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Alexander Broersen
 

Alexander Broersen

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    Alexander Broersen Alexander Broersen Presentation Transcript

    • 3D fusion of coronary CT angiography with IVUS images for comparing quantitative analyses A. Broersen Division of Image Processing (LKEB) Department of Radiology Leiden University Medical Center
    • Introduction source: Wikipedia
    • Introduction
      • Atherosclerotic coronary artery disease
        • plaque development / calcified components
        • stenosis / ulceration / rupture / thrombus
      • Measurements within:
        • computed tomography angiography (CTA)
        • intravascular ultrasound (IVUS)
      • (Semi-)Automatic quantification:
        • improve diagnostic accuracy
        • reduce observer variability
    • Multi-Slice CT Angiography
      • fast, minimally invasive imaging
      • 3D anatomical view
      • complete coronary tree
      • lumen detection
      • calcification detection
    • CTA vessel analysis
      • path-line detection
      • extract longitudinal and transversal slices
      • lumen detection
      • automatic quantification:
        • stenosis
      1. 2. 3. 4.
    • Restrictions without vessel wall contours
      • plaque burden
      • vessel remodeling
      • plaque eccentricity
      eccentric concentric proximal distal
    • Intravascular Ultrasound
      • considered ‘Gold Standard’
      • invasive imaging
      • 2D cross-sectional view
      • single vessel
      • high resolution lumen detection
      • high resolution vessel wall detection
      catheter acquisition circular image artery
    • IVUS vessel analysis
      • create a straight pseudo 3D reconstruction
      • longitudinal detection lumen / vessel wall contours
      • transversal detection lumen / vessel wall contours
      • automatic quantification:
        • stenosis
        • plaque burden
        • remodeling index
      1. 2. 3.
    • Approach
      • Goals on coronary CTA data :
      • improve lumen detection
      • create and validate vessel wall detection
      • quantitatively extract parameters using the vessel wall
      • Fuse IVUS images with CTA data, for verification of quantifications and comparison of analyses
    • Method
      • Acquisition
      • Contouring
      • Mapping
      • Registration
      • Quantification
      • Create generic modules in MeVisLab : environment for medical image processing & visualization
      “ Coronary CT angiography: IVUS image fusion for quantitative plaque and stenosis analyses, Marquering, H.A.; Dijkstra, J.; Besnehard, Q.J.A.; Duthé, J.P.M.; Schuijf, J.D.; Bax, J.J. & Reiber, J.H.C., Medical Imaging: Visualization, Image-guided Procedures, and Modeling, 2008 ”
    • 3. Mapping
      • Landmarks:
      • bifurcations
      • calcifications
      • Pitfalls:
      • cardiac motion causes sections to repeat themselves
      • no constant pullback speed
    • 4. Registration
      • Landmarks:
      • bifurcations
      • surrounding tissue
      • Pitfalls:
      • cardiac motion causes rotations / displacement catheter
      • blooming effects in CTA at calcified spots
    • 5. Quantitative measurements
      • Lumen defines:
      • stenosis
      • Lumen and vessel wall define:
      • plaque burden
      • plaque eccentricity
      • remodeling index
      • Measurements are obtained of both CTA and IVUS contours
    • Comparisons - CTA lumen - CTA vessel - IVUS lumen - IVUS vessel
    • Example mapping in MeVisLab
    • Summary
      • With a complete fusion between CTA and IVUS we can:
      • validate all CTA lumen and vessel wall contours
      • compare results of both quantitative analyses
      • extract more information from CTA
      • more insight into characteristics of IVUS images
    • Acknowledgements
      • LKEB
      • M. Frenay
      • P. Kitslaar
      • Dr. J. Dijkstra
      • Dr. B. Stoel
      • Prof. H.J.C. Reiber
      • (former members)
      • Dr. H.A. Marquering
      • Dr. E. Oost
      • LUMC – Dept. Cardiology
      • J.M.J. Boogers
      • J.E. van Velzen
      • F.R. de Graaf
      • Dr. J.D. Schuijf
      • Prof. E.E. van der Wall
      • Prof. J.J. Bax