Thrive365.com mHealth business for global Diabetes sufferers

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Thrive365 is the only global patented global scoring system with an online and offline offering for people suffering with Diabetes see thrive365.com or the APP store at Apple. It has had $15m sunk into it working with the American Diabetes Association tennessee, USDA, Telcare, Daibetes Daily, FitBit. It revolutionises people with Daibetes as they can now take photos of the nutritional data on food in the grocery store and have it scored! allows restaurant choices in the moment scored, it allows blood glucose results and fitness levels to be saved and sent to their doctors.

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  • And as you know, the numbers continue to escalate. Currently, 24 million people in the United States have diabetes, and a staggering 57 million are at risk of developing diabetes. The healthcare costs associated with diabetes are quite significant—adding up to $48 billion each year.
  • Thrive365.com mHealth business for global Diabetes sufferers

    1. 1. © 2013 Pilot Lite Ventures 1 Thrive365 an mHealth Wellness platform for people with Type 2 & Pre-Diabetes It is an Online – offline – App – device integration – Data business www.thrive365.com
    2. 2. © 2013 Pilot Lite Ventures “Diabetes is big, is growing out of control, and current spending accounts for around 10 per cent of the National Health Service (NHS) budget.” (2) By 2025 it is expected that 5 million people in the UK will suffer from diabetes.3 2.9M people in the UK with diabetes (1) $15Bn Spent by the NHS in 2011, which is 10% of the NHS budget. (3) 850,000 who have diabetes but haven’t been diagnosed (1) One in 10 deaths in adults in the Europe Region can be attributed to diabetes, representing close to 600,000 people in 2011. (1) 52.8M People (20-79) with diabetes in 2011 out of a population (20-79) of 653 million (1) $131Bn Spent on healthcare in Europe in 2011, accounting for almost one-third of global healthcare expenditures due to diabetes. This is predicted to increase to 157 billion in 2030 (1) 64.2M People (20-79) predicted to have diabetes in 2030 of a population of 673 million (1) Age is an important risk factor for type 2 diabetes. In Europe in 2011, a third of the population of the region was over 50 years of age, and this is expected to increase to over 40% by 2030. (1) “Diabetes is now the biggest single cause of amputation, stroke, blindness, and end stage kidney failure.” Barbara Young, Chief Executive Diabetes UK (2) The Middle East and North Africa region has the highest comparative prevalence of diabetes (11.0%). Rapid economic development coupled with ageing populations have resulted in a dramatic increase in the prevalence of diabetes. (1) 32.6M People (20-79) with diabetes in 2011 out of a population (20-79) of 356 million. (1) $10.9Bn Spent on healthcare in the Middle East and North Africa region in 2011. Healthcare expenditures due to diabetes in the region account for just 2.3% of the total global figure. However, these expenditures are expected to double by 2030. 59.7M People (20-79) with diabetes in 2030 out of a population (20- 79) of 539 million. (1) Six out of the world’s top ten countries for highest prevalence (%) of diabetes are in the Middle East and North Africa Region – Kuwait, Lebanon, Qatar, Saudi Arabia, Bahrain and the United Arab Emirates. (1) Diabetes is a Major Problem in the USA affecting 1 in 12 people today, and 1 in 9 by 2030 26M people in the US with Diabetes $116Bn spent each year on direct medical costs for diabetes 79M people in the US who are pre-diabetic Diabetes is considered the most difficult disease to treat by Health Care Professionals How big is the problem?
    3. 3. © 2013 Pilot Lite Ventures Thrive365 is a best in class mHealth business, working with leading partners to create the worlds first seamless fully integrated Diabetes on and off line scoring system 3 Disease Management Behavioral Rewards Food Databases Marketing and Brand Leverage Grocery Chains Glucometer Monitoring Activity & Weight Monitoring Gyms & Health Clubs Restaurants Insurance Providers Health and Diabetes Content Providers Employers 3 Working with ADA in Tennessee
    4. 4. © 2013 Pilot Lite Ventures Thrive365 allows consumers to register for free and pay to upgrade to the online/offline monthly service as well as a free and paid for APP 4 $4.99
    5. 5. © 2013 Pilot Lite Ventures Thrive365 is an mHealth platform firstly aimed at Diabetes but allows other programmes/businesses aim at other disease states or health/wellness challenges to be launched off it e.g. Obesity, Sugar, Sodium etc… The Assets Associated and strength of Thrive365 • A system developed from the ground up specifically for people with non insulin dependent type 2 diabetes • Built on a solid investment of over $15 million in R&D to develop the full program • Legal advisory clearance of language and claims for Thrive365 • Anchored around a Patented system based on a unique and proprietary food scoring algorithm which can be extended/restricted to allow other wellness/health challenges to be reflected • Leverages three gold standard food scoring databases to provide food scores for raw ingredients, packaged goods and restaurant menu databases with strong interconnectivity • Location based services to access restaurant menu item scores in real time based on location • Established partner eco-system and strong partner relationships • Formal endorsement from a panel of scientific advisors as a nutrition system for people with type 2 diabetes • A fully functional on-line web site and iOS app for iPhones and iPads • Extensive potential for big data including capture of behavioural, clinical and experiential data • A potential opportunity for a Corporate investor to de-risk itself as a target for litigation • Thrive365 just in the Diabetes space is creating an $80M+ mHealth USA business by delivering significant and measurable improved health outcomes for people with diabetes Business as well as strong IRR: 142% and 77% gross profit, the cash can be reinvested into further Health/Wellness budgets Thrive365Launched in Tennessee in August 2013 with the ADA! The ADA have invited Thrive365 to other ADA events as they believe its best class!! Thrive365 best in class Approved partners: Working with ADA in Tennessee
    6. 6. © 2013 Pilot Lite Ventures Thrive365 is now available on the US iTunes app store and on the web 6 www.thrive365.com
    7. 7. Thrive365’s Consumer Journey - What happens after you Register online and then to decide the use the APP? Get your Thrive Score •Register for the Program on web or app •Enter your personal info •Accept T’s & C’s •Get your personalised Thrive score* •Score is split out over 3 meals and a snack Eat at Home to ADA Nutritional Guidelines •Select meal plan •Select recipes •Add favorites and recipes •Food and top up suggestions •Record what you’ve eaten Eat Out to ADA Nutritional Guidelines •Location services identify nearby restaurants and their menus •Menu and top up suggestions •Select menu items from app and enter as eaten Stay Active •Track physical activity and sleep quality with FitBit activity monitoring device •Auto upload data via wireless RFID •Data transferred seamlessly to Thrive365 website for review and feedback Track Blood Glucose •Measure blood glucose on a TelCare glucometer •Auto upload onto TelCare database and into Thrive •Review blood glucose fluctuations relative to food intake and physical activity Stay Motivated •Participate in online ‘Diabetes ‘Community •Celebrate progress •Regularly scheduled check-in •Encouragement •Tips to manage Diabetes •Optional recipe suggestions •Site activity reminders © 2013 Pilot Lite Ventures
    8. 8. 8 The National Restaurant selection guide show orange PINS for Thrive365 restaurants this can be used for store locators as well – a liberation for Diabetes sufferers! Location services enable users to find restaurants close by that provide a Thrive365 score to all their menu items
    9. 9. © 2013 Pilot Lite Ventures Personal Smart Phone App Food & Purchase Data Device Data Lab Data Personal online data and activity profile Personalization 9 Planned developments include direct purchases from grocery stores, mobile payments for products, and a number of innovative app technologies that will further facilitate food entry and tracking ➤ Location based services, restaurants in area, and menu scoring ➤ Helps select and order food based on a personalized points system from the menus available ➤ Supports barcode scanning of food items in grocery stores or at home to simplify food selection ➤ Barcode is linked to the food database – store bought ➤ Provides over- eating and other alerts ➤ Links to a blood glucometer to measure blood sugar and captures the information directly into the App ➤ Tracks user exercise patterns and records into App and profile Thrive365 brings together Clinical, Behavioral and Experiential Data, seamlessly allowing consumer devices to link wirelessly and seamlessly with two way API’s T365 scores & Glucose levels for week of October 29
    10. 10. © 2013 Pilot Lite Ventures 10 • Thrive365 is in Market & launched at the ADA “Drive to Stop Diabetes” Event in Bristol, TN August 2013 A NASCAR event that attracted over 160,000 people to Bristol TN Strong active support from the ADA Opportunity to personally interact with over 1,000 people with diabetes Invited by the American Diabetes Association to launch at their “Drive to Stop Diabetes” event in Bristol, TN 1 in 2 NASCAR fans have Diabetes
    11. 11. © 2013 Pilot Lite Ventures A Committed and Capable team of key exec’s supported by a wider team Executives Role Relevant Experience Pier Massa CEO Director Business Development Virgin Life Care - a key leader in the launch of Virgin's health rewards program in the US. Actively responsible for developing the business concept, defining the company's customer processes and refining the rewards model. Mike Princi Commercial Director and CFO An ex-senior consultant in Accenture’s Corporate Strategy Practice with significant financial, M&A, partnering and commercial negotiation. A West Point graduate and Cornell MBA, Mike was an officer in the US Army and a graduate of the Airborne and Ranger schools. Matina Massa Operations & Technology Director US Launch Program Manager for Virgin Life Care. Responsible for the program management of the US market launch. Her role included responsibility for compliance, Business Continuity and Security processes. John Wiest Marketing Director Experienced Sales & Marketing executive with a successful track record of creating new domestic and international ventures businesses from $2 MM to $300 MM in revenue in the food, beverage and specialty retail sectors. Jackie Wilmot Partner Accounts Director Director, Innovation Enterprises at Humana. Led the development and launch of a national sales and marketing strategy for Virgin Life Care which resulted in the successful launch of the newest Virgin Group product 'Health Miles' in the USA. 11 Board Members Relevant Experience Pier Massa CEO Thrive Director Business Development Virgin Life Care - a key leader in the launch of Virgin's health rewards program in the US. Actively responsible for developing the business concept, defining the company's customer processes and refining the rewards model. Non Executive Director Thrive365 Mike Anstey Founded, funded, managed and exited six businesses worldwide. He has personally raised $120m over the last 6 years. He has launched and operated businesses for corporates across the USA, ASIA, UK, Europe and UAE, working with some of the largest brands in the world including Unilever, Sony, Royal Mail Todd Abraham SVP R&D Director Mondelēz He has global experience of global R&D from within Kraft Foods and now Mondelez International. Having spent 15 years at Pillsbury and Kraft as well as a stint with P&G he truly does have significant experience within the market of Diabetes and R&D deployment
    12. 12. © 2013 Pilot Lite Ventures In Conclusion, Thrive 365 … • Has a competent and capable management team who have successfully taken similar products to market • Addresses an ever growing global problem bolstered by the rise in obesity and an increasing ageing population and meets a true customer need • The system is unique: there is nothing in market to help people with diabetes manage and enjoy food, while at the same time establishing better glycemic control • Thrive365 owns the intellectual property for the Patented food scoring system which is at the heart of the system • Is creating an $80M+ mHealth business by delivering significant and measurable improved health outcomes for people with diabetes • Thrive365 is building an ecosystem of partners to deliver a full and engaging customer experience • Is concurrently ensuring that the outputs add value to the individual participants and the full ecosystem of partners, including payors and employers • Thrive365 provides an entry point into big data for Healthcare, starting with diabetes with potential expansion into other disease states • As a significant concurrent opportunity is allows MNC’s to clearly state they are looking to launch a business which also aids in mitigating and minimizing potential litigation around its core products 12
    13. 13. © 2013 Pilot Lite Ventures APPENDIX 1 Select example Blood Glucose curves* with Commentary Thrive365 is an mHealth business for people with Diabetes * These are strictly examples and do not purport to be a representative sample – Abstracts numbered 564.9 and 564.22 provide the robust scientific evidence behind the Thrive365 program.
    14. 14. © 2013 Pilot Lite Ventures • The following slides are averaged 24 hour blood glucose curves, measured at days 24 to 28 of treatment (yellow curve), and then again at days 52 to 56 of treatment (green curve). The baseline curve (dark blue) is actually an average of 8 days of data (two separate 4 day periods separated by 6 days). • All slides have the same scaling, where the vertical access indicates plasma glucose levels in mg/dl, and the horizontal access is time of day starting at midnight and finishing at midnight. • There are a couple of key things to pay attention to as we go through the slides: – Look to see if the treatment curves, yellow at 4 weeks and then green at 8 weeks, generally fall at or below the baseline blue curve, showing that we did, or did not, help manage blood glucose levels. – When someone already has well controlled blood glucose levels, falling somewhere between 100 and 150 mg/dl, were we able to maintain this control while at the same time dramatically expanding their world of food? – Recognize that for some people, we did not help manage glucose levels (about 15% of participants) – Finally, remember that these people had, on average, 45 minutes of instruction in how to use the system, they were provided a spiral bound book with about 1,000 foods, and given a Palm Pilot PDA (monochrome display) which had a food “look-up” function for those who could actually use a Palm Pilot. There were no support groups, support lines, 1-800 numbers to call. Participants had a refresher, if needed at 4 weeks which was typically 15 minutes induration. These results, which are typical, followed a net intervention of about one hour.
    15. 15. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day First, notice that this person had levels exceeding 300 mg/dL early in the morning, for an extended period of time, which we have been able to drop by about 50 points, and dramatically shorten in duration. Second, whereas the majority of the waking hours were spent above 200 at baseline, the majority of the waking hours are below 200 when using the Thrive 365 system.
    16. 16. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day In this case, the individual had reasonably well controlled glucose levels, falling between 100 and 150 mg/dL. While we lowered levels to around 100 during sleep, it would be fair to say that we did not improve glucose control during the day, but essentially maintained the control already established. However, we did this while simultaneously expanding food choice, and making diet management much simpler.
    17. 17. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day This individual we did not seem to be able to help at all. Blood glucose levels were high and bouncing everywhere at baseline, and seemed to stay that way for the full 8 weeks. Difficult to say why this might have been the case, but highlights the point that no treatment or diet regimen is perfect for everyone.
    18. 18. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day This individual was doing a decent, but not great, job of managing his/her glucose levels, with three problem areas, possibly around meals (averaging over 200 mg/dL in the mid-afternoon). However, at the end of the 8 week period (green curve), glucose levels were staying primarily within the 100 to 150 mg/dL range (with a slight dip below those levels during the night).
    19. 19. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day At first blush, this may look like we had no real impact on glucose levels. But if you look more closely, you will see that even though this person had very well controlled glucose levels, we lowered those levels even further throughout the day, with just a slight bump around 10 or 11 am. This is one of my favourite slides, simply because it shows that we can help people who thought that they had things well under control, and make their lives simpler while expanding their food choices, all at the same time.
    20. 20. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day For this person, I would argue that we did not improve, nor did we worsen, their glucose management. However, repeating what I have said before, managing their diet was much easier.
    21. 21. © 2013 Pilot Lite Ventures 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 400.0 450.0 0:00 3:00 6:00 9:00 12:00 15:00 18:00 21:00 0:00 Avg Base 1,2 MIDTRT ENDTRT SubcutaneousGlucose mg/dL Time of Day Finally, the improvement for this individual is dramatic at the 4 week time-point (they withdrew from the study before the 8 week measures for an unrelated medical issue). Notice how stable the glucose levels are throughout the night. And during the day, when previously the levels would rise above 200 mg/dL and stay there for hours at a time, eating per the Thrive 365 system helped to keep the levels between 100 and 150 mg/dL, on average.

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