Integumentary system

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Integumentary system

  1. 1. 5 The Integumentary System
  2. 2. Skin (Integument) <ul><li>Consists of three major regions </li></ul><ul><ul><li>Epidermis – outermost superficial region </li></ul></ul><ul><ul><li>Dermis – middle region </li></ul></ul><ul><ul><li>Hypodermis (superficial fascia) – deepest region </li></ul></ul>
  3. 3. Skin (Integument) Figure 5.1
  4. 4. Epidermis <ul><li>Composed of keratinized stratified squamous epithelium, consisting of four distinct cell types and four or five layers </li></ul><ul><li>Cell types include keratinocytes, melanocytes, Merkel cells, and Langerhans’ cells </li></ul><ul><li>Outer portion of the skin is exposed to the external environment and functions in protection </li></ul>
  5. 5. Cells of the Epidermis <ul><li>Keratinocytes – produce the fibrous protein keratin </li></ul><ul><li>Melanocytes – produce the brown pigment melanin </li></ul><ul><li>Langerhans’ cells – epidermal macrophages that help activate the immune system </li></ul><ul><li>Merkel cells – function as touch receptors in association with sensory nerve endings </li></ul>
  6. 6. <ul><li>Deepest epidermal layer firmly attached to the dermis </li></ul><ul><li>Consists of a single row of the youngest keratinocytes </li></ul><ul><li>Cells undergo rapid division, hence its alternate name, stratum germinativum </li></ul>Layers of the Epidermis: Stratum Basale (Basal Layer)
  7. 7. Layers of the Epidermis: Stratum Basale (Basal Layer) Figure 5.2b
  8. 8. <ul><li>Cells contain a weblike system of intermediate filaments attached to desmosomes </li></ul><ul><li>Melanin granules and Langerhans’ cells are abundant in this layer </li></ul>Layers of the Epidermis: Stratum Spinosum (Prickly Layer)
  9. 9. <ul><li>Thin; three to five cell layers in which drastic changes in keratinocyte appearance occurs </li></ul><ul><li>Keratohyaline and lamellated granules accumulate in the cells of this layer </li></ul>Layers of the Epidermis: Stratum Granulosum (Granular Layer)
  10. 10. <ul><li>Thin, transparent band superficial to the stratum granulosum </li></ul><ul><li>Consists of a few rows of flat, dead keratinocytes </li></ul><ul><li>Present only in thick skin </li></ul>Layers of the Epidermis: Stratum Lucidum (Clear Layer)
  11. 11. <ul><li>Outermost layer of keratinized cells </li></ul><ul><li>Accounts for three quarters of the epidermal thickness </li></ul><ul><li>Functions include: </li></ul><ul><ul><li>Waterproofing </li></ul></ul><ul><ul><li>Protection from abrasion and penetration </li></ul></ul><ul><ul><li>Rendering the body relatively insensitive to biological, chemical, and physical assaults </li></ul></ul>Layers of the Epidermis: Stratum Corneum (Horny Layer)
  12. 12. Dermis <ul><li>Second major skin region containing strong, flexible connective tissue </li></ul><ul><li>Cell types include fibroblasts, macrophages, and occasionally mast cells and white blood cells </li></ul><ul><li>Composed of two layers – papillary and reticular </li></ul>
  13. 13. Layers of the Dermis: Papillary Layer <ul><li>Papillary layer </li></ul><ul><ul><li>Areolar connective tissue with collagen and elastic fibers </li></ul></ul><ul><ul><li>Its superior surface contains peglike projections called dermal papillae </li></ul></ul><ul><ul><li>Dermal papillae contain capillary loops, Meissner’s corpuscles, and free nerve endings </li></ul></ul>
  14. 14. Layers of the Dermis: Reticular Layer <ul><li>Reticular layer </li></ul><ul><ul><li>Accounts for approximately 80% of the thickness of the dermis </li></ul></ul><ul><ul><li>Collagen fibers in this layer add strength and resiliency to the skin </li></ul></ul><ul><ul><li>Elastin fibers provide stretch-recoil properties </li></ul></ul>
  15. 15. Hypodermis <ul><li>Subcutaneous layer deep to the skin </li></ul><ul><li>Composed of adipose and areolar connective tissue </li></ul>
  16. 16. Skin Color <ul><li>Three pigments contribute to skin color </li></ul><ul><ul><li>Melanin – yellow to reddish-brown to black pigment, responsible for dark skin colors </li></ul></ul><ul><ul><ul><li>Freckles and pigmented moles – result from local accumulations of melanin </li></ul></ul></ul><ul><ul><li>Carotene – yellow to orange pigment, most obvious in the palms and soles of the feet </li></ul></ul><ul><ul><li>Hemoglobin – reddish pigment responsible for the pinkish hue of the skin </li></ul></ul>
  17. 17. Sweat Glands <ul><li>Different types prevent overheating of the body; secrete cerumen and milk </li></ul><ul><ul><li>Eccrine sweat glands – found in palms, soles of the feet, and forehead </li></ul></ul><ul><ul><li>Apocrine sweat glands – found in axillary and anogenital areas </li></ul></ul><ul><ul><li>Ceruminous glands – modified apocrine glands in external ear canal that secrete cerumen </li></ul></ul><ul><ul><li>Mammary glands – specialized sweat glands that secrete milk </li></ul></ul>
  18. 18. Sebaceous Glands <ul><li>Simple alveolar glands found all over the body </li></ul><ul><li>Soften skin when stimulated by hormones </li></ul><ul><li>Secrete an oily secretion called sebum </li></ul>
  19. 19. Structure of a Nail <ul><li>Scalelike modification of the epidermis on the distal, dorsal surface of fingers and toes </li></ul>Figure 5.4
  20. 20. Hair <ul><li>Filamentous strands of dead keratinized cells produced by hair follicles </li></ul><ul><li>Contains hard keratin which is tougher and more durable than soft keratin of the skin </li></ul><ul><li>Made up of the shaft projecting from the skin, and the root embedded in the skin </li></ul><ul><li>Consists of a core called the medulla, a cortex, and an outermost cuticle </li></ul><ul><li>Pigmented by melanocytes at the base of the hair </li></ul>
  21. 21. Hair Function and Distribution <ul><li>Functions of hair include: </li></ul><ul><ul><li>Helping to maintain warmth </li></ul></ul><ul><ul><li>Alerting the body to presence of insects on the skin </li></ul></ul><ul><ul><li>Guarding the scalp against physical trauma, heat loss, and sunlight </li></ul></ul><ul><li>Hair is distributed over the entire skin surface except </li></ul><ul><ul><li>Palms, soles, and lips </li></ul></ul><ul><ul><li>Nipples and portions of the external genitalia </li></ul></ul>
  22. 22. Hair Follicle <ul><li>Root sheath extending from the epidermal surface into the dermis </li></ul><ul><li>Deep end is expanded forming a hair bulb </li></ul><ul><li>A knot of sensory nerve endings (a root hair plexus) wraps around each hair bulb </li></ul><ul><li>Bending a hair stimulates these endings, hence our hairs act as sensitive touch receptors </li></ul>
  23. 23. Hair Follicle Figure 5.6a
  24. 24. Hair Follicle Figure 5.6c
  25. 25. Hair Thinning and Baldness <ul><li>Alopecia – hair thinning in both sexes </li></ul><ul><li>True, or frank, baldness </li></ul><ul><ul><li>Genetically determined and sex-influenced condition </li></ul></ul><ul><ul><li>Male pattern baldness – caused by follicular response to DHT </li></ul></ul>
  26. 26. Types of Hair <ul><li>Vellus – pale, fine body hair found in children and the adult female </li></ul><ul><li>Terminal – coarse, long hair of eyebrows, scalp, axillary, and pubic regions </li></ul>
  27. 27. Functions of the Integumentary System <ul><li>Protection – chemical, physical, and mechanical barrier </li></ul><ul><li>Body temperature regulation is accomplished by: </li></ul><ul><ul><li>Dilation (cooling) and constriction (warming) of dermal vessels </li></ul></ul><ul><ul><li>Increasing sweat gland secretions to cool the body </li></ul></ul><ul><li>Cutaneous sensation – exoreceptors sense touch and pain </li></ul>
  28. 28. Functions of the Integumentary System <ul><li>Metabolic functions – synthesis of vitamin D in dermal blood vessels </li></ul><ul><li>Blood reservoir – skin blood vessels store up to 5% of the body’s blood volume </li></ul><ul><li>Excretion – limited amounts of nitrogenous wastes are eliminated from the body in sweat </li></ul>
  29. 29. Skin Cancer <ul><li>Most skin tumors are benign and do not metastasize </li></ul><ul><li>A crucial risk factor for nonmelanoma skin cancers is the disabling of the p53 gene </li></ul><ul><li>Newly developed skin lotions can fix damaged DNA </li></ul>
  30. 30. Skin Cancer <ul><li>The three major types of skin cancer are: </li></ul><ul><ul><li>Basal cell carcinoma </li></ul></ul><ul><ul><li>Squamous cell carcinoma </li></ul></ul><ul><ul><li>Melanoma </li></ul></ul>
  31. 31. Basal Cell Carcinoma <ul><li>Least malignant and most common skin cancer </li></ul><ul><li>Stratum basale cells proliferate and invade the dermis and hypodermis </li></ul><ul><li>Slow growing and do not often metastasize </li></ul><ul><li>Can be cured by surgical excision in 99% of the cases </li></ul>
  32. 32. Squamous Cell Carcinoma <ul><li>Arises from keratinocytes of stratum spinosum </li></ul><ul><li>Arise most often on scalp, ears, and lower lip </li></ul><ul><li>Grows rapidly and metastasizes if not removed </li></ul><ul><li>Prognosis is good if treated by radiation therapy or removed surgically </li></ul>
  33. 33. Melanoma <ul><li>Cancer of melanocytes is the most dangerous type of skin cancer because it is: </li></ul><ul><ul><li>Highly metastatic </li></ul></ul><ul><ul><li>Resistant to chemotherapy </li></ul></ul>
  34. 34. Melanoma <ul><li>Melanomas have the following characteristics (ABCD rule) </li></ul><ul><ul><li>A: Asymmetry; the two sides of the pigmented area do not match </li></ul></ul><ul><ul><li>B: Border is irregular and exhibits indentations </li></ul></ul><ul><ul><li>C: Color (pigmented area) is black, brown, tan, and sometimes red or blue </li></ul></ul><ul><ul><li>D: Diameter is larger than 6 mm (size of a pencil eraser) </li></ul></ul>
  35. 35. Melanoma <ul><li>Treated by wide surgical excision accompanied by immunotherapy </li></ul><ul><li>Chance of survival is poor if the lesion is over 4 mm thick </li></ul>
  36. 36. Burns <ul><li>First-degree – only the epidermis is damaged </li></ul><ul><ul><li>Symptoms include localized redness, swelling, and pain </li></ul></ul><ul><li>Second-degree – epidermis and upper regions of dermis are damaged </li></ul><ul><ul><li>Symptoms mimic first degree burns, but blisters also appear </li></ul></ul><ul><li>Third-degree – entire thickness of the skin is damaged </li></ul><ul><ul><li>Burned area appears gray-white, cherry red, or black; there is no initial edema or pain (since nerve endings are destroyed) </li></ul></ul>
  37. 37. Rule of Nines <ul><li>Estimates the severity of burns </li></ul><ul><li>Burns considered critical if: </li></ul><ul><ul><li>Over 25% of the body has second-degree burns </li></ul></ul><ul><ul><li>Over 10% of the body has third-degree burns </li></ul></ul><ul><ul><li>There are third-degree burns on face, hands, or feet </li></ul></ul>
  38. 38. Rule of Nines Figure 5.8a
  39. 39. Developmental Aspects of the Integument: Fetal <ul><li>Epidermis develops from ectoderm </li></ul><ul><li>Dermis and hypodermis develop from mesoderm </li></ul><ul><li>Lanugo – downy coat of delicate hairs covering the fetus </li></ul><ul><li>Vernix caseosa – substance produced by sebaceous glands that protects the skin of the fetus in the amnion </li></ul>
  40. 40. <ul><li>Skin and hair become oilier and acne may appear </li></ul><ul><li>Skin shows the effects of cumulative environmental assaults around age 30 </li></ul><ul><li>Scaling and dermatitis become more common </li></ul>Developmental Aspects of the Integument: Adolescent to Adult
  41. 41. <ul><li>Epidermal replacement of cells slows and skin becomes thinner </li></ul><ul><li>Skin becomes dry and itchy </li></ul><ul><li>Subcutaneous fat layer diminishes, leading to intolerance of cold </li></ul><ul><li>Decreased elasticity and loss of subcutaneous tissue leads to wrinkles </li></ul><ul><li>Decreased numbers of melanocytes and Langerhans’ cells increase the risk of skin cancer </li></ul>Developmental Aspects of the Integument: Old Age

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