Renal Physiology (III) - Renal Tubular Processing

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by dr Mohammed Abel Gawad (drgawad@gmail.com): Nephrology Specialist at Kidney & Urology Center - Alexandria - Egypt. website: www.nephrotube.blogspot.com

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Renal Physiology (III) - Renal Tubular Processing

  1. 1. 1RENAL PHYSIOLOGY (III) m RENAL TUBULAR PROCESSING Mohammed Abdel Gawad
  2. 2. OBJECTIVES2  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  3. 3. OBJECTIVES3  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  4. 4. Formation of URINE in 3 steps4 Tubular Tubular Reabsorption SecretionGlomerular Excretion Filtration
  5. 5. RENAL CIRCULATION5
  6. 6. Formation of URINE in 3 steps6
  7. 7. Formation of URINE in 3 steps7
  8. 8. OBJECTIVES8  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  9. 9. Cell Membrane9 Polar heads love water & dissolve. Non-polar tails hide from water.
  10. 10. Forms of Membrane Transport10
  11. 11. Forms of Membrane Transport11
  12. 12. PASSIVE TRANSPORT12  With concentration gradient (downhill)  No need for energy
  13. 13. Diffusion through phospholipid bilayer13
  14. 14. Diffusion through phospholipid bilayer14 inside cell lipid K O2 Na glucose a.a. CO2 outside cell
  15. 15. Leak Channels15
  16. 16. Leak Channels16 high low
  17. 17. Facilitated Diffusion17
  18. 18. Facilitated Diffusion18 high low
  19. 19. ACTIVE TRANSPORT19 • Against concentration gradient (UPhill) • need energy (ATP, CP)
  20. 20. Primary Active Transport20
  21. 21. Primary Active Transport21
  22. 22. Secondary Active Transport22
  23. 23. Secondary Active Transport23
  24. 24. Secondary Active Transport24
  25. 25. Secondary Active Transport25 Tubular InterstitialTubular Tubular Cell Interstitial Tubular Cell lumen Fluidlumen co-transport Fluid counter-transport (symport) (antiport) out in out in Na+ Na+ glucose H+Co-transporters will move one moiety, Counter-transporters will move onee.g. glucose, in the same direction as moiety, e.g. H+, in the opposite directionthe Na+. to the Na+.
  26. 26. Pinocytosis26  Some parts of the tubule, especially the proximal tubule, reabsorb large molecules such as proteins by pinocytosis.
  27. 27. OBJECTIVES27  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  28. 28. Proximal Convoluted Tubule28
  29. 29. Proximal Convoluted Tubule Reabsorption29 phosphate phosphate
  30. 30. Proximal Convoluted Tubule Reabsorption30  Some parts of the tubule, especially the proximal tubule, reabsorb large molecules such as proteins by pinocytosis.
  31. 31. Proximal Convoluted Tubule Secretion31
  32. 32. Proximal Convoluted Tubule Secretion32  The proximal tubule is also an important site for secretion of:  organic acids and bases such as bile salts,oxalate, urate, and catecholamines.  drugs penicillin and salicylates  toxins  PAH
  33. 33. OBJECTIVES33  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  34. 34. Loop of Henle34 (Descending Limb)
  35. 35. Loop of Henle35 (Ascending Limb)
  36. 36. Loop of Henle36 (Ascending Limb)
  37. 37. OBJECTIVES37  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  38. 38. Early Distal Convoluted Tubule38
  39. 39. Early Distal Convoluted Tubule39
  40. 40. Late Distal Convoluted Tubule Collecting Duct40
  41. 41. Late Distal Convoluted Tubule Collecting Duct41
  42. 42. Late Distal Convoluted Tubule Collecting Duct42
  43. 43. OBJECTIVES43  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  44. 44. Urea Tubular Handling44
  45. 45. Sodium Tubular Handling45 65% 8-10% 25%
  46. 46. Water Tubular Handling46 65% by osmosis 15% (obligatory Under effect of reabsorption) ADH (Facultative reabsorption) 15-20% by osmosis (obligatory reabsorption)
  47. 47. OBJECTIVES47  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Hormones & Kidney Tubules  Tubular Transport Maxima
  48. 48. Hormones & Kidney Tubules48
  49. 49. OBJECTIVES49  Formation of urine  Forms of membrane Transport  PCT Function  Loop of Henle Function  DCT Function  Urea, Na & Water Tubular Handling  Tubular Transport Maxima
  50. 50. Tubular transport maxima (Tm)50  It is the maximum amount of a substance in mg, which can be reabsorbed or secreted per minute.  TmG with normal blood glucose level = 375 mg/min for men, 300 mg/min for women
  51. 51. 51 Follow On www.nephrotube.blogspot.com & Facebook Group NephroTube
  52. 52. 52 Gawad

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