• Save
Renal Physiology (III) - Renal Tubular Processing
Upcoming SlideShare
Loading in...5
×
 

Renal Physiology (III) - Renal Tubular Processing

on

  • 3,409 views

by dr Mohammed Abel Gawad (drgawad@gmail.com): Nephrology Specialist at Kidney & Urology Center - Alexandria - Egypt. website: www.nephrotube.blogspot.com

by dr Mohammed Abel Gawad (drgawad@gmail.com): Nephrology Specialist at Kidney & Urology Center - Alexandria - Egypt. website: www.nephrotube.blogspot.com

Statistics

Views

Total Views
3,409
Views on SlideShare
3,399
Embed Views
10

Actions

Likes
7
Downloads
108
Comments
2

2 Embeds 10

http://study.myllps.com 8
http://www.slashdocs.com 2

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Renal Physiology (III) - Renal Tubular Processing Renal Physiology (III) - Renal Tubular Processing Presentation Transcript

  • 1RENAL PHYSIOLOGY (III) m RENAL TUBULAR PROCESSING Mohammed Abdel Gawad
  • OBJECTIVES2  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • OBJECTIVES3  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Formation of URINE in 3 steps4 Tubular Tubular Reabsorption SecretionGlomerular Excretion Filtration
  • RENAL CIRCULATION5
  • Formation of URINE in 3 steps6
  • Formation of URINE in 3 steps7
  • OBJECTIVES8  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Cell Membrane9 Polar heads love water & dissolve. Non-polar tails hide from water.
  • Forms of Membrane Transport10
  • Forms of Membrane Transport11
  • PASSIVE TRANSPORT12  With concentration gradient (downhill)  No need for energy
  • Diffusion through phospholipid bilayer13
  • Diffusion through phospholipid bilayer14 inside cell lipid K O2 Na glucose a.a. CO2 outside cell
  • Leak Channels15
  • Leak Channels16 high low
  • Facilitated Diffusion17
  • Facilitated Diffusion18 high low
  • ACTIVE TRANSPORT19 • Against concentration gradient (UPhill) • need energy (ATP, CP)
  • Primary Active Transport20
  • Primary Active Transport21
  • Secondary Active Transport22
  • Secondary Active Transport23
  • Secondary Active Transport24
  • Secondary Active Transport25 Tubular InterstitialTubular Tubular Cell Interstitial Tubular Cell lumen Fluidlumen co-transport Fluid counter-transport (symport) (antiport) out in out in Na+ Na+ glucose H+Co-transporters will move one moiety, Counter-transporters will move onee.g. glucose, in the same direction as moiety, e.g. H+, in the opposite directionthe Na+. to the Na+.
  • Pinocytosis26  Some parts of the tubule, especially the proximal tubule, reabsorb large molecules such as proteins by pinocytosis.
  • OBJECTIVES27  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Proximal Convoluted Tubule28
  • Proximal Convoluted Tubule Reabsorption29 phosphate phosphate
  • Proximal Convoluted Tubule Reabsorption30  Some parts of the tubule, especially the proximal tubule, reabsorb large molecules such as proteins by pinocytosis.
  • Proximal Convoluted Tubule Secretion31
  • Proximal Convoluted Tubule Secretion32  The proximal tubule is also an important site for secretion of:  organic acids and bases such as bile salts,oxalate, urate, and catecholamines.  drugs penicillin and salicylates  toxins  PAH
  • OBJECTIVES33  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Loop of Henle34 (Descending Limb)
  • Loop of Henle35 (Ascending Limb)
  • Loop of Henle36 (Ascending Limb)
  • OBJECTIVES37  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Early Distal Convoluted Tubule38
  • Early Distal Convoluted Tubule39
  • Late Distal Convoluted Tubule Collecting Duct40
  • Late Distal Convoluted Tubule Collecting Duct41
  • Late Distal Convoluted Tubule Collecting Duct42
  • OBJECTIVES43  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Urea Tubular Handling44
  • Sodium Tubular Handling45 65% 8-10% 25%
  • Water Tubular Handling46 65% by osmosis 15% (obligatory Under effect of reabsorption) ADH (Facultative reabsorption) 15-20% by osmosis (obligatory reabsorption)
  • OBJECTIVES47  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  • Hormones & Kidney Tubules48
  • OBJECTIVES49  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Tubular Transport Maxima
  • Tubular transport maxima (Tm)50  It is the maximum amount of a substance in mg, which can be reabsorbed or secreted per minute.  TmG with normal blood glucose level = 375 mg/min for men, 300 mg/min for women
  • 51 Follow On www.nephrotube.blogspot.com & Facebook Group NephroTube
  • 52 Gawad