When fibrin is split by plasmin, positive tests for fibrin degradation (split) products, identified by the letters X, Y, D, and E, are produced. These products have an anticoagulant action and inhibit clotting when they are present in excess in the circulation. Increased levels of FDPs may occur with a variety of pathologic processes in which clot formation and lysis occur. This test is done to establish the diagnosis of DIC and other thromboembolic disorders.
Increased FSP and FDP are associated with DIC and are seen in: Venous thrombosis Primary fibrinolysis Thoracic and cradiac surgery or renal transplantation Acute myocardial infarction PE Carcinoma Liver disease