Drugs pharmacology in lung disease
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Drugs pharmacology in lung disease

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Drugs pharmacology in lung disease Presentation Transcript

  • 1. Drugs Pharmacology in Lung Disease By M.H.Farjoo M.D. , Ph.D. Shahid Beheshti University of Medical Science
  • 2. Drugs Pharmacology in Lung Disease  Introduction  Practical Issues  Use of Drugs in Lung disease  Pulmonary Adverse Effects of DrugsM.H.Farjoo
  • 3. Introduction  The lungs are among drug absorptive sites.  The lungs mainly remove volatile substances, (eg: anesthetic gases & antiasthmatics).  They have a large surface area for absorption of drugs.  Debilitating illnesses such as chronic lung disorders interfere with appetite and GI function.M.H.Farjoo
  • 4. Practical Issues  With NG tubes, medications may be aspirated into the lungs (Disadvantages)  Patients should be positioned appropriately to prevent aspiration of oral drugs into the lungs.  Do not give oral drugs to excessively sedated or unconscious clients to avoid aspiration.  Spinal anesthesia is preferred for surgery in elderly people with chronic lung disease.M.H.Farjoo
  • 5. Use of Drugs in Lung disease  In chronic lung disease, respiratory infections may be prevented by measures such as:  Immunizations with pneumococcal pneumonia vaccine (a single dose)  Influenza vaccine (annually)  Prenatal corticosteroids promote surfactant production to decrease respiratory distress syndrome in preterm infants.M.H.Farjoo
  • 6. Pulmonary Adverse Effects of Drugs  Passive smoking (“second hand” smoke) increases the risks of cancer & lung disease.  Inhalation of crack cocaine causes respiratory symptoms in 25% of users and include:  Bronchitis & bronchospasm  Cough & dyspnea  Pneumonia & pulmonary edema  Fatal lung hemorrhage.M.H.Farjoo
  • 7. Pulmonary Adverse Effects of Drugs (Cont’d)  Marijuana (hashish) possibly increases the risk of mouth, throat, and lung cancer  Some carcinogens are much higher in marijuana smoke than in tobacco smoke.  Blockade of β2 receptors in bronchial tree causes constriction in people with lung diseases.  In asthmatic children, beclomethasone caused growth inhibition.M.H.Farjoo
  • 8. Pulmonary Adverse Effects of Drugs (Cont’d)  Digoxin toxicity may result from hypoxia due to lung disease, which increases myocardial sensitivity to digoxin  Amiodarone accumulates in the lung and even in low doses fatal pulmonary fibrosis occurs in 1% of patients.M.H.Farjoo
  • 9. Pulmonary Adverse Effects of Drugs (Cont’d)  Concomitant disease can complicate interpretation of drug adverse effects.  Dyspnea in a patient with lung disease receiving amiodarone could be due to the drug or the lung disease.  The presence of chronic lung disease and dyspnea, should be considered in selection of antiarrhythmics.M.H.Farjoo
  • 10. Thank you Any question?