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Antimalarial Drugs
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Antimalarial Drugs

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Antimalarial drugs

Antimalarial drugs

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    Antimalarial Drugs Antimalarial Drugs Presentation Transcript

    • ANTIMALARIAL DRUGS Prepared by, Mr. Namdeo Shinde M. Pharm SATARA COLLEG OF PHARMACY, SATARA (Maharashtra) India-415004.
    • Malaria parasites: Plasmodium vivax Plasmodium falciparum Plasmodium malarae Plasmodium ovale Half lifecycle of Plasmodia is completed in body of mosquito and remaining half in human liver and RBCs.
    • Malaria lifecycle Sporozoites (in mosquito saliva) Primary schizonts Reinjected back into mosquito (Human liver) Merozoites In RBCs produces toxines Gametocytes Secondary schizonts (in RBCs) (Human liver)
    • Life cycle of Plasmodium
    • Symptoms of malaria Chill Fever Pain in joints Vomiting If malaria not treated early complicates into anaemia and jaundice.
    • Antimalarial drugs Drugs which kills P. Vivax and P. falciparum and used for prophylaxis and treatment of malaria are called antimalarial drugs. CLASSIFICATION PRIMARY SCHIZONTICIDES Primaquine SECONDARY SCHIZONTICIDES Chloroquine-Primaquine Blood SCHIZONTICIDES Chloroquine, Quinine GAMETOCITES Primaquine SPORONTICIDES Chlorguanil, Pyremethamine
    • Mechanism of antimalarials Chloroquine concentrates in RBCs and kills secondary schizontes by increasing basicity of plasmodial cell Artemisinin derivatives release highly reactive peroxide radicals which destroy plasmodial cell. Sporonticides inhibit plasmodial dihydrofolate reductase
    • QUININE CVS- Hypotension, Cardiac depression GIT- Bitter stomachic CNS- Anaesthetic Weak analgesic and antipyretic Uterus- Causes abortion Endocrine- Releases insulin and lower blood sugars
    • CHLOROQUINE THERAPEUTIC USES Acute malaria Prophylaxis of malaria Rheumatoid arthritis ADVERSE EFFECTS Epigastric distress, Nausea, vomiting, headache Loss of vision due to retinal damage, Skin rash Loss of hearing CONTRAINDICATIONS Eye dysfunction Heart diseases Cautiously used in liver diseases With antiarrythmic drugs
    • PREPARATIONS Tab. Primaquine 15mg daily/2weeks Tab. Quinine sulphate 600mg TDS oral for 5 days tab. Sulfadoxime 500mg+ Pyremethamine 25mg oral Inj. Artemether 80 mg BD i.m. 1st day then 80 mg OD oral