3D fusion of coronary CT angiography with IVUS images for comparing quantitative analyses A. Broersen Division of Image Pr...
Introduction source: Wikipedia
Introduction <ul><li>Atherosclerotic coronary artery disease </li></ul><ul><ul><li>plaque development / calcified componen...
Multi-Slice CT Angiography <ul><li>fast, minimally invasive imaging </li></ul><ul><li>3D anatomical view </li></ul><ul><li...
CTA vessel analysis <ul><li>path-line detection </li></ul><ul><li>extract longitudinal and transversal slices </li></ul><u...
Restrictions  without  vessel wall contours <ul><li>plaque burden </li></ul><ul><li>vessel remodeling </li></ul><ul><li>pl...
Intravascular Ultrasound <ul><li>considered ‘Gold Standard’ </li></ul><ul><li>invasive imaging </li></ul><ul><li>2D cross-...
IVUS vessel analysis <ul><li>create a straight pseudo 3D reconstruction </li></ul><ul><li>longitudinal detection lumen / v...
Approach <ul><li>Goals on coronary CTA data : </li></ul><ul><li>improve lumen detection  </li></ul><ul><li>create and vali...
Method <ul><li>Acquisition </li></ul><ul><li>Contouring </li></ul><ul><li>Mapping </li></ul><ul><li>Registration </li></ul...
3. Mapping <ul><li>Landmarks: </li></ul><ul><li>bifurcations </li></ul><ul><li>calcifications </li></ul><ul><li>Pitfalls: ...
4. Registration <ul><li>Landmarks: </li></ul><ul><li>bifurcations </li></ul><ul><li>surrounding tissue </li></ul><ul><li>P...
5. Quantitative measurements <ul><li>Lumen defines: </li></ul><ul><li>stenosis </li></ul><ul><li>Lumen and vessel wall def...
Comparisons - CTA lumen - CTA vessel - IVUS lumen - IVUS vessel
Example mapping in MeVisLab
Summary <ul><li>With a  complete  fusion between CTA and IVUS we can: </li></ul><ul><li>validate all CTA lumen and vessel ...
Acknowledgements <ul><li>LKEB </li></ul><ul><li>M. Frenay </li></ul><ul><li>P. Kitslaar </li></ul><ul><li>Dr. J. Dijkstra ...
Upcoming SlideShare
Loading in...5
×

Alexander Broersen

741

Published on

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
741
On Slideshare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
0
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Transcript of "Alexander Broersen"

  1. 1. 3D fusion of coronary CT angiography with IVUS images for comparing quantitative analyses A. Broersen Division of Image Processing (LKEB) Department of Radiology Leiden University Medical Center
  2. 2. Introduction source: Wikipedia
  3. 3. Introduction <ul><li>Atherosclerotic coronary artery disease </li></ul><ul><ul><li>plaque development / calcified components </li></ul></ul><ul><ul><li>stenosis / ulceration / rupture / thrombus </li></ul></ul><ul><li>Measurements within: </li></ul><ul><ul><li>computed tomography angiography (CTA) </li></ul></ul><ul><ul><li>intravascular ultrasound (IVUS) </li></ul></ul><ul><li>(Semi-)Automatic quantification: </li></ul><ul><ul><li>improve diagnostic accuracy </li></ul></ul><ul><ul><li>reduce observer variability </li></ul></ul>
  4. 4. Multi-Slice CT Angiography <ul><li>fast, minimally invasive imaging </li></ul><ul><li>3D anatomical view </li></ul><ul><li>complete coronary tree </li></ul><ul><li>lumen detection </li></ul><ul><li>calcification detection </li></ul>
  5. 5. CTA vessel analysis <ul><li>path-line detection </li></ul><ul><li>extract longitudinal and transversal slices </li></ul><ul><li>lumen detection </li></ul><ul><li>automatic quantification: </li></ul><ul><ul><li>stenosis </li></ul></ul>1. 2. 3. 4.
  6. 6. Restrictions without vessel wall contours <ul><li>plaque burden </li></ul><ul><li>vessel remodeling </li></ul><ul><li>plaque eccentricity </li></ul>eccentric concentric proximal distal
  7. 7. Intravascular Ultrasound <ul><li>considered ‘Gold Standard’ </li></ul><ul><li>invasive imaging </li></ul><ul><li>2D cross-sectional view </li></ul><ul><li>single vessel </li></ul><ul><li>high resolution lumen detection </li></ul><ul><li>high resolution vessel wall detection </li></ul>catheter acquisition circular image artery
  8. 8. IVUS vessel analysis <ul><li>create a straight pseudo 3D reconstruction </li></ul><ul><li>longitudinal detection lumen / vessel wall contours </li></ul><ul><li>transversal detection lumen / vessel wall contours </li></ul><ul><li>automatic quantification: </li></ul><ul><ul><li>stenosis </li></ul></ul><ul><ul><li>plaque burden </li></ul></ul><ul><ul><li>remodeling index </li></ul></ul>1. 2. 3.
  9. 9. Approach <ul><li>Goals on coronary CTA data : </li></ul><ul><li>improve lumen detection </li></ul><ul><li>create and validate vessel wall detection </li></ul><ul><li>quantitatively extract parameters using the vessel wall </li></ul><ul><li>Fuse IVUS images with CTA data, for verification of quantifications and comparison of analyses </li></ul>
  10. 10. Method <ul><li>Acquisition </li></ul><ul><li>Contouring </li></ul><ul><li>Mapping </li></ul><ul><li>Registration </li></ul><ul><li>Quantification </li></ul><ul><li>Create generic modules in MeVisLab : environment for medical image processing & visualization </li></ul>“ Coronary CT angiography: IVUS image fusion for quantitative plaque and stenosis analyses, Marquering, H.A.; Dijkstra, J.; Besnehard, Q.J.A.; Duthé, J.P.M.; Schuijf, J.D.; Bax, J.J. & Reiber, J.H.C., Medical Imaging: Visualization, Image-guided Procedures, and Modeling, 2008 ”
  11. 11. 3. Mapping <ul><li>Landmarks: </li></ul><ul><li>bifurcations </li></ul><ul><li>calcifications </li></ul><ul><li>Pitfalls: </li></ul><ul><li>cardiac motion causes sections to repeat themselves </li></ul><ul><li>no constant pullback speed </li></ul>
  12. 12. 4. Registration <ul><li>Landmarks: </li></ul><ul><li>bifurcations </li></ul><ul><li>surrounding tissue </li></ul><ul><li>Pitfalls: </li></ul><ul><li>cardiac motion causes rotations / displacement catheter </li></ul><ul><li>blooming effects in CTA at calcified spots </li></ul>
  13. 13. 5. Quantitative measurements <ul><li>Lumen defines: </li></ul><ul><li>stenosis </li></ul><ul><li>Lumen and vessel wall define: </li></ul><ul><li>plaque burden </li></ul><ul><li>plaque eccentricity </li></ul><ul><li>remodeling index </li></ul><ul><li>Measurements are obtained of both CTA and IVUS contours </li></ul>
  14. 14. Comparisons - CTA lumen - CTA vessel - IVUS lumen - IVUS vessel
  15. 15. Example mapping in MeVisLab
  16. 16. Summary <ul><li>With a complete fusion between CTA and IVUS we can: </li></ul><ul><li>validate all CTA lumen and vessel wall contours </li></ul><ul><li>compare results of both quantitative analyses </li></ul><ul><li>extract more information from CTA </li></ul><ul><li>more insight into characteristics of IVUS images </li></ul>
  17. 17. Acknowledgements <ul><li>LKEB </li></ul><ul><li>M. Frenay </li></ul><ul><li>P. Kitslaar </li></ul><ul><li>Dr. J. Dijkstra </li></ul><ul><li>Dr. B. Stoel </li></ul><ul><li>Prof. H.J.C. Reiber </li></ul><ul><li>(former members) </li></ul><ul><li>Dr. H.A. Marquering </li></ul><ul><li>Dr. E. Oost </li></ul><ul><li>LUMC – Dept. Cardiology </li></ul><ul><li>J.M.J. Boogers </li></ul><ul><li>J.E. van Velzen </li></ul><ul><li>F.R. de Graaf </li></ul><ul><li>Dr. J.D. Schuijf </li></ul><ul><li>Prof. E.E. van der Wall </li></ul><ul><li>Prof. J.J. Bax </li></ul>

×