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Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
Pharmacologic management of parkinsonism
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Pharmacologic management of parkinsonism

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The underlined words are hyperlinks; please click on them to see the whole presentation.

Please tell me what you think about my slides, you can write to: mh_farjoo@yahoo.com

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  • 1. Pharmacologic Management of Parkinsonism & Other Movement Disorders By M.H.Farjoo M.D. , Ph.D. Shahid Beheshti University of Medical Science
  • 2. Parkinson Disease  Parkinson Disease  Incidence & prevalence  Introduction  Treatment  Drug PicturesM.H.Farjoo
  • 3. Introduction of Parkinson  After james parkinson (1755–1824), British physician  Characterized by:  Rigidity  Bradykinesia  Tremor at rest  Postural instability  Is usually idiopathic  Reduction of dopamine in the basal ganglia of the brain  Normal balance of cholinergic and dopaminergic neurons is lostM.H.Farjoo
  • 4. Treatment of Parkinson  Dopamine?  Does not cross the blood-brain barrier  Levodopa?  Most of levodopa is metabolized extracerebrally to dopamine  Only 1–3% of levodopa enters the brain  Combination with a Dopa decarboxylase inhibitor (Carbidopa) is necessary  Best results are obtained in the first few years of treatmentM.H.Farjoo
  • 5. Treatment of Parkinson (Cont’d)  Adverse Effects of Levodopa:  Gastrointestinal Effects  Cardiovascular Effects  Dyskinesias  Behavioral Effects  Fluctuations in Response (on-off phenomenon)  brownish discoloration of saliva, urine, or vaginal secretionsM.H.Farjoo
  • 6. Treatment of Parkinson (Cont’d)  Dopamine Agonists  Monoamine Oxidase Inhibitors  Catechol-O-Methyltransferase Inhibitors  Acetylcholine-Blocking Drugs  Surgical ProceduresM.H.Farjoo
  • 7. Summary In English
  • 8. Thank you Any question?

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