Technologies for isolating albumin from aqueous solution

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Technologies for isolating albumin from aqueous solution

  1. 1. REQUEST # 67677 Technologies for Isolating Albumin from Aqueous Solution RESPONSE DUE DATE: November 21, 2011 MANAGER: T. Hayama, Ph.D. SOLUTION PROVIDER HELP DESK EMAIL: PhD@ninesigma.com PHONE:+1-216-283-3901 Opportunity Joint development, development contract, material/product supply (click buttons above) Timeline Feasibility validation: about half year Completion of development: 1~2 year Financials Up to US$100,000 per year (details to be discussed)REQUEST FOR PROPOSAL DESCRIPTION BACKGROUNDNineSigma, representing a multi-billion dollar food The client, a foods/functional foods manufacturer,manufacturer, invites proposals for highly efficient is trying to re-use various by-products from theirand low-cost technologies for isolating albumin processes. In particular, albumin is a solublefrom aqueous solutions resulting from the protein derived from cereal, and it has been usedprocessing of cereals. as a health food for its effect in lowering blood sugar levels. Therefore, it would be veryRequirements for Technology: significant if it could be efficiently recovered from  Evidence or reason that albumin can be by-products. isolated from aqueous solution (it is acceptable that other water-soluble proteins In order to recover albumin from aqueous solution, remain) the client has designed a purification process that  Should be reusable or low-cost uses alginic acid, a type of polysaccharide thickener, as part of the production process. In theInformation about the albumin and aqueous current process, however, after the albumin hassolution: been trapped with alginic acid, it is necessary to  Albumin: recover the alginic acid attached with albumin and ○ Molecular weight: approximately 12 kDa desorb the albumin from the alginic acid by using ○ Solubility: soluble in water salt. Therefore, these steps are one major factor ○ Thermal stability: denatures at that leads to high cost. approximately ≥ 90°C  Aqueous solution: The client has issued this open request in order to ○ A suspension, but impurities can be simplify or reduce the cost of this process as a way removed by preprocessing of trying to lower the cost of the entire ○ Albumin concentration: 0.03% manufacturing process. To solve this problem, a ○ Contents: water (≥ 95%), carbohydrates wide variety of technical approaches are (several %), insoluble or water-soluble anticipated, such as protein-purification proteins (several %), minerals (several %) technologies in the pharmaceutical field, recycling technologies for processing sludge, and the use of alginic acid derivatives that have been developed for various purposes. Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com RFP format and graphics© Copyright 2011 NineSigma, Inc
  2. 2. NineSigma Request # 67677 Technologies for Isolating Albumin from Aqueous Solution Page 2ANTICIPATED APPROACHES RESPONDING TO THIS REQUESTAnticipated approaches include, but are notnecessarily limited to, the following: NON-CONFIDENTIAL DISCLOSURE  Ion-exchange resins By submitting a Response you represent that the  Albumin-specific affinity ligands Response does not and will not be deemed to contain  Alginic acid solidification any confidential information of any kind whatsoever.  Other polysaccharide thickeners Your Response should be an executive summary (about (carrageenan, pectin, guar gum, etc.) 3 pages). The Response should briefly describe the technical approach and provide information onAPPROACHES NOT OF INTEREST technology performance, background, and description of the responding team and their related experience. AThe following approaches will not be considered: Response Template is available from our website.  Ultrafiltration, molecular sieves, etc. By submitting a Response, you acknowledge thatANTICIPATED COLLABORATIVE PARTNERS NineSigma’s client reserves the sole and absolute right and discretion to select for award all, some, or none ofAnticipated researchers or organizations for the Responses received for this announcement.collaboration include, but are not necessarily NineSigma’s client also may choose to select onlylimited to, the following: specific tasks within a proposal for award. NineSigmas client has the sole and absolute discretion to determine  Researchers who have purification all award amounts. technologies for human serum albumin  Researchers who have developed resin materials using alginic acid RESPONSE EVALUATION  Engineers who have used alginic acid for NineSigma’s client will evaluate the Response using the purposes such as sludge or biomass following criteria: processing  Overall scientific and technical merit of theANTICIPATED PROJECT PHASES OR PROJECT PLAN proposed approach  Approach to proof of concept or performanceThe client will review proposals and key  Potential for proprietary position (i.e., is thepublications. They may ask clarifying questions technology novel or protectable)before selecting suitable candidates for  Economic potential of conceptcollaboration. Once candidates are selected, the  Respondent’s capabilities and related experience  Realism of the proposed plan and cost estimatesclient will execute non-disclosure agreements(NDA) if necessary, seek further information The client will contact respondents with highlydisclosure, and discuss possible development responsive proposals for next steps.approaches.Once the best candidates will be selected, theclient will execute contracts or joint developmentagreements with partners and proceed to verify theproposed technology.Specifics of the collaboration will be negotiatedbetween the parties concerned.ITEMS TO BE INCLUDED IN THE PROPOSALResponses should use the following template(https://www.myninesigma.com/sites/public/_layouts/ProposalTemplates/Response_Template_67677.doc) and include the following items:  Overview of the proposed technology  Development status  Development plan  Overview of the organization and prior results Offices: Cleveland - USA, Tokyo - Japan, Leuven - Belgium www.ninesigma.com

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