4.c. Students know how 9.b. Students know how the mutations in the DNA nervous system meditatessequence of a gene may or may communication betweennot affect the expression of the different parts of the body and gene or the sequence of amino the body’s interactions with the acids in the encoded protein. environment.
What is Alzheimer’s? Alzheimer’s is a disease When you get Alzheimer’s Some changes would be:that attacks the brain nerve you start to have some knowledge, speaking, and cell. changes. behavior. People who mostly get this Alzheimers is the 6th causes disease are people from to death. ages 65 and older.
HistoryWhen: They found the disease in 1906.Who: The founder is Dr. Alois Alzheimer. He is aGerman Physician.How: A woman of 51 years of age suffered from a strangebrain disorder. She had symptoms like: Memory lost,language problems, and behavior changes.
How Mutation Causes Alzheimer’s Disease APP: Provides instructions Alzheimer’s is caused by for making a protein calledgene mutations that can be There are three which are amyloid precursor.passed to you from one of APP, PSEN1,& PSEN2. your parents. PSEN1: makes protein for Presenilin 1 *APOE (Apolipoprtein E): It PSEN2: makes a protein works with lipids in the called Presenilin 2. body to make molecules.
Symptoms There are ten symptoms which are:1. Memory loss2. Problems with language3. Disorientation of time and place4. Misplacing things5. Problems with abstract thinking6. Changing in mood and behavior7. Changes in personality8. Loss of initiative9. Poor or decreased judgment10. Difficulties performing familiar tasks
Women are Risk Factors affected more because they they live longer then Risk Factor : Age men. It affects 10% of the It affects 35% of thepopulation over the age population over the age of 65. of 85.
Risk Factors Risk Factor: Family HistoryIf you have someone related to When it runs in the familyyou and they have Alzheimer’s Genetically or environmental it you are most likely to get it. plays a role. The chances of you getting Alzheimer’s increases if more than one family member has it.
GeneticallyRisk Genes: it increases the possibility of getting a disease, but don’t hope that it will come. Deterministic Genes: directly causes the disease and anyone who inherits it will get the disease. Scientist have been identifying many risk genes implicated in Alzheimer’s disease. This is called Familiar Alzheimer’s Disease. Many family members in many generations are affected. The Earliest you Everyone gets APOE from both parents. can get it is at age 30-40. Those who get APOE-e4 from one parenthave chances of getting Alzheimer’s. if you get it from both you have higher risks.
Complex Age, family, and Genetically risk factors We may get these factors from well, lifestyle, and effectiveInteraction can never be changed. management. This can cause you Head Head injury and Alzheimers are very Alzheimer’s especially when Trauma occur Trauma linked together. repeatedly and involves loss of consciousness. It leads to brain health A heartbeat pumps 20-Heart-Head and heart health. The brain is linked by one 25% of your blood to your head. When you of the body’s richest get Alzheimers it mayConnection networks of blood vessels. damage the heart and blood vessels.
ContinuationGeneral Healthy aging might Try to have good weight. Avoid alcohol,Healthy help keep your brain as well as your body fit. stay socially connected, and exercise your brainAging and body.
How To Help: Alzheimer’s Walk This organization has This walk brings It used to be called raised more than together families, Memory Walk in $300 million for friends, and 1989. research, education, caregivers. and programs.
Relation1.• The gene has something to do in which you get or don’t get Alzheimers. You get the genes from your parents.2.• The nervous system is part on which Alzheimer’s Disease makes the body communication stop. The brain sends messages back and forth to the body.
"Alzheimer’s Association National Office." Alzheimer’s Association National Office. Web. 14 Nov. 11. <www.alz.org/alzheimers_disease_cause_risk_factors.asp>. "Alzheimers Association - Walk." Alzheimers Association - Walk. Web. 09 May 2012. <http://www.alz.org/oc/in_my_community_walk.asp>. "Alzheimers Disease Fact Sheet." National Institute on Aging. Web. 09 May 2012. <http://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet>. "Alzheimers Foundation of America." Alzheimers Foundation of America. Web. 09 May 2012. <http://www.alzfdn.org/AboutAlzheimers/definition.html>. "APOE." - Apolipoprotein E. Web. 24 May 2012. <http://ghr.nlm.nih.gov/gene/APOE>. "The Facts on Alzheimers Disease." The Facts on Alzheimers Disease. Web. 09 May 2012. <http://www.ahaf.org/alzheimers/about/understanding/facts.html>.