CNS TUMORS Alina Valdes, M.D.
<ul><li>Devastating  effects </li></ul><ul><li>High mortality  rates </li></ul><ul><li>Benign tumors may be  unresectable ...
Classification   <ul><li>World Health Organization  classification </li></ul><ul><ul><li>Primary tumors classified on basi...
Clinical Manifestations <ul><li>Symptoms  from intracranial tumors </li></ul><ul><ul><li>Compression  of brain by tumor an...
<ul><li>Symptoms from  primary  brain tumors  slowly progressive </li></ul><ul><li>Symptoms from  metastatic  tumors more ...
<ul><li>Generalized symptoms </li></ul><ul><ul><li>Headache </li></ul></ul><ul><ul><ul><li>Most common  generalized sympto...
<ul><li>Focal symptoms </li></ul><ul><ul><li>Frontal lobe  tumors </li></ul></ul><ul><ul><ul><li>May be massive before sym...
<ul><ul><li>Parietal lobe  tumors </li></ul></ul><ul><ul><ul><li>Subtle signs or more dramatic like hemianesthesia </li></...
<ul><ul><li>Temporal lobe  tumors </li></ul></ul><ul><ul><ul><li>Personality changes, auditory hallucinations, complex par...
Patient Evaluation <ul><li>Careful  neuro exam </li></ul><ul><li>Contrast-enhanced  CT scan or MRI </li></ul><ul><ul><li>M...
<ul><li>Biopsy </li></ul><ul><ul><li>Accurate histological diagnosis </li></ul></ul><ul><ul><li>Detect other disease like ...
Treatment   <ul><li>Surgery </li></ul><ul><ul><li>Most patients with  primary  tumors </li></ul></ul><ul><ul><li>Many pati...
<ul><li>Increased intracranial pressure </li></ul><ul><ul><li>Most patients have brain edema and benefit from  glucocortic...
<ul><li>Radiation </li></ul><ul><ul><ul><li>Conventional  – external beam </li></ul></ul></ul><ul><ul><ul><ul><li>Uses dir...
<ul><li>Chemotherapy </li></ul><ul><ul><li>Not  used as sole therapy </li></ul></ul><ul><ul><li>Major obstacle is  blood-b...
Malignant Astrocytomas <ul><li>Group of heterogeneous tumors:  glioblastoma multiforme, anaplastic astrocytoma, and anapla...
<ul><li>Anaplastic astrocytoma and anaplastic oligodendroglioma </li></ul><ul><ul><li>Median survival of  4 to 5 years </l...
Glioma involving most of the left parietal lobe  – seen to the right on this axial CT scan (arrow). The appearance is of a...
Cystic glioblastoma of the brain stem  (arrowed), clearly demonstrated by MRI. The sagittal section shows that the tumor i...
Meningiomas   <ul><li>Arise  outside  brain </li></ul><ul><li>Generally grow  slowly </li></ul><ul><li>Benign in  90%  of ...
Meningioma in the occipital  lobe , as revealed on contrast-enhanced CT scan. The patient presented with a contralateral h...
CT scan showing a right frontal meningioma with a vascular capsule . The contrast-enhancement technique used in this scan ...
MRI picture of a right frontal meningioma  (same patient as in slide 21). MRI shows the fissures of the brain more clearly...
MRI sagitttal view  of the patient seen in slides 21 and 22 . This view demonstrates the relationship of the meningioma to...
CNS Lymphoma <ul><li>Increasing  in incidence </li></ul><ul><li>No  evidence of lymphoma outside CNS if primary </li></ul>...
<ul><li>40% of immunocompetent  and  nearly 100% of AIDS  patients have  multifocal  lymphoma when diagnosed </li></ul><ul...
<ul><li>Treatment </li></ul><ul><ul><li>Corticosteroids : cytotoxic effects on lymphoma cells; not sufficient </li></ul></...
Metastatic Tumors to the Brain <ul><li>Comprise  most  of intracranial tumors </li></ul><ul><li>Common : lung, breast, and...
<ul><li>Treatment </li></ul><ul><ul><li>Corticosteroids  – dexamethasone in brain edema </li></ul></ul><ul><ul><li>Radiati...
Multiple cerebral metastases in a patient with carcinoma of the breast , demonstrated on CT scan. Axial ‘cuts’ at other le...
Spinal Cord Tumors <ul><li>Much  less common  than brain </li></ul><ul><li>Extradural or intradural </li></ul><ul><ul><li>...
<ul><li>Symptoms usually from  compression  of normal structures or  compromise  of blood supply  not invasion  of parench...
<ul><li>Treatment with  surgical resection </li></ul><ul><ul><li>High-grade astrocytoma followed by radiation </li></ul></...
Subdural lipoma  demonstrated by MRI in sagittal section. The lipoma (large arrows) is severely compressing the spinal cor...
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CNS Tumors

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CNS Tumors

  1. 1. CNS TUMORS Alina Valdes, M.D.
  2. 2. <ul><li>Devastating effects </li></ul><ul><li>High mortality rates </li></ul><ul><li>Benign tumors may be unresectable so incurable </li></ul><ul><li>Malignant if cannot be removed completely </li></ul><ul><li>Incidence increases with advancing age after childhood, when second most common cancer </li></ul><ul><li>No environmental agent known to be causative except for vinyl chloride with gliomas and CNS radiation with several tumors </li></ul><ul><li>No evidence supports viral origin </li></ul>
  3. 3. Classification <ul><li>World Health Organization classification </li></ul><ul><ul><li>Primary tumors classified on basis of cell origin </li></ul></ul><ul><li>Most primary tumors of neuroepithelial origin </li></ul><ul><ul><li>From malignant transformation of astrocytes, ependymocytes, and oligodendrocytes </li></ul></ul><ul><li>Gliomas most common </li></ul><ul><ul><li>Arise from astrocytes </li></ul></ul><ul><li>Metastases more likely than primary CNS tumor in patient with known systemic malignant disease </li></ul>
  4. 4. Clinical Manifestations <ul><li>Symptoms from intracranial tumors </li></ul><ul><ul><li>Compression of brain by tumor and presence of associated edema </li></ul></ul><ul><ul><li>Infiltration and destruction of brain parenchyma by tumor cells </li></ul></ul><ul><li>Rigid cranial cavity so benign and malignant tumors may cause symptoms </li></ul>
  5. 5. <ul><li>Symptoms from primary brain tumors slowly progressive </li></ul><ul><li>Symptoms from metastatic tumors more acute </li></ul><ul><ul><li>Grow more rapidly and associated with edema </li></ul></ul><ul><ul><li>Hemorrhage into tumor </li></ul></ul><ul><li>May present with generalized symptoms from increased intracranial pressure or focal symptoms from areas of compromise </li></ul>
  6. 6. <ul><li>Generalized symptoms </li></ul><ul><ul><li>Headache </li></ul></ul><ul><ul><ul><li>Most common generalized symptom and first in ½ of adults </li></ul></ul></ul><ul><ul><ul><li>Infrequently from tumor itself but rather from increased intracranial pressure </li></ul></ul></ul><ul><ul><li>Changes in mood or personality </li></ul></ul><ul><ul><li>Decrease in appetite </li></ul></ul><ul><ul><li>Nausea </li></ul></ul><ul><ul><li>Projectile vomiting – in children </li></ul></ul><ul><ul><li>Generalized or focal seizures – in 20% of patients </li></ul></ul>
  7. 7. <ul><li>Focal symptoms </li></ul><ul><ul><li>Frontal lobe tumors </li></ul></ul><ul><ul><ul><li>May be massive before symptoms cause problems </li></ul></ul></ul><ul><ul><ul><li>Progressive difficulty with concentration and memory, personality changes, and lack of spontaneity </li></ul></ul></ul><ul><ul><ul><li>Urinary incontinence and gait disorder </li></ul></ul></ul><ul><ul><ul><li>Appearance of primitive reflexes in bifrontal disease </li></ul></ul></ul>
  8. 8. <ul><ul><li>Parietal lobe tumors </li></ul></ul><ul><ul><ul><li>Subtle signs or more dramatic like hemianesthesia </li></ul></ul></ul><ul><ul><ul><li>Righ t: spatial disorientation or left homonymous hemianopia </li></ul></ul></ul><ul><ul><ul><li>Left : receptive aphasia or right homonymous hemianopia </li></ul></ul></ul>
  9. 9. <ul><ul><li>Temporal lobe tumors </li></ul></ul><ul><ul><ul><li>Personality changes, auditory hallucinations, complex partial seizures, and quadrantanopia </li></ul></ul></ul><ul><ul><ul><li>Uncal herniation if large enough </li></ul></ul></ul><ul><ul><li>Metastatic spread of primary CNS tumors to sites outside CNS rare </li></ul></ul><ul><ul><li>Spread to meninges and spinal cord occurs with most malignant CNS tumors </li></ul></ul>
  10. 10. Patient Evaluation <ul><li>Careful neuro exam </li></ul><ul><li>Contrast-enhanced CT scan or MRI </li></ul><ul><ul><li>MRI superior </li></ul></ul><ul><ul><ul><li>More useful in imaging posterior fossa </li></ul></ul></ul><ul><ul><ul><li>More sensitive in detecting parenchymal invasion </li></ul></ul></ul><ul><li>CT scan without contrast not adequate for primary or metastatic tumors </li></ul><ul><li>Cerebral angiography only when tumor blood supply needed prior to resection </li></ul>
  11. 11. <ul><li>Biopsy </li></ul><ul><ul><li>Accurate histological diagnosis </li></ul></ul><ul><ul><li>Detect other disease like abscess </li></ul></ul><ul><ul><li>Open craniotomy or MRI-guided or CT-guided stereotactic techniques </li></ul></ul><ul><ul><li>In 20% of patients with metastatic tumors, CNS biopsy helpful in identifying primary site </li></ul></ul><ul><li>Lumbar puncture </li></ul><ul><ul><li>Helpful only if suspect leptomeningeal involvement </li></ul></ul><ul><ul><li>Contraindicated when intracranial mass lesion present </li></ul></ul>
  12. 12. Treatment <ul><li>Surgery </li></ul><ul><ul><li>Most patients with primary tumors </li></ul></ul><ul><ul><li>Many patients with solitary brain metastasis </li></ul></ul><ul><ul><li>May relieve symptoms for many months if debulk tumor when surgical cure unlikely </li></ul></ul><ul><ul><li>No extensive resection with brain stem tumors </li></ul></ul><ul><ul><li>Radical resection not recommended for tumors in language or sensorimotor areas, basal ganglia, or corpus callosum due to neuro dysfunction </li></ul></ul><ul><ul><li>Not recommended for CNS lymphoma: multifocal and respond to chemo and radiation combination </li></ul></ul>
  13. 13. <ul><li>Increased intracranial pressure </li></ul><ul><ul><li>Most patients have brain edema and benefit from glucocorticoids , usually dexamethasone </li></ul></ul><ul><ul><li>In life-threatening edema with signs of herniation, can give mannitol with dexamethasone </li></ul></ul><ul><li>Anticonvulsants </li></ul><ul><ul><li>Given if develop seizures </li></ul></ul><ul><ul><li>Given if at risk of developing seizures before performing biopsy or surgery: many patients don’t need postoperatively </li></ul></ul>
  14. 14. <ul><li>Radiation </li></ul><ul><ul><ul><li>Conventional – external beam </li></ul></ul></ul><ul><ul><ul><ul><li>Uses direct X-rays to whole-brain or focal area </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Whole-brain radiation associated with long-term toxicity, like dementia and gait disturbance </li></ul></ul></ul></ul><ul><ul><ul><li>Brachytherapy </li></ul></ul></ul><ul><ul><ul><ul><li>Implantation of permanent or temporary radiation “seeds” within tumor </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Allows higher doses to tumor while preserving normal tissue </li></ul></ul></ul></ul><ul><ul><ul><li>“ Radiosurgery ” </li></ul></ul></ul><ul><ul><ul><ul><li>Converging more than 200 beams of radiation onto small, well-defined tumors </li></ul></ul></ul></ul>
  15. 15. <ul><li>Chemotherapy </li></ul><ul><ul><li>Not used as sole therapy </li></ul></ul><ul><ul><li>Major obstacle is blood-brain barrier </li></ul></ul><ul><ul><li>CNS tumors often drug resistant </li></ul></ul><ul><ul><li>Biodegradable wafers impregnated with nitrosurea BCNU placed into tumor after resection </li></ul></ul><ul><ul><li>Oligodendrogliomas unusually sensitive </li></ul></ul><ul><ul><li>CNS lymphomas treated with combination chemo and radiation </li></ul></ul>
  16. 16. Malignant Astrocytomas <ul><li>Group of heterogeneous tumors: glioblastoma multiforme, anaplastic astrocytoma, and anaplastic oligodendroglioma </li></ul><ul><li>Glioblastoma multiforme </li></ul><ul><ul><li>Worst prognosis with median survival <12 mos . </li></ul></ul><ul><ul><li>Surgery and radiation to improve symptoms and quality of life </li></ul></ul><ul><ul><li>If relapse, benefit of treatment short-lived </li></ul></ul>
  17. 17. <ul><li>Anaplastic astrocytoma and anaplastic oligodendroglioma </li></ul><ul><ul><li>Median survival of 4 to 5 years </li></ul></ul><ul><ul><li>Oligodendroglioma or mixed benefit most from chemo after surgery </li></ul></ul><ul><ul><li>Recurrent treated same as glioblastoma multiforme </li></ul></ul>
  18. 18. Glioma involving most of the left parietal lobe – seen to the right on this axial CT scan (arrow). The appearance is of a cystic tumor, but biopsy and histological confirmation are necessary to be certain of its nature.
  19. 19. Cystic glioblastoma of the brain stem (arrowed), clearly demonstrated by MRI. The sagittal section shows that the tumor involves the posterior part of the brainstem and extends into the cerebellum.
  20. 20. Meningiomas <ul><li>Arise outside brain </li></ul><ul><li>Generally grow slowly </li></ul><ul><li>Benign in 90% of cases </li></ul><ul><li>Complete resection should be attempted </li></ul><ul><li>Risk of recurrence proportionate to extent of resection </li></ul><ul><li>If partial resection, give postop radiation </li></ul><ul><li>If malignant, radiation given </li></ul><ul><li>Chemotherapy not used </li></ul>
  21. 21. Meningioma in the occipital lobe , as revealed on contrast-enhanced CT scan. The patient presented with a contralateral homonymous hemianopia.
  22. 22. CT scan showing a right frontal meningioma with a vascular capsule . The contrast-enhancement technique used in this scan demonstrates the classic appearance of a densely enhancing, sharply marginated tumor, tightly against the dura.
  23. 23. MRI picture of a right frontal meningioma (same patient as in slide 21). MRI shows the fissures of the brain more clearly than CT; it shows the tumor well, and parts of its vascular supply appear as hypodense images (arrows).
  24. 24. MRI sagitttal view of the patient seen in slides 21 and 22 . This view demonstrates the relationship of the meningioma to the dura and skull very clearly, and shows the vascular capsule posteriorly (arrow).
  25. 25. CNS Lymphoma <ul><li>Increasing in incidence </li></ul><ul><li>No evidence of lymphoma outside CNS if primary </li></ul><ul><li>Most often occur deep in frontal lobe so less likely to present with seizures than other primary and metastatic CNS neoplasms </li></ul><ul><li>Presenting complaints – headache, personality changes, and focal symptoms </li></ul>
  26. 26. <ul><li>40% of immunocompetent and nearly 100% of AIDS patients have multifocal lymphoma when diagnosed </li></ul><ul><li>>40% of patients have leptomeningeal involvement – rarely symptomatic </li></ul><ul><li>20% of patients have involvement of one or both eyes </li></ul><ul><li>May be confused with metastatic disease since often multifocal </li></ul><ul><li>Surgical resection not indicated </li></ul>
  27. 27. <ul><li>Treatment </li></ul><ul><ul><li>Corticosteroids : cytotoxic effects on lymphoma cells; not sufficient </li></ul></ul><ul><ul><li>Combination of systemic chemotherapy before whole-brain radiation </li></ul></ul><ul><li>5-year survival rates with combined therapy as high as 30% </li></ul><ul><li>If complete response to chemotherapy, may defer radiation due to associated late effects </li></ul>
  28. 28. Metastatic Tumors to the Brain <ul><li>Comprise most of intracranial tumors </li></ul><ul><li>Common : lung, breast, and melanoma </li></ul><ul><li>Present with headache, seizures, focal symptoms, depression, and changes in mental status </li></ul><ul><li>Metastases usually multifocal </li></ul><ul><li>Rapidly growing tumors can cause massive edema </li></ul>
  29. 29. <ul><li>Treatment </li></ul><ul><ul><li>Corticosteroids – dexamethasone in brain edema </li></ul></ul><ul><ul><li>Radiation </li></ul></ul><ul><ul><li>Surgery possible if solitary or easily resectable and systemic disease well controlled </li></ul></ul><ul><ul><li>Not usually respond to chemotherapy because of blood-brain barrier </li></ul></ul>
  30. 30. Multiple cerebral metastases in a patient with carcinoma of the breast , demonstrated on CT scan. Axial ‘cuts’ at other levels in the brain demonstrated further lesions.
  31. 31. Spinal Cord Tumors <ul><li>Much less common than brain </li></ul><ul><li>Extradural or intradural </li></ul><ul><ul><li>Most extradural are metastasis from other sites </li></ul></ul><ul><ul><li>Intradural described as </li></ul></ul><ul><ul><ul><li>Extramedullary : arising outside spinal cord, e.g. schwannomas and meningiomas </li></ul></ul></ul><ul><ul><ul><li>Intramedullary : arising within spinal cord, e.g. ependymomas and astrocytomas </li></ul></ul></ul><ul><li>Most common location is thoracic area </li></ul>
  32. 32. <ul><li>Symptoms usually from compression of normal structures or compromise of blood supply not invasion of parenchyma </li></ul><ul><li>Early symptoms are back pain and distal paresthesias ; then loss of sensation and weakness below level of tumor and loss of bowel and bladder control </li></ul><ul><li>MRI most useful and mostly replaced myelography </li></ul><ul><li>Urgent evaluation if progressive deficits </li></ul>
  33. 33. <ul><li>Treatment with surgical resection </li></ul><ul><ul><li>High-grade astrocytoma followed by radiation </li></ul></ul><ul><ul><li>Epidural metastasis treated with high doses of corticosteroids and surgery or radiation </li></ul></ul><ul><ul><li>Surgical decompression if acute onset of symptoms or if pathology not known </li></ul></ul>
  34. 34. Subdural lipoma demonstrated by MRI in sagittal section. The lipoma (large arrows) is severely compressing the spinal cord (small arrows).
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