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Ashg presentation 2010
Ashg presentation 2010
Ashg presentation 2010
Ashg presentation 2010
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  • Introduction to OGT OGT was founded by Professor Ed Southern in 1995 to commercialise his work in the area of Microarrays. The pioneering work in the field by Ed Southern and the team at OGT has resulted in OGT having both a world renowned patent portfolio in oligonucleotide microarrays together with considerable expertise in the design and deployment of microarrays in the life science setting. The Company is based in Oxford. We have 64 people on site and are growing strongly (36%) from 47 employees at the beginning of 2009. Strong financial resources from microarray patent licensingR&D focussed on microarrayscytogenetics products and servicesmicroarray service – large outsourced projects
  • Introduce Steve Rich
  • Platform:OGT have access to many (all?) of the major array platforms through our licensing programs, and it can be said that as a result we are “platform agnostic”. As a result, we select our platforms based upon two main factors:The quality of the results generated for the application(s) in question, based on both internal proof – of – concept and peer reviewed publicationsThe platforms that are most commonly requested by our customersUsing CNV analysis as an example, the Agilent platform provides significant benefits for this application…. Long oligos (60mers) exhibit a signal to noise ratio an order of magnitude greater than SNP genotyping arrays†
  • 20,000 samples
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Annotation Track Sources:Syndromes – OMIM and DECIPHERGenes – Ensembl, with links to UCSC and other gene-focussed online databasesExons – EnsemblRecombination Hotspots – Eichler paperCNVs – Database of Genomic Variants (DGV)Decipher – DECIPHER patientsConfirmation – Soon to link to Empire
  • Introduce Steve Rich
  • Introduce Steve Rich
  • General outsourced services: CRUK, ICRCustom aCGH services: UVA,, Leuven, Wessex, Sanger, UCSD, CSHLCustom aCGH products: Karolinska, Emory, GreenwoodCustom Methylation Services: Greenwood
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