Stem Cell Therapy
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  • OSF: Chronic inflammation and progressive fibrosis of the lamina proria and CT causing trismus.\n\nIntralesional injections induce angiogenesis in the lesion which in turn decreases the extent of fibrosis leading to significant increase in mouth opening.\n
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Stem Cell Therapy Presentation Transcript

  • 1. 1RCsDP Stem Cell Therapy Contents Omar Hamad AlKadhiOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 2. 2 RCsDP ContentsNotes on Stem Cells Regenerative Medicine Types Definition and Properties •Definition and Properties •Types Contents •Regenerative Medicine •Notes on Stem Cells Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 3. 3RCsDP What is a Stem Cell? Definition and Properties • Stem cells are found in multi-cellular organisms. They reproduce through mitosis and can differentiate into specialized cells such as red blood cells or nerve cells. ContentsOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 4. 4RCsDP Properties of Stem Cells Definition and Properties Contents • Capability of dividing and renewal for long periods • Unspecialized • They can produce specialized cell types (Potency)Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 5. 5RCsDP Types of Stem Cells Types 1. Adult 2. Embryonic: A. Found in children and adult A. Found in blastocyst 4-5 days Contents tissues embryo 50-150 pluripotent cells in the inner cell mass B. Pluripotent in the umbilical cord B. Derived from embryos at in vitro fertilization clinics C. Most of them are multipotent C. Can differentiate into all D. Act as a repair system specialized tissues maintaining normal turnover D. Promising for future therapy E. Form umbilical cord blood and bone marrowOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 6. 6RCsDP Types of Stem Cells Types Potency 1. Totipotent: Can make an organism from the fusion of sperm and egg Contents 2. Pluripotent: Can differentiate into all 200 body cells types 3. Multipotent: Can differentiate into various cell types of closely related cells 4. Oligopotent: Can differentiate into a few number of cell types 5. Unipotent: Can only produce their own typeOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 7. 7RCsDP Dental Pulp Stem Cells Types (DPSCs) • They are pluripotent stem cells that 5. Chondrocytes have the potential to differentiate into a variety of cell types. They are 6. Adipocytes Contents found in the soft lining tissues of dental pulp. They are mesenchymal cells and have the potential to 7. Bone and tissues from the oral differentiate into: cavity 1. Cardiomyocytes 2. Neuronal 3. Myocytes 4. OsteocytesOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 8. 8RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) Contents • It is based on stem cells, signals (growth factors) and scaffoldsOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 9. 9RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) Contents • Several cases of oral Submucous Fibrosis have been treated with intralesional injections of autologous bone marrow stem cells.Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 10. 10RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) Contents • In a study on dogs stem cells were s u c c e s s f u l ly s t i mu l a t e d w i t h Morphogenetic Protein 2 (BMP2) to differentiate into odontoblastsOmar Hamad Alkadhi, RCsDP December 14, 2010
  • 11. 11RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) • Mouse ES cells, mixed together with hydroxyapatite/tricalcium phosphate (HA/ TCP) powders, have been transplanted into tooth sockets of Sprague-Dawley rats. Although immature bone tissue was observed after 12 weeks, no dentin Contents or pulp-like tissue was found in the implants. • H. K. Kang, S. Roh, G. Lee, S.-D. Hong, H. Kang, and B.-M. Min, “Osteogenic potential of embryonic stem cells in tooth sockets,” International Journal of Molecular Medicine, vol. 21, no. 5, pp. 539–544, 2008.Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 12. 12RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) • the most successful regenerated tooth structures were obtained using cells from mouse embryonic tooth buds harvested E11~14.5. Other reports indicated the formation of recognizable tooth structures, containing organized Contents enamel, dentin, and a well-defined tooth pulp, by seeding dissociated postnatal tooth bud derived epithelial and mesenchymal cells onto biodegradable materials • C. S.Young, S. Terada, J. P.Vacanti, M. Honda, J. D. Bartlett, and P. C.Yelick, “Tissue engineering of complex tooth structures on biodegradable polymer scaffolds,” Journal of Dental Research, vol. 81, no. 10, pp. 695–700, 2002.Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 13. 13RCsDP Stem Cell Therapy Regenerative Medicine (Regenerative Medicine) • Human DPSCs seeded onto a 3D PGA matrix and grown in vitro formed new tissue with a cellularity similar to that of native pulp Contents • D. J. Mooney, C. Powell, J. Piana, and B. Rutherford, “Engineering dental pulp-like tissue in vitro,” Biotechnology Progress, vol. 12, no. 6, pp. 865–868, 1996.Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 14. 14 RCsDP Notes on Stem CellsNotes on Stem Cells • Stem cells can be grown and specialized into tissues such as muscles and nerves in cell cultures Contents • Embryonic stem cells are hard to control. If they were injected directly into another body, they will cause a teratoma and transplant rejection. • drug tests, experiment to study development and gene control and stem cell therapy • Adult stem cells can produce cells of tissues in which they reside such as hematopoietic stem cells in the bone marrow can produce different kinds of blood cells but not cells of other tissues such as nerves and brain cells. • Recent research is suggesting that adult stem cells can produce cells of a completely different type of tissue Omar Hamad Alkadhi, RCsDP December 14, 2010
  • 15. ohk1st@gmail.com 15RCsDP Contents Thank YouOmar Hamad AlKadhi, RCsDP January 23, 2011