC founder Mohit Patel …

Presentation from 10/15/13 on innovative startup producing cost effective nano particle kits to get large amounts of DNA into cells without damaging them. Genetix Fusion LLC founder Mohit Patel explains how nanotech makes this possible and the enormous time and cost problems they're able to address. Join OpenlyDisruptive.org for live access to more disruptive innovation events.

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Transcript

  • 1. The next generation of Gene Delivery Mohit B. Patel
  • 2. What is Nano? Macro Nano Millionth  (10-­‐6)     Human  Being   6  feet  tall   Micro Billionth  (10-­‐9)     Red  Blood  Cell   8  micrometer   DNA   2nm  wide  
  • 3. Nanotechnology Energy Nanomedicine Nanosensors Broad  range  of  applica<ons  
  • 4. Genetic Material Tissue   Gene   Cell   Body   Chromosome   DNA  
  • 5. Genetic Disorders Illness  caused  by  an  abnormality  in  an  individuals   DNA/gene.  
  • 6. Gene Delivery Gene Delivery Gene Expression Research applications: Genetic disorders, gene therapy, protein production, functional genomics, disease diagnostics and agriculture crop enhancement
  • 7. Gene Delivery Transfection: Laboratory procedure to delivery foreign DNA into host cells.
  • 8. Physical methods Electropora5on   Gene  gun   Microinjec5on   Advantage:  Can  transfer  large  DNA  molecules   Disadvantage:  Highly  cytotoxic  and  expensive  
  • 9. Biological methods Advantage:  Stable  transfec<on   Disadvantage:  High  risk  and  <me  consuming  
  • 10. Chemical methods Calcium  phosphate   Lipids   Nanotubes   Advantage:  Good  efficiency   Disadvantage:  Cytotoxic  and  limited  gene<c  informa<on  
  • 11. Limitations of Existing Products •  Toxic to cells $6000 and 30 days / year for each scientist •  Limited size (kilobases, kb) •  Poor efficiency •  Time consuming •  Inconsistent results •  Costly 11   “Transfection market clamors for silver bullet.”
  • 12. Solution: Janus Transfection Kit™ Janus Transfection Kit™ utilizes a new class of chemical reagent for DNA transformation and transfection. New Class = non-lipid, non-viral and non-dendrimer based transfection reagent Janus Transfection Kit™ Proprietary Platform Technology 12  
  • 13. Janus Transfection Reagent™ STEP 1 STEP 2 STEP 3
  • 14. Efficiency: Janus Transfection Kit™ 60 50 40 30 20 10 0 Yeast Colony forming units Colony forming units Bacteria Janus Transfection Promega's Product Reagent™ 600 500 400 300 200 100 0 Mammalian cells Number of cells transfomed 0.00% Janus Transfection Reagent™ Control Standard Reagent Plants 100.00% 50.00% Janus Transfection Reagent™ 60 50 40 30 20 10 0 Janus Transfection Reagent™ Control
  • 15. Competitive Advantages Janus Transfection Kit™ will save each researcher an estimated 65% of cost and 50% of time. Company In-House Invitrogen Sigma Aldrich Promega Qiagen DNA Size <7kb ~9-12kb ~11kb ~7-10kb ~9-12kb Toxicity High High Low Low Medium Genetix Fusion >20kb None Very High 15   Cell Versatility Low High Medium Medium Medium Price $ 413 $ 485 $ 333 $ 440 $ 288 $ 350
  • 16. Solution: Janus Transfection Kit™ Enables use of larger DNA High efficiency Non-mutagenic and non-cytotoxic Broad range of applications
  • 17. Transfection Market $13.4 Billion market DNA and RNA delivery $346 Million Genetix Fusion accessible market Academia 68% ($235 M) Pre-packaged kits 75% ($259 M)
  • 18. Critical Milestones Launch first product Genetix Fusion founded Alpha prototype tested Initial funding raised May 2012 PCT application Provisional patent Beta prototype 1% Market (~5500 units) Controlled market release January 2018 January 2014 Establish operations Today January 2015 Strategic distribution partner 4% Market (~28000 units)
  • 19. Now Seeking 1.  Academic researchers for beta testing 2.  Collaborative opportunities 3.  Distribution partner 4.  Seed stage investment
  • 20. REDEFINING TRANSFECTION Contact us: mohitpatel87@gmail.com www.genetixfusion.com (314) 516-4607

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