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Production of insulin from microbial culture
 

Production of insulin from microbial culture

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    Production of insulin from microbial culture Production of insulin from microbial culture Presentation Transcript

    • PRODUCTION OF INSULIN FROM MICROBIAL CULTURE RUI BAI MUHAMMAD AKLIL BIN AYOB YANGJIE CUI CHEN 60351 : CORE BIOTECHNOLOGY 1
    • CONTENT 1. 2. 3. 4. 5. Abstract Introduction Main process of insulin production Significance of human insulin Conclusion
    • Abstract     Hormone secreted by pancreas Control blood sugar level Lack of insulin caused diabetes mellitus Industrial production by manipulating genetic engineering and microbial
    • Introduction    Protein generated by beta cell of pancreas (islet of Langerhans) Exist in animal: porcine and bovine Build up of 51 amino acids    30 amino acids form chain B 21 amino acids form chain A 2 chain linked by disulfide bonds
    • (Introduction)…cont www.bio.davidson.edu www.depositphotos.com
    • (Introduction)…cont   Diabetes mellitus (DM) lack of insulin to control blood sugar level Need to insulin therapy to keep healthy www.som.uq.edu.au
    • Main process of insulin production Microorganisms Fungi Yeast
    • Microorganisms Kinds of bacteria E. coli www.google.com.hk
    • Genetic Engineering http://blogs.swa-
    • Microbial Fermentation
    • Significance of human insulin   1978: insulin from animal; pig and cow Switch to microbial culture. Why?  Quantity & quality is better   E. coli culture is convenient   No allergy and side effect Cheaper for commercial Predictable  Problems easily solved
    • Conclusion     Insulin market grown at 7% annual rate Company: Novo Nordisk, Eli Lilly & Sanofi Aventis Cost : £75 – 200 per vial Different delivery ways www.novonordisk.com
    • Thank you! http://www.bd.com