Environmental diseases


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Environmental diseases

  2. 2. EXTREMES OF TEMPERATURES • THERMOREGULATION – Heat generation – Heat loss – Heat conservation • Normal core body temp- 37±0.5ᴼC • Hypothermia • hyperthermia
  3. 3. HYPOTHERMIA • Failure of body’s normal thermal regulatory mechanism to produce sufficient heat in cold environment. Core temp. falls below 35ᴼC . Protective mechanisms • Vasoconstriction • Shivering • Increase metabolism
  4. 4. Hypothermia is common in • Very young children • Elderly people • Hypothyroidism • Addison’s disease • Myxoedema • Stroke • Hepatic failure • Hypoglycemia • Exposure to extreme cold climates
  5. 5. EFFECTS OF SYSTEMIC HYPOTHERMIA • Decreased respiratory drive • Decreased O2 consumption • Decreased central and peripheral nerve conduction • Decreased GI motility • Decreased myocardial repolarization • Decreased coagulation cascade
  6. 6. Clinical features of hypothermia • Core temp of body 32ᴼ-35ᴼC • Tachypnea, tachycardia, hypertension and shivering • Impaired coordination and apathy • At temp 32-28ᴼ- shivering stops • Bradycardia, pupils dilate, reflexes slow, confusion and lethargy • Death in hypothermia is due to ventricular fibrillation
  7. 7. TREATMENT • ABC • Initiation of rewarming • Rectal temp should be measured • Monitoring of vitals, cardiac rhythm, blood sugar • Treat hypoxia • Treat fluid and electrolyte imbalance • Control arrhythmias
  8. 8. HYPOTHERMIA OF THE EXTREMITIES • FROSTNIP • CHILLBLAINS • TRENCH FOOT • FROST BITE • Cold-induced injuries to the extremities (ie, frostnip, chilblain, trench foot, and frostbite) range from mild to severe. • Cold exposure of the extremities produces immediate localized vasoconstriction followed by generalized vasoconstriction. • When the skin temperature falls to 25°C, tissue demand for oxygen is greater than what is supplied by the slowed circulation: the area becomes cyanotic.
  9. 9. • At 15°C, tissue damage occurs due to marked reduction in tissue metabolism and oxyhemoglobin dissociation. • This gives a deceptive pink, well-oxygenated appearance to the skin. • Tissue damage may result from ischemia and intravascular thromboses, endothelial damage, or by actual freezing. • Freezing (frostbite) may occur when the skin temperature drops below −4 to −10°C
  10. 10. • Frostnip is a mild temporary form of cold-induced injury. • The involved area has local paresthesias that completely resolve with passive external rewarming • Chilblains or erythema pernio are inflammatory skin changes caused by exposure to cold without actual freezing of the tissues. • These skin lesions may be red or purple papular lesions, which are painful or ,with burning or paresthesias.
  11. 11. TRENCH FOOT • Immersion foot (or hand) TRENCH FOOT is caused by prolonged immersion in cool or cold water or mud, usually < 10°C. • cold and anesthesia of the affected area. • follows with hot sensation, intense burning, and shooting pains. • part becomes pale or cyanotic with diminished pulsations due to vasospasm • blistering, swelling, redness, ecchymoses, hemorrhage, • necrosis, peripheral nerve injury, or gangrene
  12. 12. FROST BITE • Frostbite is injury from tissue freezing and formation of ice crystals in the tissue particularly the extremities. • The tissues become anesthetised. • Tissue is initially pale and doughy to touch. • Later becomes hard and insensitive to pain. • Gangrene may form. M/M • Rewarming in warm water • Protecting the injured tissue • Avoid infection • vasodilators • Surgical treatment may be reqd. to remove dead tissue
  13. 13. frostbite
  14. 14. HEAT SYNCOPE • Heat syncope or sudden collapse may result in unconsciouness • volume depletion and cutaneous vasodilation • with consequent systemic and cerebral hypotension • history of prolonged vigorous physical activity or prolonged standing in a hot humid environment. • Typically, the skin is cool and moist, the pulse is weak, and the systolic blood pressure is low • t/t –rest in recumbent position • Water and electrolyte rehydration
  15. 15. HEAT CRAMPS • Characterized by painful muscle cramps (painful skeletal ms contractions)following vigorous exercise in hot weather. • No increase in core temperature. • The patient is alert with normal vitals • Due to extracellular Na+ depletion following electrolytes loss due to persistent sweating. • Responds rapidly to salt replacement.
  16. 16. HEAT EXHAUTION • Occurs when the core temp. increases between 37ᴼC-40ᴼC following vigorous physical activity in hot environment and humidity. • It is characterized by dehydration, sodium depletion. • increased pulse, and moist skin. nausea, vomiting, • malaise, myalgias, hyperventilation, thirst, and weakness. • CNS symptoms include headache, dizziness, fatigue, anxiety, paresthesias. treatment – • removal of the pt. from hot environment • Cold sponging • Fluid replacement saline or isotonic glucose saline
  17. 17. HEAT STROKE • life-threatening medical emergency • Characterized by core temp. >40ᴼC and cerebral dysfunction . • Loss of heat regulatory mechanism. • Symptoms include all those seen in heat exhaustion with additional symptoms of dizziness, weakness, confusion, delirium, blurred vision, convulsions, collapse, and unconsiousness • Signs • Skin will be hot • No sweating • Dehydration • hyperventilation
  18. 18. TREATMENT • Treatment is aimed at rapidly reducing the core temperature (within 1 hour) while supporting circulatory and organ system function to prevent irreversible tissue damage and death. • Oral or intravenous fluid administration. • Cold sponging • Metabolic abnormalities and cardiac arrythmias should be treated
  19. 19. DROWNING
  20. 20. • Drowning describes submersion resulting in asphyxia and death. • Following inhalation of water ↓ ventilation-perfusion imbalance ↓ hypoxemia + pulmonary oedema • Absorption of large amount of water(hypotonic ) fluid leads to hemolysis • Near drowning describes a submersion event leading to injury. Submersion injury may result in aspiration,laryngospasm,hypoxemia, and acidemia • “Wet” drowning is due to aspiration of fluid or foreign material. • “Dry” drowning is due to laryngospasm or airway obstruction
  21. 21. NEAR DROWNING • The first requirement of rescue is immediate basic life support and CPR. • Patient must also be assessed for hypothermia, hypoglycemia, concurrent injuries, and medical conditions. • Clinical manifestations are hypoxemia, pulmonary edema, and hypoventilation
  22. 22. Symptoms and Signs • anxiety, dyspnea, cough, wheezing, • cyanosis, chest pain, dysrhythmia, hypotension, • vomiting, diarrhea, headache, • altered level of consciousness, neurologic deficit, • apnea • Hypothermia
  23. 23. Laboratory Findings • Arterial blood gas - Pao2 is usually decreased; Paco2 may be increased; pH is decreased. • blood sugar must be checked rapidly. • kidney function, • electrolytes, urinalysis, • blood count, • coagulation studies,
  24. 24. Treatment • A. First Aid • immediate CPR. - Ventilation, oxygenation, and circulatory support. • Hypothermia and associated trauma, especially brain and cervical spine injury, should always be suspected. • Patient must be assessed for hypoglycemia, metabolic acidosis, and concurrent medical conditions. • Rescuer should not attempt to drain water from the victim’s lungs. The “Heimlich maneuver” (subdiaphragmatic pressure) should be used only if foreign material airway obstruction is suspected.
  25. 25. • Oxygen should be administered immediately at the highest available concentration. • Oxygen saturation should be maintained at 90% or higher. • Endotracheal intubation and mechanical ventilation • Bronchodilators • Antibiotics • Hypotension is treated with vasopressors • Pulmonary oedema- diuretics • Metabolic acidosis –by proper ventilation and oxygenation • Hypothermia should be corrected
  26. 26. COMPLICATIONS • Dehydration • Hypotension • Hemoptysis • Pulmonary infection • Arrhythmias • ARDS
  27. 27. COLD WATER IMMERSION Death results due to • Sudden cardiac arrest • Muscle stiffness due to cold water • Hypothermia • Loss of consciousness • Further water inhalation
  29. 29. HIGH ALTITUDE ILLNESS • As altitude increases, there is a decrease in both barometric pressure and oxygen partial pressure leading to hypoxia. • Acclimatization occurs as a physiologic response to the rise in altitude and increasing hypoxia. • Acclimatisation to hypoxaemia at high altitude results in increased erythropoiesis, haemoconcentration, and hyperventilation • Physiologic changes include increases in alveolar ventilation and oxygen extraction by the tissues and increased hemoglobin level and oxygen binding • Ascent to altitudes up to 2500 m or travel in a pressurised aircraft cabin is harmless to healthy people. • Above 2500 m high-altitude illnesses may occur in previously healthy people, and above 3500 m these become common.
  30. 30. ACUTE MOUNTAIN SICKNESS • Characterized by neurologic and pulmonary symptoms. • Characterized by headache with N,V, dizziness, fatigue • Facial pallor, dyspnea and cyanosis • Later - vertigo, tinnitus, visual disturbances • Occurs in 6-24 hrs. of ascent. • M/M – Rest, analgesic and Acetazolamide (acetazolamide acts by inhibiting carbonic anhydrase enzyme causing metabolic acidosis and thus increasing ventilation.) • Prevention – slow ascent and acclimatization
  31. 31. High altitude cerebral edema • Extension of CNS symptoms of acute mountain sickness • Over >3500 m due to loss of acclimatization • Altered consciousness and ataxic gait • Confusion, Behavioral changes, Hallucinations • Seizures, ff by obtundation,and coma M/M –immediate descent - O2 - steroids (dexamethasone) - diuretics( mannitol)
  32. 32. High altitude pulm edema • High-altitude pulmonary edema is a serious complication of hypoxia induced pulmonary hypertension • The hallmark is markedly elevated pulmonary artery pressure followed by pulmonary edema. It usually occurs at levels above 3000 meters • Early symptoms may appear within 6–36 hours after arrival at a high-altitude area. • These include persistent dry cough, shortness of breath, headache, fatigue, dyspnea at rest, and chest tightness. • Later, wheezing, orthopnea ,and hemoptysis may occur as pulmonary edema worsens
  33. 33. • Physical findings include tachycardia, mild fever, tachypnea, cyanosis, prolonged respiration, and rales and rhonchi • The patient may become confused or comatose TREATMENT • The patient must rest in the semi-Fowler position (head raised), and • 100% oxygen must be administered. • Immediate descent is essential. • Nifedepin to reduce the pulmonary arterial pressure
  34. 34. DYSBARISM & DECOMPRESSION SICKNESS • Dysbarism and decompression sickness are physiologic problems that result from altitude changes and the environmental pressure effects on gases in the body during underwater descent and ascent, particularly when scuba diving is followed closely by air travel or hiking to high altitudes • As a diver descends, the gases in the body compress; gases dissolve in blood and tissues. During the ascent, gases in the body expand.
  35. 35. • Dysbarism results from gas compression or expansion in parts of the body that have limited compliance • results in pneumomediastinum, pneumothorax, and rupture of the pulmonary vein causing arterial gas embolism • gastric rupture, bowel obstruction or perforation, or pneumoperitoneum. • Less serious conditions can also occur such as ear squeeze, sinus squeeze, headache, tooth squeeze.
  36. 36. • Decompression sickness occurs when the ascent is too rapid and gas bubbles form and cause damage depending on their location (eg, coronary, pulmonary, spinal or cerebral blood vessels, joints, soft tissue).
  37. 37. Clinical Findings • The range of clinical manifestations varies depending on the location of the gas bubble formation or the compressibility of gases in the body. • Symptom onset may be immediate, within minutes or hours (in the majority), or present up to 36 hours later. • Decompression sickness symptoms include pain in the joints • skin pruritus or burning , or rashes; • labyrinthine decompression sickness characterized by vertigo); • pulmonary decompression sickness causing inspiratory pain, cough, and respiratory distress • arterial gas embolism (cerebral or pulmonary)
  38. 38. Treatment • Decompression sickness must be considered if symptoms are temporally related to recent diving or altitude or pressure changes within the past 48 hours. • Immediate consultation with a diving medicine or hyperbaric oxygen specialist is indicated • Continuous administration of 100% oxygen is indicated and beneficial for all patients. • Aspirin may be given for pain. Opioids should be used very cautiously,
  40. 40. RADIATION EXPOSURE • Damage from radiation is determined by the source, type, quantity, duration, bodily location, and susceptibility and accumulation of exposures of the person. • Radiation exposure from medical diagnostic imaging has dramatically risen over the past few decades; medical imaging radiation dosing needs to be standardized and regulated in order to minimize necessary radiation exposure
  41. 41. • Radiation occurs from both nonionizing and ionizing radiation sources. • Nonionizing radiation is low energy, resulting in injuries related to local thermal damage (ie, microwave, ultraviolet, visible light and radiowave). • Ionizing radiation is high energy, causing bodily damage in several ways (ie, cellular disruption, DNA damage, and mutations). • Ionizing radiation is either electromagnetic (ie, x- rays and gamma rays) or particulate (ie, alpha or beta particles, neutrons, and protons • X rays, CT Scan, MRI and Radiotherapy
  42. 42. • The energy absorbed by a unit mass of a tissue is the radiation dose. • This is measured in grays (Gy) and is useful to assess the high dose exposure. • Effective dose to cause damage to a particular tissue is measured in sieverts (Sv). This is useful to assess chronic low dose exposure. • Effect depends on the dose and tissue penetration.
  43. 43. • Radiation exposure results in early and delayed effects. • Early effects involve damage of the rapidly dividing cells (ie, the mucosa, skin, and bone marrow). • This may be manifested as nausea, vomiting, and decreased lymphocyte count over hours to days after exposure. • Delayed effects include malignancy, reproduction abnormalities, liver, kidney, and central nervous system and immune system dysfunction
  44. 44. Clinical Findings A. Injury to Superficial Structures • Acute radiation exposure to the skin and mucous membranes may cause erythema, destruction of fingernails, • Chronic damage includes skin scarring, atrophy, and xerostomia. Radiation effects on the eyes include cataracts, dry eye syndrome, and retinopathy
  45. 45. B. Injury to Deep Structures • Hematopoietic system radiation exposure causes injury to the bone marrow that may vary from transient decreases to complete destruction of blood elements. • Hematopoietic effects consisting of anemia, thrombocytopenia, and bone marrow suppression. • Bone marrow failure is the main cause of death within the first few months following exposure to radiation
  46. 46. • Nervous system structures are sensitive to radiation. • The brain and spinal cord are much more sensitive than the peripheral nerves. • cardiovascular system effects of ionizing radiation result in damage to the heart and coronary arteries. • Delayed effects from radiation include obliterative endarteritis; coronary artery disease; pericarditis with effusion; or constrictive pericarditis, • Pulmonary system cause pneumonitis or pulmonaryFibrosis.
  47. 47. • Gastrointestinal system radiation results in mucositis and mucosal edema within hours or days after exposure. • Symptoms include odynophagia, anorexia, nausea, vomiting, dehydration, and weakness. Delayed effects include hepatitis, liver dysfunction, and intestinal stenosis. • The stomach and colon are the gastrointestinal organs most at risk for cancer. • Urogenital system radiation effects are dose- dependent, infertility • Endocrine system organs are relatively resistant to low or moderate doses of radiation. The thyroid gland is the endocrine gland at highest risk for cancer induction from internal radiation exposure.
  48. 48. C. Systemic Reaction (Acute Radiation Syndrome) • Acute radiation syndrome is due to an exposure to high doses of ionizing radiation over a brief time course. • The symptom onset is within hours to days depending on the dose. • Symptoms include anorexia, nausea, vomiting, weakness, exhaustion, and lassitude. • Dehydration, anemia, and infection may follow
  49. 49. TREATMENT • Treatment is focused on decontamination, • Symptomatic relief, supportive care, and psychosocial support. • Adequate hydration • Marrow transplantation for marrow aplasia • Chelating agents