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Regolazione ipotalamica del sonno e ritmo circadiano

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Hypothalamic regulation of sleep and circadian rhythms AWAKE group meeting Alex Dimitriu, MD Saper, Scammel, Lu Nature, Volume 437 October 2005
Baron Constantin von Economo - 1916 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Agenda ,[object Object],[object Object],[object Object],[object Object]
Von Economo’s Encephalitis ,[object Object],[object Object],[object Object],[object Object]
Von Economo ,[object Object],[object Object]
Hypothalamus
Hypothalamus
RAS ,[object Object],[object Object],[object Object]
Reticular Activating System – 2 branches ,[object Object],[object Object],[object Object],[object Object],[object Object]
PPT LDT Neurons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The 2nd activating Pathway ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Second Pathway (RED) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Second Pathway (RED) ,[object Object],[object Object],[object Object],[object Object]
Ascending Arousal System
Encephalitis Lethargica ,[object Object]
Hypersomnia vs. Insomnia ,[object Object],[object Object],[object Object]
VLPO promotes sleep ,[object Object],[object Object],[object Object],[object Object]
VentroLateral Preoptic Nucleus (Hypothalamus)
VLPO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
VLPO ,[object Object],[object Object],[object Object],[object Object],[object Object]
The Flip Flop Switch ,[object Object],[object Object],[object Object],[object Object],[object Object]
Instability of the Switch ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unstable Switch ,[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
Narcolepsy ,[object Object],[object Object],[object Object]
Hypocretin ,[object Object],[object Object],[object Object],[object Object]
Hypocretin ,[object Object],[object Object],[object Object],[object Object]
Why we sleep… ,[object Object],[object Object],[object Object],[object Object],[object Object]
Why we sleep… Homeostatic ,[object Object],[object Object],[object Object],[object Object],[object Object]
… blocks adenosine receptors.
Circadian regulation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Circardian Regulation ,[object Object],[object Object],[object Object],[object Object]
Circadian Regulation - DMH ,[object Object],[object Object],[object Object]
 
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FIN

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