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Anatomy & Physiology 121 (MT/ESM) Bone Structure Part # 2
Stages of Intramembranous Ossification <ul><li>An ossification center appears in the fibrous connective tissue membrane </...
Endochondral Ossification <ul><li>Begins in the second month of development </li></ul><ul><li>Uses hyaline cartilage “bone...
Stages of Endochondral Ossification <ul><li>Formation of bone collar </li></ul><ul><li>Cavitation of the hyaline cartilage...
Postnatal Bone Growth <ul><li>Growth in length of long bones </li></ul><ul><ul><li>Cartilage on the side of the epiphyseal...
Functional Zones in Long Bone Growth <ul><li>Growth zone – cartilage cells undergo mitosis, pushing the epiphysis away fro...
Long Bone Growth and Remodeling <ul><li>Growth in length – cartilage continually grows and is replaced by bone as shown  <...
Long Bone Growth and Remodeling Figure 6.10
<ul><li>During infancy and childhood, epiphyseal plate activity is stimulated by growth hormone </li></ul><ul><li>During p...
Bone Remodeling <ul><li>Remodeling unit s – packets of adjacent osteoblasts and osteoclasts.  These are also helped by str...
Bone Deposition <ul><li>1) This occurs whenever a bone is injured or where added bone strength is required.  </li></ul><ul...
Bone Resorption <ul><li>1) Bone resorption is accomplished by osteoclasts.  </li></ul><ul><li>2) Move along a bone surface...
Importance of Ionic Calcium in the Body <ul><li>Calcium is necessary for: </li></ul><ul><ul><li>Transmission of nerve impu...
Control of Remodeling <ul><li>Two control loops regulate bone remodeling </li></ul><ul><ul><li>Hormonal mechanism maintain...
Hormonal Mechanism <ul><li>Rising blood Ca 2+  levels trigger the thyroid to release calcitonin </li></ul><ul><li>Calciton...
Response to Mechanical Stress <ul><li>Wolff’s law  –  a bone grows or remodels in response to the demands placed on it.  <...
Response to Mechanical Stress <ul><li>1) Mechanical stress determines where the bone is remodeled.  </li></ul><ul><li>2) M...
Response to Mechanical Stress Figure 6.13
Bone Fractures (Breaks) <ul><li>Bone fractures are classified by: </li></ul><ul><ul><li>The position of the bone ends afte...
Types of Bone Fractures <ul><li>Nondisplaced – bone ends retain their normal position </li></ul><ul><li>Displaced – bone e...
Types of Bone Fractures <ul><li>Transverse – the fracture is perpendicular to the long axis of the bone </li></ul><ul><li>...
Common Types of Fractures <ul><li>Comminuted – bone fragments into three or more pieces; common in the elderly </li></ul><...
Common Types of Fractures <ul><li>Epiphyseal – epiphysis separates from diaphysis along epiphyseal line; occurs where cart...
Common Types of Fractures Table 6.2.1
Common Types of Fractures Table 6.2.2
Common Types of Fractures Table 6.2.3
Homeostatic Imbalances <ul><li>Osteomalacia </li></ul><ul><ul><li>Bones are inadequately mineralized causing softened, wea...
Homeostatic Imbalances <ul><li>Rickets </li></ul><ul><ul><li>Bones of children are inadequately mineralized causing soften...
Homeostatic Imbalances <ul><li>Osteoporosis </li></ul><ul><ul><li>Group of diseases in which bone reabsorption outpaces bo...
Osteoporosis: Treatment <ul><li>Calcium and vitamin D supplements </li></ul><ul><li>Increased weight-bearing exercise </li...
Paget’s Disease <ul><li>Characterized by excessive bone formation and breakdown </li></ul><ul><li>Pagetic bone with an exc...
Paget’s Disease <ul><li>Usually localized in the spine, pelvis, femur, and skull </li></ul><ul><li>Unknown cause (possibly...
Developmental Aspects of Bones <ul><li>Mesoderm gives rise to embryonic mesenchymal cells, which produce membranes and car...
Developmental Aspects of Bones <ul><li>By age 25, nearly all bones are completely ossified </li></ul><ul><li>In old age, b...
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Lecture bone structure & markings #2clas

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Bone Structure & Markings Pt 2 Notes for Anatomy I

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  1. 1. Anatomy & Physiology 121 (MT/ESM) Bone Structure Part # 2
  2. 2. Stages of Intramembranous Ossification <ul><li>An ossification center appears in the fibrous connective tissue membrane </li></ul><ul><li>Bone matrix is secreted within the fibrous membrane </li></ul><ul><li>Woven bone and periosteum form </li></ul><ul><li>Bone collar of compact bone forms, and red marrow appears </li></ul>
  3. 3. Endochondral Ossification <ul><li>Begins in the second month of development </li></ul><ul><li>Uses hyaline cartilage “bones” as models for bone construction </li></ul><ul><li>Requires breakdown of hyaline cartilage prior to ossification </li></ul>
  4. 4. Stages of Endochondral Ossification <ul><li>Formation of bone collar </li></ul><ul><li>Cavitation of the hyaline cartilage </li></ul><ul><li>Invasion of internal cavities by the periosteal bud, and spongy bone formation </li></ul><ul><li>Formation of the medullary cavity; appearance of secondary ossification centers in the epiphyses </li></ul><ul><li>Ossification of the epiphyses, with hyaline cartilage remaining only in the epiphyseal plates </li></ul>
  5. 5. Postnatal Bone Growth <ul><li>Growth in length of long bones </li></ul><ul><ul><li>Cartilage on the side of the epiphyseal plate closest to the epiphysis is relatively inactive </li></ul></ul><ul><ul><li>Cartilage abutting the shaft of the bone organizes into a pattern that allows fast, efficient growth </li></ul></ul><ul><ul><li>Cells of the epiphyseal plate proximal to the resting cartilage form three functionally different zones: growth, transformation, and osteogenic </li></ul></ul>
  6. 6. Functional Zones in Long Bone Growth <ul><li>Growth zone – cartilage cells undergo mitosis, pushing the epiphysis away from the diaphysis </li></ul><ul><li>Transformation zone – older cells enlarge, the matrix becomes calcified, cartilage cells die, and the matrix begins to deteriorate </li></ul><ul><li>Osteogenic zone – new bone formation occurs </li></ul>
  7. 7. Long Bone Growth and Remodeling <ul><li>Growth in length – cartilage continually grows and is replaced by bone as shown </li></ul><ul><li>Remodeling – bone is resorbed and added by appositional growth as shown </li></ul>
  8. 8. Long Bone Growth and Remodeling Figure 6.10
  9. 9. <ul><li>During infancy and childhood, epiphyseal plate activity is stimulated by growth hormone </li></ul><ul><li>During puberty, testosterone and estrogens: </li></ul><ul><ul><li>Initially promote adolescent growth spurts </li></ul></ul><ul><ul><li>Cause masculinization and feminization of specific parts of the skeleton </li></ul></ul><ul><ul><li>Later induce epiphyseal plate closure, ending longitudinal bone growth </li></ul></ul>Hormonal Regulation of Bone Growth During Youth
  10. 10. Bone Remodeling <ul><li>Remodeling unit s – packets of adjacent osteoblasts and osteoclasts. These are also helped by stress-sensing osteocytes. </li></ul>
  11. 11. Bone Deposition <ul><li>1) This occurs whenever a bone is injured or where added bone strength is required. </li></ul><ul><li>2) For optimal bone deposit, a healthy diet rich in proteins, vitamin C, vitamin D, vitamin A, and several minerals is essential. </li></ul><ul><li>3) New matrix of bone is deposited by osteocytes </li></ul><ul><li>4) Once proper conditions are present: </li></ul><ul><ul><li>A) Calcium salts are deposited all at once </li></ul></ul><ul><ul><li>B) Found throughout the bone matrix. </li></ul></ul>
  12. 12. Bone Resorption <ul><li>1) Bone resorption is accomplished by osteoclasts. </li></ul><ul><li>2) Move along a bone surface, digging grooves as they break down the matrix. </li></ul><ul><li>3) lysosomal enzymes and hydochloric acid. These: </li></ul><ul><ul><li>A) Digest organic matter </li></ul></ul><ul><ul><li>B) Convert calcium salts into soluble forms that pass easily into solution. </li></ul></ul><ul><ul><li>4) The bone’s nutrients are then released into the blood. </li></ul></ul>
  13. 13. Importance of Ionic Calcium in the Body <ul><li>Calcium is necessary for: </li></ul><ul><ul><li>Transmission of nerve impulses </li></ul></ul><ul><ul><li>Muscle contraction </li></ul></ul><ul><ul><li>Blood coagulation </li></ul></ul><ul><ul><li>Secretion by glands and nerve cells </li></ul></ul><ul><ul><li>Cell division </li></ul></ul>
  14. 14. Control of Remodeling <ul><li>Two control loops regulate bone remodeling </li></ul><ul><ul><li>Hormonal mechanism maintains calcium homeostasis in the blood </li></ul></ul><ul><ul><li>Mechanical and gravitational forces acting on the skeleton </li></ul></ul>
  15. 15. Hormonal Mechanism <ul><li>Rising blood Ca 2+ levels trigger the thyroid to release calcitonin </li></ul><ul><li>Calcitonin stimulates calcium salt deposit in bone </li></ul><ul><li>Falling blood Ca 2+ levels signal the parathyroid glands to release PTH </li></ul><ul><li>PTH signals osteoclasts to degrade bone matrix and release Ca 2+ into the blood </li></ul>
  16. 16. Response to Mechanical Stress <ul><li>Wolff’s law – a bone grows or remodels in response to the demands placed on it. </li></ul><ul><li>1) A bone’s anatomy reflects the common stresses it encounters </li></ul><ul><ul><li>A) Explains why bones are the thickest depending on their stresses. </li></ul></ul><ul><ul><li>B) Explains the featureless bones of the fesure and the atrophied bodies of bedridden people- situations in which bones are not stressed. </li></ul></ul>
  17. 17. Response to Mechanical Stress <ul><li>1) Mechanical stress determines where the bone is remodeled. </li></ul><ul><li>2) Mechanical forces determine which osteoclasts are most sensitive to PTH stimulation so that the bone in the least stressed areas is broken down. </li></ul>
  18. 18. Response to Mechanical Stress Figure 6.13
  19. 19. Bone Fractures (Breaks) <ul><li>Bone fractures are classified by: </li></ul><ul><ul><li>The position of the bone ends after fracture </li></ul></ul><ul><ul><li>The completeness of the break </li></ul></ul><ul><ul><li>The orientation of the bone to the long axis </li></ul></ul><ul><ul><li>Whether or not the bones ends penetrate the skin </li></ul></ul>
  20. 20. Types of Bone Fractures <ul><li>Nondisplaced – bone ends retain their normal position </li></ul><ul><li>Displaced – bone ends are out of normal alignment </li></ul><ul><li>Complete – bone is broken all the way through </li></ul><ul><li>Incomplete – bone is not broken all the way through </li></ul><ul><li>Linear – the fracture is parallel to the long axis of the bone </li></ul>
  21. 21. Types of Bone Fractures <ul><li>Transverse – the fracture is perpendicular to the long axis of the bone </li></ul><ul><li>Compound (open) – bone ends penetrate the skin </li></ul><ul><li>Simple (closed) – bone ends do not penetrate the skin </li></ul>
  22. 22. Common Types of Fractures <ul><li>Comminuted – bone fragments into three or more pieces; common in the elderly </li></ul><ul><li>Spiral – ragged break when bone is excessively twisted; common sports injury </li></ul><ul><li>Depressed – broken bone portion pressed inward; typical skull fracture </li></ul><ul><li>Compression – bone is crushed; common in porous bones </li></ul>
  23. 23. Common Types of Fractures <ul><li>Epiphyseal – epiphysis separates from diaphysis along epiphyseal line; occurs where cartilage cells are dying </li></ul><ul><li>Greenstick – incomplete fracture where one side of the bone breaks and the other side bends; common in children </li></ul>
  24. 24. Common Types of Fractures Table 6.2.1
  25. 25. Common Types of Fractures Table 6.2.2
  26. 26. Common Types of Fractures Table 6.2.3
  27. 27. Homeostatic Imbalances <ul><li>Osteomalacia </li></ul><ul><ul><li>Bones are inadequately mineralized causing softened, weakened bones </li></ul></ul><ul><ul><li>Main symptom is pain when weight is put on the affected bone </li></ul></ul><ul><ul><li>Caused by insufficient calcium in the diet, or by vitamin D deficiency </li></ul></ul>
  28. 28. Homeostatic Imbalances <ul><li>Rickets </li></ul><ul><ul><li>Bones of children are inadequately mineralized causing softened, weakened bones </li></ul></ul><ul><ul><li>Bowed legs and deformities of the pelvis, skull, and rib cage are common </li></ul></ul><ul><ul><li>Caused by insufficient calcium in the diet, or by vitamin D deficiency </li></ul></ul>
  29. 29. Homeostatic Imbalances <ul><li>Osteoporosis </li></ul><ul><ul><li>Group of diseases in which bone reabsorption outpaces bone deposit </li></ul></ul><ul><ul><li>Spongy bone of the spine is most vulnerable </li></ul></ul><ul><ul><li>Occurs most often in postmenopausal women </li></ul></ul><ul><ul><li>Bones become so fragile that sneezing or stepping off a curb can cause fractures </li></ul></ul>
  30. 30. Osteoporosis: Treatment <ul><li>Calcium and vitamin D supplements </li></ul><ul><li>Increased weight-bearing exercise </li></ul><ul><li>Hormone (estrogen) replacement therapy (HRT) slows bone loss </li></ul><ul><li>Natural progesterone cream prompts new bone growth </li></ul><ul><li>Statins increase bone mineral density </li></ul>
  31. 31. Paget’s Disease <ul><li>Characterized by excessive bone formation and breakdown </li></ul><ul><li>Pagetic bone with an excessively high ratio of woven to compact bone is formed </li></ul><ul><li>Pagetic bone, along with reduced mineralization, causes spotty weakening of bone </li></ul><ul><li>Osteoclast activity wanes, but osteoblast activity continues to work </li></ul>
  32. 32. Paget’s Disease <ul><li>Usually localized in the spine, pelvis, femur, and skull </li></ul><ul><li>Unknown cause (possibly viral) </li></ul><ul><li>Treatment includes the drugs Didronate and Fosamax </li></ul>
  33. 33. Developmental Aspects of Bones <ul><li>Mesoderm gives rise to embryonic mesenchymal cells, which produce membranes and cartilages that form the embryonic skeleton </li></ul><ul><li>The embryonic skeleton ossifies in a predictable timetable that allows fetal age to be easily determined from sonograms </li></ul><ul><li>At birth, most long bones are well ossified (except for their epiphyses) </li></ul>
  34. 34. Developmental Aspects of Bones <ul><li>By age 25, nearly all bones are completely ossified </li></ul><ul><li>In old age, bone resorption predominates </li></ul><ul><li>A single gene that codes for vitamin D docking determines both the tendency to accumulate bone mass early in life, and the risk for osteoporosis later in life </li></ul>
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