Section 2, Chapter 7
Bone Homeostasis
Homeostasis of Bone Tissue
Calcium is constantly exchanged between the blood and bone.
Bone resorption = Osteoclasts break...
Nutrients that effect bone homeostasis

Vitamin D – promotes Ca2+ absorption in small intestine
• Vitamin D deficiency = s...
Hormones that affect bone homeostasis
Calcitonin
• Secreted from thyroid gland
• Promotes bone deposition

Parathyroid Hor...
Hormones that affect bone homeostasis
Growth Hormone (GH)
• Secreted from pituitary gland
• Promotes bone growth at epiphy...
Hormones that affect bone homeostasis
Sex Hormones (testosterone & estrogen)
• Promotes long bone growth at puberty
• Sex ...
Incomplete Fractures
Greenstick
fracture

Fissured
fracture
Complete Fractures

Transverse
fracture

Oblique
fracture

Comminuted
fracture

Spiral
fracture
When a bone breaks blood vessels rupture and the periosteum tears.
The repair of a broken bone occurs in 5 general steps.
...
Step 2. temporary spongy bone

Step 3. cartilaginous callus

Osteoblasts invade from
periosteum and deposit
temporary spon...
Step 4. bony callus

Step 5. bone remodeling

Osteoblasts replace the
cartilaginous callus with bone,
forming a bony callu...
Over time, osteoclasts outnumber osteoblasts, and
more bone is resorbed than can be deposited. Bone
mass decreases as a re...
Ways to delay or prevent osteoporosis:
1. Exercise daily.

2. Consume enough calcium and
vitamin D every day.
3. Do not sm...
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section 2, chapter 7: skeletal system

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section 2, chapter 7: skeletal system

  1. 1. Section 2, Chapter 7 Bone Homeostasis
  2. 2. Homeostasis of Bone Tissue Calcium is constantly exchanged between the blood and bone. Bone resorption = Osteoclasts breakdown bone releasing calcium into the blood. Bone resorption occurs when blood [Ca2+] is low and it’s stimulated by parathyroid hormone (PTH). Bone deposition = Osteoblasts deposit new bone from calcium in the blood stream. Bone deposition occurs when blood [Ca2+] is high and it’s stimulated by the hormone calcitonin.
  3. 3. Nutrients that effect bone homeostasis Vitamin D – promotes Ca2+ absorption in small intestine • Vitamin D deficiency = softened and deformed bones • Osteomalacia in adults • Rickets in children Vitamin A – balances bone resorption and deposition • Vitamin A deficiency = retards bone development Vitamin C – is required for collagen synthesis. • Vitamin C deficiency = results in fragile bones
  4. 4. Hormones that affect bone homeostasis Calcitonin • Secreted from thyroid gland • Promotes bone deposition Parathyroid Hormone (PTH) • Secreted from parathyroid glands • Promotes bone resorption Figure 7.13 Hormonal regulation of blood calcium and resorption
  5. 5. Hormones that affect bone homeostasis Growth Hormone (GH) • Secreted from pituitary gland • Promotes bone growth at epiphyseal plates Pituitary Gigantism over secretion of GH during childhood Pituitary Dwarfism insufficient GH during childhood Acromegaly • Over secretion of GH as an adult • Occurs after epiphyseal plates have sealed • Enlargement of hands, feet, nose
  6. 6. Hormones that affect bone homeostasis Sex Hormones (testosterone & estrogen) • Promotes long bone growth at puberty • Sex hormones also stimulate ossification at epiphyseal plates. Effects of Exercise on bone homeostasis Contracting muscles pull on bones and promotes bone thickening Figure 7.12 The thickened bone on the left is better able to withstand forces from muscle contractions.
  7. 7. Incomplete Fractures Greenstick fracture Fissured fracture
  8. 8. Complete Fractures Transverse fracture Oblique fracture Comminuted fracture Spiral fracture
  9. 9. When a bone breaks blood vessels rupture and the periosteum tears. The repair of a broken bone occurs in 5 general steps. Step 1. hematoma formation Blood soon forms a hematoma (blood clot). Hematoma in foot
  10. 10. Step 2. temporary spongy bone Step 3. cartilaginous callus Osteoblasts invade from periosteum and deposit temporary spongy bone. Fibroblasts deposit a mass of fibrocartilage “cartilaginous callus” & Phagocytes remove hematoma Osteoclasts remove bony debris
  11. 11. Step 4. bony callus Step 5. bone remodeling Osteoblasts replace the cartilaginous callus with bone, forming a bony callus Osteoclasts remove excess bone, remodeling the bone the bone close to its original shape.
  12. 12. Over time, osteoclasts outnumber osteoblasts, and more bone is resorbed than can be deposited. Bone mass decreases as a result. Osteopenia “low bone mass” • Progresses towards osteoporosis Osteoporosis “porous bone” • Bones develop spaces and canals • Bones are fragile and easily broken • Common in menopausal women (from the low estrogen levels) Bone loss is rapid in menopausal women due to reduced estrogen
  13. 13. Ways to delay or prevent osteoporosis: 1. Exercise daily. 2. Consume enough calcium and vitamin D every day. 3. Do not smoke. End of Chapter 7, Section 2

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